CN104435063B - A kind of external application promotes the pharmaceutical composition and its application of wound healing - Google Patents
A kind of external application promotes the pharmaceutical composition and its application of wound healing Download PDFInfo
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- CN104435063B CN104435063B CN201410817267.XA CN201410817267A CN104435063B CN 104435063 B CN104435063 B CN 104435063B CN 201410817267 A CN201410817267 A CN 201410817267A CN 104435063 B CN104435063 B CN 104435063B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses pharmaceutical compositions and its application that a kind of external application promotes wound healing, the composition is made of available auxiliary material on Chinese medical extract and pharmacy, the Chinese medical extract is oriental blueberry leaf extract, is made using the ethanol solution of volume fraction 90%-100% as solvent by cold soaking extraction method.Pharmaceutical composition of the invention can effectively facilitate anal fistula healing postoperative wound surface by external curing, shorten the healing time of anal fistula patient postoperative wound, and further increase cure rate.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of external application promotion wound healing and its application more particularly to a kind of promotion anuses
The pharmaceutical composition of fistula healing, belongs to medicating active ingredients new opplication technical field.
Background technique
The fast and effective healing of postoperative wound is to treat the key point of the perianals such as anal fistula.Due to the particular portion of disease
Position and the particularity of lesion and the special physiological function of the daily defecation of anus, the anal fistula surface of a wound have its own feature.These features
So that anal fistula wound healing becomes a more complicated process, there is the contradictions that pollution is repaired again with reparation, recontamination, no
Only need to keep the cleaning of the surface of a wound, will also diminish inflammation reaction, therefore wound healing is slow, the course for the treatment of is relatively long, patient suffering is big
It ridicules.
Summary of the invention
After being furtherd investigate by the active component to medicinal material, provide a kind of short treating period,
The pharmaceutical composition and medical usage for promoting wound healing that be curative for effect, having no toxic side effect.
The object of the present invention is achieved like this:
A kind of external application promotes the pharmaceutical composition of wound healing, by auxiliary material group available on Chinese medical extract and pharmacy
At, it is characterised in that: the Chinese medical extract is oriental blueberry leaf extract, and the ethanol solution with volume fraction 90%-100% is
Solvent is made by cold soaking extraction method.
Preferably, external application as described above promotes the pharmaceutical composition of wound healing, and the oriental blueberry leaf extract is by such as
Lower step is made: oriental blueberry leaf being placed in the ethanol solution of 8-12 times of volume fraction 90%-100%, normal temperature and pressure soak extraction
12-48h, filter paper filtering repeat to extract 2-4 times, and merging filtrate is concentrated to obtain the final product.
In a most preferred embodiment of the invention, external application as described above promotes the pharmaceutical composition of wound healing,
It is characterized by: the volume fraction of the ethanol solution is 95%.
It should be noted that oriental blueberry leaf raw material of the present invention selects Ericaceae blueberry platymiscium blueberry
The blade of Vaccinium bracteatum Thunb..
It is further preferred that external application as described above promotes the pharmaceutical composition of wound healing to be cream, ointment, coagulate
Jelly, lotion.
It is found by experimental study, the oriental blueberry leaf extract prepared by above-mentioned technique is promoting wound healing (especially anus
The healing of all postoperative wounds) in terms of it is significant in efficacy.Therefore, second object of the present invention is to provide a kind of new medical use,
Application of the i.e. above-mentioned Chinese medical extract in the drug that preparation promotes wound healing；Or above-mentioned Chinese medical extract promotees in preparation
The application in drug healed into crissum postoperative wound.
Compared with prior art, pharmaceutical composition of the invention can effectively facilitate anal fistula postoperative wound by external curing and be cured
It closes, shortens the healing time of anal fistula patient postoperative wound, and further increase cure rate.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention is further described, but of the invention
Protection scope be not limited to these examples.It is all to be included in this hair without departing substantially from the change of present inventive concept or equivalent substitute
Within bright protection scope.
Embodiment 1: cold soaking extraction method prepares oriental blueberry leaf dry cream
It weighs dry oriental blueberry leaf 150g, under normal temperature and pressure, is extracted using cold soaking extraction method, steps are as follows: by oriental blueberry leaf
After shredding, be placed in the ethyl alcohol of 1.5L volume fraction 95%, stirring make to be uniformly mixed, normal temperature and pressure soak extraction for 24 hours, filter paper mistake
Filter takes filter residue and the ethyl alcohol of 1.5L volume fraction 95% to continues to mix and extracts 18h, then filter paper filtering, takes filter residue and 1.5L volume
12h is extracted in the ethyl alcohol mixing of score 95%, and 3 filtrates are merged, and is evaporated concentration and dry cream is made, weigh 11.07g, calculate yield
It is 7.38%.
Embodiment 2: cold soaking extraction method prepares oriental blueberry leaf dry cream
It weighs dry oriental blueberry leaf 1kg, under normal temperature and pressure, is extracted using cold soaking extraction method, steps are as follows: oriental blueberry leaf is cut
After broken, be placed in the ethyl alcohol of 10L volume fraction 95%, stirring be it is uniformly mixed, normal temperature and pressure soak extraction for 24 hours, filter paper filtering,
It takes filter residue and the ethyl alcohol of 9L volume fraction 95% to continues to mix and extracts 18h, then filter paper filtering, take filter residue and 8L volume fraction 95%
Ethyl alcohol mixing extract 12h, 3 filtrates are merged, concentration is evaporated and dry cream is made, weigh 69.16g, calculating yield is 6.92%.
Embodiment 3: the preparation of ointment
Preparation process:
(1) the oriental blueberry leaf dry cream that the preparation of embodiment 2 is weighed by recipe quantity, crushes, sieves with 100 mesh sieve, spare；
(2) 1,2-PD for measuring recipe quantity, is added in 500ml distilled water, stirs evenly, and step (1) preparation is then added
Oriental blueberry leaf dried cream powder, be stirred to dissolve；
(3) carboxymethyl cellulose and glycerol are mixed, is then added in the solution that step (2) obtain, adds poly- sorb
Ester 80, stirs evenly, and places after being swelled into gel, adds the sodium hydrate aqueous solution containing ethylparaben, adds distillation
Water is to enough.
Embodiment 4: oriental blueberry leaf ointment studies the clinical trial of anal fistula postoperative wound
Initial surgery treats patient 60 of anal fistula, is classified as test group and control group by random digits table, and each 36
Example, through two groups of patients of statistical analysis, there was no significant difference in terms of gender, age, the course of disease and anal fistula parting, is comparable.
On the basis of conventional intravenous applications antibiotic is anti-infectious, postoperative same day control group patient 1:5000 potassium permanganate
Solution 1500ml hip bath treatment, method are as follows: it first smokes wash anus while hot, 15min in water is seated in after water temperature is down to 40-50 DEG C, it is early
Evening each 1 time.The postoperative same day, test group add oriental blueberry leaf ointment to treat using hot water hip-bath, method are as follows: add boiling water in basin
1500ml first smokes wash anus while hot, 15min in water is seated in after water temperature is down to 40-50 DEG C, and oriental blueberry leaf is then smeared at the surface of a wound
Ointment (preparation of the embodiment of the present invention 3), each 1 time sooner or later.
After two groups of patients treat 20d, count wound healing time, i.e., from the patients surgery same day, until the surface of a wound completely on
Number of days needed for skin.In addition, as follows referring to the curative effect evaluation standard that Standards for Diagnosis and Curative Effect of Chinese Medical Symptom formulates test: curing
It disappears for symptom, sign after treatment, wound heals completely；Improving is that symptom and sign improve, and wound does not heal completely；It is not cured
It is unchanged for symptom and sign.Two groups of curative effects and the statistical result of healing time are referring to table 1.
Table 1 is the comparitive study of the two groups
The healing time of 2 two groups of healing patients of table compares
Compared with the control group,*P < 0.05,**P < 0.01.
Claims (1)
1. a kind of application of Chinese medical extract in the pharmaceutical composition that preparation promotes the healing of crissum postoperative wound, wherein drug
Composition is made of available auxiliary material on Chinese medical extract and pharmacy, it is characterised in that: the Chinese medical extract is south candle
Leaf extract is made using ethanol solution as solvent by cold soaking extraction method；
The oriental blueberry leaf extract is made as follows: oriental blueberry leaf is placed in the ethanol solution of 8-12 times of volume fraction 95%
In, normal temperature and pressure soak extraction 12-48h, filter paper filtering repeats to extract 2-4 times, and merging filtrate is concentrated to obtain the final product；
The pharmaceutical composition is cream, and the 1L cream includes following component:
Oriental blueberry leaf dried cream powder 5g, carboxymethyl cellulose 60g, 1,2-PD 100ml, glycerol 200ml, ethylparaben 2g gather
80 50g of sorb ester, remaining is distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410817267.XA CN104435063B (en) | 2014-12-23 | 2014-12-23 | A kind of external application promotes the pharmaceutical composition and its application of wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410817267.XA CN104435063B (en) | 2014-12-23 | 2014-12-23 | A kind of external application promotes the pharmaceutical composition and its application of wound healing |
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| Publication Number | Publication Date |
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| CN104435063A CN104435063A (en) | 2015-03-25 |
| CN104435063B true CN104435063B (en) | 2019-03-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410817267.XA Active CN104435063B (en) | 2014-12-23 | 2014-12-23 | A kind of external application promotes the pharmaceutical composition and its application of wound healing |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972026A (en) * | 2010-09-21 | 2011-02-16 | 湖南凯勒迪化学科技有限公司 | Vaccinium bracteatum health product and preparation method thereof |
-
2014
- 2014-12-23 CN CN201410817267.XA patent/CN104435063B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972026A (en) * | 2010-09-21 | 2011-02-16 | 湖南凯勒迪化学科技有限公司 | Vaccinium bracteatum health product and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 乌饭树叶的化学成分研究;姚士;《中国优秀硕士论文全文数据库医药卫生科技辑》;20131215(第S2期);第39，84页 |
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| Publication number | Publication date |
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| CN104435063A (en) | 2015-03-25 |
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