CN105232856B - A kind of pharmaceutical composition and its application for postoperative wound healing - Google Patents
A kind of pharmaceutical composition and its application for postoperative wound healing Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical compositions for postoperative wound healing and its application, the pharmaceutical composition to be extracted through decocting by traditional Chinese medicinal material raw materials, and the traditional Chinese medicinal material raw materials are made of rice galingale herb and manynerve embelia fruit.Using pharmaceutical composition of the present invention, patient wound's healing rate is fast, rapid-action, using in 20 minutes can feels pain alleviate, healing skin and original tissue height coincide, and not will produce scar.
Description
Technical field
The invention belongs to technical field of plant extraction, in particular to a kind of medicine group for postoperative wound healing
Close object and its application.
Background technology
With the development of modern medicine, the various diseases of operative treatment have become a kind of important means of therapeutic treatment.Operation
Refer to using knife, cut, the operations such as the medical instruments such as needle cut off patient's local body, suture, cures or diagnose the illness, remove
Pathological tissues, damaged tissue repair, transplant organ are gone to improve the function of body and a kind of medical procedure of form.Medical operating
It can be divided into Sterile surgery, cleaning-contaminated operation, contaminated operation according to its notch.Sterile surgery is related to human body sterile region, operation
It is wound part no inflammation, not damaged；Cleaning-contaminated operation refer to lower respiratory tract, upper lower digestive tract, urogenital tract or
Operation through the above organ is posted there are a large amount of human bodies due to operative site and grows flora, when operation may contaminated operation wound be led to
Infection；Contaminated operation refers to since gastrointestinal tract, urinary tract, biliary tract body fluid largely overflow or open wound causes hand without expanding wound etc.
The serious tight dirty operation of art wound.Wound is once by pathogen contamination, it is easy to generate infection, or even suppurate, severe patient is very
To the life for threatening patient.
At present for the general using suture and western medical treatment of the therapeutic wound healing of surgical site infections, sterilize to wound,
Disinfection, prevents from infecting using antibiotic, the method wrapped up with hospital gauze after sewing up a wound.Bactericidal antiphlogistic mostly uses antibiotic
And sulfa drug, this therapy are only suitable for the treatment of a phase, it is poor to the second stage of Wound healing and bone regeneration effect, and to the damage of skin
It is very serious, be not suitable for using, now there are also using medicine for external application, such as adhesive plaster, but their often not anti-inflammatory
Function, and poor with the antiphlogistic antibacterial adaptability of Western medicine, it is internal still the inflammation the phenomenon that be easy to cause surface healing, causes
The wound obstinate of patient, hangs in the balance.In addition, the modern surgery not medication on wound, the healing of wound is to lean on body certainly
Body is organized to repair.2-3 days after surgery general, patient replaces a dressing, it is therefore an objective to for observation and clean wound.Doctor trained in Western medicine
The tissue repairing ability of patient itself is fully relied on for the healing of wound, wound healing is slow, and increases the pain of patient.
Invention content
In view of the deficiencies in the prior art, it is an object of the invention to by further being furtherd investigate to folk remedy, provide
A kind of pharmaceutical composition and its application for postoperative wound healing.
In order to achieve the object of the present invention, inventor is finally obtained by a large amount of animal experiments and clinical application experimental study
Obtained following technical solution：
It is a kind of for postoperative wound healing pharmaceutical composition, the pharmaceutical composition by traditional Chinese medicinal material raw materials through decocting extract and
At the traditional Chinese medicinal material raw materials are made of rice galingale herb and manynerve embelia fruit.Preferably, the medicine to heal as described above for postoperative wound
Compositions, rice galingale herb therein select the dry root of the sub- big sedge Carex brownii Tuckerm. of sedge；Its
In manynerve embelia fruit be the more arteries and veins Embelia laeta Embelia oblongifolia Hemsl. of Myrsinacea plant dry fruit.
It is further preferred that the pharmaceutical composition to heal as described above for postoperative wound, rice galingale herb therein and horse
The amount ratio of sweet osmanthus is 1：1.6-5.0.It should be noted that it was found that use of the manynerve embelia fruit compared with rice galingale herb in raw material in experiment
The extract obtained when measuring more has the synergistic effect of ideal wound healing promoting, if the dosage of manynerve embelia fruit and rice galingale herb
When than being less than 1.5, then drug effect straight line declines.Still further preferably, the medicine group to heal as described above for postoperative wound
Object is closed, the amount ratio of rice galingale herb and manynerve embelia fruit therein is 1：2-3.
Wound repair is one of the research hotspot in surgical field always, by the healing after tissue damage on traditional theory
Journey is divided into three Main Stages of inflammation and exudation, the hyperplasia of granulation tissue and cicatrization and remodeling, but with molecular biosciences
The understanding of wound repair is gradually goed deep into rapid development, is counted as again respectively in relation to the agglutination after tissue injury now
The process of repairing cell proliferation, differentiation, migration, apoptosis and disappearance is planted, while it is series of different cell, structure egg again
In vain, growth factor and protein kinase etc. form the interactive result of network type.Chinese Traditional Medicine has uniqueness to wound repair
Theoretical system, external application Chinese medicine have it is unique promote be cured curative effect, the mechanism of wound healing is primarily directed to wound healing
Various factors play its multiple target point, too many levels, multi-level comprehensive regulation effect.The present inventor utilizes Chinese medical extract
Liquid is given the rat skin surface of a wound and is treated, and the wound skin of postoperative 3,6,9, the 14d extract groups of the present invention healing rate that is averaged is aobvious
It writes and is higher than model control group；HE dyeing shows that compared with model comparison, the inflammatory cell of postoperative 3,6,9d extract group is apparent
It reduces, new granulation tissue is thicker, new capillary vessel is intensive, epidermis healing rate is very fast, shows Chinese medical extract of the present invention
The reparation of experimental skin trauma can be remarkably promoted.Based on the experimental result, second object of the present invention is to provide one kind
Pharmaceutical applications, i.e.,：The feedstock composition being made of rice galingale herb and manynerve embelia fruit is in the external used medicine for preparing wound healing
Using；The feedstock composition being made of with manynerve embelia fruit rice galingale herb is being prepared for answering in the external used medicine of postoperative wound healing
With.
Compared with prior art, the present invention, which breaches, only uses antibiotic and partly sterilised in Traditional wound clinical care,
Fully rely on the self-healing ability of patient itself, the tissue remodeling of long time act on heal (time is long, easy to produce scar,
Even infect) limitation, reduce the pain of patient.Using pharmaceutical composition of the present invention, patient wound's healing rate is fast, works
Soon, using in 20 minutes can feels pain alleviate, healing skin and original tissue height coincide, and not will produce scar.In addition,
Since used raw material sources are in plant, toxic side effect is small, has very important clinical application significance.
Specific implementation mode
It is the specific preparation example and effete test embodiment of Chinese medical extract according to the present invention below, to the technology of the present invention
Scheme and technique effect, which are done, to be further described, but protection scope of the present invention is not limited to the embodiment.It needs to illustrate
It is that rice galingale herb selects the dry root of the sub- big sedge Carex brownii Tuckerm. of sedge in embodiment；Manynerve embelia fruit
For the dry fruit of the more arteries and veins Embelia laeta Embelia oblongifolia Hemsl. of Myrsinacea plant.
The preparation of 1 Chinese medical extract A of embodiment
Rice galingale herb 3kg is weighed, is crushed with FW135 type medicinal herb grinders, adds water to cover medicinal material and impregnates 1h, then decoct 3 times,
It is added for the first time after the heating of 30L water is boiled and is cooked by slow fire 2h, it is for use to filter out liquid；Rear slow boiling is boiled in second of addition 27L water heating
1.5h is decocted, it is for use to filter out liquid；Third time is added after the heating of 24L water is boiled and is cooked by slow fire 1.0h, and it is for use to filter out liquid；Merge three times
Filtrate is filtered again, is collected filtrate, is concentrated into thick paste, 60 DEG C of low-temperature bake 7h are ground into fine powder, sieve with 100 mesh sieve, obtain Chinese medicine
Extract A dried cream powder.
The preparation of 2 Chinese medical extract B of embodiment
Manynerve embelia fruit 3kg is weighed, is crushed with FW135 type medicinal herb grinders, adds water to cover medicinal material and impregnates 1h, then decoct 3 times,
It is added for the first time after the heating of 30L water is boiled and is cooked by slow fire 2h, it is for use to filter out liquid；Rear slow boiling is boiled in second of addition 27L water heating
1.5h is decocted, it is for use to filter out liquid；Third time is added after the heating of 24L water is boiled and is cooked by slow fire 1.0h, and it is for use to filter out liquid；Merge three times
Filtrate is filtered again, is collected filtrate, is concentrated into thick paste, 60 DEG C of low-temperature bake 7h are ground into fine powder, sieve with 100 mesh sieve, obtain Chinese medicine
Extract B dried cream powder.
The preparation of 3 Chinese medical extract C of embodiment
Rice galingale herb 1kg and manynerve embelia fruit 2kg are weighed, is crushed with FW135 type medicinal herb grinders, adds water to cover medicinal material and impregnates 1h,
Then it decocts 3 times, is added for the first time after the heating of 30L water is boiled and is cooked by slow fire 2h, it is for use to filter out liquid；Second of addition 27L water adds
Heat is cooked by slow fire 1.5h after boiling, and it is for use to filter out liquid；Third time is added after the heating of 24L water is boiled and is cooked by slow fire 1.0h, filters out liquid
For use；Merge filtrate three times, filter again, collects filtrate, be concentrated into thick paste, 60 DEG C of low-temperature bake 7h are ground into fine powder, mistake
100 mesh sieve, and obtain Chinese medical extract C dried cream powders.
Influence experiment of 4 Chinese medical extract of embodiment to rat wound healing
Cleaning grade SD rats 75, half male and half female, weight 180-220g, animal conventinal breeding, raising temperature 26~28
℃.After rat adaptable fed 1 week, through chloraldurate (300mg/kg) intraperitoneal injection of anesthesia, the depilation of 5% vulcanized sodium back is used
After the disinfection of 75% cotton ball soaked in alcohol, manufacture diameter about 2.5cm's with card punch in the nearly stern lateral ridge column both sides same area of rat back
The surface of a wound 2, skin circle full-thickness excisional, hemostasis form mechanical damage animal model.All rat single cages are fed, freely fully
Drinking-water.
Rat model 75 is only randomly divided into model control group, positive controls and Chinese medical extract A, B, C group, every group 15
Only.Chinese medical extract A, B, component C not Shi Yong each embodiment Chinese medical extract A, B, C for preparing, each Chinese medical extract dried cream powder
Be separately added into be configured in water for injection 2% liquid, 0.5mL using syringe (by the way of being added dropwise for the administration of each partial smearing
Drug is slowly immersed in wound, the surface of a wound is gently rubbed repeatedly after administration, drug is made to fully absorb), positive controls application weight
(bEGF, bFGF-ESSEX, Yisheng Biological Pharmaceutical Co., Ltd., Shuhai, traditional Chinese medicines are accurate for group human/bovine basic fibroblast growth factor spray
Word S10980077), it is provided under spray 1 every time according to product description, model control group applies physiological saline, and method is same to be extracted
Object group.Each group is respectively administered once sooner or later daily, for 2 weeks.Rat wound healing situation is observed, healing early stage, whether there is or not ooze out, go out
Blood, later stage wound healing and cicatrization etc. record wound healing time.Using different after transparent sulfate membrane graphical method record wound
The surface of a wound area of time, i.e., 0d, 3d, 6d after system is created, 9d, 14d, 21d with onionskin paint the surface of a wound figure, then by figure
It retouches to lattice paper, surface of a wound area is indicated with the lattice number of lattice, and calculate each of every animal compared with (0d) before coating
The wound healing percentage of surface of a wound different time.Wound healing percentage=[(before medication behind product-medication before product/medication
Area)] × 100%.
In addition, each group is postoperative respectively at the upper random each extraction 3 of the 3rd, 6,9,14,21 day time point, chloraldurate
After (300mg/kg) anesthesia, cut away from each 0.3cm on the outside of the surface of a wound, the full thickness skin centered on the surface of a wound and subcutaneous tissue, and locate
Dead animal cuts wound tissue, and 10% formalin is fixed, paraffin embedding.Take the skin histology conventional section of embedding, HE dyes
After color, the formational situation of light microscopic observation granulation tissue and collagen evaluates wound healing quality.
Test result is as follows：
(1) it is postoperative for 24 hours, model control group and Chinese medical extract B group rat wound moists, damaged tissues take on a red color, have and ooze
Go out liquid, positive group, Chinese medical extract A and C the group surface of a wound start a little blush occur, show that granulation tissue is being grown.Postoperative 3d,
Model control group and Chinese medical extract B group surface of a wound rednesses mitigate, and have a little diffusate, positive group, Chinese medical extract A and C group meat
Bud tissue growth is apparent, part grown thin layer or point columnar epithelium, surface of a wound periphery and basal part granulation tissue growth it is vigorous see it is fresh
Red granulation tissue, is in granular form, tactile easy bleeding.Chinese medical extract C groups are compared with A groups, and the surface of a wound is dry and edge of wound skin is received
Contracting is apparent.
(2) postoperative 6d, model control group and Chinese medical extract B group wound moists have exudate, shrink unobvious, rarely seen
Thin layer granulation, has no apparent newborn epithelium, positive group, the drying of Chinese medical extract A and C group wound, without infection, the surface of a wound is basic
It is filled by granulation tissue.Positive group, the hard scab of Chinese medical extract A and C group surface of a wound knot black, the surface of a wound in Chinese medical extract A groups
Tie kermesinus scab.Postoperative 9d, model control group and Chinese medical extract B group granulation tissues are slowly grown, and surface of a wound skin starts to receive
Contracting, start to form a scab, positive group, Chinese medical extract A and C the group surface of a wound all filled by new granulation tissue, Chinese medical extract C groups
Part crust it is natural or it is non-natural fall off, newborn epidermis is tender and thin, takes on a red color, Chinese medical extract A group surface of a wound knot black scabs.
(3) postoperative 14d, model control group and the Chinese medical extract B groups surface of a wound are filled by granulation tissue substantially, are born dark
Red scab, positive group, Chinese medical extract A and C group crust largely falls off and scar is apparent, on the Chinese medical extract C group surface of a wound
Decrustation is in pale red more than scar after Chinese medical extract A groups and C group decrustations, is taken on a red color in A groups.Postoperative 21d each groups
The surface of a wound heals substantially, and model control group and Chinese medical extract B groups scar are apparent and take on a red color, positive group, Chinese medical extract A and C
Group scar area reduces and in yellowish pink.
(4) postoperative 3~9d, positive group, the healing rate of Chinese medical extract A and C group be apparently higher than model control group, difference
Statistically significant (P ＜ 0.05 or P ＜ 0.01)；The healing rate of postoperative 14d, Chinese medical extract C groups are apparently higher than model pair
According to group, difference is statistically significant (P ＜ 0.01), other groups of healing rate (P ＞ not statistically significant compared with model control group
0.05)。
1 each group rat skin healing rate of table compares (n=6, %)
Compared with model control group,★P ＜ 0.05,★★P ＜ 0.01.
(5) the HE coloration results of wound tissue are shown：Postoperative 3d has under each group scab newborn epidermis tongue and inflammation thin
There are a small amount of FB cells in the infiltration of born of the same parents.Positive group, Chinese medical extract A and C group inflammatory cell it is less.Postoperative 6d, positive group, in
The newborn epidermis of medicament extract A and C group obviously thickens, the apparent hyperplasia of granulation tissue, and intradermal is shown in that thin vessels grow into and find a large amount of
FB cells；Model control group and Chinese medical extract B groups show stronger inflammatory reaction, and epidermis is thin, and FB cells are apparent
Less than Chinese medical extract A and C group.Postoperative 9d, FB cells are largely proliferated in each group tissue, and new capillary vessel is more, each group glue
It is former disorganized.Positive group, Chinese medical extract A and C group epidermis substantially heal and have apparent layered structure, model pair
The surface of a wound and layered structure unobvious are not yet completely covered according to group and Chinese medical extract B groups epidermis.Positive group, Chinese medical extract A
With C group inflammatory infiltration unobvious, model control group and Chinese medical extract B groups still have inflammatory infiltration phenomenon.Postoperative 14d, each group FB
Cell and capillary are less.Positive group, Chinese medical extract A and C group FB cells significantly reduce and newborn collagen marshalling, carefully
Born of the same parents' differentiation is apparent, wound healing.Model control group and Chinese medical extract B group inflammatory cells are reduced, and FB cells are more, form epidermis
Layered structure, but newborn collagen is disorganized.Postoperative 21d, each group surface of a wound heal substantially, and inflammatory cell has all disappeared substantially, respectively
Group FB cells and capillary are less.Positive group, Chinese medical extract A and C group epidermis close to normal cell, each layer differentiation is bright
Aobvious, iuntercellular has a large amount of collagen, collagenous fibres to become coarseer, aligned orderly at this time；Model control group and Chinese medical extract B
The group surface of a wound is covered by newborn epidermis completely, but the cell of epidermis is also relatively immature, and the collagenous fibres of skin corium are tiny, arrangement
It is disorderly.
Claims (5)
1. it is a kind of for postoperative wound healing pharmaceutical composition, the pharmaceutical composition by traditional Chinese medicinal material raw materials through decocting extract and
At, which is characterized in that the traditional Chinese medicinal material raw materials are made of rice galingale herb and manynerve embelia fruit, the dosage of the rice galingale herb and manynerve embelia fruit
Than being 1：1.6-5.0.
2. the pharmaceutical composition according to claim 1 for postoperative wound healing, which is characterized in that the rice galingale herb
Select the dry root of the sub- big sedge Carex brownii Tuckerm. of sedge；The manynerve embelia fruit is planted for Myrsinacea
The dry fruit of the more arteries and veins Embelia laeta Embelia oblongifolia Hemsl. of object.
3. the pharmaceutical composition according to claim 1 for postoperative wound healing, which is characterized in that the rice galingale herb
Amount ratio with manynerve embelia fruit is 1：2-3.
4. application of the feedstock composition being made of rice galingale herb and manynerve embelia fruit in the external used medicine for preparing wound healing, institute
The amount ratio of the rice galingale herb and manynerve embelia fruit stated is 1：1.6-5.0.
5. the feedstock composition being made of with manynerve embelia fruit rice galingale herb is being prepared for answering in the external used medicine of postoperative wound healing
With the amount ratio of the rice galingale herb and manynerve embelia fruit is 1：1.6-5.0.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455405A (en) * | 2009-01-04 | 2009-06-17 | 江中药业股份有限公司 | Food or medicine capable of promoting wound healing after operation |
| CN103285332A (en) * | 2013-06-20 | 2013-09-11 | 高群 | Pharmaceutical composition for promoting post-operation wound healing |
| CN103393953A (en) * | 2013-08-18 | 2013-11-20 | 郑宏伟 | Traditional Chinese medicine ointment for promoting postoperative wound healing, and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455405A (en) * | 2009-01-04 | 2009-06-17 | 江中药业股份有限公司 | Food or medicine capable of promoting wound healing after operation |
| CN103285332A (en) * | 2013-06-20 | 2013-09-11 | 高群 | Pharmaceutical composition for promoting post-operation wound healing |
| CN103393953A (en) * | 2013-08-18 | 2013-11-20 | 郑宏伟 | Traditional Chinese medicine ointment for promoting postoperative wound healing, and preparation method thereof |
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