CN104411685B - 3‑o‑杂芳基‑巨大戟二萜醇 - Google Patents

3‑o‑杂芳基‑巨大戟二萜醇 Download PDF

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CN104411685B
CN104411685B CN201380033726.9A CN201380033726A CN104411685B CN 104411685 B CN104411685 B CN 104411685B CN 201380033726 A CN201380033726 A CN 201380033726A CN 104411685 B CN104411685 B CN 104411685B
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ingenol
acetonide
compound
pyridyl
trifluoromethyl
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CN104411685A (zh
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梁锡福
T·霍格博格
B·诺雷马克
K·曼森
C·里特斯嘉德
G·格鲁-索伦森
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Leo Pharma AS
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D491/04—Ortho-condensed systems
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EP3060304A1 (en) 2013-10-25 2016-08-31 Leo Laboratories Limited A method for topically treating actinic keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate)
WO2016191835A1 (pt) * 2015-06-03 2016-12-08 Amazônia Fitomedicamentos Ltda. Método de preparação de ingenol-5,20-acetonida, método de preparação de 3-etinil-3-hidroxi-4.7.7-trimetilbiciclo[4.1.0] heptano-2-carbaldeído, método de preparação do composto 2,2-dimetil-4-etinil-5 -trifenilfosforanilideno-1,3-dioxano e composto intermediário
US12502369B2 (en) 2015-11-11 2025-12-23 K-Gen, Inc. Methods of cancer treatment
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