CN117503793A - Application of burdock root polysaccharide in preparation of medicine for treating burn - Google Patents
Application of burdock root polysaccharide in preparation of medicine for treating burn Download PDFInfo
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- 235000003130 Arctium lappa Nutrition 0.000 title claims abstract description 84
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 82
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 82
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- 239000003814 drug Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
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- 230000035876 healing Effects 0.000 abstract description 7
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 9
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- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
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- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
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- 206010040893 Skin necrosis Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses application of burdock root polysaccharide in preparation of a medicament for treating burn, and belongs to the technical field of traditional Chinese medicines. The invention takes burdock root polysaccharide as the only active ingredient and prepares the medicament for treating burn. The results show that the burdock root polysaccharide can effectively treat burn and prevent the progressive deepening of the burn wound surface, and the burdock root polysaccharide can improve the healing capacity and the healing quality of the wound surface.
Description
Technical Field
The invention relates to application of burdock root polysaccharide in preparation of a medicament for treating burn, and belongs to the technical field of traditional Chinese medicines.
Background
A burn is a damage to skin or other organ tissue that is caused primarily by high temperature, or by radiation, electricity, friction, or contact with chemicals. Burn is not only one of the most damaging wounds, but also one of the major public health problems worldwide, and has high mortality and disability rate. World health organization (World Health Organization, WHO) shows that 6700 thousands of people experience burns each year worldwide, and more than 30 tens of thousands die from burns, greatly creating a worldwide medical burden. The wound surface is always a difficult point for clinically treating burn, and how to effectively prevent the progressive deepening of the wound surface is one of the core targets of burn treatment. However, the clinical medicine for preventing and treating the progressive deepening of the wound surface has a great significance in developing the medicine for effectively preventing and treating the burn wound surface.
Burdock (Arctium Lappa l.) is a two-year old herb of the family of the asteraceae, also known as east American ginseng, white muscle ginseng. The burdock root is a good medicine and food homologous plant, and the polysaccharide content is highest except moisture, which is about 25%. Studies show that burdock root polysaccharide has remarkable effects on anti-tumor, blood fat reducing, antithrombotic and other aspects, but the research on the effect of burdock root polysaccharide on burn wound surfaces has no relevant report at home and abroad at present.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides application of burdock root polysaccharide in preparing a medicament for treating burn, the burdock root polysaccharide can effectively prevent progressive deepening of burn wound surfaces, and the burdock root polysaccharide can improve the wound surface healing capacity and healing quality.
In order to achieve the above purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides the use of burdock root polysaccharide in the manufacture of a medicament for treating burns.
Further, in the above technical scheme, the burdock root polysaccharide is the only active ingredient.
Further, in the technical scheme, the concentration of the burdock root polysaccharide is 2.5-95 wt%.
Further, in the technical scheme, the application of the preparation method in preparing the medicine for inhibiting early progressive deepening of the burn skin wound and promoting wound repair and healing is provided.
Furthermore, in the technical scheme, the application of the composition in preparing the medicine for protecting the tissue structure of each layer of skin is provided.
Further, in the above technical solution, the skin each layer tissue structure includes: epidermal, dermal and subcutaneous tissue.
Further, in the technical scheme, burdock root polysaccharide is mixed with auxiliary materials of corresponding formulations to prepare one or more of solution, lotion, spirit, tincture, suspension, cream, ointment, cream, gel, medicine-containing auxiliary materials and the like.
The beneficial effects are that:
the burdock root polysaccharide has the effects of inhibiting burn skin necrosis, protecting the tissue structures of each skin, preventing the progressive deepening of burn wounds and promoting the healing of the burn wounds, and can be applied to the preparation of medicaments for treating burn. And because of the medicinal and edible plant sources, the burdock root polysaccharide has the characteristic of high safety.
Proved by the verification, the burdock root polysaccharide has remarkable treatment effect on the skin burn of rats, effectively prevents the progressive deepening of the burn wound surface, and improves the healing capacity and the healing quality of the wound surface.
The invention uses burdock root polysaccharide as the only active ingredient and is used for treating skin burn. Compared with the model group, the burn degree of the group using 1wt% sodium carboxymethyl cellulose solution is not relieved, but after 5wt% or 10wt% burdock root polysaccharide solution is added into the 1wt% sodium carboxymethyl cellulose solution, the burn degree is obviously reduced, and the burn treatment effect of the 10wt% burdock root polysaccharide solution is better.
The invention sets burdock root polysaccharide ointment and burdock root polysaccharide gel, and results show that the dosage forms can also play the roles of reducing the burn degree and promoting the wound healing.
Drawings
FIG. 1 shows the HE staining results of the skin from the normal group.
Fig. 2 shows the results of HE staining of skin in burn groups.
FIG. 3 shows the results of HE staining of skin from burn+1wt% sodium carboxymethylcellulose solution group.
FIG. 4 shows the results of HE staining of skin from burn+2.5wt% burdock root polysaccharide solution group.
FIG. 5 shows the results of HE staining of skin from burn+5 wt% burdock root polysaccharide solution group.
FIG. 6 shows the results of HE staining of skin from burn+10 wt% burdock root polysaccharide solution group.
FIG. 7 shows the results of HE staining of skin from burn+50 wt% burdock root polysaccharide solution group.
FIG. 8 shows the results of HE staining of skin from burn+95 wt% burdock root polysaccharide solution group.
Fig. 9 shows skin HE staining results of burn +100% burdock root polysaccharide dry powder.
Fig. 10 shows the HE staining results for the normal group of skin.
Fig. 11 shows the results of HE staining of skin in burn groups.
Fig. 12 shows the results of HE staining of skin of burn + gel group.
FIG. 13 shows the results of HE staining of skin from burn+5 wt% Arctium lappa polysaccharide gel group.
FIG. 14 shows the results of HE staining of skin from burn+10wt% burdock root polysaccharide gel set.
Detailed Description
The invention will be better explained by the following detailed description of the embodiments with reference to the drawings.
In order that the above-described aspects may be better understood, exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
The preparation method of the burdock root polysaccharide comprises the following steps:
(1) Peeling radix Arctii, cleaning, slicing, oven drying at 60deg.C, and pulverizing.
(2) Decocting in water at 80deg.C for 3 hr at a ratio of 1:15, filtering with gauze, collecting filtrate, and decocting the residue with water for 3-4 times.
(3) The filtrate is collected and filtered by a common filter paper, and insoluble impurities are primarily removed.
(4) The filtrate was concentrated by rotary evaporation to a suitable volume, 3 volumes of absolute ethanol was added, and the mixture was stirred and allowed to stand overnight, and the solution was layered.
(5) Collecting the lower precipitate, rotary evaporating, drying, and adding appropriate amount of water to dissolve radix Arctii polysaccharide.
(6) Repeating the steps 4-5 for 3-4 times, collecting burdock root polysaccharide water solution, and freeze drying to obtain burdock root polysaccharide dry product.
The formula of the burdock root polysaccharide solution with the weight percentage of 5 percent comprises: burdock root polysaccharide: 5g, 1% by weight sodium carboxymethylcellulose solution was used to volume to 100ml.
The formula of the burdock root polysaccharide solution with the weight percentage of 10 percent comprises: burdock root polysaccharide: 10g, 1% by weight sodium carboxymethylcellulose solution was used to volume 100ml.
5wt% of burdock root polysaccharide gel: up water: 74.48g, burdock root polysaccharide: 4g, carbomer 2020:0.8g, triethanolamine: 0.8g of ethylparaben: 0.08g.
The formula of the burdock root polysaccharide gel comprises the following components by weight percent: up water: 70.48g of burdock root polysaccharide: 8g, carbomer 2020:0.8g, triethanolamine: 0.8g of ethylparaben: 0.08g.
EXAMPLE 1 burdock root polysaccharide treatment of deep burn rats
(1) Construction of classical deep II degree burn rat model
Male adult SD rats (6-8 weeks, weight 180-220 g) were anesthetized with isoflurane inhalation, and the back was cut off in the area to be molded until the back skin was completely exposed. Setting the temperature of a super temperature control scald apparatus (YLS-5Q) with the diameter of 2.5cm to be 100 ℃ for 6s, and causing a deep II degree burn wound surface.
(2) Animal experiment group
Male adult SD rats (6-8 weeks, weight 180-220 g) were purchased from the university of major company SPF laboratory animal center.
1) Normal group: the rat skin was adhered using a normal temperature metal sheet.
2) Burn group: 100 ℃ and 6s, and the deep II degree burn wound surface of the rat skin is caused.
3) Burn+1 wt% sodium carboxymethyl cellulose solution group: 1wt% sodium carboxymethylcellulose is applied immediately after burn, once every 6 hours.
4) Burn+2.5wt% burdock root polysaccharide solution group: 2.5wt% burdock root polysaccharide solution is smeared immediately after burn, and is smeared once every 6 hours.
5) Burn+5 wt% burdock root polysaccharide solution group: the solution of burdock root polysaccharide with the weight percent of 5 is smeared immediately after burn, and is smeared once every 6 hours.
6) Burn +10wt% burdock root polysaccharide solution group: immediately after burn, the solution of the burdock root polysaccharide with the weight percent of +10wt% is smeared once every 6 hours.
7) Burn +50wt% burdock root polysaccharide solution group: immediately after burn, the solution of +50wt% burdock root polysaccharide is smeared once every 6 hours.
8) Burn +95wt% burdock root polysaccharide solution group: immediately after burn, the solution of +50wt% burdock root polysaccharide is smeared once every 6 hours.
9) Burn +100% burdock root poly dry powder: the dry powder of the burdock root polysaccharide of +100% is smeared immediately after burn, and the powder is smeared once every 6 hours.
(3) Rat sacrifice and material drawing
Immediately taking the medicine after burn, anaesthetizing after 72 hours, cutting the skin tissue at the wound edge which is 2-3mm away from the wound surface, fixing by using paraformaldehyde, embedding by paraffin, and performing HE staining on the cut slice.
Experimental results
As shown in FIG. 1, the HE staining results of the skin of the normal group showed that the skin tissue of each layer was intact.
Fig. 2 shows the results of HE staining of skin in burn groups. The results show that the epidermis is necrotic, thinned, basal layer of epidermis layer, acantha layer, granular layer, cuticle layer, fused together; the reticular layer of dermis is injured, but the deep dermis and the deep structure of the skin accessories therein are still healthy, and collagen fibers at the upper part of dermis are swollen and fused; the procollagen structure disappeared. Blood vessel congestion, stasis or thrombosis can be seen in the dermis and arterioles and venules in the skin; necrosis of the wall of the great vein in the subcutaneous tissue, and agglutination of erythrocytes in the lumen; the myofiber texture partially disappeared and fused. It is suggested that burn groups of skin are characterized by deep II degree or even III degree burns.
FIG. 3 shows the results of HE staining of skin from burn+1wt% sodium carboxymethylcellulose solution group. The results show that the whole epidermis is necrotic, and the basal layer, the acantha layer, the granular layer and the cuticle of the epidermis are fused together, so that the epidermis is thinned; the reticular dermis is injured, but the deep dermis and the deep structure of the skin accessories therein are still healthy, the collagen fibers at the upper part of the dermis are swollen and fused, and the procollagen structure disappears. Blood vessel congestion, stasis or thrombosis can be seen in the dermis and arterioles and venules in the skin; the wall of the great vein in subcutaneous tissue is necrotic and the erythrocytes in the lumen are aggregated. The myofiber texture partially disappeared and fused. It is suggested that deep II to III burns still have the characteristics.
FIG. 4 shows the results of HE staining of skin from burn+2.5wt% burdock root polysaccharide solution group. The results showed that the stratum corneum, stratum granulosum, and stratum spinosum cells were necrotic, but basal lamina cells were healthy and the epidermis was stratified. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is suggested to be characterized by shallow II degree to deep II degree burns.
FIG. 5 shows the results of HE staining of skin from burn+5 wt% burdock root polysaccharide solution group. The results showed full-thickness necrosis of the epidermis, but it was seen that different numbers of basal cells remained, and the epidermis delaminated. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is characterized by shallow II degree to deep II degree burn, and has a directional shallow II degree recovery trend.
FIG. 6 shows the results of HE staining of skin from burn+10 wt% burdock root polysaccharide solution group. The results show that the epidermis is partially necrotic and basal lamina and acantha cells remain healthy in the epidermis. The epidermis is a layer of stratum corneum and the granulosum cells are not clear in structure and fuse with each other, and the nipple layer is deformed. The dermal papilla layer and the reticular layer are infiltrated by a great amount of inflammatory cells, but have no leucocyte infiltration zone. The myometrium has inflammatory cell infiltration. The fat layer and fascia layer are scattered with leukocyte infiltration, and the number of free red blood cells is large. The burn has the characteristics of shallow II degree burn, and has a directional I degree recovery trend.
FIG. 7 shows the results of HE staining of skin from burn+50 wt% burdock root polysaccharide solution group. The results showed full-thickness necrosis of the epidermis, but it was seen that different numbers of basal cells remained, and the epidermis delaminated. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is suggested to be characterized by shallow II degree to deep II degree burns.
FIG. 8 shows the results of HE staining of skin from burn+95 wt% burdock root polysaccharide solution group. The results showed full-thickness necrosis of the epidermis, but it was seen that different numbers of basal cells remained, and the epidermis delaminated. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is suggested to be characterized by shallow II degree to deep II degree burns.
Fig. 9 shows skin HE staining results of burn +100% burdock root polysaccharide dry powder. The results showed full-thickness necrosis of the epidermis, but it was seen that different numbers of basal cells remained, and the epidermis delaminated. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is suggested to be characterized by shallow II degree to deep II degree burns.
The experimental results show that: the normal group of rats has complete skin tissues, the skin epidermis of the burn group has full necrosis, and the dermis reticular layer is injured, and the burn degree is between the deep II degree and the deep III degree. The 1% sodium carboxymethyl cellulose solution has no obvious relieving effect, and the skin of the treatment group treated by the burdock root polysaccharide solution shows different degrees of improvement, wherein 2.5wt%, 50wt%, 95wt% burdock root polysaccharide solution and 100% burdock root polysaccharide dry powder can relieve burned skin to a range between deep II degree and shallow II degree; the burdock root polysaccharide solution with the weight percent of 5 can relieve the burnt skin between deep II degree and shallow II degree, and has a trend of recovering to the shallow II degree; the 10wt% burdock root polysaccharide solution can relieve burnt skin to shallow degree II, and has a tendency to recover from degree I.
EXAMPLE 2 burdock root polysaccharide gel treatment of deep burn rats
(1) The skin burn, sacrifice and sampling method of the rats were the same as in example 1, and the groups were as follows:
1) Normal group: the rat skin was adhered using a normal temperature metal sheet.
2) Burn group: 100 ℃ and 6s, and the deep II degree burn wound surface of the rat skin is caused.
3) Burn + gel group: the gel is applied immediately after burn, once every 6 hours.
4) Burn +5wt% burdock root polysaccharide gel group: the gel of burdock root polysaccharide is smeared at 5wt% immediately after burn, and is smeared once every 6 hours.
5) Burn +10wt% burdock root polysaccharide gel group: the gel of burdock root polysaccharide is applied at an amount of 10wt% immediately after burn, and is applied every 6 hours.
(2) Experimental results
FIG. 10 shows the HE staining results of the normal group of skin, indicating that the skin tissue of each layer was intact.
Fig. 11 shows the results of HE staining of skin in burn groups. The results show that the epidermis is necrotic, thinned, basal layer of epidermis layer, acantha layer, granular layer, cuticle layer, fused together; the reticular layer of dermis is injured, but the deep dermis and the deep structure of the skin accessories therein are still healthy, and collagen fibers at the upper part of dermis are swollen and fused; the procollagen structure disappeared. Blood vessel congestion, stasis or thrombosis can be seen in the dermis and arterioles and venules in the skin; necrosis of the wall of the great vein in the subcutaneous tissue, and agglutination of erythrocytes in the lumen; the myofiber texture partially disappeared and fused. It is suggested that the burn has the characteristics of deep II degree burn and even III degree burn.
Fig. 12 shows the results of HE staining of skin of burn + gel group. The results showed full-thickness necrosis of the epidermis, but it was seen that different numbers of basal cells remained, and the epidermis delaminated. The dermal papilla layer has obvious congestion, leukocyte infiltration, discrete collagen fibers and swelling. The burn is suggested to be characterized by shallow II degree to deep II degree burns. The burn is characterized by shallow II degree to deep II degree burn, and has a directional shallow II degree recovery trend.
FIG. 13 shows the results of HE staining of skin from burn+5 wt% Arctium lappa polysaccharide gel group. The results show that the epidermis is partially necrotic and basal lamina and acantha cells remain healthy in the epidermis. The epidermis is a layer of stratum corneum and granulosum cells are not clear in structure and fuse with each other. The dermal papilla layer and the reticular layer are infiltrated by a small amount of inflammatory cells. The muscle layer is infiltrated by inflammatory cells, the fat layer is infiltrated by white blood cells, and the number of free red blood cells is large. The burn is characterized by shallow II degree to deep II degree burn, and has a directional shallow II degree recovery trend.
FIG. 14 shows the results of HE staining of skin from burn+10wt% burdock root polysaccharide gel set. The results show that the epidermis is partially necrotic and basal lamina and acantha cells remain healthy in the epidermis. The stratum corneum and the stratum granulosum are not clear in cell structure and fuse with each other, so that the nipple layer is deformed. The dermal papilla layer and reticular layer are infiltrated by inflammatory cells, the fat layer and fascia layer are infiltrated by white blood cells, and the red blood cells are aggregated. The burn has the characteristics of shallow II degree burn, and has a directional I degree recovery trend.
The experimental results show that: the normal group of rats has complete skin tissues, the skin epidermis of the burn group has full necrosis, and the dermis reticular layer is injured, and the burn degree is between the deep II degree and the deep III degree. The gel matrix has no obvious relieving effect, and the skin treated by the burdock root polysaccharide gel has different degrees of improvement, wherein 5 weight percent of burdock root polysaccharide gel can relieve the burnt skin between deep II degree and shallow II degree and has a tendency of recovering to shallow II degree; the 10wt% burdock root polysaccharide gel can relieve burnt skin to shallow degree II and has a degree I recovery trend.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (7)
1. Application of burdock root polysaccharide in preparing medicine for treating burn is provided.
2. The use according to claim 1, wherein the burdock root polysaccharide is the only active ingredient.
3. The use according to claim 1 or 2, wherein the concentration of burdock root polysaccharide is 2.5wt% to 95wt%.
4. The use according to claim 1 or 2, characterized by the use in the preparation of a medicament for inhibiting early progressive deepening of the wound surface of burn skin, promoting wound repair and healing.
5. Use according to claim 1 or 2, in the preparation of a medicament for protecting the structure of the tissues of the skin.
6. The use according to claim 5, wherein the skin-layer tissue structure comprises: epidermal, dermal and subcutaneous tissue.
7. The use according to any one of claims 1-6, wherein burdock root polysaccharide is formulated with adjuvants of corresponding formulation into one or more of solution, lotion, spirit, tincture, suspension, cream, ointment, cream, gel, medicated adjuvants, etc.
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| RU2159628C2 (en) * | 1996-07-01 | 2000-11-27 | Малеева Галина Лаврентьевна | Antiburn agent and method of preparation thereof |
| CN107279847A (en) * | 2017-07-03 | 2017-10-24 | 黑龙江省科学院大庆分院 | A kind of black burdock making process of candied of maturation and its black burdock dried meat of made maturation |
| RU2656398C1 (en) * | 2017-02-22 | 2018-06-05 | федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") | Method for producing water-soluble polysaccharides from leaves of great burdock |
| RU2706333C1 (en) * | 2018-10-15 | 2019-11-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" (ФГАОУ ВО "КФУ им. В.И. Вернадского") | Ointment for wound healing |
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| RU2159628C2 (en) * | 1996-07-01 | 2000-11-27 | Малеева Галина Лаврентьевна | Antiburn agent and method of preparation thereof |
| RU2656398C1 (en) * | 2017-02-22 | 2018-06-05 | федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") | Method for producing water-soluble polysaccharides from leaves of great burdock |
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| RU2706333C1 (en) * | 2018-10-15 | 2019-11-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" (ФГАОУ ВО "КФУ им. В.И. Вернадского") | Ointment for wound healing |
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