CN103933045A - Anthelmintic and preparation method thereof - Google Patents
Anthelmintic and preparation method thereof Download PDFInfo
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- CN103933045A CN103933045A CN201410203497.7A CN201410203497A CN103933045A CN 103933045 A CN103933045 A CN 103933045A CN 201410203497 A CN201410203497 A CN 201410203497A CN 103933045 A CN103933045 A CN 103933045A
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- starch
- praziquantel
- anthelmintic
- fenbendazole
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Abstract
The invention discloses an anthelmintic for pets and a preparation method thereof. The anthelmintic disclosed by the invention is prepared from the following components: 83.3-87.2% of fenbendazole and 12.8-16.7% of praziquantel. The invention further provides the preparation method of the anthelmintic. The components are matched according to a specific proportion; the fenbendazole is wide in anthelmintic spectrum; the praziquantel has low toxicity to dogs, cats and the like; conversion products of the fenbendazole and the praziquantel can effectively interfere transportation of glucose by polypides in dogs and cats; the fenbendazole and the praziquantel are matched according to a specific proportion, so that the anthelmintic can take effect rapidly and is unnecessary to take on an empty stomach; in addition, the polypide-repelling degree is relatively thorough.
Description
Technical field
The present invention relates to house pet medication field, relate in particular to a kind of anthelmintic drug.
Background technology
For pet parasite expelling medication, though simple fenbendazole, the wide the intestines and stomach absorbance of benzothiazole miaow class anthelmintic anthelmintic spectrum are low, praziquantel is expelling tenia at its Main Function of most clinical cases, but generally all needs (medicine) being taken before meal to use.
Summary of the invention
The object of this invention is to provide and a kind ofly expel in pet body various polypides and anthelmintic spectrum is wide, anthelmintic takes effect thoroughly and the anthelmintic drug of using without (medicine) being taken before meal.
According to an aspect of the present invention, provide a kind of anthelmintic drug, configured by following mass percent:
Fenbendazole 83.3～87.2%;
Praziquantel 12.8～16.7%.
Preferably, in some embodiments,
Fenbendazole 84.2～85%;
Praziquantel 15～15.8%.
A preparation method for anthelmintic drug, comprises the following steps:
(1) fenbendazole, praziquantel take and put into extraction pot by formula proportion;
(2) take 8 times of water to step (1) all components weight summation of weight and add in extraction pot, continuing to boil 2 hours;
(3) step (2) products therefrom is leached to filtrate from extraction pot, filtrate is for subsequent use;
(4) take 6 times of water to step (1) all components weight summation of weight and add in the extraction pot of step (3), continuing to boil 1.3 hours;
(5) step (4) products therefrom is leached to filtrate from extraction pot, and this filtrate is mixed with step (3) gained filtrate, leave standstill 2 hours, obtain upper clear supernate for subsequent use;
(6) claim according to the weight of step (5) gained upper clear supernate, separately taking glucose, starch and magnesium stearate configures by following mass percent: step (5) gained runny plaste 4%～10%, glucose 30%～50%, starch 30%～50%, magnesium stearate 0.6%～1%;
(7) take in addition the starch solution that starch and water preparation quality percentage ratio are 5%, and to mix homogeneously with step (5) gained runny plaste be starch runny plaste slurry, the quality of this starch solution be all components that takes in step (6) quality summation 10%;
(8) get the interior stirring and evenly mixing of glucose, starch impouring mixer taking in step (6);
(9) getting step (7) gained starch runny plaste starches in the mixer that is sprinkled upon at the uniform velocity equably step (8) and stirs 8～10 minutes;
(10) get step (9) products therefrom and granulate, dry, and mix with the magnesium stearate taking in step (6), tabletting.
In some embodiments, mixer is trough-type mixture machine.
Its beneficial effect is, in this formula, fenbendazole is benzimidazole anthelmintic, it not only has height anthelmintic activity to gastrointestinal nematode parasites adult and larva, and net filaria, fasciola and cestode are had to good result, also have extremely strong killing egg effect, for the house pet such as dog, cat to effects such as ancylostome, Trichocephalus, ascarid, cestodes obviously, can effectively kill migrating larva; Praziquantel is all effective to schistosomicide, cestode, cysticercosis, clonorchis sinensis, lung fluke, fasciloopsis, can there is tetanic property to polypide muscle and shrink and generation spastic paralysis in it, praziquantel has rapidly and significantly damaging action to polypide cortex in addition, causes the swelling of syncytium crust, occurs cavity, form bulla, outstanding body surface, the rotten to the corn diabrosis of final epidermis, body secretion almost all disappears, circular muscle and longitudinal muscle also successively dissolve rapidly, and praziquantel also can suppress the synthetic of polypide nucleic acid and protein in addition.
Said components, fenbendazole anthelmintic spectrum is wide, and praziquantel is little to the toxicity such as dog, cat, and its conversion product can effectively disturb the transhipment of polypide to glucose in dog, cat body, coordinates by special ratios, instant effect, without (medicine) being taken before meal use, and anthelmintic degree is more thorough.
Detailed description of the invention
Embodiment 1:
Raw material total amount is 100g.Wherein, fenbendazole 83.3g, praziquantel 16.7g.
Preparation technology:
(1) fenbendazole, praziquantel take and put into extraction pot by formula proportion;
(2) take 8 times of water 800g to step (1) all components weight summation of weight and add in extraction pot, continuing to boil 2 hours;
(3) step (2) products therefrom is leached to filtrate from extraction pot, filtrate is for subsequent use;
(4) take 6 times of water 600g to step (1) all components weight summation of weight and add in the extraction pot of step (3), continuing to boil 1.3 hours;
(5) step (4) products therefrom is leached to filtrate from extraction pot, and this filtrate is mixed with step (3) gained filtrate, leave standstill 2 hours, obtain upper clear supernate for subsequent use;
(6) according to the weight of step (5) gained upper clear supernate, separately taking glucose, starch and magnesium stearate configures by following mass percent: step (5) products therefrom 4%～10%, glucose 30%～50%, starch 30%～50%, magnesium stearate 0.6%～1%;
(7) take in addition the starch solution that starch and water preparation quality percentage ratio are 5%, and to mix homogeneously with step (5) gained runny plaste be starch slurry, the quality of this starch solution be all components that takes in step (6) quality summation 10%;
(8) get the interior stirring and evenly mixing of glucose, starch impouring trough-type mixture machine taking in step (6);
(9) getting step (7) gained starch slurry is sprinkled upon at the uniform velocity equably in the trough-type mixture machine of step (8) and stirs 8～10 minutes;
(10) get step (9) products therefrom and granulate, dry, and mix with the magnesium stearate taking in step (6), tabletting.
Embodiment 2:
Raw material total amount is 100g.Wherein, fenbendazole 87.2g, praziquantel 12.8g.
Preparation technology is with embodiment 1.
Embodiment 3:
Raw material total amount is 100g.Wherein, fenbendazole 84.2g, praziquantel 15.8g.
Preparation technology is with embodiment 1.
Embodiment 4:
Raw material total amount is 100g.Wherein, fenbendazole 85g, praziquantel 15g.
Preparation technology is with embodiment 1.
By the ill dog of product feeding of the present invention, a day dose is: make the every 120g of medicine by each embodiment method, mix feed for pet 15kg and feed, drinking-water 15kg, every day 1-2 time, takes 100g for each every, be used in conjunction 3-5 day, oral through gastrointestinal absorption to reach treatment disease object.
The applicable cases contrast of the present embodiment and the anthelmintic of other medicines treatment dog:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| Ⅰ | 20 of blank groups | 38.7 | 33.2 | 68.0 |
| Ⅱ | 20 of sulfamethazine groups | 13.2 | 75.0 | 15.1 |
| Ⅲ | 1 group 15 of embodiment | 6.8 | 88.7 | 9.4 |
| Ⅳ | 2 groups 17 of embodiment | 4.5 | 94.4 | 7.0 |
| Ⅴ | 3 groups 15 of embodiment | 5.8 | 92.9 | 11.6 |
| Ⅵ | 4 groups 14 of embodiment | 2.4 | 89.4 | 8.0 |
By the ill cat of product feeding of the present invention, a day dose is: make the every 60g of medicine by each embodiment, mix feed for pet 15kg and feed, drinking-water 15kg, every day 1-2 time, takes 50g for each every, is used in conjunction 3-5 day, orally treats disease object through gastrointestinal absorption to reach.
The applicable cases contrast of the present embodiment and the anthelmintic of other medicines treatment cat:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| Ⅰ | 20 of blank groups | 45.7 | 26.2 | 71.9 |
| Ⅱ | 20 of sulfamethazine groups | 15.5 | 81.6 | 17.5 |
| Ⅲ | 1 group 21 of embodiment | 3.2 | 92.8 | 5.0 |
| Ⅳ | 2 groups 17 of embodiment | 6.2 | 89.2 | 2.4 |
| Ⅴ | 3 groups 19 of embodiment | 5.8 | 92.9 | 11.6 |
| Ⅵ | 4 groups 15 of embodiment | 2.2 | 94.1 | 6.0 |
This clinical effectiveness statistical analysis, present composition treatment group and sulfamethazine group extremely significantly (P < 0.05) of difference compared with aspect cure rate.
This formula is except being applicable to dog cat, and equally applicable to some common Rodents house pets, as lop, imperial cat etc., but amount need reduce in body weight ratio.
These are only more excellent embodiment of the present invention in sum, should be understood that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also do some improvement, within also should be considered as protection scope of the present invention.
Claims (4)
1. anthelmintic drug, is characterized in that, configures by following mass percent:
Fenbendazole 83.3～87.2%;
Praziquantel 12.8～16.7%.
2. anthelmintic drug according to claim 1, is characterized in that:
Fenbendazole 84.2～85%;
Praziquantel 15～15.8%.
3. the preparation method of anthelmintic drug according to claim 1 and 2, is characterized in that, comprises the following steps:
(1) fenbendazole, praziquantel take and put into extraction pot by formula proportion;
(2) take 8 times of water to step (1) all components weight summation of weight and add in extraction pot, continuing to boil 2 hours;
(3) step (2) products therefrom is leached to filtrate from extraction pot, filtrate is for subsequent use;
(4) take 6 times of water to step (1) all components weight summation of weight and add in the extraction pot of step (3), continuing to boil 1.3 hours;
(5) step (4) products therefrom is leached to filtrate from extraction pot, and this filtrate is mixed with step (3) gained filtrate, leave standstill 2 hours, obtain upper clear supernate for subsequent use;
(6) according to the weight of step (5) gained upper clear supernate, separately taking glucose, starch and magnesium stearate configures by following mass percent: step (5) products therefrom 4%～10%, glucose 30%～50%, starch 30%～50%, magnesium stearate 0.6%～1%;
(7) take in addition the starch solution that starch and water preparation quality percentage ratio are 5%, and to mix homogeneously with step (5) products therefrom be starch slurry, the quality of this starch solution be all components that takes in step (6) quality summation 10%;
(8) get the interior stirring and evenly mixing of glucose, starch impouring mixer taking in step (6);
(9) getting step (7) gained starch slurry is sprinkled upon at the uniform velocity equably in the mixer of step (8) and stirs 8～10 minutes;
(10) get step (9) products therefrom and granulate, dry, and mix with the magnesium stearate taking in step (6), tabletting.
4. the preparation method of anthelmintic drug according to claim 3, is characterized in that, described mixer is trough-type mixture machine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410203497.7A CN103933045A (en) | 2014-05-14 | 2014-05-14 | Anthelmintic and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267230A (en) * | 2015-10-12 | 2016-01-27 | 青岛农业大学 | Compound fenbendazole tablet |
| CN105287613A (en) * | 2015-10-12 | 2016-02-03 | 青岛农业大学 | Preparation method of compound fenbendazole tablet |
| RU2614711C2 (en) * | 2015-01-19 | 2017-03-28 | Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" | Complex antiparasitic "azinal plus" - 3 compound for chemotherapy and prevention of trihotsefaleze, hookworm and echinococcosis for dogs |
| CN115105506A (en) * | 2022-05-27 | 2022-09-27 | 镇江威特药业有限责任公司 | Anthelmintic composition for animals and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2001015547A2 (en) * | 1999-08-28 | 2001-03-08 | Hartmut Klocke | Active agent preparation for veterinary use and method for the production thereof |
| US20050226908A1 (en) * | 2004-04-07 | 2005-10-13 | Akzo Nobel N.V. | Efficacious composition of a benzimidazole, an avermectin and praziquantel and related methods of use |
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2014
- 2014-05-14 CN CN201410203497.7A patent/CN103933045A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001015547A2 (en) * | 1999-08-28 | 2001-03-08 | Hartmut Klocke | Active agent preparation for veterinary use and method for the production thereof |
| US20050226908A1 (en) * | 2004-04-07 | 2005-10-13 | Akzo Nobel N.V. | Efficacious composition of a benzimidazole, an avermectin and praziquantel and related methods of use |
Non-Patent Citations (2)
| Title |
|---|
| 张晓燕，欧阳五庆: "《复方吡喹酮纳米乳的研制》", 《动物医学进展》, vol. 34, no. 9, 30 September 2013 (2013-09-30), pages 36 - 39 * |
| 徐莲英 主编: "《中药药剂学》", 31 July 1998, article "《片剂的辅料》", pages: 148-152 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2614711C2 (en) * | 2015-01-19 | 2017-03-28 | Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" | Complex antiparasitic "azinal plus" - 3 compound for chemotherapy and prevention of trihotsefaleze, hookworm and echinococcosis for dogs |
| CN105267230A (en) * | 2015-10-12 | 2016-01-27 | 青岛农业大学 | Compound fenbendazole tablet |
| CN105287613A (en) * | 2015-10-12 | 2016-02-03 | 青岛农业大学 | Preparation method of compound fenbendazole tablet |
| CN105267230B (en) * | 2015-10-12 | 2018-08-24 | 青岛农业大学 | A kind of compound Fenbendazole tablet |
| CN115105506A (en) * | 2022-05-27 | 2022-09-27 | 镇江威特药业有限责任公司 | Anthelmintic composition for animals and preparation method thereof |
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Application publication date: 20140723 |