CN104364256A - 降伊波加因碱的立体选择性全合成 - Google Patents
降伊波加因碱的立体选择性全合成 Download PDFInfo
- Publication number
- CN104364256A CN104364256A CN201280058362.5A CN201280058362A CN104364256A CN 104364256 A CN104364256 A CN 104364256A CN 201280058362 A CN201280058362 A CN 201280058362A CN 104364256 A CN104364256 A CN 104364256A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- conditions
- group
- noribogaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(CC(CC12)C3)C1N3CCc1c2[n](*)c2c1cc(*)cc2 Chemical compound CCC(CC(CC12)C3)C1N3CCc1c2[n](*)c2c1cc(*)cc2 0.000 description 9
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568568P | 2011-12-08 | 2011-12-08 | |
| US61/568,568 | 2011-12-08 | ||
| PCT/US2012/067629 WO2013085850A2 (en) | 2011-12-08 | 2012-12-03 | Stereoselective total synthesis of noribogaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104364256A true CN104364256A (zh) | 2015-02-18 |
Family
ID=48575047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280058362.5A Pending CN104364256A (zh) | 2011-12-08 | 2012-12-03 | 降伊波加因碱的立体选择性全合成 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8937061B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2788355A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2015509076A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104364256A (cg-RX-API-DMAC7.html) |
| CA (2) | CA3122767C (cg-RX-API-DMAC7.html) |
| HK (1) | HK1204604A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL232724A (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014CN04160A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013085850A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201403995B (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| CA2806232A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| WO2013085850A2 (en) | 2011-12-08 | 2013-06-13 | Demerx, Inc. | Stereoselective total synthesis of noribogaine |
| CA2858105A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| WO2013112673A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Synthetic voacangine |
| EP2934541A4 (en) | 2012-12-20 | 2016-08-03 | Demerx Inc | SUBSTITUTED NORIBOGAIN |
| CA2942638C (en) | 2013-03-15 | 2026-03-10 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| EA201691647A1 (ru) | 2014-02-18 | 2017-01-30 | Демеркс, Инк. | Способы кратковременного и долгосрочного лечения зависимости от лекарственных средств |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| ES2867174T3 (es) | 2014-11-26 | 2021-10-20 | Demerx Inc | Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
| GB2611705B (en) | 2019-07-15 | 2024-03-27 | Demerx Inc | Methods for the non-toxic treatment for opioid drug withdrawal combining noribogaine and cannabinoids |
| US20240100062A1 (en) | 2022-09-14 | 2024-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of Treatment With an Iboga Alkaloid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100311725A1 (en) * | 1997-09-04 | 2010-12-09 | Demerx, Inc. | Noribogaine in the treatment of pain and drug addiction |
| CN102225937A (zh) * | 2011-05-04 | 2011-10-26 | 中国科学院昆明植物研究所 | 抗肿瘤生物碱类化合物，其药物组合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2813873A (en) * | 1957-11-19 | Derivatives of the ibogaine alkaloids | ||
| US3639408A (en) * | 1967-06-03 | 1972-02-01 | Shionogi & Co | Process for the preparation of isoquinuclidine derivatives |
| WO1996003127A1 (en) | 1994-07-25 | 1996-02-08 | Nda International, Inc. | A method of treating chemical dependency in mammals and a composition therefor |
| US5616575A (en) * | 1995-12-04 | 1997-04-01 | Regents Of The University Of Minnesota | Bioactive tricyclic ibogaine analogs |
| US7220737B1 (en) * | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| WO2013085850A2 (en) | 2011-12-08 | 2013-06-13 | Demerx, Inc. | Stereoselective total synthesis of noribogaine |
-
2012
- 2012-12-03 WO PCT/US2012/067629 patent/WO2013085850A2/en not_active Ceased
- 2012-12-03 IN IN4160CHN2014 patent/IN2014CN04160A/en unknown
- 2012-12-03 CA CA3122767A patent/CA3122767C/en active Active
- 2012-12-03 CN CN201280058362.5A patent/CN104364256A/zh active Pending
- 2012-12-03 HK HK15103583.0A patent/HK1204604A1/xx unknown
- 2012-12-03 JP JP2014545969A patent/JP2015509076A/ja active Pending
- 2012-12-03 EP EP12855135.5A patent/EP2788355A4/en not_active Withdrawn
- 2012-12-03 CA CA2856551A patent/CA2856551C/en active Active
- 2012-12-07 US US13/708,834 patent/US8937061B2/en active Active
-
2014
- 2014-05-20 IL IL232724A patent/IL232724A/en not_active IP Right Cessation
- 2014-05-30 ZA ZA2014/03995A patent/ZA201403995B/en unknown
- 2014-09-15 US US14/486,804 patent/US9403837B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100311725A1 (en) * | 1997-09-04 | 2010-12-09 | Demerx, Inc. | Noribogaine in the treatment of pain and drug addiction |
| CN102225937A (zh) * | 2011-05-04 | 2011-10-26 | 中国科学院昆明植物研究所 | 抗肿瘤生物碱类化合物，其药物组合物及其制备方法和应用 |
Non-Patent Citations (3)
| Title |
|---|
| BARRY M. TROST等，: ""A Total Synthesis of Racemic and Optically Active Ibogamine. Utilization and Mechanism of a New Silver Ion Assisted Palladium Catalyzed Cyclization"", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 * |
| DAVID M. HODGSON等，: ""Enantioselective Access to Isoquinuclidines by Tropenone Desymmetrization and Homoallylic Radical Rearrangement: Synthesis of (+)-Ibogamine"", 《ORG. LETT.》 * |
| 杨秀伟等，: ""44种生物碱类化合物对人鼻咽癌细胞株KB和人白血病细胞株HL-60细胞增殖抑制活性的筛选"", 《中国现代中药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL232724A0 (en) | 2014-08-03 |
| EP2788355A2 (en) | 2014-10-15 |
| WO2013085850A3 (en) | 2014-12-18 |
| CA2856551A1 (en) | 2013-06-13 |
| US8937061B2 (en) | 2015-01-20 |
| JP2015509076A (ja) | 2015-03-26 |
| WO2013085850A2 (en) | 2013-06-13 |
| US9403837B2 (en) | 2016-08-02 |
| ZA201403995B (en) | 2016-09-28 |
| EP2788355A4 (en) | 2015-10-21 |
| US20130165647A1 (en) | 2013-06-27 |
| US20150005492A1 (en) | 2015-01-01 |
| CA3122767C (en) | 2023-03-28 |
| HK1204604A1 (en) | 2015-11-27 |
| IL232724A (en) | 2017-07-31 |
| IN2014CN04160A (cg-RX-API-DMAC7.html) | 2015-07-17 |
| CA3122767A1 (en) | 2013-06-13 |
| CA2856551C (en) | 2021-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150218 |