CN104379571A - 用于制备festinavir的硫亚胺和亚砜方法 - Google Patents

用于制备festinavir的硫亚胺和亚砜方法 Download PDF

Info

Publication number
CN104379571A
CN104379571A CN201380027023.5A CN201380027023A CN104379571A CN 104379571 A CN104379571 A CN 104379571A CN 201380027023 A CN201380027023 A CN 201380027023A CN 104379571 A CN104379571 A CN 104379571A
Authority
CN
China
Prior art keywords
compound
solution
contact
tms
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380027023.5A
Other languages
English (en)
Chinese (zh)
Inventor
A·奥尔蒂斯
T·本科维奇
石中平
P·P·德什潘德
郭直惟
D·R·克罗嫩塔尔
C·斯福加塔基斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CN104379571A publication Critical patent/CN104379571A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201380027023.5A 2012-05-23 2013-05-22 用于制备festinavir的硫亚胺和亚砜方法 Pending CN104379571A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650553P 2012-05-23 2012-05-23
US61/650,553 2012-05-23
PCT/US2013/042150 WO2013177243A1 (en) 2012-05-23 2013-05-22 Sulfilimine and sulphoxide methods for producing festinavir

Publications (1)

Publication Number Publication Date
CN104379571A true CN104379571A (zh) 2015-02-25

Family

ID=48534517

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380027023.5A Pending CN104379571A (zh) 2012-05-23 2013-05-22 用于制备festinavir的硫亚胺和亚砜方法

Country Status (5)

Country Link
US (1) US9249171B2 (https=)
EP (1) EP2852583A1 (https=)
JP (1) JP2015523337A (https=)
CN (1) CN104379571A (https=)
WO (1) WO2013177243A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160060252A1 (en) 2013-04-16 2016-03-03 Bristol-Myers Squibb Company 5-methyluridine method for producing festinavir
WO2014201122A1 (en) 2013-06-13 2014-12-18 Bristol-Myers Squibb Company Tert-butyl-sulphoxide method for producing festinavir
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
JP7025064B2 (ja) * 2018-08-09 2022-02-24 ヤマサ醤油株式会社 ４’－置換ヌクレオシド誘導体の立体選択的合成法
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
IL316425A (en) * 2022-04-22 2024-12-01 Rome Therapeutics Inc Dihydro-3'-deoxy-4'-ethynylthymidines and related compounds and their uses in the treatment of medical conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777432A (zh) * 2003-02-19 2006-05-24 耶鲁大学 用于治疗病毒感染尤其是hiv感染的抗病毒核苷类似物和方法
EP2277878A1 (en) * 2008-04-10 2011-01-26 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0454193A (ja) * 1990-05-25 1992-02-21 Japan Tobacco Inc ２’，３’―ジデオキシ―２’，３’―ジデヒドロ―β―リボヌクレオシドの製造方法
NZ567272A (en) 2005-09-26 2012-02-24 Pharmasset Inc Modified 4'-nucleosides as antiviral agents
CN101784532B (zh) 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
WO2009084655A1 (ja) * 2007-12-27 2009-07-09 Oncolys Biopharma Inc. 4'-エチニルd4Tの製造方法
JP5485138B2 (ja) 2008-03-28 2014-05-07 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
DE102009034346B4 (de) 2009-07-23 2013-01-24 Kone Corp. Antriebssystem für eine Personenförderanlage
EP2537851B1 (en) 2010-02-15 2015-06-10 Nissan Chemical Industries, Ltd. Process for preparation of b-glycoside compounds
EP2537839B1 (en) 2010-02-15 2016-12-14 Nissan Chemical Industries, Ltd. B-dihydrofuran deriving compound, method for producing b-dihydrofuran deriving compound or b-tetrahydrofuran deriving compound, b -glycoside compound, method for producing b-glycoside compound, and method for producing 4'-ethynyl d4t and analogue compounds thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777432A (zh) * 2003-02-19 2006-05-24 耶鲁大学 用于治疗病毒感染尤其是hiv感染的抗病毒核苷类似物和方法
EP2277878A1 (en) * 2008-04-10 2011-01-26 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOSUGI, HIROSHI.,ET AL.: "Lewis Acid-Mediated Carbon-Carbon Bond Forming Reaction Using The Pummerer Rearrangement Products From Chiral β-Hydroxy Sulfoxides", 《CHEMISTRY LETTERS》 *
PIERFRANCESCO B.,ET AL.: "Chiral Homoenolate Anion Equivalents: Synthesis of Optically Pure 5-Substituted Furan-2(5H)-ones", 《J.CHEM.SOC.,CHEM.COMMUN.》 *

Also Published As

Publication number Publication date
US20150140610A1 (en) 2015-05-21
US9249171B2 (en) 2016-02-02
WO2013177243A1 (en) 2013-11-28
EP2852583A1 (en) 2015-04-01
JP2015523337A (ja) 2015-08-13

Similar Documents

Publication Publication Date Title
CN104379571A (zh) 用于制备festinavir的硫亚胺和亚砜方法
KR20170073649A (ko) 치환된 뉴클레오시드 유사체의 제조 방법
Sato et al. Environmentally friendly C-glycosylation of phloroacetophenone with unprotected D-glucose using scandium (III) trifluoromethanesulfonate in aqueous media: key compounds for the syntheses of mono-and di-C-glucosylflavonoids
CN115521337A (zh) 一种瑞德西韦中间体的合成方法
CN118772081A (zh) 一种制备n-甲基-2,3-二氢苯并噻嗪-4-酮的方法
CN102933585B (zh) Carba-核苷合成及其中使用的新型中间体
EP3647304B1 (en) Method for preparing 2-fluoroacrylate
CN101781301B (zh) 一种制备恩替卡韦的方法
CN106146536A (zh) 一种依维莫司的制备方法
KR100908363B1 (ko) 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법
US8193354B2 (en) Process for preparation of Gemcitabine hydrochloride
CN103483409A (zh) 一种制备奈拉滨的合成方法
CN104513241B (zh) 瑞加德松新中间体及其制备方法和应用
CN113004155A (zh) α,ω-二氨基九乙二醇的制备方法
Miller et al. A novel synthesis of 4′-thionucleosides and a potential stereospecific route to pyrimidine nucleosides
Kumar et al. Allyl tetrahydropyranyl ether: a versatile alcohol/thiol protecting reagent
CN108424432B (zh) 一种3’-氧-甲氧乙基核苷的制备方法
CN116462643B (zh) 一种氘标记的多西他赛的合成方法
CN116082420B (zh) 一种eps-g7的化学合成方法
CN112979695B (zh) 1,2-二脂肪酰-sn-甘油-3-磷脂酰丝氨酸的制备方法
CN120192442B (zh) 一种含核糖环的GalNAc化合物的制备方法
CN111732562A (zh) 一种抗肿瘤药物盐酸吉西他滨中间体的制备方法
CN113583036B (zh) 一种化合物的制备方法
Deshpande et al. A general and efficient route to 3′-deoxy-3′-N-, S-, and C-substituted altropyranosyl thymines from 2′, 3′-O-anhydro-mannopyranosylthymine
CN101880285A (zh) 一种烯丙基取代喜树碱化合物的合成方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150225

WD01 Invention patent application deemed withdrawn after publication