Background technology
Recurrent oral ulceration is called again " aphtha ", is a kind of take outbreak periodically repeatedly as the oral mucosa limitation ulcerative lesions of characteristics, but spontaneous recovery can occur in any position of oral mucosa.With the mucosa that lip, cheek, soft palate or the gums etc. in oral cavity are located, single or a plurality of circular or oval ulcer that differ in size occur, the greyish white or blue pseudomembrane ulcer of surface coverage, clear border, mucosa is red and little swollen on every side, and local causalgia is principal character.It easily recurs, the cycle is short, and very easily infects, such as untimely treatment, and the Relapse rate outbreak, it is lasting to delay, and also can transfer " behcet's syndrome " to, even involve internal organs, has caused great misery for patient's work and life.The recurrent oral ulceration cause of disease is complicated, and clinical treatment will be according to different inducements, and pointedly treatment could obtain good curative effect.As: remove psychentonia pressure, calmness, sleep peacefully, smoking cessation, wine etc.; Local for ulcer, can adopt the part to embrocate pain relieving, antiinflammatory promotes the medicine that heals.As: the cod-liver oil paste, the prednisone paste, nourishing yin shengjisan, ulcer ointment etc., perhaps local anaesthetics is embrocated in front part on the feed, to ease the pain; Or adopt hormone and antibiotic therapy with respite patient's misery, but the infringement that the toxic and side effects such as dysbacteriosis that easily form cause health.
The traditional Chinese medical science is thought: feelings will is unsuccessful and undermine heart spleen; Hyperactivity of fire caused by deficiency of YIN, pyretic toxicity is burnt bright, inner clip is damp and hot, on steam in mouth and the above-mentioned all diseases that arrive.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire, interior impairment of ZANG FU-organs intenseness of heat are the main causes of causing a disease, the main sick dirty heart and the spleen of being.
According to theory of Chinese medical science, for the pathogeny of recurrent oral ulceration, take heat clearing and damp drying, tonifying-Yin and nourishing-stomach, clearing away heart-fire as the Therapeutic Principle, carry out dialectical composition of prescription, to reach the purpose for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind ofly prepare conveniently, the medicine source is wide, cost is low, the Chinese medicine composition of evident in efficacy, reliable effect, the treatment recurrent oral ulceration that has no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of recurrent oral ulceration is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: Rhizoma Picrorhizae 10-30 part, Cortex Phellodendri 5-20 part, Flos Lonicerae 5-15 part, Cortex Moutan 10-30 part, Folium Eriobotryae 5-20 part, Rhizoma Pinelliae 5-20 part, Radix Scrophulariae 10-40 part, Rhizoma Zingiberis 5-20 part, Fructus Amomi 5-15 part, Fructus Gardeniae 5-20 part, Radix Ophiopogonis 5-15 part, Cortex Cinnamomi 5-20 part, Radix Astragali 5-15 part, Fructus Corni 10-40 part, Fructus Ligustri Lucidi 5-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Radix Scutellariae 5-20 part, Radix Glycyrrhizae 5-15 part.
The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of recurrent oral ulceration is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: 20 parts of Rhizoma Picrorhizae, 15 parts of Cortex Phellodendris, 10 parts of Flos Loniceraes, 25 parts of Cortex Moutans, 15 parts of Folium Eriobotryaes, 15 parts of the Rhizoma Pinelliaes, 30 parts of Radix Scrophulariaes, 15 parts of Rhizoma Zingiberiss, 10 parts of Fructus Amomis, 15 parts of Fructus Gardeniaes, 10 parts of Radix Ophiopogonis, 12 parts of Cortex Cinnamomis, 10 parts of the Radixs Astragali, 30 parts of Fructus Corni, 8 parts of Fructus Ligustri Lucidi, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Radix Scutellariaes, 8 parts in Radix Glycyrrhizae.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In the Chinese medicine composition of the present invention: Rhizoma Picrorhizae has reducing the asthenic fever, the effect of the infantile malnutrition with fever that disappears, heat clearing and damp drying, eliminating fire and detoxication; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging except the effect of steaming, skin ulcer is treated in detoxifcation; Flos Lonicerae has the effect of heat-clearing and toxic substances removing, wind-heat dissipating; Cortex Moutan has the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; Folium Eriobotryae has the effect of lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm; The Rhizoma Pinelliae has drying dampness to eliminate phlegm, the effect of stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Radix Scrophulariae has the effect of removing heat from blood YIN nourishing, eliminating fire and detoxication; Rhizoma Zingiberis has that warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the effect of warming the lung to resolve fluid-retention; Fructus Amomi has removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy;
Fructus Gardeniae has the effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Has the effect that YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire Radix Ophiopogonis; Cortex Cinnamomi have mend that fire is supporing yang, the effect of dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow; The Radix Astragali has that benefiting QI for strengthening the superficies, tonifying the lung spleen invigorating, arresting sweating take off admittedly, the effect of wind dispelling fortune poison; Fructus Corni has the effect of invigorating the liver and kidney, arresting seminal emission gas, solid collapse; Fructus Ligustri Lucidi has the merit that nourishing the liver and kidney, tonifying YIN nourish blood; The Pseudobulbus Bletillae (Rhizoma Bletillae) has the effect of astringing to arrest bleeding, detumescence and promoting granulation; Radix Scutellariae has the effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention; Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription.Drug component in the present composition is through dialectical compatibility, complements each other using, and has synergism, plays altogether the effect that clearing away heat-fire, YIN nourishing appetizing, detoxifcation are treated skin ulcer, detumescence and promoting granulation, recurrent oral ulceration reached the purpose for the treatment of both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, the medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the usefulness that is decocted in water for oral dose.Through the clinical practice checking, it is evident in efficacy, reliable effect, and the property of medicine is gentle, toxic and side effects do not occur, total effective rate 94.8%, cure rate reaches 38.4%.
The specific embodiment
The present invention will be further described below in conjunction with embodiment.
Embodiment 1
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, its raw material of Chinese medicine by following weight proportion forms: Rhizoma Picrorhizae 20g, Cortex Phellodendri 15g, Flos Lonicerae 10g, Cortex Moutan 25g, Folium Eriobotryae 15g, Rhizoma Pinelliae 15g, Radix Scrophulariae 30g, Rhizoma Zingiberis 15g, Fructus Amomi 10g, Fructus Gardeniae 15g, Radix Ophiopogonis 10g, Cortex Cinnamomi 12g, Radix Astragali 10g, Fructus Corni 30g, Fructus Ligustri Lucidi 8g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Scutellariae 15g, Radix Glycyrrhizae 8g.
Embodiment 2
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, its raw material of Chinese medicine by following weight proportion forms: Rhizoma Picrorhizae 15g, Cortex Phellodendri 20g, Flos Lonicerae 5g, Cortex Moutan 15g, Folium Eriobotryae 10g, Rhizoma Pinelliae 20g, Radix Scrophulariae 10g, Rhizoma Zingiberis 12g, Fructus Amomi 5g, Fructus Gardeniae 20g, Radix Ophiopogonis 5g, Cortex Cinnamomi 20g, Radix Astragali 5g, Fructus Corni 20g, Fructus Ligustri Lucidi 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Scutellariae 5g, Radix Glycyrrhizae 10g.
Embodiment 3
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, its raw material of Chinese medicine by following weight proportion forms: Rhizoma Picrorhizae 10g, Cortex Phellodendri 15g, Flos Lonicerae 12g, Cortex Moutan 20g, Folium Eriobotryae 8g, Rhizoma Pinelliae 5g, Radix Scrophulariae 40g, Rhizoma Zingiberis 10g, Fructus Amomi 15g, Fructus Gardeniae 10g, Radix Ophiopogonis 15g, Cortex Cinnamomi 10g, Radix Astragali 15g, Fructus Corni 25g, Fructus Ligustri Lucidi 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 8g, Radix Scutellariae 20g, Radix Glycyrrhizae 5g.
Embodiment 4
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, its raw material of Chinese medicine by following weight proportion forms: Rhizoma Picrorhizae 30g, Cortex Phellodendri 10g, Flos Lonicerae 8g, Cortex Moutan 30g, Folium Eriobotryae 5g, Rhizoma Pinelliae 10g, Radix Scrophulariae 20g, Rhizoma Zingiberis 5g, Fructus Amomi 8g, Fructus Gardeniae 12g, Radix Ophiopogonis 8g, Cortex Cinnamomi 5g, Radix Astragali 20g, Fructus Corni 10g, Fructus Ligustri Lucidi 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Radix Scutellariae 10g, Radix Glycyrrhizae 15g.
Embodiment 5
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, its raw material of Chinese medicine by following weight proportion forms: Rhizoma Picrorhizae 25g, Cortex Phellodendri 5g, Flos Lonicerae 15g, Cortex Moutan 10g, Folium Eriobotryae 20g, Rhizoma Pinelliae 12g, Radix Scrophulariae 15g, Rhizoma Zingiberis 20g, Fructus Amomi 12g, Fructus Gardeniae 5g, Radix Ophiopogonis 15g, Cortex Cinnamomi 15g, Radix Astragali 8g, Fructus Corni 40g, Fructus Ligustri Lucidi 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Radix Scutellariae 12g, Radix Glycyrrhizae 12g.
Chinese medicine composition in embodiment of the invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, add cold water and cover powder, soaked 15~20 minutes, add water again and do not have approximately 8 centimetres of powder, decoct.Adopt intense fire to decoct at a simmer, boil rear with slow fire boiling 20~30 minutes; Second decocts, and adds water and does not have approximately 6 centimetres of powder, the water rear decoction 15~20 minutes of boiling.Twice decoction extracting juice that removes slag merges.
A kind of Chinese medicine composition for the treatment of recurrent oral ulceration, clinical efficacy is summed up:
One, general data: this Chinese medicine composition is applied to clinical observation case 98 examples, male 46 examples wherein, women 52 examples, 15~65 years old age.The shortest person of the course of disease 2 days, elder reaches 60 days, average 8 days.
Two, diagnostic criteria:
1, the ulcer of single or several diameters 3~5mm occurs with oral mucosa, scorching hot pain is cardinal symptom;
2, onset is very fast, healing in general about 7 days, if down here, then the course of disease prolongs.More normal easily recurrence after;
3, examination of mouth: stomatocace is shown shallow, and is circular or oval, 1~2 at least of quantity, and more than 10 at most, the surface has faint yellow secretions to adhere to, and mucosa is mostly congested around the ulcer.
Three, usage and dosage: during clinical practice, the amounts of components in the compositions is taken the circumstances into consideration increase and decrease according to patient's body weight, age and symptom.Five days is a course for the treatment of, one day potion, twice extracting juice of decocting be 400ml approximately, minute early, late twice half an hour ante cibum warm taking.The thing that period in a medicine avoids pungent food, stimulates.
Four, criterion of therapeutical effect:
1, cure: the oral ulcer healing, local without sense of discomfort;
2, take a turn for the better: although recurrence is arranged during aphtha, quantity reduces, and degree alleviates;
3, do not heal: aphtha symptom and ulcer are without significant change.
Five, therapeutic effect: in this clinical observation case, take medicine 1-6 the course for the treatment of, cure 67 examples, 26 examples that take a turn for the better, 5 examples do not heal.Toxic and side effects does not occur during the treatment.
Six, model case:
Case 1:
Yuan, the woman, 42 years old, body of the tongue was light red, and there is indentation on both sides, and there is many places ulcer on oral cavity palate and tongue both sides, and are not of uniform size, little red.Pulse condition is superficially and silly soft.Vexed not peaceful, diet is subjected to certain influence because mouth is painful, defecates slightly half congealed, and is the eumenorrhea, remaining without other disease of obviously giving prominence to.Take 1 course for the treatment of of medicament of Chinese medicine composition preparation of the present invention, symptom disappears substantially, aphtha healing residue small size ulcer; Continue to strengthen 2 courses for the treatment of, all symptoms all disappear, and cure.
Case 2:
Willow, man, 17 years old, pain in mouthful, xerostomia, feverish sensation in the palms and soles.2 of aphthas, diameter are less than 0.5 centimetre, and be slight congested on every side.Red tongue, tongue is few, thready and rapid pulse.Take 1 course for the treatment of of medicament of Chinese medicine composition preparation of the present invention, the aphtha area diminishes, and xerostomia is improved; Continuous take 1 course for the treatment of, symptom all disappears, recovery from illness.