CN104436049A - 一种治疗心脏病的中药组合物 - Google Patents

一种治疗心脏病的中药组合物 Download PDF

Info

Publication number
CN104436049A
CN104436049A CN201410736081.1A CN201410736081A CN104436049A CN 104436049 A CN104436049 A CN 104436049A CN 201410736081 A CN201410736081 A CN 201410736081A CN 104436049 A CN104436049 A CN 104436049A
Authority
CN
China
Prior art keywords
parts
radix
rhizoma
herba
fructus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410736081.1A
Other languages
English (en)
Inventor
刘世民
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410736081.1A priority Critical patent/CN104436049A/zh
Publication of CN104436049A publication Critical patent/CN104436049A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及一种治疗心脏病的中药组合物，它包含三七、黄连、人参、赤芍、三棱、莪术、白芍、白术、瓜蒌等。本发明所述的中药组合物互相影响，协同作用，治疗心脏病效果显著，值得临床推广。

Description

一种治疗心脏病的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗心脏病的中药组合物。
背景技术
心脏病是一类常见的循环系统疾病，具体病种很多。循环系统由心脏、血管和调节血液循环的神经体液组织构成，循环系统疾病也称为心血管病，在内科疾病中属常见病，最为多见，危害极大。而且西医目前并无特异性治疗药物。
发明内容
本发明的目的是提供一种治疗心脏病的中药组合物。
为了实现本发明的目的，本发明提供一种治疗心脏病的中药组合物，它包含下列重量份的物质：三七8-12份、黄连6-10份、人参6-10份、赤芍15-20份、三棱15-20份、莪术10-15份、白芍15-20份、白术10-15份、瓜蒌10-15份、牡丹皮15-20份、郁金15-20份、柴胡15-20份、丹参20-25份、香附20-25份、茯苓10-15份、元胡15-20份、槟榔10-15份、陈皮10-15份、山楂10-15份、生地20-25份、桂枝6-10份、枳壳10-15份、牛膝20-25份、甘草10-12份、佛手10-15份、厚朴10-15份和柏子仁20-25份。
优选地，本发明所述的治疗心脏病的中药组合物包含下列重量份的物质：三七10份、黄连8份、人参8份、赤芍18份、三棱16份、莪术12份、白芍18份、白术12份、瓜蒌12份、牡丹皮17份、郁金18份、柴胡16份、丹参22份、香附23份、茯苓12份、元胡18份、槟榔13份、陈皮12份、山楂12份、生地23份、桂枝8份、枳壳12份、牛膝22份、甘草11份、佛手13份、厚朴12份和柏子仁 22份。
优选地，本发明所述的治疗心脏病的中药组合物还包含下列重量份的物质：长管假茉莉1-20份、无风独摇草10-20份、水蓑衣5-15份、元宝草10-15份、云苔草1-15份、水翁花10-20份、双色龙胆5-10份、水晶花5-10份、石莽草5-15份、头巾草5-15份、抱树莲10-20份和虎皮草15-25份。
优选地，本发明所述的治疗心脏病的中药组合物还包含下列重量份的物质：长管假茉莉10份、无风独摇草15份、水蓑衣10份、元宝草12份、云苔草10份、水翁花15份、双色龙胆8份、水晶花8份、石莽草10份、头巾草10份、抱树莲15份和虎皮草20份。
优选地，所述中药组合物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
本发明还提供组合物在制备治疗心脏病的药物中的用途，所述组合物包含下列重量份的物质：三七8-12份、黄连6-10份、人参6-10份、赤芍15-20份、三棱15-20份、莪术10-15份、白芍15-20份、白术10-15份、瓜蒌10-15份、牡丹皮15-20份、郁金15-20份、柴胡15-20份、丹参20-25份、香附20-25份、茯苓10-15份、元胡15-20份、槟榔10-15份、陈皮10-15份、山楂10-15份、生地20-25份、桂枝6-10份、枳壳10-15份、牛膝20-25份、甘草10-12份、佛手10-15份、厚朴10-15份和柏子仁20-25份。
优选地，所述组合物包含下列重量份的物质：三七10份、黄连8份、人参8份、赤芍18份、三棱16份、莪术12份、白芍18份、白术12份、瓜蒌12份、牡丹皮17份、郁金18份、柴胡16份、丹参22份、香附23份、茯苓12份、元胡18份、槟榔13份、陈皮12份、山楂12份、生地23份、桂枝8份、枳壳12份、牛膝22份、甘草11份、佛手13份、厚朴12份和柏子仁22份。
优选地，所述组合物还包含下列重量份的物质：长管假茉莉1-20份、无风独摇草10-20份、水蓑衣5-15份、元宝草10-15份、云苔草1-15份、水翁花10-20份、双色龙胆5-10份、水晶花5-10份、石莽 草5-15份、头巾草5-15份、抱树莲10-20份和虎皮草15-25份。
优选地，所述组合物还包含下列重量份的物质：长管假茉莉10份、无风独摇草15份、水蓑衣10份、元宝草12份、云苔草10份、水翁花15份、双色龙胆8份、水晶花8份、石莽草10份、头巾草10份、抱树莲15份和虎皮草20份。
优选地，所述药物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
在本发明的组合物中，长管假茉莉、无风独摇草、水蓑衣、元宝草滋阴养血，以复脉气之本，为君药；云苔草、水翁花、三七、黄连、人参、赤芍、三棱补充正气辅助君药，以资气血生化之源，使健脾化血之功益著，为臣药；双色龙胆、水晶花、石莽草、头巾草、抱树莲、虎皮草、莪术、白芍、白术、瓜蒌、牡丹皮、郁金、柴胡、丹参、香附、茯苓、元胡、槟榔、陈皮、山楂、生地、桂枝、枳壳、牛膝、佛手、厚朴和柏子仁甘润养血，滋心阴、养心血、充血脉之力更强，为佐药；甘草调和诸药，为使药。
本发明所述的中药组合物互相影响，协同作用，相辅相成，共奏君臣佐使之功，治疗心脏病效果显著，值得临床推广。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例本发明的汤剂
称取三七10克、黄连8克、人参8克、赤芍18克、三棱16克、莪术12克、白芍18克、白术12克、瓜蒌12克、牡丹皮17克、郁金18克、柴胡16克、丹参22克、香附23克、茯苓12克、元胡18克、槟榔13克、陈皮12克、山楂12克、生地23克、桂枝8克、枳 壳12克、牛膝22克、甘草11克、佛手13克、厚朴12克、柏子仁22克、长管假茉莉10克、无风独摇草15克、水蓑衣10克、元宝草12克、云苔草10克、水翁花15克、双色龙胆8克、水晶花8克、石莽草10克、头巾草10克、抱树莲15克和虎皮草20克，加入5000毫升水，在装有冷凝管的烧瓶中加热回流3小时，然后过滤，得到滤液1和滤渣1；2)向滤渣1中加入3000毫升水，在装有冷凝管的烧瓶中加热2小时，过滤，得到滤液2和滤渣2；3)合并所述滤液1、滤液2，冷却至室温，即得。
毒性试验
急性毒性试验：应用NIH小鼠60只，SPF级，雌雄各半，体重17～24g，进行急性毒性试验。小鼠随机分为两组，每组30只，即对照组和给药组，实验前禁食12小时；调整实施例中制备的汤剂，使得浓度为7.36g生药/ml，灌胃，灌胃容积为5ml/kg(即单次给予中药组合物量为36.8g生药/kg)，对照组给予等量生理盐水，一天给药2次，给药间隔时间6小时，给药后连续观察14天，并记录小鼠的毒性反应及死亡数。实验结果表明：与对照组比较，给药后小鼠未见明显差异，实验连续观察14天，小鼠全身状况、饮食、饮水、体重增长均正常。选择处死给药组小鼠，显微镜下检查：心、肝、肺、胃内及胸腺等重要脏器，未见异常改变。小鼠口服灌胃本发明的汤剂LD50＞36.8g生药/kg，每日最大给药量为73.6g生药/kg/日。本发明的药物临床用药量为6.52g生药/日/人，成人体重以60kg计，平均用中药组合物量为0.109g生药/kg/日。按体重计：小鼠(平均体重以21g计)口服灌胃本发明的中药的耐受量为临床用量的675倍。因此本发明内服的中药组合物急性毒性低，临床用药安全。
长期毒性试验：应用SD大鼠，体重200g±10g，雌雄各半。使用实施例中制备的汤剂来进行测试。配制高、中、低三个剂量组，分别为临床用药量的300、150、75倍，用含2重量％阿拉伯树胶的生 理盐水1∶1混合。采用灌胃给药方式，连续用药16周(1.0ml/100g体重，每天2次)及停药4周后，结果表明：本发明药物对大鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响，脏器肉眼没有发现异样变化和组织学检查结果表明，用药16周及停药4周后，大鼠各个脏器均无明显改变。说明本发明内服的中药组合物对大鼠长期用药后毒性小，停药后也没有异样反应，应用安全。
实验例
临床资料
收治高血压性心脏病患者50例，其中男25例，女25例，年龄38-76岁，平均(56.3±12.7)岁。所有病例均符合1999年世界卫生组织/国际高血压联盟高血压诊断标准，且均行心电图及超声心动图检查，确诊为高血压性心脏病。
使用实施例中制备的汤剂来进行治疗，每日2次，本发明的药物临床用药量为6.52g生药/日/人。连续治疗1个月。
观察指标
患者入院后第1天、第7天及治疗1个月时清晨空腹抽静脉血检测NT-proBNP和Cys C。NT-proBNP采用胶体金/双向侧流免疫法检测，检测范围0-15000pg·mL-1；Cys C采用增强免疫比浊法检测，正常参考值范围0.63-1.44mg·L-1。所有患者入院后第1天及治疗1个月时行心脏彩超检查，并监测血压变化。
统计学处理 
对数据进行片方检验，应用SPSS 13.0软件处理。P＜0.05说明疗效差异显著，有统计学意义。
结果
经过治疗，患者不同时间NT-proBNP和Cys C比较结果见下表 
与本组第1天比较，*1P＜0.05；与本组第7天比较，*2P＜0.05
NT-proBNP在治疗第7天和治疗1个月水平均较治疗第1天显著降低(均P＜0.05)，并且治疗1个月后的水平均较治疗第7天显著降低(P＜0.05)。Cys C在治疗1个月水平均较治疗第1天和第七天显著降低(均P＜0.05)。说明本发明的药物具有明确的降压效果。

Claims (10)

1.一种治疗心脏病的中药组合物，其特征在于，它包含下列重量份的物质：三七8-12份、黄连6-10份、人参6-10份、赤芍15-20份、三棱15-20份、莪术10-15份、白芍15-20份、白术10-15份、瓜蒌10-15份、牡丹皮15-20份、郁金15-20份、柴胡15-20份、丹参20-25份、香附20-25份、茯苓10-15份、元胡15-20份、槟榔10-15份、陈皮10-15份、山楂10-15份、生地20-25份、桂枝6-10份、枳壳10-15份、牛膝20-25份、甘草10-12份、佛手10-15份、厚朴10-15份和柏子仁20-25份。
2.根据权利要求1所述的治疗心脏病的中药组合物，其特征在于，它包含下列重量份的物质：三七10份、黄连8份、人参8份、赤芍18份、三棱16份、莪术12份、白芍18份、白术12份、瓜蒌12份、牡丹皮17份、郁金18份、柴胡16份、丹参22份、香附23份、茯苓12份、元胡18份、槟榔13份、陈皮12份、山楂12份、生地23份、桂枝8份、枳壳12份、牛膝22份、甘草11份、佛手13份、厚朴12份和柏子仁22份。
3.根据权利要求1或2所述的治疗心脏病的中药组合物，其特征在于，它还包含下列重量份的物质：长管假茉莉1-20份、无风独摇草10-20份、水蓑衣5-15份、元宝草10-15份、云苔草1-15份、水翁花10-20份、双色龙胆5-10份、水晶花5-10份、石莽草5-15份、头巾草5-15份、抱树莲10-20份和虎皮草15-25份。
4.根据权利要求3所述的治疗心脏病的中药组合物，其特征在于，它还包含下列重量份的物质：长管假茉莉10份、无风独摇草15份、水蓑衣10份、元宝草12份、云苔草10份、水翁花15份、双色龙胆8份、水晶花8份、石莽草10份、头巾草10份、抱树莲15份和虎皮草20份。
5.根据权利要求1所述的治疗心脏病的中药组合物，其特征在于，所述中药组合物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
6.组合物在制备治疗心脏病的药物中的用途，其特征在于，所述组合物包含下列重量份的物质：三七8-12份、黄连6-10份、人参6-10份、赤芍15-20份、三棱15-20份、莪术10-15份、白芍15-20份、白术10-15份、瓜蒌10-15份、牡丹皮15-20份、郁金15-20份、柴胡15-20份、丹参20-25份、香附20-25份、茯苓10-15份、元胡15-20份、槟榔10-15份、陈皮10-15份、山楂10-15份、生地20-25份、桂枝6-10份、枳壳10-15份、牛膝20-25份、甘草10-12份、佛手10-15份、厚朴10-15份和柏子仁20-25份。
7.根据权利要求6所述的用途，其特征在于，所述组合物包含下列重量份的物质：三七10份、黄连8份、人参8份、赤芍18份、三棱16份、莪术12份、白芍18份、自术12份、瓜蒌12份、牡丹皮17份、郁金18份、柴胡16份、丹参22份、香附23份、茯苓12份、元胡18份、槟榔13份、陈皮12份、山楂12份、生地23份、桂枝8份、枳壳12份、牛膝22份、甘草11份、佛手13份、厚朴12份和柏子仁22份。
8.根据权利要求6或7所述的用途，其特征在于，所述组合物还包含下列重量份的物质：长管假茉莉1-20份、无风独摇草10-20份、水蓑衣5-15份、元宝草10-15份、云苔草1-15份、水翁花10-20份、双色龙胆5-10份、水晶花5-10份、石莽草5-15份、头巾草5-15份、抱树莲10-20份和虎皮草15-25份。
9.根据权利要求8所述的用途，其特征在于，所述组合物还包含下列重量份的物质：长管假茉莉10份、无风独摇草15份、水蓑衣10份、元宝草12份、云苔草10份、水翁花15份、双色龙胆8份、水晶花8份、石莽草10份、头巾草10份、抱树莲15份和虎皮草20份。
10.根据权利要求6所述的用途，其特征在于，所述药物可以是片剂、分散片、胶囊剂、软胶囊剂或汤剂。
CN201410736081.1A 2014-12-08 2014-12-08 一种治疗心脏病的中药组合物 Pending CN104436049A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410736081.1A CN104436049A (zh) 2014-12-08 2014-12-08 一种治疗心脏病的中药组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410736081.1A CN104436049A (zh) 2014-12-08 2014-12-08 一种治疗心脏病的中药组合物

Publications (1)

Publication Number Publication Date
CN104436049A true CN104436049A (zh) 2015-03-25

Family

ID=52883310

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410736081.1A Pending CN104436049A (zh) 2014-12-08 2014-12-08 一种治疗心脏病的中药组合物

Country Status (1)

Country Link
CN (1) CN104436049A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020861A1 (zh) * 2015-08-05 2017-02-09 浙江众康药业有限公司 头花蓼组合物抗幽门螺旋杆菌的用途
CN110292618A (zh) * 2018-03-21 2019-10-01 刘世民 一种治疗心脏病的中药组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110079564A (ko) * 2009-12-31 2011-07-07 (주)아모레퍼시픽 인삼 열매 추출물을 함유하는 미토콘드리아 활성화를 위한 조성물
CN103784820A (zh) * 2014-02-23 2014-05-14 曹小松 用于治疗心血瘀阻型冠心病的中药配方及中药胶囊

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110079564A (ko) * 2009-12-31 2011-07-07 (주)아모레퍼시픽 인삼 열매 추출물을 함유하는 미토콘드리아 활성화를 위한 조성물
CN103784820A (zh) * 2014-02-23 2014-05-14 曹小松 用于治疗心血瘀阻型冠心病的中药配方及中药胶囊

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
赵家勇: "冠心病中医治疗的体会", 《医学信息》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020861A1 (zh) * 2015-08-05 2017-02-09 浙江众康药业有限公司 头花蓼组合物抗幽门螺旋杆菌的用途
CN110292618A (zh) * 2018-03-21 2019-10-01 刘世民 一种治疗心脏病的中药组合物

Similar Documents

Publication Publication Date Title
CN103784933B (zh) 复发性口腔溃疡散
CN105287812A (zh) 一种治疗肠易激综合征的药物组合物及其用途
CN104436049A (zh) 一种治疗心脏病的中药组合物
CN103816431B (zh) 一种治疗缺铁性贫血的中药组合物
CN104491459A (zh) 一种治疗肿瘤的中药组合物
CN103933280A (zh) 一种治疗痰阻心脉型冠心病pci术后心绞痛的中药组合物及其应用
CN103520684B (zh) 一种降血糖的中药复合物
CN103536879B (zh) 一种治疗糖尿病的药物组合物以及制备方法
CN102204956B (zh) 一种用于中风恢复期的中药组合物及其制备方法
CN105727089A (zh) 含艾叶的药物组合物用于制备治疗肠易激综合症药物中的用途
CN103301380B (zh) 一种疏肝理气的中药组合物及其制备方法
CN104547105A (zh) 一种降血糖的药剂
CN104587389A (zh) 一种治疗颈肩腰腿痛的中药组合物
CN110292618A (zh) 一种治疗心脏病的中药组合物
CN102805795B (zh) 一种治疗急性胸胁部软组织损伤的中药组合物及其应用
CN102416147B (zh) 一种治疗戒毒人员的躁狂症的药物组合物
CN112546190B (zh) 一种治疗骨髓增生异常综合征的中药组合物及其制备方法和应用、蜜丸
CN102727730B (zh) 治疗男性不育的复方中药制剂及其制备方法
CN106729327A (zh) 一种治疗气血两虚兼肾虚型月经不调的中药组合物
CN104523854A (zh) 一种治疗流产后月经失调的药物组合物
CN105853796A (zh) 一种医治习惯性流产的药物组合物
CN105435047A (zh) 一种治疗原发性高血压的中药组合物及其应用
CN106511881B (zh) 一种用于补肾安胎的中药组合物及其制备方法
CN104940554A (zh) 一种治疗心脏病的中药组合物
CN105232609A (zh) 一种治疗功能性消化不良的中药组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150325