CN104306517A - 一种治疗风湿性关节炎的药剂 - Google Patents
一种治疗风湿性关节炎的药剂 Download PDFInfo
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Abstract
本发明涉及一种治疗风湿性关节炎的药剂，它包含下列重量份的物质：山莓200-500份、川山橙根100-300份、女菀100-300份、牛毛七100-200份、水蓼150-300份、白苋100-300份、白花鬼针草150-300份、老鼠刺100-200份、老枪谷根100-200份、扭肚藤100-200份、旱柳50-200份和钩栗100-300份。本发明所述的药剂互相影响，协同作用，治疗风湿性关节炎效果显著，值得临床推广。
Description
技术领域
本发明涉及医药领域，具体来说涉及一种治疗风湿性关节炎的药剂。
背景技术
风湿性关节炎是临床上一种常见的风湿性疾病，作为一种慢性或急性结缔组织炎症，其具有复发率高、能够侵犯心脏的特点。风湿性关节炎的典型临床表现就是风湿热，主要表现为游走性关节炎、轻度或中度发热等。
发明内容
本发明的目的是提供一种治疗风湿性关节炎的药剂。
为了实现本发明的目的，本发明提供一种治疗风湿性关节炎的药剂，它包含下列重量份的物质：山莓200-500份、川山橙根100-300份、女菀100-300份、牛毛七100-200份、水蓼150-300份、白苋100-300份、白花鬼针草150-300份、老鼠刺100-200份、老枪谷根100-200份、扭肚藤100-200份、旱柳50-200份和钩栗100-300份。
优选地，本发明所述的治疗风湿性关节炎的药剂包含下列重量份的物质：山莓260份、川山橙根180份、女菀200份、牛毛七180份、水蓼160份、白苋200份、白花鬼针草160份、老鼠刺130份、老枪谷根150份、扭肚藤130份、旱柳90份和钩栗150份。
优选地，本发明所述的治疗风湿性关节炎的药剂包含下列重量份的物质：山莓350份、川山橙根130份、女菀240份、牛毛七160份、水蓼210份、白苋280份、白花鬼针草220份、老鼠刺160份、老枪谷根120份、扭肚藤170份、旱柳130份和钩栗230份。
优选地，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
本发明还提供药剂在制备治疗风湿性关节炎的药物中的用途，所述药剂包含下列重量份的物质：山莓200-500份、川山橙根100-300份、女菀100-300份、牛毛七100-200份、水蓼150-300份、白苋100-300份、白花鬼针草150-300份、老鼠刺100-200份、老枪谷根100-200份、扭肚藤100-200份、旱柳50-200份和钩栗100-300份。
优选地，所述药剂包含下列重量份的物质：山莓260份、川山橙根180份、女菀200份、牛毛七180份、水蓼160份、白苋200份、白花鬼针草160份、老鼠刺130份、老枪谷根150份、扭肚藤130份、旱柳90份和钩栗150份。
优选地，所述药剂包含下列重量份的物质：山莓350份、川山橙根130份、女菀240份、牛毛七160份、水蓼210份、白苋280份、白花鬼针草220份、老鼠刺160份、老枪谷根120份、扭肚藤170份、旱柳130份和钩栗230份。
优选地，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
目前已公认“整体观念”、“辨证施治”、“复方使用”、“复方配伍用药如用兵”是中医最科学最有效的几大优势，其中“复方配伍用药如用兵”是非常科学的中医药原创理论。中医组方中各药如行兵布阵那样环环相扣的严密配伍，是其优于西药配方的有效手段。中医方剂理论认为，每一方剂，不仅需要根据病因病机选择合适的药剂妥善配伍，同时也应该符合方剂的基本结构，即“君、臣、佐、使”的组方配伍理论，所谓“君、臣、佐、使”的组方配伍，就是其建立在对疾病病机的全方位判断基础上的科学配比。中医用方通过多环节、多靶点整合调节的生物学机制，可以取得比西药更持久、更绿色天然无毒副作用的治疗效果，而这种疗效是建立在上述中医传统原创理论的正确指导之上的，本发明正遵循了这一原则。
在本发明的组合物中，川山橙根和女菀能够清热解毒，为君药；山莓、牛毛七、水蓼、白苋能通络清热舒筋，为臣药；白花鬼针草、老鼠刺、老枪谷根、扭肚藤、旱柳可以达到通络化湿、清热透表的作用，为佐药；钩栗调和诸药，为使药。本发明所述的药物组合物互相影响，协同作用，相辅相成，共奏君臣佐使之功，治疗风湿性关节炎效果显著，值得临床推广。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例本发明的汤剂
称取山莓260克、川山橙根180克、女菀200克、牛毛七180克、水蓼160克、白苋200克、白花鬼针草160克、老鼠刺130克、老枪谷根150克、扭肚藤130克、旱柳90克和钩栗150克，加入8000毫升水，在装有冷凝管的烧瓶中加热回流5小时，然后过滤，得到滤液1和滤渣1；2)向滤渣1中加入5000毫升水，在装有冷凝管的烧瓶中加热3小时，过滤，得到滤液2和滤渣2；3)向滤渣2中加入3000毫升水，在装有冷凝管的烧瓶中加热1小时，过滤，得到滤液3和滤渣3；以及4)合并所述滤液1、滤液2和滤液3，冷却至室温，即得。
毒性试验
急性毒性试验：应用NIH小鼠60只，SPF级，雌雄各半，体重17～24g，进行急性毒性试验。小鼠随机分为两组，每组30只，即对照组和给药组，实验前禁食12小时；调整实施例中制备的汤剂，使得浓度为4.51g生药/ml，灌胃，灌胃容积为5ml/kg(即单次给药剂量为22.55g生药/kg)，对照组给予等量生理盐水，一天给药2次，给药间隔时间6小时，给药后连续观察14天，并记录小鼠的毒性反应及死亡数。实验结果表明：与对照组比较，给药后小鼠未见明显差异，实验连续观察14天，小鼠全身状况、饮食、饮水、体重增长均正常。选择处死给药组小鼠，显微镜下检查：心、肝、肺、胃内及胸腺等重要脏器，未见异常改变。小鼠口服灌胃本发明的汤剂LD50>22.55g生药/kg，每日最大给药量为45.1g生药/kg/日。本发明的药物临床用药量为6.39g生药/日/人，成人体重以60kg计，平均用药剂量为0.1065g生药/kg/日。按体重计：小鼠(平均体重以21g计)口服灌胃本发明的中药的耐受量为临床用量的423倍。因此本发明内服的药物组合物急性毒性低，临床用药安全。
长期毒性试验：应用SD大鼠，体重200g±10g，雌雄各半。使用实施例中制备的汤剂来进行测试。配制高、中、低三个剂量组，分别为临床用药量的300、150、75倍，用含2重量％阿拉伯树胶的生理盐水1:1混合。采用灌胃给药方式，连续用药16周(1.0ml/100g体重，每天2次)及停药4周后，结果表明：本发明药物对大鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响，脏器肉眼没有发现异样变化和组织学检查结果表明，用药16周及停药4周后，大鼠各脏器均无明显改变。说明本发明内服的药物组合物对大鼠长期用药后毒性小，停药后也没有异样反应，应用安全。
实验例
一般资料
选取2012年12月至2014年2月来我院治疗的风湿性关节炎患者一共100例。上述患者均符合风湿性关节炎的诊断标准，并以关节肿胀、大关节活动性受限、游走性多发性疼痛为主要临床症状。其中治疗组男50例，女50例。年龄为35-69岁。
使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.39g生药/日/人。连续治疗10天。
疗效评价标准
显效:治疗后，患者的临床症状消失或基本消失，肢体功能活动基本恢复正常；有效:患者的临床症状明显减轻，肢体功能活动有所恢复；无效:患者的临床症状及肢体功能活动没有明显变化。
结果
经过治疗，100例患者中，显效72例，有效26例，无效2例，总有效率98％。
典型案例
张某，男，60岁，离休干部。症状：自觉全身关节疼痛此起彼伏，骨节蹉跎。近几个月来疼痛加剧，见面虚浮，苍白无华，畏寒肢冷，两手肿胀指、腕、踝关节肿胀僵硬，尤其左膝关节弯曲不力，步履艰难。舌质红，苔薄白，舌根腻，脉细涩数。使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.39g生药/日/人。连续治疗10天。治疗后，患者的临床症状消失，肢体功能活动恢复正常，关节肿痛僵硬明显好转，左膝关节功能明显改善，患者可正常行走。
Claims (8)
1.一种治疗风湿性关节炎的药剂，其特征在于，它包含下列重量份的物质：山莓200-500份、川山橙根100-300份、女菀100-300份、牛毛七100-200份、水蓼150-300份、白苋100-300份、白花鬼针草150-300份、老鼠刺100-200份、老枪谷根100-200份、扭肚藤100-200份、旱柳50-200份和钩栗100-300份。
2.根据权利要求1所述的治疗风湿性关节炎的药剂，其特征在于，它包含下列重量份的物质：山莓260份、川山橙根180份、女菀200份、牛毛七180份、水蓼160份、白苋200份、白花鬼针草160份、老鼠刺130份、老枪谷根150份、扭肚藤130份、旱柳90份和钩栗150份。
3.根据权利要求1所述的治疗风湿性关节炎的药剂，其特征在于，它包含下列重量份的物质：山莓350份、川山橙根130份、女菀240份、牛毛七160份、水蓼210份、白苋280份、白花鬼针草220份、老鼠刺160份、老枪谷根120份、扭肚藤170份、旱柳130份和钩栗230份。
4.根据权利要求1所述的治疗风湿性关节炎的药剂，其特征在于，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
5.药剂在制备治疗风湿性关节炎的药物中的用途，其特征在于，所述药剂包含下列重量份的物质：山莓200-500份、川山橙根100-300份、女菀100-300份、牛毛七100-200份、水蓼150-300份、白苋100-300份、白花鬼针草150-300份、老鼠刺100-200份、老枪谷根100-200份、扭肚藤100-200份、旱柳50-200份和钩栗100-300份。
6.根据权利要求5所述的用途，其特征在于，所述药剂包含下列重量份的物质：山莓260份、川山橙根180份、女菀200份、牛毛七180份、水蓼160份、白苋200份、白花鬼针草160份、老鼠刺130份、老枪谷根150份、扭肚藤130份、旱柳90份和钩栗150份。
7.根据权利要求5所述的用途，其特征在于，所述药剂包含下列重量份的物质：山莓350份、川山橙根130份、女菀240份、牛毛七160份、水蓼210份、白苋280份、白花鬼针草220份、老鼠刺160份、老枪谷根120份、扭肚藤170份、旱柳130份和钩栗230份。
8.根据权利要求5所述的用途，其特征在于，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
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