CN104435234A - 一种治疗妇科口腔干燥症的药物组合物 - Google Patents

一种治疗妇科口腔干燥症的药物组合物 Download PDF

Info

Publication number
CN104435234A
CN104435234A CN201410741724.1A CN201410741724A CN104435234A CN 104435234 A CN104435234 A CN 104435234A CN 201410741724 A CN201410741724 A CN 201410741724A CN 104435234 A CN104435234 A CN 104435234A
Authority
CN
China
Prior art keywords
parts
herba
radix
pharmaceutical composition
flos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410741724.1A
Other languages
English (en)
Inventor
董梅
薛迎峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410741724.1A priority Critical patent/CN104435234A/zh
Publication of CN104435234A publication Critical patent/CN104435234A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/616—Echinodermata, e.g. starfish, sea cucumbers or sea urchins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及一种治疗妇科口腔干燥症的药物组合物，它包含下列重量份的物质：合欢花50-100份、远志50-100份、甘草50-150份、罗汉果10-100份、栀子50-100份等。本发明所述的药物组合物互相影响，协同作用，治疗妇科口腔干燥症的效果显著，值得临床推广。

Description

一种治疗妇科口腔干燥症的药物组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗妇科口腔干燥症的药物组合物。
背景技术
妇女口腔干燥症中医称“干燥综合征”，是较为常见的疾病。口腔干燥症临床表症为：口腔干燥、味觉减退、鼻腔干燥结痂、嗅觉不灵、声音嘶哑，也可波及眼、皮肤、波及眼可见干燥性眼角炎、眼内异物感、烧灼感、眼痒、眼干。波及皮肤及阴道有干燥、烧灼感、紫瘫、红斑、皮下小结等。
发明内容
本发明的目的是提供一种治疗妇科口腔干燥症的药物组合物。
为了实现本发明的目的，本发明提供一种治疗妇科口腔干燥症的药物组合物，它包含下列重量份的物质：合欢花50-100份、远志50-100份、甘草50-150份、罗汉果10-100份和栀子50-100份。
优选地，本发明所述的治疗妇科口腔干燥症的药物组合物包含下列重量份的物质：合欢花70份、远志80份、甘草100份、罗汉果50份和栀子60份。
优选地，本发明所述的治疗妇科口腔干燥症的药物组合物还包含下列重量份的物质：矩形叶鼠刺100-200份、金盏菊100-200份、荡皮参100-200份、红花100-200份、荩草100-200份、连翘100-200份、胡枝子100-200份、荔枝草100-200份、儿茶100-200份、南瓜子100-200份、柳叶菜100-200份、莱菔子100-200份、罗布麻100-200份、金边桑100-200份、兔毛蒿100-200份、赤芍100-200份、狗牙根100-200份、白术100-200份、马蹄蕨100-200份、乳香100-200份、牛膝100-200份、香石藤100-200份、草龙100-200份和香茶菜100-200份。
优选地，本发明所述的治疗妇科口腔干燥症的药物组合物还包含下列重量份的物质：矩形叶鼠刺180份、金盏菊150份、荡皮参170份、红花130份、荩草130份、连翘120份、胡枝子140份、荔枝草150份、儿茶130份、南瓜子160份、柳叶菜150份、莱菔子110份、罗布麻130份、金边桑150份、兔毛蒿120份、赤芍160份、狗牙根150份、白术110份、马蹄蕨110份、乳香120份、牛膝130份、香石藤120份、草龙130份和香茶莱130份。
优选地，所述药物组合物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
本发明还提供组合物在制备治疗妇科口腔干燥症的药物中的用途，所述组合物包含下列重量份的物质：合欢花50-100份、远志50-100份、甘草50-150份、罗汉果10-100份和栀子50-100份。
优选地，所述组合物包含下列重量份的物质：合欢花70份、远志80份、甘草100份、罗汉果50份和栀子60份。
优选地，所述组合物还包含下列重量份的物质：矩形叶鼠刺100-200份、金盏菊100-200份、荡皮参100-200份、红花100-200份、荩草100-200份、连翘100-200份、胡枝子100-200份、荔枝草100-200份、儿茶100-200份、南瓜子100-200份、柳叶菜100-200份、莱菔子100-200份、罗布麻100-200份、金边桑100-200份、兔毛蒿100-200份、赤芍100-200份、狗牙根100-200份、白术100-200份、马蹄蕨100-200份、乳香100-200份、牛膝100-200份、香石藤100-200份、草龙100-200份和香茶菜100-200份。
优选地，所述组合物还包含下列重量份的物质：矩形叶鼠刺180份、金盏菊150份、荡皮参170份、红花130份、荩草130份、连翘120份、胡枝子140份、荔枝草150份、儿茶130份、南瓜子160份、柳叶菜150份、莱菔子110份、罗布麻130份、金边桑150份、兔毛蒿120份、赤芍160份、狗牙根150份、白术110份、马蹄蕨110份、乳香120份、牛膝130份、香石藤120份、草龙130份和香茶菜130份。
优选地，所述药物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
目前已公认“整体观念”、“辨证施治”、“复方使用”、“复方配伍用药如用兵”是中医最科学最有效的几大优势，其中“复方配伍用药如用兵”是非常科学的中医药原创理论。中医组方中各药如行兵布阵那样环环相扣的严密配伍，是其优于西药配方的有效手段。中医方剂理论认为，每一方剂，不仅需要根据病因病机选择合适的药物组合物妥善配伍，同时也应该符合方剂的基本结构，即“君、臣、佐、使”的组方配伍理论，所谓“君、臣、佐、使”的组方配伍，就是其建立在对疾病病机的全方位判断基础上的科学配比。中医用方通过多环节、多靶点整合调节的生物学机制，可以取得比西药更持久、更绿色天然无毒副作用的治疗效果，而这种疗效是建立在上述中医传统原创理论的正确指导之上的，本发明正遵循了这一原则。
在本发明的组合物中，矩形叶鼠刺和金盏菊清热凉血，滋阴补阳，补脾止泻，养肺益阴，为君药；合欢花、远志、荡皮参、红花、荩草、连翘养肾生津清热，生津止渴，渗湿利水，健脾和中，为臣药；罗汉果、栀子、胡枝子、荔枝草、儿茶、南瓜子、柳叶菜、莱菔子、罗布麻、金边桑、兔毛蒿、赤芍、狗牙根、白术、马蹄蕨、乳香、牛膝、香石藤、草龙、香茶菜具有清热凉血、活血化瘀等功能，为佐药；甘草调和诸药，为使药。
本发明所述的药物组合物互相影响，协同作用，相辅相成，共奏君臣佐使之功，治疗妇科口腔干燥症的效果显著，值得临床推广。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例 本发明的汤剂
称取合欢花70克、远志80克、甘草100克、罗汉果50克、栀子60克、矩形叶鼠刺180克、金盏菊150克、荡皮参170克、红花130克、荩草130克、连翘120克、胡枝子140克、荔枝草150克、儿茶130克、南瓜子160克、柳叶菜150克、莱菔子110克、罗布麻130克、金边桑150克、兔毛蒿120克、赤芍160克、狗牙根150克、白术110克、马蹄蕨110克、乳香120克、牛膝130克、香石藤120克、草龙130克和香茶菜130克，加入10升水，在装有冷凝管的烧瓶中加热回流3小时，然后过滤，得到滤液1和滤渣1；2)向滤渣1中加入4升水，在装有冷凝管的烧瓶中加热2小时，过滤，得到滤液2和滤渣2；3)合并所述滤液1、滤液2，冷却至室温，即得。
毒性试验
急性毒性试验：应用NIH小鼠60只，SPF级，雌雄各半，体重17～24g，进行急性毒性试验。小鼠随机分为两组，每组30只，即对照组和给药组，实验前禁食12小时；调整实施例中制备的汤剂，使得浓度为7.61g生药/ml，灌胃，灌胃容积为5ml/kg(即单次给予药物组合物量为38.05g生药/kg)，对照组给予等量生理盐水，一天给药2次，给药间隔时间6小时，给药后连续观察14天，并记录小鼠的毒性反应及死亡数。实验结果表明：与对照组比较，给药后小鼠未见明显差异，实验连续观察14天，小鼠全身状况、饮食、饮水、体重增长均正常。选择处死给药组小鼠，显微镜下检查：心、肝、肺、胃内及胸腺等重要脏器，未见异常改变。小鼠口服灌胃本发明的汤剂LD50＞38.05g生药/kg，每日最大给药量为76.1g生药/kg/日。本发明的药物临床用药量为6.67g生药/日/人，成人体重以60kg计，平均用药物组合物量为0.111g生药/kg/日。按体重计：小鼠(平均体重以21g计)口服灌胃本发明的中药的耐受量为临床用量的686倍。因此本发明内服的药物组合物急性毒性低，临床用药安全。
长期毒性试验：应用SD大鼠，体重200g±10g，雌雄各半。使用实施例中制备的汤剂来进行测试。配制高、中、低三个剂量组，分别为临床用药量的300、150、75倍，用含2重量％阿拉伯树胶的生理盐水1∶1混合。采用灌胃给药方式，连续用药16周(1.0ml/100g体重，每天2次)及停药4周后，结果表明：本发明药物对大鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响，脏器肉眼没有发现异样变化和组织学检查结果表明，用药16周及停药4周后，大鼠各个脏器均无明显改变。说明本发明内服的药物组合物对大鼠长期用药后毒性小，停药后也没有异样反应，应用安全。
实验例
诊断标准
1、以口腔干燥作为主要表现，口中苦涩，舌部运动不灵活，吞咽困难，口唇干裂、有鳞屑，口角易皲裂，常有严重进行性龋齿。同时还可伴有皮肤干燥、眼干、咽干、鼻腔干燥的症状。半数患者皮肤干燥，有鳞屑和痒感，因搔抓而苔癣化；眼干燥无泪，结膜充血，角膜干燥；上呼吸道黏膜萎缩，鼻黏膜干燥结痂。
2、半数以上的病人合并有类风湿性关节炎、贫血等全身性疾病。
3、唾液腺的改变为特征性变化，表现为淋巴细胞浸润，杂有浆轴胞，结缔组织增生，呈纤维化。
4、实验室检查：类风湿因子多为阳性。
选取2013年2月至2014年5月我院收治的妇科口腔干燥症患者50例。年龄在27-63岁，平均(41.3±5.9)岁。使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.67g生药/日/人。连续治疗3天。
疗效评价标准
临床痊愈：症状全部消失，理化检查结果正常；显效：主要症状部分消失，理化检查结果接近正常；无效：主要症状及理化检查没有改变。
结果
经过治疗，50例患者中，临床痊愈41例，显效9例，总有效率为100％。
典型病例
李某，38岁，女，身体健康，1998年来我院口腔科就诊。患者自诉口咽干燥、味觉减退、鼻腔干结痂，嗅觉不灵，声音嘶哑，曾用抗生素及维生素类药物，病程已达半年之久未见好转。使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.67g生药/日/人。连续治疗3天。症状全部消失，理化检查结果正常，病情痊愈。
胡某某，33岁，女，口腔干燥，味觉减退，眼痒眼干，声音嘶哑等，使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.67g生药/日/人。连续治疗3天。症状全部消失，理化检查结果正常，病情痊愈。

Claims (10)

1.一种治疗妇科口腔干燥症的药物组合物，其特征在于，它包含下列重量份的物质：合欢花50-100份、远志50-100份、甘草50-150份、罗汉果10-100份和栀子50-100份。
2.根据权利要求1所述的治疗妇科口腔干燥症的药物组合物，其特征在于，它包含下列重量份的物质：合欢花70份、远志80份、甘草100份、罗汉果50份和栀子60份。
3.根据权利要求1或2所述的治疗妇科口腔干燥症的药物组合物，其特征在于，它还包含下列重量份的物质：矩形叶鼠刺100-200份、金盏菊100-200份、荡皮参100-200份、红花100-200份、荩草100-200份、连翘100-200份、胡枝子100-200份、荔枝草100-200份、儿茶100-200份、南瓜子100-200份、柳叶菜100-200份、莱菔子100-200份、罗布麻100-200份、金边桑100-200份、兔毛蒿100-200份、赤芍100-200份、狗牙根100-200份、白术100-200份、马蹄蕨100-200份、乳香100-200份、牛膝100-200份、香石藤100-200份、草龙100-200份和香茶菜100-200份。
4.根据权利要求3所述的治疗妇科口腔干燥症的药物组合物，其特征在于，它还包含下列重量份的物质：矩形叶鼠刺180份、金盏菊150份、荡皮参170份、红花130份、荩草130份、连翘120份、胡枝子140份、荔枝草150份、儿茶130份、南瓜子160份、柳叶菜150份、莱菔子110份、罗布麻130份、金边桑150份、兔毛蒿120份、赤芍160份、狗牙根150份、白术110份、马蹄蕨110份、乳香120份、牛膝130份、香石藤120份、草龙130份和香茶菜130份。
5.根据权利要求1所述的治疗妇科口腔干燥症的药物组合物，其特征在于，所述药物组合物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
6.组合物在制备治疗妇科口腔干燥症的药物中的用途，其特征在于，所述组合物包含下列重量份的物质：合欢花50-100份、远志50-100份、甘草50-150份、罗汉果10-100份和栀子50-100份。
7.根据权利要求6所述的用途，其特征在于，所述组合物包含下列重量份的物质：合欢花70份、远志80份、甘草100份、罗汉果50份和栀子60份。
8.根据权利要求6或7所述的用途，其特征在于，所述组合物还包含下列重量份的物质：矩形叶鼠刺100-200份、金盏菊100-200份、荡皮参100-200份、红花100-200份、荩草100-200份、连翘100-200份、胡枝子100-200份、荔枝草100-200份、儿茶100-200份、南瓜子100-200份、柳叶菜100-200份、莱菔子100-200份、罗布麻100-200份、金边桑100-200份、兔毛蒿100-200份、赤芍100-200份、狗牙根100-200份、白术100-200份、马蹄蕨100-200份、乳香100-200份、牛膝100-200份、香石藤100-200份、草龙100-200份和香茶菜100-200份。
9.根据权利要求8所述的用途，其特征在于，所述组合物还包含下列重量份的物质：矩形叶鼠刺180份、金盏菊150份、荡皮参170份、红花130份、荩草130份、连翘120份、胡枝子140份、荔枝草150份、儿茶130份、南瓜子160份、柳叶菜150份、莱菔子110份、罗布麻130份、金边桑150份、兔毛蒿120份、赤芍160份、狗牙根150份、白术110份、马蹄蕨110份、乳香120份、牛膝130份、香石藤120份、草龙130份和香茶菜130份。
10.根据权利要求6所述的用途，其特征在于，所述药物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
CN201410741724.1A 2014-12-05 2014-12-05 一种治疗妇科口腔干燥症的药物组合物 Pending CN104435234A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410741724.1A CN104435234A (zh) 2014-12-05 2014-12-05 一种治疗妇科口腔干燥症的药物组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410741724.1A CN104435234A (zh) 2014-12-05 2014-12-05 一种治疗妇科口腔干燥症的药物组合物

Publications (1)

Publication Number Publication Date
CN104435234A true CN104435234A (zh) 2015-03-25

Family

ID=52882496

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410741724.1A Pending CN104435234A (zh) 2014-12-05 2014-12-05 一种治疗妇科口腔干燥症的药物组合物

Country Status (1)

Country Link
CN (1) CN104435234A (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012153677A (ja) * 2011-01-28 2012-08-16 Nippon Zettoc Co Ltd 口腔用組成物
CN103340799A (zh) * 2013-07-15 2013-10-09 柳州两面针股份有限公司 金钮扣提取物在制备口腔护理用品中的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012153677A (ja) * 2011-01-28 2012-08-16 Nippon Zettoc Co Ltd 口腔用組成物
CN103340799A (zh) * 2013-07-15 2013-10-09 柳州两面针股份有限公司 金钮扣提取物在制备口腔护理用品中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王玉贤等: "《增液汤》", 31 January 2013, 中药医药科技出版社 *

Similar Documents

Publication Publication Date Title
CN100369613C (zh) 一种治疗和改善慢性疲劳综合症的组合物及其制备方法
CN104338078A (zh) 一种治疗妊娠期肝内胆汁淤积症的药物组合物
CN102488838B (zh) 治疗病毒性心肌炎的中药组合物
CN104491733A (zh) 一种中药制剂用于制备治疗贫血、气虚乏力药物中的用途
CN111840456A (zh) 用于治疗呼吸系统疾病的中药组合物
CN104257800A (zh) 一种治疗痤疮的药剂
CN102106993B (zh) 一种治疗脂肪肝的中药组合物及其制备方法
CN104491459A (zh) 一种治疗肿瘤的中药组合物
CN108498755A (zh) 治疗心脑血管疾病的中药组合物及其制备方法和用途
CN104173946A (zh) 一种用于治疗慢性胃炎的药茶
CN104547105A (zh) 一种降血糖的药剂
CN104435234A (zh) 一种治疗妇科口腔干燥症的药物组合物
CN102204956B (zh) 一种用于中风恢复期的中药组合物及其制备方法
CN104523854A (zh) 一种治疗流产后月经失调的药物组合物
CN104147317A (zh) 一种治疗男性不育症的药剂
CN104587389A (zh) 一种治疗颈肩腰腿痛的中药组合物
CN104474073B (zh) 一种护理产后尿潴留的药剂
CN104586914A (zh) 一种治疗脂肪肝的药剂
CN104491077A (zh) 一种治疗类风湿性关节炎的药物组合物
CN103239652B (zh) 治疗慢性肾脏疾病的药物组合物及其制备方法和应用
CN101181342A (zh) 具有抗肝癌活性的药物组合物
CN104306517A (zh) 一种治疗风湿性关节炎的药剂
CN105853582A (zh) 一种含有艾叶的治疗胆石症的药物制剂及其制备方法
CN104147423A (zh) 一种治疗中风后手足麻木的汤药
CN100333777C (zh) 改善放化疗后肠胃功能的药物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150325