CN104367763A - 治疗糖尿病足的中药 - Google Patents

治疗糖尿病足的中药 Download PDF

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CN104367763A
CN104367763A CN201410682839.8A CN201410682839A CN104367763A CN 104367763 A CN104367763 A CN 104367763A CN 201410682839 A CN201410682839 A CN 201410682839A CN 104367763 A CN104367763 A CN 104367763A
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赵兰华
王敏
孟凡娟
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Abstract

本发明涉及中药配方领域，具体地说是一种治疗糖尿病足的中药，其特征是由如下重量份的原料药制成，积雪草15～20、亚乎奴10～15、千里光8～12、红景天10～12、细辛10～15、猫爪草6～10、地骨皮20～25、儿茶6～8、楹木10～12、蓝布正12～15、佛指甲15～20、牛筋条8～10、螃蟹七12～16、肿节风6～10、白蔹15～20、一叶萩16～18、紫花地丁12～16、透骨草3～5、花拐藤根3～5，将上述19味原料药用水浸泡，煎熬后去渣得滤液。本发明成本低、无毒副作用，治疗治疗糖尿病足疗效高。

Description

治疗糖尿病足的中药
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗糖尿病足的中药。
背景技术
众所周知，糖尿病足是由遗传因素与环境因素长期共同作用导致的内分泌代谢紊乱性疾病，已被世界卫生组织(WHO)列为人类的“三大”杀手之一。对于糖尿病的治疗，传统中医多以“三消”进行论治，即上消(肺燥)多饮，中消(胃热)多食，下消(肾虚)多尿，认为其病机为阴虚燥热，故以养阴清热作为治疗方法，实践证明这种方法已不适于糖尿病的辩证治疗；当代一些医家在糖尿病的治疗上虽然采用了一些新的辩证分型方法，但综观其治疗方法，仍以养阴清热为主，同时加用益气生津、活血化瘀、理气化痰、温肾补肾等治法，其本质并没有大的发展和变化；现代西医认为糖尿病的关键在于胰岛功能障碍。或是胰岛素分泌不足，或是胰岛素受体结合率低下，致使摄入人体的糖不能使机体充分利用，积聚于血液中出现高血糖。
随糖尿病病情进展，糖尿病足是糖尿病中晚期常见并发症，特点为下肢远端神经异常和不同程度周围血管病变相关的足部溃疡、感染和(或)深层组织破坏。轻者表现为足部畸形、皮肤干燥和发凉、胼胝(高危足)，重者可出现足部溃疡、坏疽，最终不得不“截肢”致残，使患者及家属对治疗效果不满意。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种治疗糖尿病足的中药，成本低、无毒副作用，治疗治疗糖尿病足疗效高。
本发明解决上述技术问题采用的技术方案是：一种治疗糖尿病足的中药，其特征是由如下重量份的原料药制成，积雪草15～20、亚乎奴10～15、千里光8～12、红景天10～12、细辛10～15、猫爪草6～10、地骨皮20～25、儿茶6～8、楤木10～12、蓝布正12～15、佛指甲15～20、牛筋条8～10、螃蟹七12～16、肿节风6～10、白蔹15～20、一叶萩16～18、紫花地丁12～16、透骨草3～5、花拐藤根3～5，将上述19味原料药用水浸泡，煎熬后去渣得滤液。
本发明的有益效果是，成本低、无毒副作用，治疗治疗糖尿病足疗效高。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用积雪草、亚乎奴、千里光、红景天、细辛、猫爪草、地骨皮、儿茶、楤木、蓝布正、佛指甲、牛筋条、螃蟹七、肿节风、白蔹、一叶萩、紫花地丁、透骨草、花拐藤根为原料药制备而成。其组分(重量份)每副药为积雪草18、亚乎奴13、千里光10、红景天11、细辛12、猫爪草8、地骨皮22、儿茶7、楤木11、蓝布正13、佛指甲17、牛筋条9、螃蟹七14、肿节风8、白蔹17、一叶萩17、紫花地丁14，透骨草4、花拐藤根4。取上述19味原料药总重量为230克，加水1100-1200ml，浸泡4-5小时，然后用武火煮沸文火煎熬至60分钟左右，去渣得滤液200ml左右，药渣再加水300-400ml左右，煎熬30分钟左右，去渣得滤液100ml左右，共得300ml左右药汁，即制得本发明汤剂，装入无菌玻璃瓶内，密封瓶盖备用。每日1剂分早晚2次口服。
本发明积雪草清热解毒，利湿消肿，益脑提神。具有滋补、消炎、愈合伤口、利尿通便和镇定作用；亚乎奴消肿止痛，止血，生肌。用于外伤肿痛，创伤出血；千里光清热解毒，明目退翳，杀虫止痒。主流感，上呼吸道感染，肺炎，急性扁桃体炎，肋腺炎，急性肠，三味共为君药；红景天有补气清肺、益智养心、收涩止血、散瘀消肿的功效。主治气虚体弱、病后畏寒、气短乏力、肺热咳嗽、咯血、白带腹泻、跌打损伤等；细辛解表散寒，祛风止痛，通窍，温肺化饮。用于风寒感冒，头痛，牙痛，鼻塞流涕，鼻鼽，鼻渊，风湿痹痛，痰饮喘咳，两味助君为臣药；佐以猫爪草、地骨皮、儿茶，猫爪草治肺结核，疟疾，瘰疬痰核，疔疮，虫蛇咬伤，偏头痛，疟疾，牙痛；地骨皮凉血除蒸，清肺降火。用于阴虚潮热、骨蒸盗汗、肺热咳嗽、咯血、衄血；儿茶清热，生津，化痰，敛疮，生血。用于水泻，肠粘膜炎，口腔破溃，湿疹，咳嗽，刀伤出血；楤木主治风湿关节痛，腰腿酸痛，肾虚水肿，消渴，胃脘痛，跌打损伤，骨折，吐血，衄血，疟疾，漆疮，骨髓炎，深部脓疡；蓝布正镇痛，降压，调经，祛风除湿。用于高血压病，头晕头痛，月经不调，小腹痛，白带，小儿惊风，风湿腰腿痛，外用治痈疖肿毒，跌打损伤；佛指甲清热解毒，止血，祛风湿。治咽喉肿痛，鼻衄，风热头昏，风湿关节痛，鼻疳，湿疹，疮毒；牛筋条祛风活络，解毒消肿，止血止痛。用于风湿麻木，筋骨疼痛，跌打损伤，脾肿大，虚寒胃痛，肾炎水肿，风寒头痛；螃蟹七燥湿，祛风，化痰，散结。主中风口眼喎斜，半身不遂，破伤风口噤，颈项强直，小儿惊风，痰咳，痈疽肿毒；肿节风抗菌消炎凉血清热解毒，祛风通络，活血散结。用于肺炎、阑尾炎、蜂窝组织炎属热毒壅盛证候者；白蔹有清热解毒、散结止痛、生肌敛疮的功效；一叶萩活血舒筋，健脾益肾。治风湿腰痛、四肢麻木、偏瘫、阳痿、面神经麻痹、小儿麻痹后遗症；紫花地丁具有清热解毒，凉血消肿，清热利湿的作用，主治疔疮，痈肿，瘰疬，黄疸，痢疾，腹泻；透骨草有活血化瘀、利尿解毒、通经透骨之功效；花拐藤根活络行血，除湿去风。治跌打损伤，关节痛风，共为使药。
本发明各原料还可按下表所列比例(重量份)混合的实施例来实现，其加工方法与实施例一相同。
下面结合我院进行的临床试验对本发明作进一步、详细地描述：
1、病例选择：60例糖尿病足患者，其中男41例，女19例，年龄43-82岁，平均(58.0±7.6)岁；糖尿病病程1-25年，平均(11.0±5.5)年；糖尿病足病程1-8年，平均(3.1±1.8)年，其中糖尿病足病程≥3年者31例。入院时空腹血糖6.0-19.0mmol/L，糖化血红蛋白(6.5-11.8)％；并发糖尿病视网膜病变者19例，糖尿病肾病者2例，合并高血压者44例，合并高脂血症者52例。合并感染者60例，主要以混合感染为主(2种及2种以上细菌)，最常见细菌依次为金黄色葡萄球菌(占26.8％)，大肠埃希菌占18.5％)，表皮葡萄球菌(占15.0％)，变形杆菌(占11.0％)，肠球菌(占10.4％)，阴沟杆菌(占8.5％)，溶血葡萄球菌(占6.3％)，铜绿假单胞菌(占3.5％)。参照Wagner分级标准[2]，其中0级0例，I-IV级43例，V级17例。
2、治疗过程：
2.3.1全身治疗
在糖尿病饮食基础上，使用胰岛素及口服降糖药，控制空腹血糖＜7.0mmol/L，餐后2h血糖＜10.0mmol/L；若有感染者，根据病原学药敏结果联合使用抗生素，以及控制血压、降脂、改善循环、营养神经；加强营养支持及纠正贫血等。
2.3.2创面护理
用1％碘伏消毒创口周围皮肤，再将3％过氧化氢10～20ml注入脓腔或感染创面，待其充分发生反应后，再用生理盐水冲洗，采用蚕食清创法，逐步清除坏死组织、骨坏死及窦腔内的老化白色假膜等。然后外涂京万红油膏，用砂布覆盖创口，每天换药1次。
2.3.3本发明的治疗糖尿病足的中药内服，每日1剂分早晚2次口服，共治疗四个周时间。
3、诊断及分级标准：
糖尿病的诊断参照1999年WHO的诊断标准。糖尿病足临床诊断参照《糖尿病足国际临床指南》[3]，并行足部X线摄片了解骨质情况，多普勒检查观察下肢周围血管和神经状况。糖尿病足分级参照Wagner分级标准[2]：0级：有发生足部溃疡的高度危险性，但尚没有溃疡形成；1级：有浅表性溃疡，没有临床感染征象，但可出现胼胝；2级：有较深的足部溃疡，可伴有蜂窝组织炎，但无深部脓肿和骨髓炎的形成；3级：可出现深部感染、骨髓炎和脓肿；4级：有局限性坏疽；5级：坏疽累及整个足部。
4、疗效评定：治疗后观察创面愈合情况及不良反应发生情况。判定标准参照中药新药临床研究指导原则标准[4]：临床治愈为局部肿胀消失，皮肤颜色恢复正常，溃疡面完全愈合；显效为局部肿胀及皮肤颜色改善，溃疡面缩小70％以上；有效为局部肿胀及皮肤颜色改善，溃疡面缩小30％以上；无效为达不到有效指标。总有效率为治愈率、显效率和有效率之和。
5、治疗效果：本发明的治疗糖尿病足的中药联合抗生素治疗4周，总有效率达到100％。
分级 例数 治愈 显效 有效 无效 有效率
0 0 0 0 0 0 0
I-IV 43 18 20 5 0 100％
V 17 0 8 9 0 100％
合计 60 18 28 14 0 100％

Claims (1)

1.一种治疗糖尿病足的中药，其特征在于：由如下重量份的原料药制成，积雪草15～20、亚乎奴10～15、千里光8～12、红景天10～12、细辛10～15、猫爪草6～10、地骨皮20～25、儿茶6～8、楤木10～12、蓝布正12～15、佛指甲15～20、牛筋条8～10、螃蟹七12～16、肿节风6～10、白蔹15～20、一叶萩16～18、紫花地丁12～16、透骨草3～5、花拐藤根3～5，将上述19味原料药用水浸泡，煎熬后去渣得滤液。
CN201410682839.8A 2014-11-11 2014-11-11 治疗糖尿病足的中药 Pending CN104367763A (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106344850A (zh) * 2016-11-04 2017-01-25 盛芳 护理糖尿病足的中药组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
胡华娟等: "100条糖尿病足处方用药规律分析", 《现代医院》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106344850A (zh) * 2016-11-04 2017-01-25 盛芳 护理糖尿病足的中药组合物

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