CN104402862A - 艾立替尼的制备方法 - Google Patents
艾立替尼的制备方法 Download PDFInfo
- Publication number
- CN104402862A CN104402862A CN201410635005.1A CN201410635005A CN104402862A CN 104402862 A CN104402862 A CN 104402862A CN 201410635005 A CN201410635005 A CN 201410635005A CN 104402862 A CN104402862 A CN 104402862A
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- CN
- China
- Prior art keywords
- base
- morpholine
- ethyl
- preparation
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410635005.1A CN104402862B (zh) | 2014-11-12 | 2014-11-12 | 艾立替尼的制备方法 |
US15/524,749 US10221155B2 (en) | 2014-11-12 | 2015-09-16 | Method for preparing Alectinib |
PCT/CN2015/089736 WO2016074532A1 (zh) | 2014-11-12 | 2015-09-16 | 艾立替尼的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410635005.1A CN104402862B (zh) | 2014-11-12 | 2014-11-12 | 艾立替尼的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104402862A true CN104402862A (zh) | 2015-03-11 |
CN104402862B CN104402862B (zh) | 2016-10-05 |
Family
ID=52640542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410635005.1A Active CN104402862B (zh) | 2014-11-12 | 2014-11-12 | 艾立替尼的制备方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10221155B2 (zh) |
CN (1) | CN104402862B (zh) |
WO (1) | WO2016074532A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016074532A1 (zh) * | 2014-11-12 | 2016-05-19 | 苏州明锐医药科技有限公司 | 艾立替尼的制备方法 |
CN106518842A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种艾乐替尼的制备方法 |
CN110452215A (zh) * | 2018-05-08 | 2019-11-15 | 新发药业有限公司 | 一种艾乐替尼中间体及艾乐替尼的制备方法 |
CN112028874A (zh) * | 2020-09-10 | 2020-12-04 | 苏州富德兆丰生化科技有限公司 | 艾立替尼的合成方法 |
CN112585126A (zh) * | 2018-09-04 | 2021-03-30 | 中外制药株式会社 | 四环化合物的制备方法 |
WO2022051983A1 (zh) * | 2020-09-10 | 2022-03-17 | 苏州富德兆丰生化科技有限公司 | 艾立替尼的合成方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3649116A1 (en) | 2017-07-05 | 2020-05-13 | Fresenius Kabi Oncology Limited | A process for preparing alectinib or a pharmaceutically acceptable salt thereof |
WO2019211868A1 (en) * | 2018-04-30 | 2019-11-07 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl) piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile hydrochloride |
EP3556754A1 (en) | 2018-12-07 | 2019-10-23 | Fresenius Kabi iPSUM S.r.l. | Process for the preparation of alectinib |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102459172A (zh) * | 2009-06-10 | 2012-05-16 | 中外制药株式会社 | 四环化合物 |
CN103052386A (zh) * | 2010-08-20 | 2013-04-17 | 中外制药株式会社 | 含有四环化合物的组合物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5006987B2 (ja) * | 2010-11-22 | 2012-08-22 | 中外製薬株式会社 | 4環性化合物を含む医薬 |
CN104402862B (zh) | 2014-11-12 | 2016-10-05 | 苏州明锐医药科技有限公司 | 艾立替尼的制备方法 |
-
2014
- 2014-11-12 CN CN201410635005.1A patent/CN104402862B/zh active Active
-
2015
- 2015-09-16 US US15/524,749 patent/US10221155B2/en not_active Expired - Fee Related
- 2015-09-16 WO PCT/CN2015/089736 patent/WO2016074532A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102459172A (zh) * | 2009-06-10 | 2012-05-16 | 中外制药株式会社 | 四环化合物 |
CN103052386A (zh) * | 2010-08-20 | 2013-04-17 | 中外制药株式会社 | 含有四环化合物的组合物 |
Non-Patent Citations (2)
Title |
---|
KAZUTOMO KINOSHITA ET AL.: "Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
WEI SHEN,ET AL.: "Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016074532A1 (zh) * | 2014-11-12 | 2016-05-19 | 苏州明锐医药科技有限公司 | 艾立替尼的制备方法 |
US10221155B2 (en) | 2014-11-12 | 2019-03-05 | Suzhou Miracpharma Technology, Co., Ltd. | Method for preparing Alectinib |
CN106518842A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种艾乐替尼的制备方法 |
CN110452215A (zh) * | 2018-05-08 | 2019-11-15 | 新发药业有限公司 | 一种艾乐替尼中间体及艾乐替尼的制备方法 |
CN110452215B (zh) * | 2018-05-08 | 2020-07-17 | 新发药业有限公司 | 一种艾乐替尼中间体及艾乐替尼的制备方法 |
CN112585126A (zh) * | 2018-09-04 | 2021-03-30 | 中外制药株式会社 | 四环化合物的制备方法 |
CN112585126B (zh) * | 2018-09-04 | 2024-05-07 | 中外制药株式会社 | 四环化合物的制备方法 |
CN112028874A (zh) * | 2020-09-10 | 2020-12-04 | 苏州富德兆丰生化科技有限公司 | 艾立替尼的合成方法 |
CN112028874B (zh) * | 2020-09-10 | 2021-12-24 | 苏州富德兆丰生化科技有限公司 | 艾立替尼的合成方法 |
WO2022051983A1 (zh) * | 2020-09-10 | 2022-03-17 | 苏州富德兆丰生化科技有限公司 | 艾立替尼的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
US20170247352A1 (en) | 2017-08-31 |
WO2016074532A1 (zh) | 2016-05-19 |
US10221155B2 (en) | 2019-03-05 |
CN104402862B (zh) | 2016-10-05 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200515 Address after: 211200 Qinhuai Road, Lishui, Nanjing Yong Yang Street, No. Avenue, No. 288 Patentee after: Nanjing Zhiwu Intelligent Technology Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201116 Address after: 274600 South Outer Ring Road, northwest, juancheng Development Zone, Heze City, Shandong Province Patentee after: Juancheng Tairui Chemical Co., Ltd Address before: 211200 Qinhuai Road, Lishui, Nanjing Yong Yang Street, No. Avenue, No. 288 Patentee before: Nanjing Zhiwu Intelligent Technology Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of iritinib Effective date of registration: 20220318 Granted publication date: 20161005 Pledgee: Shandong juancheng Rural Commercial Bank Co.,Ltd. Pledgor: Juancheng Tairui Chemical Co.,Ltd. Registration number: Y2022980002706 |