CN104922304A - Externally-applied pharmaceutical composition for promoting healing of wound - Google Patents
Externally-applied pharmaceutical composition for promoting healing of wound Download PDFInfo
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- CN104922304A CN104922304A CN201510228330.0A CN201510228330A CN104922304A CN 104922304 A CN104922304 A CN 104922304A CN 201510228330 A CN201510228330 A CN 201510228330A CN 104922304 A CN104922304 A CN 104922304A
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Abstract
The invention discloses an externally-applied pharmaceutical composition for promoting the healing of a wound. The pharmaceutical composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight through water extraction and alcohol precipitation: 40 to 60 parts of sambucus chinensis, 33 to 46 parts of ramie leaves, 21 to 30 parts of common bluebeard herbs, 33 to 46 parts of dark plums, and 9 to 18 parts of rheum officinale. By using the externally-applied pharmaceutical composition for promoting the healing of the wound, the growth of a desmocyte and a newly born capillary can be promoted at the early stage of the healing of a trauma, and meanwhile, the infiltration of an inflammatory cell on the surface of the trauma can be restrained; the maturity of a granulation tissue, the formation of collagen and the proliferation of an epidermis can be promoted at the middle and later stages of the healing of the trauma, the excoriation of an old blood scab is quickened, and the effect of promoting the healing of the wound in skin is realized.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, in particular to a kind of externally-applied medicinal composition promoting wound healing.
Background technology
Wound is the function and integrity division organized in health.In daily life, the skin burn that accidentally causes because taking action or scald often can occur, the lighter's pain is rubescent, severe one is bubbled, and even exfoliation is downright bad, hinders to bone.As cured not in time, pathogenic factor and antibacterial invade, and not only can expand wound surface, skin ulceration, even cause infection, produce septicemia, cause death.At present, costly, treatment cycle is long for burn and scald, dermopathic western medical treatment, the difficulty and the burn and scald in rural area, dermatosis patient are sought medical advice, and process will scar not in time.Wound healing process of tissue reparation is realized by mutual network-linkeds of several basic link (key element) such as inflammatory cell reaction, repair cell reaction, extracellular matrix reaction and cytokine (somatomedin) effects.Empyrosis wound surface weakens due to inflammatory reaction, and cell proliferation is suppressed, and growth factor expression reduces, extracellular matrix habituation, local organization hypoxic-ischemic, the factors such as traumatic part accompanying infection, hemorrhage, edema, and the wound healing that slows down.
Summary of the invention
The object of the present invention is to provide a kind of externally-applied medicinal composition promoting wound healing.In order to realize object of the present invention, inventor, by furtheing investigate folk remedy and improving, finally obtains following technical scheme:
A kind of externally-applied medicinal composition promoting wound healing, this pharmaceutical composition is made up of active component and adjuvant, and wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 40-60 part, ramie leaf 33-46 part, Herba Caryopteridis Incanae 21-30 part, Fructus Mume 33-46 part, Radix Et Rhizoma Rhei 9-18 part.
Preferably, the externally-applied medicinal composition of promotion wound healing as above, wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 47-53 part, ramie leaf 36-42 part, Herba Caryopteridis Incanae 24-26 part, Fructus Mume 36-42 part, Radix Et Rhizoma Rhei 12-14 part.
In a prepreerence embodiment of the present invention, the externally-applied medicinal composition of promotion wound healing as above, wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 50 parts, ramie leaf 38 parts, Herba Caryopteridis Incanae 25 parts, Fructus Mume 38 parts, Radix Et Rhizoma Rhei 13 parts.
It should be noted that, traditional Chinese medicinal material raw materials source of the present invention is as follows: Herba Sambuci Chiensis selects the dry root of Caprifoliaceae Sambucus plant Herba Sambuci Chiensis Sambucus chinensis Lindl..Ramie leaf selects the dried leaves of contrayerva Boehmeria Boehmeria nivea (L.) Gaud. [Urtica nivea L.].Herba Caryopteridis Incanae selects the dry root of Verenaceae Herba Caryopteridis Incanae platymiscium Herba Caryopteridis Incanae Caryopteris incana (Thunb.) Miq..The dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb.et Zucc. selected by Fructus Mume.Radix Et Rhizoma Rhei selects the dry root of polygonum rheum palmatum Rheum palmatum L.
The preparation method of externally-applied medicinal composition of the present invention is as follows: get traditional Chinese medicinal material raw materials Herba Sambuci Chiensis 40-60 part, ramie leaf 33-46 part, Herba Caryopteridis Incanae 21-30 part, Fructus Mume 33-46 part, Radix Et Rhizoma Rhei 9-18 part, decoct with water and extract 1-4h, decocting liquid adds ethanol after concentrated makes volume alcohol content reach 70-78% (preferred 74-76%), 0 DEG C of cold preservation 12-48 hour, filter, filtrate recycling ethanol is also concentrated, dry, obtain Chinese medicine dried cream powder, then external medicine preparation is mixed with, as gel, lotion etc. with other pharmaceutic adjuvants.
Subcrustal healing is more common in skin injury, and its wound surface forms brown hard crust, heals to carry out under crust, and healing required time is long.Crust is unfavorable for that external used medicine permeates while having protective effect to wound, and clinical intervention measure is comparatively limited to.And Chinese medicinal formulae of the present invention has been applied to for many years clinical in clinic, community, for burning, scalding, skin mucosa damage treatment, clinical application for many years points out this medicine to accelerate multiple wound healing, there is stronger permeability simultaneously, also have obvious facilitation to rat skin large area incision subcrustal healing; The growth of fibroblast, new capillary vessel can be promoted in wound healing in early days, wound surface cell infiltration can be suppressed simultaneously; Wound healing middle and late stage can promote that granulation tissue is ripe, collagen is formed and epidermal hyperplasia, accelerates outmoded blood crusts and comes off, play the effect promoting skin wound healing; Its mechanism of action may be in wound healing different phase, plays a role by acting on multiple target spot.
Accompanying drawing explanation
Fig. 1 is each group of different time points rat skin wound healing percentage comparisons.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1: the preparation of the dry cream of Chinese medicine
Medical material formula: Herba Sambuci Chiensis 5.0kg, ramie leaf 3.8kg, Herba Caryopteridis Incanae 2.5kg, Fructus Mume 3.8kg, Radix Et Rhizoma Rhei 1.3kg.
Preparation method: the above-mentioned traditional Chinese medicinal material raw materials getting recipe quantity, cleans roguing, adds water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 12 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.15-1.20; Adding ethanol in proper amount makes volume alcohol content reach 75%, 0 DEG C of cold preservation 24 hours, and filter, filtrate recycling ethanol is also concentrated into the concentrated solution that relative density is 1.20, lyophilization, obtains the dry cream of Chinese medicine.
Embodiment 2: the preparation of Chinese medicine gel
Preparation technology:
(1) take the dry cream of Chinese medicine (5g or 10g) of embodiment 1 preparation by recipe quantity, pulverize, cross 100 mesh sieves, for subsequent use;
(2) measure the 1,2-PD of recipe quantity, add in 500ml distilled water, stir evenly, then add Chinese medicine dried cream powder prepared by step (1), be stirred to dissolve;
(3) carboxymethyl cellulose and glycerol are mixed, then add in the solution that step (2) obtains, stir, place after being swelled into gel, adding distil water is to enough.
Comparative example: the preparation of Blank gel agent
Preparation technology:
(1) measure the 1,2-PD of recipe quantity, add in 500ml distilled water, stir evenly;
(2) carboxymethyl cellulose and glycerol are mixed, then add in the solution that step (1) obtains, stir, place after being swelled into gel, adding distil water is to enough.
Embodiment 3: Chinese medicine gel promotes the experimentation of rat wound healing
Cleaning grade Wistar rat, male and female half and half, weight 180 ~ 220g, 8% sodium sulfide back depilation, returns cage after warm water cleaning.A preoperative late fasting water, operation chloral hydrate (300mg/kg) intraperitoneal injection of anesthesia on the same day 10%, with rat back spinal column for center line, designs the square wound surface that a symmetrical area is about 2.5cm × 2.5cm.After 75% alcohol disinfecting, by design complete resection skin, superficial fascia, until deep fascia superficial surface, thoroughly stop blooding.Press the capable shock stage recovery of 40mL/kg weight intraperitoneal injection of saline after wound, postoperative wound is sterilized, and single cage is fed, and freely drinks water and takes food.Following four groups are divided at random: model control group (using Blank gel prepared by comparative example) after rat modeling, Chinese medicine high dose group (uses Traditional Chinese medicine gel prepared by embodiment 2, specification 0.5%) and Chinese medicine low dose group (use embodiment 2 prepare Traditional Chinese medicine gel, specification 1.0%), often organize 12.Change dressings after modeling 0.5h, with medical cotton stick uniform application flap coverage, with 75% ethanol thorough disinfection at every turn before changing dressings, remove and carried out after left drug last time for each group.After administration, wound all keeps natural exposing state, returns cage after several minutes.Each group of morning every day, evening respectively change dressings 1 time.Within the 0th, 4,7,10,14 day after modeling success, cover skin with sterile transparent film, along the figure of wound Border delineation damaged area, cut respective graphical, take the film weight of damage wound area with analytical balance, calculate the slip of injured skin area.By following formulae discovery: film weight × 100% before wound healing area percentage=(before medication after film weight-medication film weight)/medication.
Experimental result shows, and each group rat none example in modeling and administration process is dead, and nothing obviously infects phenomenon, the mental status and active degree better.At once observe after modeling success, respectively form injury as seen and be about 2.5cm × 2.5cm size skin holostrome disappearance, until deep fascia, wound surface is moistening, and wound has a little blood and serosity to ooze out.Modeling the 4th day, the drying of each group Wound exudate forms thin layer crust, flap coverage, and wound all obviously reduces, and edge of wound shrinks.Swelling around model control group wound, there is a little sepage at edge.The each dosage of Traditional Chinese medicine gel forms that mouthful swelling is slight, and edge of wound secretions is few, and crust dry tack free, in kermesinus, that touches is softer.Modeling the 7th day, there is exudate on model control group surface, and edge of wound shrinks not obvious.Traditional Chinese medicine gel each dosage group partial rat wound surface crust local shedding, remains crust dry tack free, shrinkage, in kermesinus, the matter touched is tough, edge irregularity.Modeling the 14th day, model control group still has partial obsolescence crust not come off, and remainder is that granulation tissue is filled, and the moistening softness of wound surface, shrinks obviously.The each dosage of Traditional Chinese medicine gel is formed and is told old crust in person and come off completely, Wound Contraction and re-epithelialization remarkable, granulation tissue active growth, in cerise.During wound healing, the diversity of Traditional Chinese medicine gel high and low dose group wound healing effect is not obvious.In addition, incision Wound healing rate is shown in Fig. 1, and statistical analysis shows, and at each time point, Traditional Chinese medicine gel high and low dose group wound healing percentage rate is all apparently higher than model control group, and difference has statistical significance (P<0.01).
Claims (5)
1. one kind promotes the externally-applied medicinal composition of wound healing, this externally-applied medicinal composition is made up of active component and adjuvant, it is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 40-60 part, ramie leaf 33-46 part, Herba Caryopteridis Incanae 21-30 part, Fructus Mume 33-46 part, Radix Et Rhizoma Rhei 9-18 part.
2. the externally-applied medicinal composition of promotion wound healing according to claim 1, is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 47-53 part, ramie leaf 36-42 part, Herba Caryopteridis Incanae 24-26 part, Fructus Mume 36-42 part, Radix Et Rhizoma Rhei 12-14 part.
3. the externally-applied medicinal composition of promotion wound healing according to claim 2, is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba Sambuci Chiensis 50 parts, ramie leaf 38 parts, Herba Caryopteridis Incanae 25 parts, Fructus Mume 38 parts, Radix Et Rhizoma Rhei 13 parts.
4. according to any one of claim 1-3, promote the externally-applied medicinal composition of wound healing, it is characterized in that this pharmaceutical composition is gel, lotion.
5. according to any one of claim 1-3, promote the externally-applied medicinal composition of wound healing, it is characterized in that described traditional Chinese medicinal material raw materials Herba Caryopteridis Incanae is the root of Verenaceae Herba Caryopteridis Incanae platymiscium Herba Caryopteridis Incanae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194156A (en) * | 2015-10-28 | 2015-12-30 | 王振清 | Traditional Chinese medicine preparation for treating burns and scalds |
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
-
2015
- 2015-05-07 CN CN201510228330.0A patent/CN104922304A/en active Pending
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| 南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 张俊等: "康复新液对实验性大鼠皮肤切割伤痂下愈合的影响", 《天津医科大学学报》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194156A (en) * | 2015-10-28 | 2015-12-30 | 王振清 | Traditional Chinese medicine preparation for treating burns and scalds |
| CN105194156B (en) * | 2015-10-28 | 2020-07-17 | 王振清 | Chinese medicinal preparation for treating burn and scald |
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
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Effective date of registration: 20160226 Address after: 266000 Shandong province Qingdao City, Shandong Road No. 109 Building No. 3 3102 Taiwan Jing Applicant after: QINGDAO JINZHI HIGH AND NEW TECHNOLOGY CO., LTD. Address before: 266000 Shandong province Qingdao City, Shandong Road No. 109 Building No. 3 3102 Taiwan Jing Applicant before: Jiang Qin |
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Application publication date: 20150923 |