IN2014CN04160A - - Google Patents

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Publication number
IN2014CN04160A
IN2014CN04160A IN4160CHN2014A IN2014CN04160A IN 2014CN04160 A IN2014CN04160 A IN 2014CN04160A IN 4160CHN2014 A IN4160CHN2014 A IN 4160CHN2014A IN 2014CN04160 A IN2014CN04160 A IN 2014CN04160A
Authority
IN
India
Prior art keywords
synthesizing
methods
relates generally
noribogaine
addictive alkaloid
Prior art date
Application number
Inventor
Robert M Moriarty
Deborah C Mash
Original Assignee
Demerx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Demerx Inc filed Critical Demerx Inc
Publication of IN2014CN04160A publication Critical patent/IN2014CN04160A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

This invention relates generally to methods for synthesizing the non addictive alkaloid noribogaine.
IN4160CHN2014 2011-12-08 2012-12-03 IN2014CN04160A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161568568P 2011-12-08 2011-12-08
PCT/US2012/067629 WO2013085850A2 (en) 2011-12-08 2012-12-03 Stereoselective total synthesis of noribogaine

Publications (1)

Publication Number Publication Date
IN2014CN04160A true IN2014CN04160A (en) 2015-07-17

Family

ID=48575047

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4160CHN2014 IN2014CN04160A (en) 2011-12-08 2012-12-03

Country Status (10)

Country Link
US (2) US8937061B2 (en)
EP (1) EP2788355A4 (en)
JP (1) JP2015509076A (en)
CN (1) CN104364256A (en)
CA (2) CA3122767C (en)
HK (1) HK1204604A1 (en)
IL (1) IL232724A (en)
IN (1) IN2014CN04160A (en)
WO (1) WO2013085850A2 (en)
ZA (1) ZA201403995B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9358237B2 (en) 2010-07-23 2016-06-07 Demerx, Inc. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
IN2014CN04160A (en) 2011-12-08 2015-07-17 Demerx Inc
US8877921B2 (en) 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine
CA2858105A1 (en) * 2012-01-25 2013-08-01 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
JP2016508979A (en) 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド Substituted norbogaine
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9345711B2 (en) 2014-02-18 2016-05-24 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
AU2014383143A1 (en) 2014-02-18 2016-09-29 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
WO2015195673A2 (en) 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
PT3223906T (en) 2014-11-26 2021-05-05 Demerx Inc Methods and compositions for potentiating the action of opioid analgesics using iboga alkaloids
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
EP3955936A1 (en) 2019-04-17 2022-02-23 COMPASS Pathfinder Limited Treatment of depression and other various disorders with psilocybin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2813873A (en) * 1957-11-19 Derivatives of the ibogaine alkaloids
US3639408A (en) * 1967-06-03 1972-02-01 Shionogi & Co Process for the preparation of isoquinuclidine derivatives
MX9701430A (en) 1994-07-25 1997-12-31 Nda Int Inc A method of treating chemical dependency in mammals and a composition therefor.
US5616575A (en) * 1995-12-04 1997-04-01 Regents Of The University Of Minnesota Bioactive tricyclic ibogaine analogs
EP2246058A1 (en) * 1997-09-04 2010-11-03 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
CN102225937B (en) * 2011-05-04 2012-07-25 中国科学院昆明植物研究所 Antineoplastic alkaloid compound, and its medicine composition, preparation method and application
IN2014CN04160A (en) 2011-12-08 2015-07-17 Demerx Inc

Also Published As

Publication number Publication date
US8937061B2 (en) 2015-01-20
WO2013085850A3 (en) 2014-12-18
IL232724A0 (en) 2014-08-03
IL232724A (en) 2017-07-31
JP2015509076A (en) 2015-03-26
CA2856551A1 (en) 2013-06-13
CA2856551C (en) 2021-06-22
US9403837B2 (en) 2016-08-02
EP2788355A2 (en) 2014-10-15
EP2788355A4 (en) 2015-10-21
CA3122767A1 (en) 2013-06-13
CN104364256A (en) 2015-02-18
HK1204604A1 (en) 2015-11-27
CA3122767C (en) 2023-03-28
ZA201403995B (en) 2016-09-28
US20130165647A1 (en) 2013-06-27
WO2013085850A2 (en) 2013-06-13
US20150005492A1 (en) 2015-01-01

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