CN104436067A - Traditional Chinese medicine capsule for treating neonatal erysipelas and preparation method of traditional Chinese medicine capsule - Google Patents
Traditional Chinese medicine capsule for treating neonatal erysipelas and preparation method of traditional Chinese medicine capsule Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine capsule for treating neonatal erysipelas. The traditional Chinese medicine capsule is prepared from the following medicinal materials in parts by weight: 10 parts of arisaema consanguineum schott, 10 parts of astragalus smicus pollen, 10 parts of tokyo violet, 25 parts of bear fat, 25 parts of rhizoma curcumae longae, 10 parts of liquorice, 25 parts of radix angelicae, 25 parts of saxifraga stolonifera, 10 parts of mangnolia officinalis, 5 parts of herba portulacae and 5 parts of dasyatis akajei. A clinical experiment proves that the significant efficacy of treating neonatal erysipelas is achieved by selecting proper medicinal materials at a proper ratio; and the traditional Chinese medicine capsule is high in recovery rate, short in average cure time, safe and free of a toxic or side effect.
Description
Technical field
the present invention relates to a kind of Chinese medicine, be specifically related to a kind ofly be used for the treatment of Chinese medicine capsules of neonate erysipelas and preparation method thereof.
Background technology
neonate erysipelas is a kind of acute skin infectious disease caused by hemolytic streptococcal infection, and red red as red with local skin, shape is as cloudlet, and migration is not decided to be feature.Clinical visible high fever, local skin is red and swollen, scorching hot, harden, and marginal swell, is rapidly to and around expands, clear-cut margin, and slightly pressure is faded.Blood leukocytes increases, and how at more than 20X109/L, classifying occupies the majority with neutrophilic granulocyte.The visible streptococcus growth of hemoculture.Treatment for neonate erysipelas still lacks the effective medicine of generally recognized as safe at present.
Summary of the invention
the present invention aims to provide and is a kind ofly used for the treatment of Chinese medicine capsules of neonate erysipelas and preparation method thereof, by selecting suitable medical material and proportioning thereof, reaches the remarkable efficacy contributing to neonate erysipelas Rehabilitation, and safe without toxic side effect.
in order to achieve the above object, the present invention is by the following technical solutions: a kind of Chinese medicine capsules being used for the treatment of neonate erysipelas, is prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 8 ~ 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 8 ~ 10 parts, light lobe common violet 8 ~ 10 parts, Adeps Ursus 20 ~ 25 parts, 20 ~ 25 parts, Rhizoma Curcumae Longae, 8 ~ 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 20 ~ 25 parts, Herba Saxifragae 20 ~ 25 parts, Cortex Magnoliae Officinalis 8 ~ 10 parts, Herba Portulacae 0 ~ 5 part, 0 ~ 5 part, Carnis Dasyatis akajei gallbladder.
as preferably, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts.
as preferably, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, 5 parts, Carnis Dasyatis akajei gallbladder.
as preferably, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, Herba Portulacae 5 parts.
as preferably, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, Herba Portulacae 5 parts, 5 parts, Carnis Dasyatis akajei gallbladder.
a kind of preparation method being used for the treatment of the Chinese medicine capsules of neonate erysipelas, comprise the steps: that Rhizoma Arisaematis, light lobe common violet, Rhizoma Curcumae Longae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Herba Saxifragae, Cortex Magnoliae Officinalis, Herba Portulacae are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) Adeps Ursus, Carnis Dasyatis akajei gallbladder pulverization are put into container after mixing homogeneously with Pollen Astragali Melilotoidis (Pollen Astragali Sinici) again, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
the pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
rhizoma Arisaematis [source] this product is the dry tuber of aroid Rhizoma Arisaematis.[return through] returns lung, liver, spleen channel.[function cures mainly] drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.
pollen Astragali Melilotoidis (Pollen Astragali Sinici) [nature and flavor] is bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
light lobe common violet [source] this product is the dry herb of Violaceae Chinese violet.[nature and flavor] bitter, acrid, cold.[return through] GUIXIN, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
the fatty oil that Adeps Ursus [source] is ursidae animal black bear or brown bear.[nature and flavor] sweet in the mouth; Warm in nature.[return through] spleen channel.[function cures mainly] tonifying deficiency; Profit skin; Removing food stagnancy; Parasite killing.Main deficient win is thin; Migratory arthralgia meciless muscle arteries and veins contraction is anxious; Gather; Acne vulgaris; Tinea; Bald in vain; Ecthyma.
rhizoma Curcumae Longae [source] this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae.[nature and flavor] are pungent, bitter, temperature.[return through] returns spleen, Liver Channel.The circulation of qi promoting of [function cures mainly] removing blood stasis, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.
radix Glycyrrhizae [source] dicotyledon pulse family Radix Glycyrrhizae, root and rhizome [function cures mainly] invigorating the spleen and replenishing QI of Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
the dry root of the Radix Angelicae Dahuricae [source] the umbellate form section plant Radix Angelicae Dahuricae.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
herba Saxifragae [source] this product is the herb of saxifragaceae plant Herba Saxifragae.[nature and flavor] bitter, acrid, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing.For fever of children, cough and asthma; Otitis media is controlled in external, and auricle festers, furuncle, furuncle and phyma, eczema.
the dry dried bark of Cortex Magnoliae Officinalis [source] Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.The expectorant of [function cures mainly] dampness, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
herba Portulacae [source] this product is portulacaceous plant Herba Portulacae, with all herbal medicine.[nature and flavor] acid, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.
carnis Dasyatis akajei gallbladder [source] medical material Ji Yuan: be the gallbladder of the red ray of ray section animal, Dasyatis uarnak (Forskal) and sibling species thereof.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] stomach invigorating; Dissipating blood stasis.Main stomachache; Traumatic injury; Jaundice due to damp-heat.
the present invention compared with prior art, has following beneficial effect:
1, Chinese medicine preparation of the present invention for treatment neonate erysipelas cure rate high and safe without toxic side effect, and can related complication be prevented.Between formula medical material, compatibility is rigorous, the synergistic function produced after not only making full use of compatibility of drugs, and avoid pharmaceutically-active mutual Hangzhoupro short of money and offset or slacken original effect, more note selecting the compatibility of drugs application that can alleviate or eliminate the strong of medicine or toxic and side effects, firmly avoid the mutual compatibility of medicine and produce toxic reaction or strong side effect.By scientific compatibility, not only complicated in the state of an illness, when fast changing, the present invention can not only effectively organize and implement reasonable treatment, make it reach medicine to remove to disease, and for prevent disease progress, in invade internal organs also have good preventive effect, very valuable on clinical application.
, Chinese medicine preparation of the present invention selects high-quality Chinese crude drug to make, selected medical material compatibility is suitable, meets Chinese medicine and modern medicine study is theoretical, and utilize modern medicine pharmaceutical technology to make, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease, clinic is applied.
Detailed description of the invention
in order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
embodiment 1
take: Rhizoma Arisaematis 10 grams, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 grams, light lobe common violet 10 grams, Adeps Ursus 25 grams, 25 grams, Rhizoma Curcumae Longae, 10 grams, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 grams, Herba Saxifragae 25 grams, Cortex Magnoliae Officinalis 10 grams, Herba Portulacae 5 grams, 5 grams, Carnis Dasyatis akajei gallbladder.Comprise the steps: that Rhizoma Arisaematis, light lobe common violet, Rhizoma Curcumae Longae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Herba Saxifragae, Cortex Magnoliae Officinalis, Herba Portulacae are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) Adeps Ursus, Carnis Dasyatis akajei gallbladder pulverization are put into container after mixing homogeneously with Pollen Astragali Melilotoidis (Pollen Astragali Sinici) again, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal.
embodiment 2
take: Rhizoma Arisaematis 10 grams, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 grams, light lobe common violet 10 grams, Adeps Ursus 25 grams, 25 grams, Rhizoma Curcumae Longae, 10 grams, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 grams, Herba Saxifragae 25 grams, Cortex Magnoliae Officinalis 10 grams, Herba Portulacae 5 grams, 5 grams, Carnis Dasyatis akajei gallbladder.
preparation method, the usage and dosage of the present embodiment are identical with embodiment 1.
embodiment 3
take: Rhizoma Arisaematis 10 grams, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 grams, light lobe common violet 10 grams, Adeps Ursus 25 grams, 25 grams, Rhizoma Curcumae Longae, 10 grams, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 grams, Herba Saxifragae 25 grams, Cortex Magnoliae Officinalis 10 grams, Herba Portulacae 5 grams, 5 grams, Carnis Dasyatis akajei gallbladder.
preparation method, the usage and dosage of the present embodiment are identical with embodiment 1.
clinical data:
1, case selection:
selected the routine clinical observation of neonate erysipelas patient 42 in my section's diagnosis and treatment since 2013, clinical symptoms all meets the diagnostic criteria of erysipelas in " the disease of tcm Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine's promulgation in 1994.Patient is divided into treatment group and matched group two groups at random, treatment group 21 example, matched group 21 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
, medicament selection:
treatment group takes the Chinese medicinal capsule preparation obtained by the embodiment of the present invention 1, oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 7 days, be 1 course for the treatment of, take 1 ~ 2 course for the treatment of continuously.
matched group gives penicillin 8,000,000/d intravenous drip, the course for the treatment of same treatment group.
2 courses for the treatment of are treated in continuous smelting, contrast two groups of curative effects.
, efficacy determination:
(1) cure: affected part swelling pain disappears, and redness disappears, and neighbouring lymph node obviously reduces.
(2) take a turn for the better: affected part pain and swelling alleviate, red and swollen range shorter.
(3) do not heal: swelling pain red and swollen symptom in affected part is without improvement.
, result:
select in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 18 examples, take a turn for the better 3 examples, and do not heal 0 example, cure rate 85.71%, total effective rate 100.00%.The average cure time of curing case is 5.4 days.
cure 16 examples in matched group, take a turn for the better 3 examples, and do not heal 2 examples, cure rate 76.19%, total effective rate 90.47%.The average cure time of curing case is 8.9 days.
above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and the restriction not to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (6)
1. one kind is used for the treatment of the Chinese medicine capsules of neonate erysipelas, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 8 ~ 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 8 ~ 10 parts, light lobe common violet 8 ~ 10 parts, Adeps Ursus 20 ~ 25 parts, 20 ~ 25 parts, Rhizoma Curcumae Longae, 8 ~ 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 20 ~ 25 parts, Herba Saxifragae 20 ~ 25 parts, Cortex Magnoliae Officinalis 8 ~ 10 parts, Herba Portulacae 0 ~ 5 part, 0 ~ 5 part, Carnis Dasyatis akajei gallbladder.
2. a kind of Chinese medicine capsules being used for the treatment of neonate erysipelas according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts.
3. a kind of Chinese medicine capsules being used for the treatment of neonate erysipelas according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, 5 parts, Carnis Dasyatis akajei gallbladder.
4. a kind of Chinese medicine capsules being used for the treatment of neonate erysipelas according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, Herba Portulacae 5 parts.
5. a kind of Chinese medicine capsules being used for the treatment of neonate erysipelas according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Arisaematis 10 parts, Pollen Astragali Melilotoidis (Pollen Astragali Sinici) 10 parts, light lobe common violet 10 parts, Adeps Ursus 25 parts, 25 parts, Rhizoma Curcumae Longae, 10 parts, Radix Glycyrrhizae, the Radix Angelicae Dahuricae 25 parts, Herba Saxifragae 25 parts, Cortex Magnoliae Officinalis 10 parts, Herba Portulacae 5 parts, 5 parts, Carnis Dasyatis akajei gallbladder.
6. one kind is used for the treatment of the preparation method of the Chinese medicine capsules of neonate erysipelas, it is characterized in that, comprise the steps: that Rhizoma Arisaematis, light lobe common violet, Rhizoma Curcumae Longae, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Herba Saxifragae, Cortex Magnoliae Officinalis, Herba Portulacae are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) Adeps Ursus, Carnis Dasyatis akajei gallbladder pulverization are put into container after mixing homogeneously with Pollen Astragali Melilotoidis (Pollen Astragali Sinici) again, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
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| CN1931353A (en) * | 2006-09-27 | 2007-03-21 | 贵州师范大学 | Curcuma extract and its prepn process, medicine composition and use |
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| Title |
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| 《大众医学》编辑部: "《养生月谈》", 31 August 2014 * |
| 刘云峣等: "《中国历代中医格言大观》", 31 March 1992 * |
| 马振友: "《最新皮肤科药物手册》", 30 June 2008 * |
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