CN103623115A - Burn and scald treatment traditional Chinese medicine and preparation method thereof - Google Patents
Burn and scald treatment traditional Chinese medicine and preparation method thereof Download PDFInfo
- Publication number
- CN103623115A CN103623115A CN201210309929.3A CN201210309929A CN103623115A CN 103623115 A CN103623115 A CN 103623115A CN 201210309929 A CN201210309929 A CN 201210309929A CN 103623115 A CN103623115 A CN 103623115A
- Authority
- CN
- China
- Prior art keywords
- radix rehmanniae
- burn
- radix
- chinese medicine
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a burn and scald treatment traditional Chinese medicine and a preparation method thereof. The burn and scald treatment traditional Chinese medicine comprises, by weight, 0.9-1.1 parts of radix rehmanniae preparata, 0.9-1.1 parts of rheum, 0.9-1.1 parts of radix rehmanniae, 0.9-1.1 parts of borneol, and 7.2-8.8 parts of sesame oil. The preparation method comprises treating, crushing, screening, mixing, blending, and filling of the obtained finished product. According to the present invention, the formula is simple and easy to obtain; the technical process is simple and fast; the treatment period is short; the analgesia effect is good; the burn and scald treatment traditional Chinese medicine is applicable for treatments of deep and superficial II wound surfaces, wherein the cure rate can be 100%, and the good treatment effect can be provided when the burn and scald treatment traditional Chinese medicine is used for treating unhealed and infectious moderate and advanced stage wound surfaces after wound; hair growth is not affected and no scar is generated after curing; and the cost is low, wherein curing of a patient with the wound surface area accounted for 5% of the whole body area only requires about 2000 yuan so as to substantially reduce financial burden on patients.
Description
(1) technical field:
The present invention relates to Chinese medicine of a kind of fast cure burns, scald and preparation method thereof.
(2) background technology:
In, small-area burn accounts for the overwhelming majority of burn patient sum, inpatient's 80% be in, small-area burn, these patients if after obtaining better treatment and curing functional rehabilitation good, can continue to be engaged in routine work and daily life, and medical expense Di， family, burden on society are little.Therefore little middle Area Burn treatment more and more causes that domestic and international expert payes attention to.And wound surface medicine for external use is particularly one of important treatment measure of dark II degree wound surface of middle and small area burn wound.Because shallow II degree wound surface only damages epidermis and papillary layer of corium, the epithelial cell of the residual matrix cells of wound surface substrate, sweat gland, sebaceous gland, hair follicle and create all epidermis cell wounds after division, propagation, expansion, and be divided into each layer of epidermis, finally become normal skin.As long as prevention wound surface local infection, can heal for 7-14 days.And III degree wound surface skin holostrome and accessory structure are completely downright bad, except in diameter 5cm, there is edge of wound epithelium to creep and edge of wound shrinks and reaches outside healing, wound closure all needs to make skin graft after excision slough.Dark II degree wound surface has damaged corium deep layer, and only the residual appendages of skin, get involved and locate organizational structure disappearance, and coagulation necrosis, is covered in wound surface, forms thick and dry crust.Wound healing is by remaining appendages of skin epithelium regeneration and create all epidermis cell growth reparation of creeping, and takes longlyer, and more epithelium posterius is fragile.In addition, because wound surface has slough, adhere to, under crust, remaining hair follicle, sweat gland have antibacterial, and traumatic infection easily occurs, and the remaining appendages of skin are destroyed, and wound healing difficulty or healing time postpone, and leave over more afterwards more serious scar tissue.
Jaskson once proposed burn wound and had following features (1) burn wound as one deck absorbent paper, and the some drugs being applied on wound surface can absorb by wound surface.(2) wound surface of warm moist, as good culture medium, is conducive to bacterial growth breeding.(3) burn wound consists of congested district, stasis district and solidification zone, and stasis district can recover.Therefore the processing of deep ii degree burn wound surface must be removed slough as early as possible, prevents traumatic infection, and the 2nd, protect the remaining appendages of skin, promote epithelial cell regeneration, expansion.
Desirable external used medicine should possess: (1) does not affect epithelial growth, and wound healing is had to facilitation; (2) Gram-negative and positive bacteria are all had to good inhibition, killing action, comprise mould fungus inhibition effect; (3) non-stimulated to wound surface, there is good analgesic effect; (4) do not cause the concurrent color change of local anaphylaxis and whole body; (6) price is acceptant.
At present both at home and abroad universal still for continuing to use decades in burn wound's medicine for external use application, this medicine after wound surface application, early stage anti-infectious function still can, but without analgesic effect, and wound surface is had to certain stimulation.Apply after this medicine, dark II degree wound surface slough is difficult for solution-off.Recently the new drug " iruxol mono " (collagenase) that goes on the market has the fibril that deeply comes unstuck, and accelerates necrotic tissue cleaning effect, but to epithelial growth without facilitation, and expensive, to clinical practice, bring restriction.The various somatomedin of current clinical use, as EGF(epithelical cell growth factor), BFGF(basic fibroblast growth factor) wound surface epithelial cell growth is had to certain promotion, be suitable for difficult healing wound surface and late wounds treatment.
(3) summary of the invention:
The object of the present invention is to provide a kind of Chinese medicine for the treatment of burn, scalding and preparation method thereof, its formula is simple and easy to get, treatment cost is low, be a kind of employing Chinese herbal and crude drugs preparations treatment burn, scald the effective medicine of illness, be applicable to dark ,QianIIDu burn wound, be specially adapted to hinder rear middle and advanced stage wound surface.There is analgesic antiphlogistic convergence, removing the necrotic tissue and promoting granulation, bacteriostasis and sterilization, promotion epithelial growth and accelerate the effects such as wound healing.
Technical scheme of the present invention: a kind of Chinese medicine for the treatment of burn, scalding, the formula that it is characterized in that it is Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei, Radix Rehmanniae, Borneolum Syntheticum and Oleum sesami, and weight ratio is Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1: Oleum sesami 7.2-8.8.
Weight ratio described above is Radix Rehmanniae Preparata 0.9: Radix Et Rhizoma Rhei 0.9: Radix Rehmanniae 0.9: Borneolum Syntheticum 0.9: Oleum sesami 7.2.
Weight ratio described above is Radix Rehmanniae Preparata 1.1: Radix Et Rhizoma Rhei 1.1: Radix Rehmanniae 1.1: Borneolum Syntheticum 1.1: Oleum sesami 8.8.
Weight ratio described above is Radix Rehmanniae Preparata 1: Radix Et Rhizoma Rhei 1: Radix Rehmanniae 1: Borneolum Syntheticum 1: Oleum sesami 8.
A preparation method for the Chinese medicine of treat burn, scalding, is characterized in that step is as follows:
(1) process: by Radix Et Rhizoma Rhei dry in the sun, Radix Rehmanniae Preparata, Radix Rehmanniae, Borneolum Syntheticum are dried respectively, obtain dry ingredients.
(2) pulverize: the dry medical material of each taste in step (1) is ground into respectively to 100-120 object powder;
(3) sieve: the powder after step (2) is pulverized is crossed 100-120 mesh sieve;
(4) mix: the powder obtaining after step (3) is sieved is by weight Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1 mixes;
(5) be in harmonious proportion: in the mixed herbal powder of step (4) by weight Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1: Oleum sesami 7.2-8.8 adds Oleum sesami to reconcile into paste finished product;
(6) make finished product fill: by the fill of paste final drug, medicament 0.5-1 liter in each Packaging Bottle.
The described dry in the sun time of above-mentioned steps (1) is 6-8 days, and bake out temperature is 50-60 degree Celsius, and drying time is 30-35 minute.
The described oven dry of above-mentioned steps (1) adopts electric oven.
Described in above-mentioned steps (2), pulverize and adopt 100-120 object pulverizer.
Described in above-mentioned steps (6), make finished product fill and adopt automatic filling machine.
Using method of the present invention: wound surface or affected part are cleaned, after sterilization, coated very thin one deck medicament, do not need blocked uply, need not wrap up I degree wound surface healing time 3-5 days, shallow II degree wound surface healing time 7.8-11.4, dark II degree wound surface healing time 14-20 days.
Pharmacology analysis of the present invention:
Radix Et Rhizoma Rhei: modern study, Radix Et Rhizoma Rhei contains the about 3-5% of anthraquinone derivatives, and wherein a part is free state, as chrysophanic acid, chrysophanol, emodin, aloe-emodin, physcione.In addition still there are conjugate that the Radix Et Rhizoma Rhei of content approximately 10% contains anthraquinone derivatives and resin, gallic acid, cinnamic acid and tannin etc.Its pharmacological property is antibacterial, and effective ingredient is anthraquinone derivative, wherein stronger with antibacterial actions such as chrysophanic acid, emodin and the large elements of Aloe.The most responsive antibacterial of experiment in vitro is staphylococcus, streptococcus, is secondly bacillus.It suppresses principle is that these anthraquinone derivatives have obvious inhibitory action to the synthetic of the nucleic acid of antibacterial and protein, and has astriction.
Radix Rehmanniae: chemical composition contains catalpol, several amino acids and sugar, mannitol, cupreol and campesterol etc.Radix Rehmanniae is cold in nature, sweet in the mouth.Have clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid, clinical in calentura excessive thirst, is suitable for burn treating.Radix Rehmanniae still has antifungic action simultaneously.
Radix Rehmanniae Preparata: sweet in the mouth, property are flat and enter blood system, function nourishing YIN and supplementing blood, vital essence replenishing and marrow benifiting.Control deficiency of YIN insufficiency of blood, the hollow institute of brains waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency extremely, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision, palpitation and insomnia, forgetful, night sweat etc.In to the practical observation of Chinese medicine, confirmed that Radix Rehmanniae Preparata concentrated decoction can alleviate rat early burn swollen tissue and minimizing wound surface oozes out and evaporation.
Radix Rehmanniae and Radix Rehmanniae Preparata Papillary, getting it can tonification, function that again can heat clearing away.
Borneolum Syntheticum: Borneolum Syntheticum be the trunk of Dipterocarpaceae aiphyllium Borneolum Syntheticum through distilling the cooling crystallization forming, mostly now be chemosynthesis.This product is mainly containing dextro Borneolum Syntheticum, separately containing humulene, the fragrant alkene of β-olive etc.This product is applied to part analgesic effect, separately has antibiotic effect.Chinese medicine document is recorded, the rotten effect of carrying pus of having of ice opiates.After clinical practice, local pus increases, but and noinvasive week inflammatory reaction, accelerate the separated solution-off of slough, promote granulation tissue growth.
Oleum sesami has the effect of heat-clearing and toxic substances removing, cooling blood and relieving pain.
Sum up: all upper each medicines mostly have antibacterial, sterilization, convergence in various degree, promote the effect of epithelial growth, then be equipped with the pain relieving effect of Borneolum Syntheticum, Oleum sesami, thereby reach the object of antiinflammatory, pain relieving, fast cure burns, scald.
Clinical case of the present invention:
Zoopery of the present invention:
Experimental program: laboratory animal is healthy, white hair, blood-shot eye illness Chinese rabbits, body weight 2.0-2.5kg, 70.
Adopt randomization, laboratory animal is divided into following group.Table 1
Animal experimental model preparation: the anesthesia of pentobarbital sodium (1%-30mg/kg) intraperitoneal, back depilation, adopts constant temperature and pressure electric pressing instrument legal system to make scalding model t=80 ℃, p=4.0kpa, diameter d=2.0cm perms; At the rabbit back of the body, make 10 the dark II degree of diameter 2.0cm wound surface, originally, after HE dyeing, the degree of depth is scalded in judgement to conventional label taking.
Wound surface is processed: each is organized medication and as above shows, 20 animals of consubstantiality test group, 10 wound surface of every rabbit back, every two wound surface one group of difference external preparation of the present invention (cream), 1% silver sulfadiazine cream, moistening ointment, povidone iodine and vaseline, change dressings every day and once observe local swelling, inflammatory reaction, wound surface slough solution-off and epithelial growth situation, and record wound healing time.Hindering latter 3 days, 7 days, 14 days, 21 days, 28 days, draws materials in part, does H.E dyeing, observes wound surface vascularization, epithelization, cell infiltration and proliferation of fibrous tissue situation, with transparent film, records scald wound size.Latter 10,20,30 days of wound, draw materials in part, and row Electronic Speculum mark is wooden standby.5,10 ,20 ,30Tian Qu merocrine secretion's thing or sepages after wound, row antibacterial culturing.
Experimental result:
The scald degree of depth of scalding model confirms through tissue slice, meets the pathological change rule of deep II degree burn wound.
1, wound surface gross examination of skeletal muscle: all animal wound surface are all drier, has no obvious infection sign.1. contrast A, B, C group: 5d wound surface has and dwindles, and 2wk-3wk dwindles obviously, healing speed is accelerated, and 28d heals completely; 2. preparation group of the present invention: 3d is shown in that wound surface has obviously and dwindles, 23d all healed; 3. contrast the visible wound surface of D group: 3d and dwindle, but healing rate slows down from 14d, during 28d, still leave over small area wound.Wound surface average area is in Table 2.
The different treatment group wound surface of table 2 average area (n=32,
mm
2)
2, om observation: 1. contrast A, B, C group; 1d after wound, visible Epidermal necrosis comes off, and the above original fibre structure in corium middle level is fuzzy, visible hemorrhagic focus, edema and the cell infiltration that is comprised of a large amount of mononuclear phagocyte and medium-sized grain cell are every band; 5d edge of wound epithelium has creeping phenomenon, and cell infiltration obviously weakens; The visible fibrocyte of 7d and blood capillary proliferation, hair follicle hypertrophy is particularly evident; Fiber three dyeing show that collagen fiber quantity, slightly more than reticular fiber and elastic fibers, is " and depositing " phenomenon; 14d collagen Shu Hanliang increases, and arranges in order, and accounts for the overwhelming majority with collagen fiber; 21d, wound surface heals completely, but newborn epithelium layer is thinner.2. preparation group of the present invention: after wound, 3d is shown in that edge of wound epithelium has creeping phenomenon, remaining pathological change is basic identical with contrast A, B, C group.3. contrast D group: after wound, 3d edge of wound epithelium has creeping phenomenon; 7d is shown in fibroblast proliferation, and fibroblast quantity is more, and new capillary vessel content is abundanter, and fiber three dyeing are shown in that collagen content is more than contrast A, B, C group, especially remarkable with 14d.
Clinical practice of the present invention:
Traumatic condition: burn wound's dark below 10%, shallow II degree wound surface, the inpatient of the little wound surface of remaining granulation (the controlled outpatient of part).
Inclusion criteria:
1, age 18-60 year inpatient, gender does not limit.
2, without severe cardiac, liver, kidney, disease of hematopoietic system and late tumor patient.
The patient that 3, can use by this programme regulation.
Test method:
According to simple random packet principle, be divided into test group and matched group.Test group 180 examples, matched group 180 examples.
Table 3 physical data
Using method:
(1) test group: first clean wound surface, then stick wound surface after preparation of the present invention is applied to antiseptic gauze, or preparation of the present invention is directly sticked to wound surface.
(2) matched group: identical with test group conventional method, outer moistening ointment, 1% silver sulfadiazine cream, povidone iodine and the vaseline oil yarn of being coated with of difference.
Project in observed result and index are followed following principle:
(1) wound surface situation of change and healing time: the healing state of omnidistance observed and recorded wound surface and healing rate.Healing speed represents with wound healing percentage rate (%) in same time, take wound healing as index, the final healing time of interpretation.
(2) wound surface inflammatory reaction: in therapeutic process, depending on traumatic infection situation by level Four standard be assessed as respectively without (-), light (+), in (++), heavy (+++), and record wound secretion and change quiet condition.Statistics inflammatory reaction and secretions extinction time.
(3) biochemical and other index inspection: all each checks once before and after treatment for food blood, routine urinalysis, liver, renal function.
(4) untoward reaction: record whole body and local excitation, anaphylaxis and untoward reaction relevant with it etc.
Clinical practice result:
L, the complete healing time comparison of all kinds of wound surface: the present invention is for shallow II degree, dark II degree, residual wound, test group shortens respectively 2,4,6d compared with matched group the average healing, learn and process difference significance (p<0.05) by statistics, in Table 4.
The complete healing time comparison of all kinds of wound surface of table 4
(p<0.05)
2, the dynamic healing rate comparison of all kinds of wound surface: the present invention, for shallow II °, dark II °, residual wound, obviously improves at each time point wound healing percentage rate compared with matched group, learns by statistics and processes difference significance (p<0.05).In Table 5.
The comparison of dynamically healing of all kinds of wound surface of table 5
3, clinical indication extinction time after all kinds of Wound treatings: the present invention is for shallow II °, dark II ° and residual wound, test group obviously shifts to an earlier date compared with matched group wound secretion and inflammatory reaction extinction time. and learn and process significance (p<0.05) by statistics, in Table 6.
Clinical indication extinction time comparison-secretions after the different Wound treatings of table 6 (t-examines face)
Clinical indication extinction time comparison-inflammatory reaction after the different Wound treatings of table 7
Conclusion (of pressure testing)
Zoopery and clinical trial show that the tropism that the present invention can activate moves, and epithelial cell is had to strong growth promoting function, and can stimulate the formation of fibrinous synthetic and new vessels, significant to repair in trauma.By zoopery and clinical test results, show, the present invention, to shallow II °, dark II ° and the residual wound of burning, all has healing acceleration effect in various degree, the most remarkable to the promoting healing effect of shallow II° ,ShenII° burn wound especially.The healing time of wound surface obviously shortens compared with matched group.Shallow II °, dark II ° and residual wound shorten respectively 2,4,6d compared with matched group.All kinds of healing speed of application the present invention treatment are obviously accelerated, and in dynamically observing, each time point wound healing percentage rate obviously improves.Ask that a healing rate improves 21%～29% while respectively observing for shallow II °; Dark II ° is improved 21%～35%; Remaining wound and improve 5%～16%, and mid-term Healing the most obvious, after wound surface infection control, apply the present invention's treatment and can obtain and satisfied effect.When application the present invention treats, wound surface inflammatory reaction and secretions extinction time have obviously in advance compared with matched group, show that the present invention has obvious antiinflammatory action.In test, do not find obvious untoward reaction, it is abnormal that various biochemical indicators are not examined chemical examination, not significant change of data exception frequency before and after blood, routine urinalysis, liver, renal function curing.Observed result demonstration, the abnormal frequency of laboratory data has the trend of dwindling, and illustrates liver, renal function, blood, routine urinalysis are had no significant effect.Through more than 2 years patient follow-ups, observe, have no wound tissue hyperplasia phenomenon.The present invention has sure curative effect to the Healing of all kinds of wound surface of promotion burn, and has good toleration, has clinical generalization value, and the while is also for the treatment of middle and small area burn wound provides another new clinical application.As can manufacture, put on market, will bring good economic benefit and social benefit.
Model case is as follows:
1, Lee XX, 5 years old, live Dou Jiaqiao village, Shi Gezhuan town, Baodi District, scald, dark II degree, scalding area is 2%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 15 days.
2, Guo XX, female, 23 years old, live Dou Jiaqiao village, Shi Gezhuan town, Baodi District, oil is scalded, dark II degree, scalding area is 3%, by after wound surface cleaning, sterilization, coats very thin one deck ointment, recovery from illness afterwards in 16 days.
3, open XX, man, 42 years old, live Dou Jiaqiao village, Shi Gezhuan town, Baodi District, scalds of motorcycle exhaust pipe, I degree, scalding area is 2%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 5 days.
4, grandson XX, Nan， 48Sui，Zhu In Shunyi District of Beijing local products company, plank fire burn, dark II degree, burn surface area is 3%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 15 days.
5, Liu XX, Jiu Gong town, Nv， 72Sui，Zhu Daxing district, Beijing, China, makes powder of firecracker burn by oneself in family, dark II degree, burn surface area is 5%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 16 days.
6, pay the Haicheng City people of XX ，Nv ，21Sui， Liaoning Province, in Tianjin, do manual work, scald, shallow II degree, scalding area is 2%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 8 days.
7, the driver of Fushun City, river XX ，Nan ，36Sui， Liaoning Province local products company, gasoline fire burn, dark II degree, burn surface area is 7%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 17 days.
8, open XX, man, 28 years old, Ma Quan township, Yangyuan County of Heb ei Province Xi Di village driver, gasoline fire burn, dark II degree, burn surface area is 8%, after wound surface is cleaned, sterilized, coats very thin one deck ointment, recovery from illness afterwards in 17 days.
9, Lee XX, Shu Yang town, Xianghe County, Nv， 49Sui，Zhu Hebei province, the asphalt heating pot scald of breaking, dark II degree, scalding area is 12%, and wound surface is cleaned, after sterilization, coats very thin one deck ointment, recovery from illness afterwards in 17 days.
Large group case summary is as follows:
The present invention promotes Healing mechanism to burn, scald wound:
1, anti-infectious function: various compositions of the present invention have certain antibacterial action; Particularly Radix Et Rhizoma Rhei has obvious inhibitory action to burn wound's common bacteria (bacillus pyocyaneus, Bacillus proteus, staphylococcus aureus etc.).
2, reduce and ooze out, restrain and become crust effect.Radix Rehmanniae Preparata concentrated decoction can alleviate rat early burn swollen tissue and minimizing wound surface oozes out and evaporation.Because majority converges crust medicine all with to contain tannin relevant, and in Radix Et Rhizoma Rhei, contain tannin.The most responsive antibacterial of experiment in vitro is staphylococcus, streptococcus, is secondly bacillus, and it suppresses principle is that these anthraquinone derivatives have obvious inhibitory action to the synthetic of the nucleic acid of antibacterial and protein, and has astriction.
3, accelerate the effect of slough solution-off, Chinese medicine document is recorded, the rotten effect of carrying pus of having of ice opiates.After clinical practice, local pus increases, but and noinvasive week inflammatory reaction, accelerate the separated solution-off of slough, promote granulation tissue growth.We in this after medicine composite preparation, can make decrustation about average ten days, than natural decrustation approximately seven to ten days in advance in clinical use.
4, wound healing effect, motherland's medical science and modern study have all proved that part Chinese medicine has granulation promoting, healing acceleration effect to wound surface.Radix Rehmanniae Preparata and Borneolum Syntheticum play decisive role aspect wound healing.May be accelerated slough separated, improved wound surface blood circulation.For epithelial cell acceleration of growth provides condition.
Superiority of the present invention: 1, fill a prescription simple and easy to get; 2, techniqueflow is simple, quick; 2, treatment cycle is short, and antiinflammatory, the poison of subsiding a swelling, purge heat, the bud of putting on flesh, clots absorbing blood, sealing healing rate are fast, I degree wound surface healing time 3-5 days, shallow II degree wound surface healing time 7.8-11.4, dark II degree wound surface healing time 14-20 days; 3, good analgesic effect, no matter how violent pain is, coat after medicament, tens second pain can disappear, make patient alleviate many miseries, this is that domestic general medicament institute is non-existent; 4, be highly suitable for the treatment of dark, shallow II degree (2 degree) wound surface, cure rate can reach 100%, after for wound, does not heal, and therapeutic effect is better the middle and advanced stage wound surface of infection; 3, after healing, do not affect hair growth, cicatrix does not fall; 4, cost is low, and every healing wound surface accounts for a patient of whole body area 5%, only need pay the expense of 2000 yuan of left and right of fund, has greatly alleviated patient's financial burden.
(4) specific embodiment:
Embodiment 1: a kind of Chinese medicine for the treatment of burn, scalding, and the formula that it is characterized in that it is Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei, Radix Rehmanniae, Borneolum Syntheticum and Oleum sesami, weight ratio is Radix Rehmanniae Preparata 0.9: Radix Et Rhizoma Rhei 0.9: Radix Rehmanniae 0.9: Borneolum Syntheticum 0.9: Oleum sesami 7.2.
A preparation method for the Chinese medicine of treat burn, scalding, is characterized in that step is as follows:
(1) process: by Radix Et Rhizoma Rhei dry in the sun, Radix Rehmanniae Preparata, Radix Rehmanniae, Borneolum Syntheticum are dried respectively, obtain dry ingredients.
(2) pulverize: the dry medical material of each taste in step (1) is ground into respectively to 100 object powder;
(3) sieve: the powder after step (2) is pulverized is crossed 100 mesh sieves;
(4) mix: the powder obtaining after step (3) is sieved is Radix Rehmanniae Preparata 0.9 by weight: Radix Et Rhizoma Rhei 0.9: Radix Rehmanniae 0.9: Borneolum Syntheticum 0.9 mixes;
(5) in the mixed herbal powder of step (4) by weight Radix Rehmanniae Preparata 0.9: Radix Et Rhizoma Rhei 0.9: Radix Rehmanniae 0.9: Borneolum Syntheticum 0.9: Oleum sesami 7.2 adds Oleum sesami to reconcile into paste finished product;
(6) make finished product fill: by the fill of paste final drug, in each Packaging Bottle, medicament is 0.5 liter.
The described dry in the sun time of above-mentioned steps (1) is 6 days, and bake out temperature is 50 degrees Celsius, and drying time is 30 minutes.
The described oven dry of above-mentioned steps (1) adopts electric oven.
Described in above-mentioned steps (2), pulverize and adopt 100 object pulverizers.
Described in above-mentioned steps (6), make finished product fill and adopt automatic filling machine.
The clinical practice of the present embodiment:
Model case 1, Lee XX, 5 years old, live Dou Jiaqiao village, Shi Gezhuan town, Baodi District, scald, dark II degree, scalding area is 2%, and wound surface is cleaned, after sterilization, coats ointment described in embodiment, recovery from illness afterwards in 15 days.
Embodiment 2: a kind of Chinese medicine for the treatment of burn, scalding, and the formula that it is characterized in that it is Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei, Radix Rehmanniae, Borneolum Syntheticum and Oleum sesami, weight ratio is Radix Rehmanniae Preparata 1.1: Radix Et Rhizoma Rhei 1.1: Radix Rehmanniae 1.1: Borneolum Syntheticum 1.1: Oleum sesami 8.8.
A preparation method for the Chinese medicine of treat burn, scalding, is characterized in that step is as follows:
(1) process: by Radix Et Rhizoma Rhei dry in the sun, Radix Rehmanniae Preparata, Radix Rehmanniae, Borneolum Syntheticum are dried respectively, obtain dry ingredients.
(2) pulverize: the dry medical material of each taste in step (1) is ground into respectively to 120 object powder;
(3) sieve: the powder after step (2) is pulverized is crossed 120 mesh sieves;
(4) mix: the powder obtaining after step (3) is sieved is Radix Rehmanniae Preparata 1.1 by weight: Radix Et Rhizoma Rhei 1.1: Radix Rehmanniae 1.1: Borneolum Syntheticum 1.1 mixes;
(5) in the mixed herbal powder of step (4) by weight Radix Rehmanniae Preparata 1.1: Radix Et Rhizoma Rhei 1.1: Radix Rehmanniae 1.1: Borneolum Syntheticum 1.1: Oleum sesami 8.8 adds Oleum sesami to reconcile into paste finished product;
(6) make finished product fill: by the fill of paste final drug, in each Packaging Bottle, medicament is 1 liter.
The 8 days described dry in the sun time of above-mentioned steps (1), bake out temperature is 60 degrees Celsius, and drying time is 35 minutes.
The described oven dry of above-mentioned steps (1) adopts electric oven.
Described in above-mentioned steps (2), pulverize and adopt 120 object pulverizers.
Described in above-mentioned steps (6), make finished product fill and adopt automatic filling machine.
The clinical practice of the present embodiment:
Model case 3, XX, man, 42 years old, live Dou Jiaqiao village, Shi Gezhuan town, Baodi District, scalds of motorcycle exhaust pipe, I degree, scalding area is 2%, and wound surface is cleaned, after sterilization, coats ointment described in the present embodiment, recovery from illness afterwards in 5 days.
Embodiment 3: a kind of Chinese medicine for the treatment of burn, scalding, and the formula that it is characterized in that it is Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei, Radix Rehmanniae, Borneolum Syntheticum and Oleum sesami, weight ratio is Radix Rehmanniae Preparata 1: Radix Et Rhizoma Rhei 1: Radix Rehmanniae 1: Borneolum Syntheticum 1: Oleum sesami 8.
A preparation method for the Chinese medicine of treat burn, scalding, is characterized in that step is as follows:
(1) process: by Radix Et Rhizoma Rhei dry in the sun, Radix Rehmanniae Preparata, Radix Rehmanniae, Borneolum Syntheticum are dried respectively, obtain dry ingredients.
(2) pulverize: the dry medical material of each taste in step (1) is ground into respectively to 110 object powder;
(3) sieve: the powder after step (2) is pulverized is crossed 110 mesh sieves;
(4) mix: the powder obtaining after step (3) is sieved is Radix Rehmanniae Preparata 1 by weight: Radix Et Rhizoma Rhei 1: Radix Rehmanniae 1: Borneolum Syntheticum 1 mixes;
(5) in the mixed herbal powder of step (4) by weight Radix Rehmanniae Preparata 1: Radix Et Rhizoma Rhei 1: Radix Rehmanniae 1: Borneolum Syntheticum 1: Oleum sesami 8 adds Oleum sesami to reconcile into paste finished product;
(6) make finished product fill: by the fill of paste final drug, in each Packaging Bottle, medicament is 1 liter.
The described dry in the sun time of above-mentioned steps (1) is 7 days, and bake out temperature is 55 degrees Celsius, and drying time is 33 minutes.
The described oven dry of above-mentioned steps (1) adopts electric oven.
Described in above-mentioned steps (2), pulverize and adopt 110 object pulverizers.
The described fill of above-mentioned steps (6) adopts automatic filling machine.
The clinical practice of the present embodiment:
Model case 9, Lee XX, Shu Yang town, Xianghe County, Nv， 49Sui，Zhu Hebei province, the asphalt heating pot scald of breaking, dark II degree, scalding area is 12%, and wound surface is cleaned, after sterilization, coats ointment described in the present embodiment, recovery from illness afterwards in 17 days.
Claims (9)
1. a Chinese medicine of treat burn, scalding, the formula that it is characterized in that it is Radix Rehmanniae Preparata, Radix Et Rhizoma Rhei, Radix Rehmanniae, Borneolum Syntheticum and Oleum sesami, weight ratio is Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1: Oleum sesami 7.2-8.8.
2. a kind of Chinese medicine for the treatment of burn, scalding according to claim 1, is characterized in that described weight ratio is Radix Rehmanniae Preparata 0.9: Radix Et Rhizoma Rhei 0.9: Radix Rehmanniae 0.9: Borneolum Syntheticum 0.9: Oleum sesami 7.2.
3. a kind of Chinese medicine for the treatment of burn, scalding according to claim 1, is characterized in that described weight ratio is Radix Rehmanniae Preparata 1.1: Radix Et Rhizoma Rhei 1.1: Radix Rehmanniae 1.1: Borneolum Syntheticum 1.1: Oleum sesami 8.8.
4. a kind of Chinese medicine for the treatment of burn, scalding according to claim 1, is characterized in that described weight ratio is Radix Rehmanniae Preparata 1: Radix Et Rhizoma Rhei 1: Radix Rehmanniae 1: Borneolum Syntheticum 1: Oleum sesami 8.
5. a preparation method for the Chinese medicine that described in claim 1-4 any one, treatment is burnt, scalded, is characterized in that step is as follows:
(1) process: by Radix Et Rhizoma Rhei dry in the sun, Radix Rehmanniae Preparata, Radix Rehmanniae, Borneolum Syntheticum are dried respectively, obtain dry ingredients.
(2) pulverize: the dry medical material of each taste in step (1) is ground into respectively to 100-120 object powder;
(3) sieve: the powder after step (2) is pulverized is crossed 100-120 mesh sieve;
(4) mix: the powder obtaining after step (3) is sieved is by weight Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1 mixes;
(5) be in harmonious proportion: in the mixed herbal powder of step (4) by weight Radix Rehmanniae Preparata 0.9-1.1: Radix Et Rhizoma Rhei 0.9-1.1: Radix Rehmanniae 0.9-1.1: Borneolum Syntheticum 0.9-1.1: Oleum sesami 7.2-8.8 adds Oleum sesami to reconcile into paste finished product;
(6) make finished product fill: by the fill of paste final drug, medicament 0.5-1 liter in each Packaging Bottle.
6. a kind of preparation method of the Chinese medicine for the treatment of burn, scalding according to claim 5, is characterized in that the described dry in the sun time of step (1) is 6-8 days, and bake out temperature is 50-60 degree Celsius, and drying time is 30-35 minute.
7. a kind of preparation method of the Chinese medicine for the treatment of burn, scalding according to claim 5, is characterized in that the described oven dry of step (1) adopts electric oven.
8. a kind of preparation method of the Chinese medicine for the treatment of burn, scalding according to claim 5, is characterized in that pulverizing and adopting 100-120 object pulverizer described in step (2).
9. a kind of preparation method of the Chinese medicine for the treatment of burn, scalding according to claim 5, is characterized in that making finished product fill described in step (6) adopts automatic filling machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210309929.3A CN103623115B (en) | 2012-08-28 | 2012-08-28 | A kind of Chinese medicine for the treatment of burn, scald and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210309929.3A CN103623115B (en) | 2012-08-28 | 2012-08-28 | A kind of Chinese medicine for the treatment of burn, scald and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103623115A true CN103623115A (en) | 2014-03-12 |
| CN103623115B CN103623115B (en) | 2016-05-04 |
Family
ID=50204799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210309929.3A Expired - Fee Related CN103623115B (en) | 2012-08-28 | 2012-08-28 | A kind of Chinese medicine for the treatment of burn, scald and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103623115B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177334A (en) * | 2016-08-23 | 2016-12-07 | 黄海军 | A kind of medicament for treating scald and preparation method thereof |
| CN111759909A (en) * | 2019-04-02 | 2020-10-13 | 范凯贤 | Ointment for treating scald and burn |
| CN111973687A (en) * | 2020-08-04 | 2020-11-24 | 王艳存 | Burn and scald ointment and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06279305A (en) * | 1993-03-25 | 1994-10-04 | Kuga Takaaki | Agent for treatment of dermatic disease such as atopic dermatitis |
| CN1228981A (en) * | 1998-06-04 | 1999-09-22 | 韦明 | Scald powder |
| CN1695693A (en) * | 2005-04-29 | 2005-11-16 | 齐柏山 | 'Binghuang' burn cream for treating burn |
| CN101612245A (en) * | 2008-06-26 | 2009-12-30 | 姚自功 | A kind of ointment for treating burn |
| CN102028762A (en) * | 2009-10-01 | 2011-04-27 | 陈恒树 | Scald ointment for diminishing inflammation and relieving pain |
| CN102343006A (en) * | 2010-07-30 | 2012-02-08 | 李普华 | Ointment for treating burns and scalds, and preparation method thereof |
| CN102526272A (en) * | 2012-01-18 | 2012-07-04 | 孔祥军 | Chinese medicine for treating burn and scalding |
-
2012
- 2012-08-28 CN CN201210309929.3A patent/CN103623115B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06279305A (en) * | 1993-03-25 | 1994-10-04 | Kuga Takaaki | Agent for treatment of dermatic disease such as atopic dermatitis |
| CN1228981A (en) * | 1998-06-04 | 1999-09-22 | 韦明 | Scald powder |
| CN1695693A (en) * | 2005-04-29 | 2005-11-16 | 齐柏山 | 'Binghuang' burn cream for treating burn |
| CN101612245A (en) * | 2008-06-26 | 2009-12-30 | 姚自功 | A kind of ointment for treating burn |
| CN102028762A (en) * | 2009-10-01 | 2011-04-27 | 陈恒树 | Scald ointment for diminishing inflammation and relieving pain |
| CN102343006A (en) * | 2010-07-30 | 2012-02-08 | 李普华 | Ointment for treating burns and scalds, and preparation method thereof |
| CN102526272A (en) * | 2012-01-18 | 2012-07-04 | 孔祥军 | Chinese medicine for treating burn and scalding |
Non-Patent Citations (1)
| Title |
|---|
| 肖合聚: "大黄油治疗烧烫伤", 《中医杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177334A (en) * | 2016-08-23 | 2016-12-07 | 黄海军 | A kind of medicament for treating scald and preparation method thereof |
| CN111759909A (en) * | 2019-04-02 | 2020-10-13 | 范凯贤 | Ointment for treating scald and burn |
| CN111973687A (en) * | 2020-08-04 | 2020-11-24 | 王艳存 | Burn and scald ointment and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103623115B (en) | 2016-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100518794C (en) | Burn cream | |
| CN102139033B (en) | Chinese medicinal composition for treating skin wound of pregnant woman after cesarean section | |
| CN102091203A (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN101879283A (en) | Novel membrane spraying preparation for skin trauma and preparation method | |
| CN101543565A (en) | Chinese medicine external-use preparation medicament for treating surgery wound infection and method for producing the same | |
| CN104857312A (en) | Traditional Chinese medicine composition for preventing and controlling wound infection and promoting wound repair | |
| CN105250696A (en) | Traditional Chinese medicine gel capable of promoting skin wound to heal and preparation method of traditional Chinese medicine gel | |
| Doanh et al. | The use of a water extract from the bark of Choerospondias axillaris in the treatment of second decree burns | |
| CN102631423A (en) | Care solution for wound cleaning | |
| CN103623115B (en) | A kind of Chinese medicine for the treatment of burn, scald and preparation method thereof | |
| CN103585347B (en) | Chinese medicinal composition for treating burns and scalds and preparation method thereof | |
| CN101380349B (en) | Specific ointment for burn and scald | |
| CN101143174A (en) | Traditional Chinese medicine formula for treating cervical erosion | |
| CN103007034B (en) | Traditional Chinese medicine composition used for treatment of residual second-degree burn wound, and preparation method thereof | |
| CN102028875B (en) | Medicament for treating open wound and preparation method thereof | |
| CN105560620A (en) | Trauma treatment traditional Chinese medicine preparation | |
| CN105457084A (en) | Surgical suture with analgesic and antibacterial effect and preparation method thereof | |
| CN101288669A (en) | Exterior-applied powder for treating pressure sore | |
| CN104189304B (en) | It is a kind of to be used to treat Chinese medicine composition of surgical wound and preparation method thereof | |
| CN105232650B (en) | A kind of ointment that treating scald and its preparation and application | |
| CN101214280B (en) | Chinese medicine for treating burn, scald and sores and preparation thereof | |
| CN104398606A (en) | Traditional Chinese medicine composition for treating burn and scald and preparation method for traditional Chinese medicine composition | |
| CN108355130A (en) | It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof | |
| CN102178795B (en) | External medicine for treating burns and scalds and preparation method of medicine | |
| CN1322867C (en) | Hemostatic wound healing Dan |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160504 Termination date: 20200828 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |