CN104382863B - A kind of fowl ivermectin effervescence granular - Google Patents
A kind of fowl ivermectin effervescence granular Download PDFInfo
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- CN104382863B CN104382863B CN201410702366.3A CN201410702366A CN104382863B CN 104382863 B CN104382863 B CN 104382863B CN 201410702366 A CN201410702366 A CN 201410702366A CN 104382863 B CN104382863 B CN 104382863B
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Abstract
A kind of fowl ivermectin effervescence granular, is made up of the raw material of following weight portion：Ivermectin：30 90 parts, citric acid：50 80 parts；Sodium acid carbonate：60 90 parts；Macrogol 6000：30 60 parts；Dextrin：60 90 parts；Glucose：80 200 parts, crushed, mix, pelletize, drying, whole grain is obtained final product.The present invention is different from common bead dosage form, and it contains gas-producing disintegrant, after effervescence granular is put into drinking-water, in the presence of gas-producing disintegrant, a large amount of bubbles are produced at once, make particle disintegration and thawing rapidly, the taste bud of stimulating animal, increased release and the action time of medicine.In addition, reagent of the present invention is conventional medicine, preparation cost is relatively low, it is easy to popularization and application.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of fowl ivermectin effervescence granular.
Background technology
Ivermectin is the derivative of AVM, the oral semi-synthetic broad-spectrum anti-parasite medicine of category.This product is to various lifes
Most of nematode in life cycle（But not all nematode）There is effect；Microfilaria to filaria volvulus is effective but invalid to adult；
Excrement strongylid to only existing in enteron aisle is also effective.The selective inhibitory action of this product, by thin with without spinal animals nerve
Born of the same parents are combined with the high-affinity of the chloride channel that muscle cell Glutamic Acid is valve, so as to cause cell membrane logical to chlorion
The increase of permeability, causes nerve cell or muscle cell hyperpolarization, parasite is benumbed or dead.This product also can be with other parts
Valve（Such as neurotransmitter g- aminobutyric acids（GABA））Chloride channel interact.The selectivity of this product is because some are fed
There is no glutamic acid-chloride channel in newborn animal body, and AVM only has low parent to mammalian ligands-chloride channel
And power.This product can not penetrate the blood-brain barrier of people.Onchocercosis and strongyloidiasis and hookworm, roundworm, whipworm, pinworm sense
Dye.Ivermectin is widely used in ox, sheep, horse, the gastrointestinal nematode parasites of pig, thread lungworm and parasitic arthropod, the intestinal nematodes of dog,
Ear mite, itch mite, heartworm and microfilaria, and poultry gastrointestinal nematode and vermin.
The conventional ivermectin formulation of clinic has peroral dosage form, external application and injection, but the medicine regular dosage form eliminates half-life period
Shorter, medication is frequent, and widely distributed in vivo.
The content of the invention
The present invention provides a kind of fowl ivermectin effervescence granular, and solving the medicine regular dosage form, to eliminate half-life period shorter, uses
Medicine is frequent, and problem widely distributed in vivo.
The purpose of the present invention is realized in the following manner：
A kind of fowl ivermectin effervescence granular, is made up of the raw material of following weight portion：Ivermectin：30-90 parts, lemon
Acid：50-80 parts；Sodium acid carbonate：60-90 parts；Macrogol 6000：30-60 parts；Dextrin：60-90 parts；Glucose：80-200
Part, crushed, mix, pelletize, drying, whole grain is obtained final product.
According to mass ratio, by the fowl with ivermectin effervescence granular and water according to 1：Fed after 1000 mixing.
Relative to prior art, the present invention is different from common bead dosage form, and it contains gas-producing disintegrant, works as effervescence granular
After being put into drinking-water, in the presence of gas-producing disintegrant, a large amount of bubbles are produced at once, make particle disintegration and thawing, thorn rapidly
The taste bud of exciting thing, increased release and the action time of medicine.In addition, reagent of the present invention is conventional medicine, system
Standby cost is relatively low, it is easy to popularization and application.
Specific embodiment
The present invention is a kind of fowl ivermectin effervescence granular, is made up of the raw material of following weight portion：Ivermectin：30-
90 parts, citric acid：50-80 parts；Sodium acid carbonate：60-90 parts；Macrogol 6000：30-60 parts；Dextrin：60-90 parts；Grape
Sugar：80-200 parts, crushed, mix, pelletize, drying, whole grain is obtained final product.
Embodiment 1：
Take ivermectin 10kg, citric acid 20kg, sodium acid carbonate 30kg, Macrogol 6000 10kg, dextrin 10kg, Portugal
Grape sugar 20kg, is crushed, and is mixed, is pelletized, drying, whole grain, obtains final product ivermectin effervescence granular.
Following examples are carried out with reference to embodiment 1, and the composition of each component is as shown in table 1 below：
The raw material of table 1 composition list position：kg
The influence of ivermectin effervescence granular prepared by the method to broiler chicken is as follows：
1st, experimental animal：
The sick broiler chicken 120 of infection global-worm illness is randomly selected, 3 groups are randomly divided into, every group 40, body weight is in 1-2kg.
2nd, Experimental agents：
5% ivermectin powder：According to mass ratio, by common commercially available ivermectin with starch according to 5:95 well mixed obtain final product.
Ivermectin effervescence granular：The effervescence granular containing ivermectin described in the embodiment of the present invention 1；
3rd, experimental technique：
1 group is blank control group, without medicine.
2 group of 5% ivermectin powder is treated, usage：The ivermectin powder spice 50kg of 100g 5%, once a day, concentrate
It is finished within 3 hours, is used in conjunction 4.
3 groups with the effervescence granular containing ivermectin of the invention, usage：100g ivermectin effervescence granulars are watered
100kg, once a day, concentration is finished for 3 hours, is used in conjunction 4.
After treatment starts, per day entry, disease fowl mental condition and death are distributed, and treatment counts therapeutic effect after 4 days, wherein：
It is invalid：After referring to 4 days, sick fowl symptom has exacerbation situation or death.
Effectively；After referring to 4 days, sick fowl symptom has change, and symptom is controlled or substantially mitigated relative to having before treatment.
Cure：After referring to 4 days, symptom disappears, and the sick fowl state of mind and feed intake recover normal condition.Its numeral has been included in
In effect numeral.
At the end of have symptom：After referring to treatment 4 days, sick fowl still has certain symptom, and its Symptoms is better than before treatment or nothing
Take on a new look, sick fowl do not cure completely, its numeral has been included in invalid number of elements and the numeral of effective number of elements.
Result of the test is as shown in table 2：
The result of the test of table 2
4th, conclusion：
From the result of the test statistical analysis of table 2,5% ivermectin powder, ivermectin effervescence granular treatment group and control group
Difference is extremely significantly (PG 0.0l).Therapeutic effect of the invention is significantly better than existing pulvis.
Products application of the invention also can reach the effect above in birds such as duck, geese.
Above-described is only the preferred embodiment of the present invention, it is noted that for a person skilled in the art,
Under the premise of general idea of the present invention is not departed from, some changes and improvements can also be made, these should also be considered as of the invention
Protection domain.
Claims (1)
1. a kind of fowl ivermectin effervescence granular, it is characterised in that be made up of the raw material of following weight portion：Ivermectin 10kg,
Citric acid 20kg, sodium acid carbonate 30kg, Macrogol 6000 10kg, dextrin 10kg, glucose 20kg, are crushed, mixing,
Granulation, dry, whole grain, obtain final product ivermectin effervescence granular.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410702366.3A CN104382863B (en) | 2014-11-29 | 2014-11-29 | A kind of fowl ivermectin effervescence granular |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410702366.3A CN104382863B (en) | 2014-11-29 | 2014-11-29 | A kind of fowl ivermectin effervescence granular |
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| CN104382863A CN104382863A (en) | 2015-03-04 |
| CN104382863B true CN104382863B (en) | 2017-07-07 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017508762A (en) | 2014-03-28 | 2017-03-30 | ガルデルマ・リサーチ・アンド・デヴェロップメント | Sootless chemical mousse containing benzoyl peroxide |
| FR3041537B1 (en) | 2015-09-29 | 2018-11-30 | Galderma Research & Development | BRIMONIDINE CONTAINING CHEMICAL FOAM WITHOUT RINSE AND USE THEREOF FOR TREATING ROSACEA. |
| FR3041541B1 (en) * | 2015-09-29 | 2018-11-30 | Galderma Research & Development | NON-RINSE CHEMICAL FOAM COMPRISING IVERMECTIN |
| FR3041538B1 (en) | 2015-09-29 | 2018-11-30 | Galderma Research & Development | NON-RINSE CHEMICAL FOAM CONTAINING CLOBETASOL PROPIONATE AND USE THEREOF IN THE TREATMENT OF PSORIASIS |
| FR3041535B1 (en) | 2015-09-29 | 2019-01-25 | Galderma Research & Development | NON-RINSE CHEMICAL FOAM CONTAINING TRIFAROTENE AND USE THEREOF IN THE TREATMENT OF ICHTYOSE |
| FR3041536B1 (en) | 2015-09-29 | 2018-11-30 | Galderma Research & Development | NON-RINSEED CHEMICAL FOAM CONTAINING TRIFAROTENE AND USE THEREOF IN THE TREATMENT OF ACNE |
| FR3041540B1 (en) * | 2015-09-29 | 2018-10-26 | Galderma Research & Development | SELF-MOUSING CLEANING COMPOSITION FOR RINSING, CONTAINING IVERMECTIN. |
| FR3041539B1 (en) | 2015-09-29 | 2018-10-26 | Galderma Research & Development | SELF-FOAMING CLEANING COMPOSITION CONTAINING CLOBETASOL PROPIONATE AND USE THEREOF IN THE TREATMENT OF PSORIASIS |
| CN105381024A (en) * | 2015-12-05 | 2016-03-09 | 河北美荷药业有限公司 | Pharmaceutical composition for treating chicken coccidiosis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283388A (en) * | 2000-05-17 | 2001-02-14 | 西北农林科技大学无公害农药研究服务中心 | Effervescent table as agricultural chemical and its preparing process |
| CN1403000A (en) * | 2002-10-10 | 2003-03-19 | 华南农业大学 | Pesticide prep of mixed nimbin and miticide |
| CN101455196A (en) * | 2008-12-23 | 2009-06-17 | 中国人民解放军海军医学研究所 | Pesticide effervescence combination and preparation method thereof |
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2014
- 2014-11-29 CN CN201410702366.3A patent/CN104382863B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283388A (en) * | 2000-05-17 | 2001-02-14 | 西北农林科技大学无公害农药研究服务中心 | Effervescent table as agricultural chemical and its preparing process |
| CN1403000A (en) * | 2002-10-10 | 2003-03-19 | 华南农业大学 | Pesticide prep of mixed nimbin and miticide |
| CN101455196A (en) * | 2008-12-23 | 2009-06-17 | 中国人民解放军海军医学研究所 | Pesticide effervescence combination and preparation method thereof |
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| CN104382863A (en) | 2015-03-04 |
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Address after: 451164 Henan economic comprehensive experimentation area, Zhengzhou port, Donggang Province Applicant after: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. Address before: 451100 Xingang, Henan, Xinzheng Port Road East Side Applicant before: ZHENGZHOU HOUYI PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20230703 Address after: No. 13-1, Taiwan Science and Technology Park, Xingang Avenue, Hangang District, Zhengzhou City, Henan Province, 450000 Patentee after: Zhengzhou Zhongnong Quick Inspection Technology Co.,Ltd. Address before: 451164 east side of Donggang Avenue, airport economic comprehensive experimental zone, Zhengzhou City, Henan Province Patentee before: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. |
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