CN102631423A - Care solution for wound cleaning - Google Patents
Care solution for wound cleaning Download PDFInfo
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- CN102631423A CN102631423A CN2012101402563A CN201210140256A CN102631423A CN 102631423 A CN102631423 A CN 102631423A CN 2012101402563 A CN2012101402563 A CN 2012101402563A CN 201210140256 A CN201210140256 A CN 201210140256A CN 102631423 A CN102631423 A CN 102631423A
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a care solution for wound cleaning. The care solution is prepared from the following active ingredients in parts by weight: 10 to 15 parts of astragalus, 10 to 15 parts of angelica, 15 to 20 parts of angelica dahurica, 10 to 15 parts of Japanese knotweed, 15 to 18 parts of sophora flavescens and 0.3 to 0.8 part of sodium bicarbonate. The care solution for wound cleaning has the effects of antibacterium, skin formation, promotion of granulation growth, pain alleviation and the like; and the fibroblast convent of granulation tissues on a wound surface is improved, so that the healing of the wound surface can be effectively promoted.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to a kind of conditioning liquid that wound cleans that is used for.
Background technology
Skin is health and the extraneous first road barrier that contacts, and can stop the intrusion of antibacterial, virus etc.But when skin sustained damage, this road barrier also had been broken, and the people knows from experience the infringement that receives antibacterial, virus.The domestic main medicine that is used for the skin degerming debridement has medical alcohol, liquor iodi mitis, povidone iodine, furacilin solution, bromo geramine solution etc. at present; Yet the zest that these medicines of clinical practice discovery have is too strong; Can not large-area applications, the clinical debridement effect that has is undesirable, even anaphylaxis is arranged.In addition, these medicines all do not promote functions such as granulation growth and analgesia.
Modern doctor trained in Western medicine surgery is to wound sterilization, sterilization, to use antibiotic and protect from infection, the method for wrapping up with hospital gauze behind the sew up wound the processing method of the traumatic wounds that operation causes.Stitching has closure of wound, promotes hemostasis and organization healing effect, be the most basic technology of modern surgery, so manual suture is present most widely used method.In addition, not medication on wound of modern surgery, the healing of wound are to lean on the tissue of body self to repair.Generally 2-3 days after surgery, the patient changed a dressing, and purpose is for observing and clean wound.This shows that doctor trained in Western medicine relies on patient's tissue repairing ability itself fully for the healing of postoperative wound, wound healing is slow, and has increased patient infection's risk.
Summary of the invention
The object of the present invention is to provide a kind of conditioning liquid that wound cleans that is used for.Functions such as that wound care liquid of the present invention has is antibiotic, conjunctiva, the growth of promotion granulation and analgesia infect and promote in control and have unique effect aspect the wound healing.
The objective of the invention is to realize like this:
A kind ofly be used for the conditioning liquid that wound cleans, be prepared from the active component of following weight portion: Radix Astragali 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Angelicae Dahuricae 15-20 part, Rhizoma Polygoni Cuspidati 10-15 part, Radix Sophorae Flavescentis 15-18 part, sodium bicarbonate 0.3-0.8 part.
Preferably, described a kind of conditioning liquid that wound cleans that is used for is prepared from the active component of following weight portion: 12 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 18 parts of the Radixs Angelicae Dahuricae, 13 parts of Rhizoma Polygoni Cuspidati, 16 parts of Radix Sophorae Flavescentiss, sodium bicarbonate 0.4-0.6 part.
Further preferably, described a kind of conditioning liquid that wound cleans that is used for, it is a lotion.
The method for preparing of the conditioning liquid that is used for the wound cleaning that the present invention relates to comprises the steps: to take by weighing the Radix Astragali, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, cleans roguing, dries, and is ground into granule; With bundle it, put in people's container, add 20-25 times of water; Soak after 20-30 minute and to decoct about 25-40 minute, filter medicinal residues and must filtrate, the adding sodium bicarbonate; Stirring and dissolving is sub-packed in the bottle of 100ml, and gland is also subsequent use in 115 ℃ of high temperature sterilize 30-60min.
Method for using: when conditioning liquid is heated to 30-40 ℃, clean a wound repeatedly with gauze or sponge libation at an ancient wedding ceremony taking liquid, or wound was directly immersed in the medicinal liquid 30-45 minute, every day 2-4 time, every dose of medicine can use 2 days repeatedly, and 6 days was 1 course of treatment.
According to the record of Chinese medicine historical data, the pharmacologically active of above-mentioned Chinese crude drug is following:
The Radix Astragali: have benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Select the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels for use.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Select the root of samphire angelica anomala for use.
Rhizoma Polygoni Cuspidati: heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.Select Polygonaceae Polygonaceae plant polygonum cuspidatum Polygonum cuspidatum Sieb.et Zucc. for use, dry rhizome and root.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Select the root of the perennial semishrub plant's Radix Sophorae Flavescentis of falling leaves for use.
Functions such as that wound care liquid of the present invention has is antibiotic, conjunctiva, the growth of promotion granulation and analgesia infect and promote in control and have unique effect aspect the wound healing.In clinical observation, wound care liquid of the present invention has than positive effect for wound healing, can be at a distance from bacterium, antibacterial promotion wound healing; Can prevent again and the wound adhesion that rebirth skin and wound are not had secondary damage, patient felt comfortable consistent the reflection after use wound care liquid was changed dressings; No pain stimulates little, salubrious to wound; The wound surface exudate obviously reduces, and wound surface does not give an offensive smell, abnormal smells from the patient delicate fragrance.
Discover through animal experiment; Result of the test according to table 1 and table 2 can find out that As time goes on, test group is compared with matched group; Has significant difference (P＜0.05) aspect rat wound surface CI or the fibroblast number; Even utmost point significant difference (P＜0.01), this explains that wound surface conditioning liquid of the present invention can improve the fibroblastic content of wound surface granulation tissue, thereby promotes wound healing effectively fast.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 wound conditioning liquid for cleaning
Prescription: Radix Astragali 120g, Radix Angelicae Sinensis 130g, Radix Angelicae Dahuricae 180g, Rhizoma Polygoni Cuspidati 130g, Radix Sophorae Flavescentis 160g, sodium bicarbonate 5g.
Method for preparing: take by weighing the Radix Astragali, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, clean roguing, dry, be ground into granule; With bundle it, put in people's container, add 25 times of water; Soak after 30 minutes and to decoct about 30 minutes, filter medicinal residues and must filtrate, add sodium bicarbonate; Stirring and dissolving is sub-packed in the bottle of 100ml, and gland is also subsequent use in 115 ℃ of high temperature sterilize 30min.
The preparation of embodiment 2 wound conditioning liquid for cleaning
Prescription: Radix Astragali 150g, Radix Angelicae Sinensis 150g, Radix Angelicae Dahuricae 150g, Rhizoma Polygoni Cuspidati 150g, Radix Sophorae Flavescentis 150g, sodium bicarbonate 3g.
Method for preparing: take by weighing the Radix Astragali, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, clean roguing, dry, be ground into granule; With bundle it, put in people's container, add 25 times of water; Soak after 20 minutes and to decoct about 40 minutes, filter medicinal residues and must filtrate, add sodium bicarbonate; Stirring and dissolving is sub-packed in the bottle of 100ml, and gland is also subsequent use in 115 ℃ of high temperature sterilize 30min.
The preparation of embodiment 3 wound conditioning liquid for cleaning
Prescription: Radix Astragali 120g, Radix Angelicae Sinensis 100g, Radix Angelicae Dahuricae 200g, Rhizoma Polygoni Cuspidati 100g, Radix Sophorae Flavescentis 180g, sodium bicarbonate 8g.
Method for preparing: take by weighing the Radix Astragali, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, clean roguing, dry, be ground into granule; With bundle it, put in people's container, add 25 times of water; Soak after 30 minutes and to decoct about 25 minutes, filter medicinal residues and must filtrate, add sodium bicarbonate; Stirring and dissolving is sub-packed in the bottle of 100ml, and gland is also subsequent use in 115 ℃ of high temperature sterilize 30min.
Embodiment 4 wound surface conditioning liquids of the present invention promote the experimentation of perianal abscess postoperative rat model wound healing
64 of cleaning level Wistar rats, male and female half and half, body constitution amount 220 ± 20g is with 1% ketalar (3mL/kg) intraperitoneal injection of anesthesia.Local preserved skin, routine disinfection, rat back cut-off directly are 1 of the circular incision of 1cm, cut off skin holostrome, subcutaneous superficial fascia until the flesh layer; (normal person's fresh excreta 10g adds normal saline 5mL, mixing with liquid manure 1mL on wound surface in the hemostasis back; Centrifugal, get supernatant, join existing usefulness) at present; Fix with oily yarn, dressing, adhesive tape, dismantle behind the 48h, see that wound has purulent secretion, has excrement stink person to be the modeling success.
Rat model is divided into matched group, test group, every group of 32 rats.Two groups of rats adopt normal saline to clean a wound, and adopt iodophor disinfection, wrapping dressing.Wherein, matched group is pressed penicillin sodium 140,000 units/kg intraperitoneal injection.Test group when simultaneously the wound surface conditioning liquid of embodiment 1 preparation being heated to 35-40 ℃, directly immersed in the medicinal liquid wound 30 minutes except that pressing penicillin sodium 140,000 units/kg intraperitoneal injection, morning, noon and afternoon every day each once.
After modeling the 3rd, 7,10,14d; Divide 4 batches (every batch every group 8 rats) to put to death rat; Cut the 0.5cm*0.5cm granulation tissue at edge of wound, put in the carnoy fluid fixedly 45min, FFPE, section; Row conventional H E dyeing adopts light microscopic and MPIAS-500 color pathological picture and text analytical system to observe.
The computing formula of wound surface CI: wound surface CI=(1-treatment back wound surface area/original wound surface area) * 100%.The result is referring to table 1.
The fibroblast number.Each BIAO and BEN is observed 5 visuals field, fibroblast number in the counting granulation tissue, and average (fibroblast number/each visual field).The result is referring to table 2.
Granulation tissue is by a large amount of blood capillaries and tiny blood vessels and abundant fibroblast.Fibroblast is the topmost cell of repair in trauma.In cell proliferation and reparation phase, one of step of most critical is the formation of granulation tissue, and the essence of granulation tissue is a large amount of fibroblast and blood capillaries.After wound formed, fibroblast bred, moves, and synthesized, secretes collagen and extracellular matrix composition, participated in the process of granulation tissue formation, wound contraction and tissue reconstruction, and its number change can have an immense impact on to wound healing.
Result of the test according to table 1 and table 2 can be found out; As time goes on; Test group is compared with matched group, has significant difference (P＜0.05) aspect rat wound surface CI or the fibroblast number, even utmost point significant difference (P＜0.01); This explains that wound surface conditioning liquid of the present invention can improve the fibroblastic content of wound surface granulation tissue, thereby promotes wound healing effectively fast.
Table 1 liang is formed face CI relatively (%)
Compare * P＜0.05, * * P＜0.01 with matched group.
Table 2 liang form fibroblast number in the face granulation tissue comparison (individual/HPF)
Compare * P＜0.05, * * P＜0.01 with matched group.
Functions such as that wound care liquid of the present invention has is antibiotic, conjunctiva, the growth of promotion granulation and analgesia infect and promote in control and have unique effect aspect the wound healing.In clinical observation, wound care liquid of the present invention has than positive effect for wound healing, can be at a distance from bacterium, antibacterial promotion wound healing; Can prevent again and the wound adhesion that rebirth skin and wound are not had secondary damage, patient felt comfortable consistent the reflection after use wound care liquid was changed dressings; No pain stimulates little, salubrious to wound; The wound surface exudate obviously reduces, and wound surface does not give an offensive smell, abnormal smells from the patient delicate fragrance.
Claims (3)
1. one kind is used for the conditioning liquid that wound cleans, and it is characterized in that: the active component following weight portion is prepared from: Radix Astragali 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Angelicae Dahuricae 15-20 part, Rhizoma Polygoni Cuspidati 10-15 part, Radix Sophorae Flavescentis 15-18 part, sodium bicarbonate 0.3-0.8 part.
2. a kind of conditioning liquid that wound cleans that is used for as claimed in claim 1, it is characterized in that: the active component following weight portion is prepared from: 12 parts of the Radixs Astragali, 13 parts of Radix Angelicae Sinensis, 18 parts of the Radixs Angelicae Dahuricae, 13 parts of Rhizoma Polygoni Cuspidati, 16 parts of Radix Sophorae Flavescentiss, sodium bicarbonate 0.4-0.6 part.
3. according to claim 1 or claim 2 a kind of is used for the conditioning liquid that wound cleans, and it is characterized in that: it is a lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210140256 CN102631423B (en) | 2012-05-09 | 2012-05-09 | Care solution for wound cleaning |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210140256 CN102631423B (en) | 2012-05-09 | 2012-05-09 | Care solution for wound cleaning |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102631423A true CN102631423A (en) | 2012-08-15 |
| CN102631423B CN102631423B (en) | 2013-06-19 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656438A (en) * | 2013-12-31 | 2014-03-26 | 伊恕嵘 | Nursing medicine for spine postoperative cuts |
| CN104435274A (en) * | 2014-12-24 | 2015-03-25 | 刘树芹 | External preparation for treating kysthitis |
| CN104524512A (en) * | 2014-12-26 | 2015-04-22 | 陈建伟 | Traditional Chinese medicine for cleaning wounds in orthopedic nursing |
| CN104971333A (en) * | 2015-07-10 | 2015-10-14 | 韩晓丽 | Traditional Chinese medicine for caring and cleaning of wounds |
| CN106309598A (en) * | 2016-11-14 | 2017-01-11 | 河南中医药大学 | Traditional Chinese medicine care solution for cleaning wound and preparation method thereof |
| CN113559187A (en) * | 2021-08-09 | 2021-10-29 | 中南大学湘雅三医院 | Traditional Chinese medicine formula for promoting wound healing and preparation method thereof |
| CN115645481A (en) * | 2022-11-17 | 2023-01-31 | 安徽天康医疗科技股份有限公司 | Ointment for quickly curing abscess and wound |
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| CN1895471A (en) * | 2006-06-20 | 2007-01-17 | 王亚贤 | Chinese-medicinal jet embrocation for healing wound and its preparation |
| CN101249190A (en) * | 2008-03-28 | 2008-08-27 | 李春华 | Anti-inflammation sterilizing Chinese medicine compound externally used coating liquid and method of preparing the same |
| CN102114114A (en) * | 2010-12-30 | 2011-07-06 | 陈国英 | Nursing disinfectant and preparation method thereof |
| CN102205018A (en) * | 2011-05-04 | 2011-10-05 | 田玲玲 | Traditional Chinese medicinal lotion for treating abdominal wall fascitis |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1895471A (en) * | 2006-06-20 | 2007-01-17 | 王亚贤 | Chinese-medicinal jet embrocation for healing wound and its preparation |
| CN101249190A (en) * | 2008-03-28 | 2008-08-27 | 李春华 | Anti-inflammation sterilizing Chinese medicine compound externally used coating liquid and method of preparing the same |
| CN102114114A (en) * | 2010-12-30 | 2011-07-06 | 陈国英 | Nursing disinfectant and preparation method thereof |
| CN102205018A (en) * | 2011-05-04 | 2011-10-05 | 田玲玲 | Traditional Chinese medicinal lotion for treating abdominal wall fascitis |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656438A (en) * | 2013-12-31 | 2014-03-26 | 伊恕嵘 | Nursing medicine for spine postoperative cuts |
| CN103656438B (en) * | 2013-12-31 | 2015-07-08 | 伊恕嵘 | Nursing medicine for spine postoperative cuts |
| CN104435274A (en) * | 2014-12-24 | 2015-03-25 | 刘树芹 | External preparation for treating kysthitis |
| CN104524512A (en) * | 2014-12-26 | 2015-04-22 | 陈建伟 | Traditional Chinese medicine for cleaning wounds in orthopedic nursing |
| CN104971333A (en) * | 2015-07-10 | 2015-10-14 | 韩晓丽 | Traditional Chinese medicine for caring and cleaning of wounds |
| CN106309598A (en) * | 2016-11-14 | 2017-01-11 | 河南中医药大学 | Traditional Chinese medicine care solution for cleaning wound and preparation method thereof |
| CN113559187A (en) * | 2021-08-09 | 2021-10-29 | 中南大学湘雅三医院 | Traditional Chinese medicine formula for promoting wound healing and preparation method thereof |
| CN115645481A (en) * | 2022-11-17 | 2023-01-31 | 安徽天康医疗科技股份有限公司 | Ointment for quickly curing abscess and wound |
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| Publication number | Publication date |
|---|---|
| CN102631423B (en) | 2013-06-19 |
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