CN104324194A - Traditional Chinese medicine preparation for treating diabetic nephropathy - Google Patents
Traditional Chinese medicine preparation for treating diabetic nephropathy Download PDFInfo
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- CN104324194A CN104324194A CN201410694448.8A CN201410694448A CN104324194A CN 104324194 A CN104324194 A CN 104324194A CN 201410694448 A CN201410694448 A CN 201410694448A CN 104324194 A CN104324194 A CN 104324194A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine preparation for treating diabetic nephropathy. The traditional Chinese medicine preparation is prepared from the following medicinal materials in parts by weight: 8 parts of atratylodes rhizome, 8 parts of radix scrophulariae, 8 parts of sesame, 8 parts of silkworm cocoon, 15 parts of tragacanth, 15 parts of Chinese yam, 10 parts of Angelica sinensis, 15 parts of Mirabilis himalaica, 8 parts of Ligusticum wallichii, 8 parts of shark liver oil, 6 parts of root of Wedelia chinensis, 12 parts of fructus rosae laevigatae, 10 parts of Yunnan madder, 6 parts of rhizome of dryopteris filix-mas and 5 parts of cubeb litsea tree. The clinical experiment proves that proper medicinal materials and ratios thereof are selected, so that the clinical symptoms of the diabetic nephropathy can be improved, and the traditional Chinese medicine preparation can achieve the effects of obviously reducing urine protein, reducing blood sugar and delaying deterioration of renal functions.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of diabetic nephropathy.
Background technology
Diabetic nephropathy is one of most important complication of diabetic.The sickness rate of China is also in rising trend, has become the second reason of End-stage renal disease at present, has been only second to various glomerulonephritis.Because it exists complicated metabolism disorder, once develop into End-stage renal disease, often more thorny than the treatment of other kidney diseases, therefore control is in time for delaying the significant of diabetic nephropathy.Clinically to the treatment of this disease, generally based on doctor trained in Western medicine, but most of medicine effect does not show, and the therapeutic effect for diabetic nephropathy is not remarkable.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine preparation for the treatment of diabetic nephropathy, it selects medical material compatibility suitable, meet Chinese medicine and modern medicine study theoretical, not only can improve the clinical symptoms of diabetic nephropathy, more obviously can reduce urine protein, blood sugar lowering, delay the deterioration of renal function.
In order to achieve the above object, the present invention is by the following technical solutions: a kind of Chinese medicine preparation for the treatment of diabetic nephropathy, is prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts, cubeb litsen tree 0 ~ 6 part.
As preferably, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts.
As preferably, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts, cubeb litsen tree 4 ~ 6 parts.
As preferably, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 8 ~ 9 parts, Radix Scrophulariae 8 ~ 9 parts, Semen Sesami 8 ~ 9 parts, Bombyx bombycis 8 ~ 9 parts, tragacanth 15 ~ 16 parts, Rhizoma Dioscoreae 15 ~ 16 parts, Radix Angelicae Sinensis lO ~ 11 part, Radix Mirabilis himalaicae 15 ~ 16 parts, Rhizoma Chuanxiong 8 ~ 9 parts, shark hepatic 8 ~ 9 parts, root 6 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 12 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 10 ~ 11 part, droplet are dripped and spent 6 ~ 7 parts, cubeb litsen tree 5 ~ 6 parts.
As preferably, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 8 parts, Radix Scrophulariae 8 parts, Semen Sesami 8 parts, Bombyx bombycis 8 parts, tragacanth 15 parts, Rhizoma Dioscoreae 15 parts, Radix Angelicae Sinensis lO part, Radix Mirabilis himalaicae 15 parts, Rhizoma Chuanxiong 8 parts, shark hepatic 8 parts, root 6 parts of bleeding, Fructus Rosae Laevigatae 12 parts, Rubiayunnanensis (Franch.) Dlels 10 part, droplet are dripped and spent 6 parts, cubeb litsen tree 5 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of diabetic nephropathy, comprise the steps: that Rhizoma Atractylodis, Radix Scrophulariae, Bombyx bombycis, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Radix Mirabilis himalaicae, Rhizoma Chuanxiong, root of bleeding, Fructus Rosae Laevigatae, Rubiayunnanensis (Franch.) Dlels, a flower, cubeb litsen tree are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) shark hepatic, tragacanth, Semen Sesami are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of diabetic nephropathy of the present invention.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
The dry rhizome of Rhizoma Atractylodis [source] feverfew Atractylodes lancea (Thunb.) DC..[function cures mainly] is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Radix Scrophulariae [source] this product is the dry root of goatweed Radix Scrophulariae.[nature and flavor] are sweet, bitter, salty, are slightly cold.[return through] returns lung, stomach, kidney channel.[function cures mainly] removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Bombyx bombycis [nature and flavor] sweet in the mouth; Warm in nature.[return through] spleen channel.[function cures mainly] stops blooding; Quench the thirst; Detoxification sore treatment.Main discharging fresh blood stool; Drench pain hematuria; Metrorrhagia; To quench one's thirst taking fluids profusely; Regurgitation leaf is eaten; Carbuncle difficulty in discharging of pus; Chancre.
Tragacanth [source] is leguminous plant Calculus Bovis from Northwest of China stilbene and the glue fat belonging to his kind of plant together.[nature and flavor] are flat, partially wet, lightly seasoned.[function cures mainly] corrects the evil of hundred tastes, raw moistening lung, cough-relieving, hemostasis, sore throat relieving profit larynx, tonneau urine, and antiinflammatory is healed skin ulcer.Cure mainly dryness and partially contain caused various diseases, as dryness of the lung dry cough, dry laryngopharynx, hoarseness, intestinal ulcer, urethra skin infection, burning sensation during urination.
Rhizoma Dioscoreae [source] this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.[nature and flavor] are sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.
The dry root of Radix Angelicae Sinensis [source] umbelliferae angelica.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The root that Radix Mirabilis himalaicae [source] is Nyctaginaceae plant Radix Mirabilis himalaicae.[nature and flavor] are warm in nature, and sweet in the mouth is micro-pungent.[function cures mainly] invigorating spleen and kidney, diuretic.
The dry rhizome of Rhizoma Chuanxiong [source] samphire Rhizoma Chuanxiong.[nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.
Root [source] Compositae that bleeds bleeds root, is used as medicine with root.[habitats distribution] Guangdong, Sichuan, Yunnan, Guizhou.[nature and flavor] are sweet, warm.[function cures mainly] warming the meridian, dredging collateral, nourishes blood, and invigorates blood circulation, the kidney invigorating.Cure mainly lumbago due to renal deficiency, deficient qi and blood, traumatic injury.
Fructus Rosae Laevigatae [source] this product is the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae.[nature and flavor] are sour, sweet, puckery, flat.[return through] returns kidney, bladder, large intestine channel.[function cures mainly] controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.
Rubiayunnanensis (Franch.) Dlels [source] Rubiaceae Rubiayunnanensis (Franch.) Dlels, with all herbal medicine.[nature and flavor] are sweet, flat.[function cures mainly] is enriched blood and is invigorated blood circulation, expelling wind and removing dampness, softening the hard mass removing mass.Cure mainly anemia, traumatic injury, chronic gastritis, lipoma, menoxenia.
Drip flower [source] Gesneriaceae Corallium Japonicum Kishinouye lettuce carex Corallium Japonicum Kishinouye lettuce tongue, with all herbal medicine.Xia Qiu gathers, and dries.[nature and flavor] are light, flat.[function cures mainly] spleen invigorating, hemostasis, blood stasis dispelling.For infantile malnutrition, traumatic injury and knife injury.
The root that cubeb litsen tree [source] is canella cubeb litsen tree and bark.Peppery, the micro-hardship of [nature and flavor] taste, puckery, fragrant, hot in nature.[function cures mainly] invigorating the stomach and promoting digestion, expelling wind and cold pain relieving.
Shark hepatic [source] medical material Ji Yuan: the cod-liver oil that liver or liver for Hexanchiade animal homalocephalus notorhynchus maculatus and other sharks obtain through refinement.[nature and flavor] sweet in the mouth; Warm in nature.[function cures mainly] spleen invigorating QI invigorating; Nourishing the liver to improve visual acuity; Removing toxic substances sore.Dominant eye conjunctival xerosis; Nyctalopia; Osteomalacia; Burn and scald; Skin ulcer; Traumatic surface is not healed for a long time.
Semen Sesami [another name] linum, spunyarn, huge victory, sesame.[source] this product is the dry mature seed of Pedaliaceae (Pedaliaceae) Sesamum plant sesame.[nature and flavor] are sweet, flat.[return through] returns liver, kidney, large intestine channel.[function cures mainly] invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
The present invention compared with prior art, has following beneficial effect:
1, Chinese medicine preparation of the present invention there is tonifying speen and tonifying kidney, invigorate blood circulation astringent or styptic treatment for spontaneous sweating, reduce effect of blood glucose, the high and safe without toxic side effect for the treatment of diabetic nephropathy cure rate.Wherein: Rhizoma Atractylodis, Radix Scrophulariae, Bombyx bombycis, tragacanth share has significant hypoglycemic activity, in addition Rhizoma Dioscoreae supplementing QI and nourishing YIN, Radix Scrophulariae removing heat from blood YIN nourishing, Rhizoma Dioscoreae replenishing QI to invigorate the spleen, Radix Angelicae Sinensis, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling lead to kidney network, Fructus Rosae Laevigatae strengthening spleen, tonifying kidney, restrain astringent or styptic treatment for spontaneous sweating, mutually benefit is helped again with Radix Mirabilis himalaicae, root of bleeding, a flower, cubeb litsen tree, get the effect of shark hepatic, Semen Sesami spleen invigorating nourishing the liver, all medicines share, not only can improve the clinical symptoms of diabetic nephropathy, more obviously can reduce urine protein, blood sugar lowering, delay the deterioration of renal function.
2, Chinese medicine preparation of the present invention selects high-quality Chinese crude drug to make, and selected medical material compatibility is suitable, meets Chinese medicine and modern medicine study theory, and utilize modern medicine pharmaceutical technology to make, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease, clinic is applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Rhizoma Atractylodis 8 grams, Radix Scrophulariae 8 grams, Semen Sesami 8 grams, Bombyx bombycis 8 grams, tragacanth 15 grams, Rhizoma Dioscoreae 15 grams, Radix Angelicae Sinensis 10 grams, Radix Mirabilis himalaicae 15 grams, Rhizoma Chuanxiong 8 grams, shark hepatic 8 grams, to bleed root 6 grams, Fructus Rosae Laevigatae 12 grams, Rubiayunnanensis (Franch.) Dlels 10 grams, drip and spend 6 grams, cubeb litsen tree 5 grams, be prepared by following processing step: by Rhizoma Atractylodis, Radix Scrophulariae, Bombyx bombycis, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Radix Mirabilis himalaicae, Rhizoma Chuanxiong, to bleed root, Fructus Rosae Laevigatae, Rubiayunnanensis (Franch.) Dlels, drip flower, cubeb litsen tree puts into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract, again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract, finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract, merge three extracting solution, filter, obtain filtrate for subsequent use, (2) shark hepatic, tragacanth, Semen Sesami are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use, (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of diabetic nephropathy of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 30 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously.
Embodiment 2
Take: Rhizoma Atractylodis 7 grams, Radix Scrophulariae 7 grams, Semen Sesami 7 grams, Bombyx bombycis 7 grams, tragacanth 14 grams, Rhizoma Dioscoreae 14 grams, Radix Angelicae Sinensis 9 grams, Radix Mirabilis himalaicae 14 grams, Rhizoma Chuanxiong 7 grams, shark hepatic 7 grams, root 5 grams of bleeding, Fructus Rosae Laevigatae 11 grams, Rubiayunnanensis (Franch.) Dlels 9 gram, droplet are dripped and spent 5 grams.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
Take: Rhizoma Atractylodis 9 grams, Radix Scrophulariae 9 grams, Semen Sesami 9 grams, Bombyx bombycis 9 grams, tragacanth 16 grams, Rhizoma Dioscoreae 16 grams, Radix Angelicae Sinensis 11 grams, Radix Mirabilis himalaicae 16 grams, Rhizoma Chuanxiong 9 grams, shark hepatic 9 grams, root 7 grams of bleeding, Fructus Rosae Laevigatae 13 grams, Rubiayunnanensis (Franch.) Dlels 11 gram, droplet are dripped and spent 7 grams, cubeb litsen tree 6 grams.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of diabetic nephropathy, select the routine clinical observation of diabetic nephropathy patient 60 of diagnosis and treatment since 2010.All cases are clarified a diagnosis as diabetic nephropathy through clinical and renal needle biopsy.Patient is divided into treatment group and matched group two groups at random, treatment group 30 example, matched group 30 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes the Chinese medicinal capsule preparation obtained by the embodiment of the present invention 1, oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 30 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously.
Matched group gives the treatments such as blood sugar lowering, blood pressure lowering, blood fat reducing and infection control according to the respective state of an illness; Within 30 days, be 1 course for the treatment of, treat 2 ~ 3 courses for the treatment of continuously.
3, efficacy determination:
(1) cure: 24h urine protein is normal.
(2) take a turn for the better: 24h urine protein comparatively treats front decline.
(3) do not heal: 24h urine protein comparatively treats front unchanged or rising.
4, result:
Select in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 10 examples, take a turn for the better 15 examples, and do not heal 5 examples, cure rate 33.3%, total effective rate 83.3%.
Cure 4 examples in matched group, take a turn for the better 15 examples, and do not heal 11 examples, cure rate 13.3%, total effective rate 63.3%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (6)
1. treat the Chinese medicine preparation of diabetic nephropathy for one kind, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts, cubeb litsen tree 0 ~ 6 part.
2. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts.
3. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 7 ~ 9 parts, Radix Scrophulariae 7 ~ 9 parts, Semen Sesami 7 ~ 9 parts, Bombyx bombycis 7 ~ 9 parts, tragacanth 14 ~ 16 parts, Rhizoma Dioscoreae 14 ~ 16 parts, Radix Angelicae Sinensis 9 ~ 11 parts, Radix Mirabilis himalaicae 14 ~ 16 parts, Rhizoma Chuanxiong 7 ~ 9 parts, shark hepatic 7 ~ 9 parts, root 5 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 11 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 9 ~ 11 part, droplet are dripped and spent 5 ~ 7 parts, cubeb litsen tree 4 ~ 6 parts.
4. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 8 ~ 9 parts, Radix Scrophulariae 8 ~ 9 parts, Semen Sesami 8 ~ 9 parts, Bombyx bombycis 8 ~ 9 parts, tragacanth 15 ~ 16 parts, Rhizoma Dioscoreae 15 ~ 16 parts, Radix Angelicae Sinensis lO ~ 11 part, Radix Mirabilis himalaicae 15 ~ 16 parts, Rhizoma Chuanxiong 8 ~ 9 parts, shark hepatic 8 ~ 9 parts, root 6 ~ 7 parts of bleeding, Fructus Rosae Laevigatae 12 ~ 13 parts, Rubiayunnanensis (Franch.) Dlels 10 ~ 11 part, droplet are dripped and spent 6 ~ 7 parts, cubeb litsen tree 5 ~ 6 parts.
5. a kind of Chinese medicine preparation for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Atractylodis 8 parts, Radix Scrophulariae 8 parts, Semen Sesami 8 parts, Bombyx bombycis 8 parts, tragacanth 15 parts, Rhizoma Dioscoreae 15 parts, Radix Angelicae Sinensis lO part, Radix Mirabilis himalaicae 15 parts, Rhizoma Chuanxiong 8 parts, shark hepatic 8 parts, root 6 parts of bleeding, Fructus Rosae Laevigatae 12 parts, Rubiayunnanensis (Franch.) Dlels 10 part, droplet are dripped and spent 6 parts, cubeb litsen tree 5 parts.
6. treat the preparation method of the Chinese medicine preparation of diabetic nephropathy for one kind, it is characterized in that, comprise the steps: that Rhizoma Atractylodis, Radix Scrophulariae, Bombyx bombycis, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Radix Mirabilis himalaicae, Rhizoma Chuanxiong, root of bleeding, Fructus Rosae Laevigatae, Rubiayunnanensis (Franch.) Dlels, a flower, cubeb litsen tree are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use;
(2) shark hepatic, tragacanth, Semen Sesami are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use;
(3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of diabetic nephropathy of the present invention.
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| CN105213716A (en) * | 2015-10-08 | 2016-01-06 | 刘凯 | A kind of Chinese medicine extract and application thereof for the treatment of diabetic nephropathy |
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| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
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| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
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