CN104352861A - Sesame-containing traditional Chinese medicine composition for treating diabetes - Google Patents
Sesame-containing traditional Chinese medicine composition for treating diabetes Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention belongs to the technical field of medicines, relates to traditional Chinese medicine compositions and particularly relates to a sesame-containing traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition for treating diabetes, disclosed by the invention, is prepared from the following medicinal raw materials in parts by weight: 15-35 parts of corn stigma, 4-12 parts of buttercup root, 2-7 parts of chuanxiong rhizome, 2-9 parts of moldavica dragonhead, 2-9 parts of sesame and 1-5 parts of glycyrrhiza uralensis. According to the traditional Chinese medicine composition for treating diabetes, disclosed by the invention, the 6 kinds of medicinal raw materials are combined according to a proportioning ratio, so that the traditional Chinese medicine composition has a synergistic function during the treatment of diabetes and is remarkable in treatment effect and free from side effect on the body of a patient when the traditional Chinese medicine composition is used for treating diabetes.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment diabetes containing linum.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature, is that China's sickness rate is high, endangers one of serious epidemic diseases.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, causes various diabetic complication.According to statistics, the mortality rate of diabetic complication is only second to cardiovascular diseases, cerebrovascular and tumor, occupies the 4th.Diabetes mellitus in China patient populations close to 4,000 ten thousand people, occupies third place in the world, compared with 0.7% of the eighties in 20th century, increases 5 times.Diabetes can be caused by h and E factor interaction, and common sympton has polydipsia, polyuria, polyphagia and becomes thin.Diabetes can cause the infringement of health multisystem; Absolute or the relative hyposecretion of insulin and target tissue cell is caused to reduce insulin sensitivity; Causing a series of metabolism disorder syndromes such as protein, fat, water and eletrolytes, is wherein outstanding feature with hyperglycemia.The medicine of current treatment diabetes is a lot, especially Western medicine, but side effect is large, and Chinese patent medicine effect is remarkable not.
Summary of the invention
Object of the present invention provides a kind of Chinese medicine composition of the treatment diabetes containing linum, this Chinese medicine composition good effect, little to person side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment diabetes of linum, be prepared from by the medicinal raw material of following weight proportion: Stigma Maydis 15 ~ 35 parts, Radix Ranunculi Ternati 4 ~ 12 parts, Rhizoma Chuanxiong 2 ~ 7 parts, Herba Dracocephali 2 ~ 9 parts, linum 2 ~ 9 parts, 1 ~ 5 part, Radix Glycyrrhizae.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Stigma Maydis is 20 ~ 30 parts.Preferred, part by weight shared by Stigma Maydis is 25 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Ranunculi Ternati is 6 ~ 10 parts.Preferred, part by weight shared by Radix Ranunculi Ternati is 8 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Rhizoma Chuanxiong is 4 ~ 6 parts.Preferred, part by weight shared by Rhizoma Chuanxiong is 5 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Herba Dracocephali is 4 ~ 7 parts.Preferred, part by weight shared by Herba Dracocephali is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by linum is 4 ~ 7 parts.Preferred, part by weight shared by linum is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.Preferred, part by weight shared by Radix Glycyrrhizae is 3 parts.
The Chinese medicine composition for the treatment of diabetes of the present invention, Traditional Chinese medicine extraction method conveniently can extract the active component of medicinal raw material, as decocted with water, or collects extracting solution and concentrated by the aqueous solution reflux, extract, of ethanol or ethanol; Add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of diabetes, that inventor is based on the pathogenetic understanding of motherland's medical science to diabetes, according to oneself clinical experience for many years, first determine a series of to the effective Chinese medicine for the treatment of diabetes from numerous Chinese medicine, then screen through clinical repeatedly checking.Wherein, Stigma Maydis, another name Semen Maydis palpus, chinese sorghum palpus, Semen Maydis must; Sweet in the mouth, light, property is put down; Return bladder, liver, gallbladder meridian; There is effect of inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.Can be used for acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann; Sweet in the mouth is pungent, warm in nature; Enter liver, lung two warp.There is effect of dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling, do not burst for scrofula, the disease such as tuberculous lymphadenitis.Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel; Have blood-activating and qi-promoting, effect of wind-expelling pain-stopping, walks and does not keep, and can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood; For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, the disease Be very effective such as rheumatic arthralgia.Herba Dracocephali, calls Dracocephalum moldabium, eye that rubs, Fructus Gardeniae flower, Herba Dracocephali, fried flour flower, Caulis et Folium Hyptidis suaveolentis, Bi Yanggu, whitely relies ocean ancient [Mongolia] etc.; For Labiatae dragonhead Herba Dracocephali, with ground all herbal medicine.Pungent, bitter, cool; There is lung heat clearing induce sweat, effect of cool liver hemostasis; For flu, headache, laryngalgia, tracheitis, asthma, jaundice, spits blood, epistaxis, dysentery, heart disease, neurasthenia, the diseases such as lyssodexis.Linum, also known as sesame, sweet in the mouth, property is put down.Main damaging the spleen and stomach, weakness with emaciation, mend in five, physical strength profiting, longue meat, fills out marrow brain, hard muscles and bones, treats incised wound, pain relieving and typhoid fever, pyrexial malaria, and it is thin tired to tell greatly rear deficiency-heat.(" Zhenglei Bencao ").Radix Glycyrrhizae, sweet in the mouth is put down; GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, the diseases such as carbuncle sore tumefacting virus, can also cushion toxicity, strong.After above-mentioned 6 taste Chinese herbal medicine press formula proportion mixing, Traditional Chinese medicine extraction method conveniently obtains the Chinese medicine composition for the treatment of diabetes of the present invention after extracting the active component of medicinal raw material.After formula proportion combination pressed by 6 taste medicines wherein, treatment diabetes have the function of Synergistic, can significantly reduce blood glucose, serum lipid concentrations, improve blood flow and anti-oxidation efficacy, treat diabetes Be very effective and have no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Stigma Maydis 25g, Radix Ranunculi Ternati 8g, Rhizoma Chuanxiong 5g, Herba Dracocephali 6g, linum 6g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material: get medicinal raw material by formula proportion, 2 times are decocted with water in medicinal raw material, be followed successively by medicinal raw material volume by water volume 10 times and 8 times that decoct for 2 times, 2 times decocting time is followed successively by 1.5 hours and 1 hour, filters and collects filtrate after each decoction; Merge 2 filtrates, obtain the extracting solution of embodiment 1 medicinal raw material, the extracting solution of embodiment 1 medicinal raw material is concentrated into relative density 1.20 (80 DEG C), obtains the extract of embodiment 1.
In above-mentioned extract, add the soluble starch of extract 2 times of weight, granulation, drying, be distributed into bag, obtain the Chinese medicinal composition granules that embodiment 1 treats diabetes.
Embodiment 2
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Stigma Maydis 35g, Radix Ranunculi Ternati 4 parts of g, Rhizoma Chuanxiong 7g, Herba Dracocephali 2g, linum 9g, Radix Glycyrrhizae 1g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Embodiment 3
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Stigma Maydis 22g, Radix Ranunculi Ternati 8g, Rhizoma Chuanxiong 6g, Herba Dracocephali 5g, linum 7g, Radix Glycyrrhizae 4g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Comparative example
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Stigma Maydis 25g, Radix Ranunculi Ternati 8 parts of g, Rhizoma Chuanxiong 5 parts of g, Herba Dracocephali 6g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Pharmacodynamics test proves:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to Chinese medicine composition of the present invention prepared by embodiment 1;
According to comparative example Chinese medicine composition prepared by comparative example;
Alloxan, SIGMA Co. produces;
Glucose estimation kit, is produced by Beijing Chemical Plant;
Insoral, commercially available.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
(3) instrument: VZS-723 spectrophotometer, electronic balance etc.
2, test method and result:
(1) medicine of the present invention is on the impact of alloxan diabetes mice hyperglycemia
(1) hyperglycemia model and grouping, is made
Get body weight 25 ± 1g Male Kunming strain mice 80, water is can't help in fasting.After 3 hours, tail vein injection alloxan normal saline solution 85mg/kg (0.5ml/ only) causes hyperglycemia model, separately by 15 body weight 25 ± 1g Male Kunming strain mice tail vein injection normal saline (0.5ml/ only), as Normal control animals.After 72 hours, above-mentioned mice fasting be can't help water 10 hours; Then get blood from its eye socket, glucose oxidase method surveys every mouse blood sugar concentration.
From the mice of 80 injection alloxan normal saline solutions, select blood glucose higher than 200mg/dL and close 60 of blood glucose value, be divided into 4 groups at random, i.e. model group, medicine group of the present invention, matched group 1 and insoral group, often organize 15.
(2), administration, survey blood sugar concentration
Five groups of mice difference gastric infusion and normal saline as follows: to the Chinese medicine composition of the medicine group gavage embodiment of the present invention 1 preparation of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To insoral group gavage insoral, medication accumulated dose: 80mg/kg; To Chinese medicine composition prepared by matched group 1 gavage comparative example of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To the normal saline of the solvent amounts such as model group gavages; The normal saline of the solvent amounts such as normal saline group gavages.
Successive administration 10 days, during administration and the ingesting of the mice respectively organized of fore-and-aft observing, movable and excretion situation situation all without exception occur.In administration in the 10th day after 1 hour, eye socket gets blood, surveys fasting plasma glucose concentration (fasting can't help water 10 hours, and method is with aforementioned).Between comparative control group 1 and model group, difference between each administration group, the results are shown in Table 1.
Table 1
Note: in table 1, compares with model group:
▲ ▲ ▲p < 0.001,
▲ ▲p < 0.05,
▲p > 0.05.
In table 1, experimental result shows: mouse mainline alloxan is after 72 hours, and mice hyperglycemia modeling success, its blood sugar concentration is significantly higher than normal saline group.Medicine group successive administration of the present invention is after 10 days, and mouse blood sugar concentration reduces to 392.3 ± 33.3mg/dL, about 54mg/dL lower than the mouse blood sugar concentration 446.3 ± 38.2mg/dL of model group.And the statistical result of medicine group of the present invention relative to model group statistical result P < 0.05, have significant difference, the blood sugar lowering therapeutic effect of medicine group of the present invention to alloxan diabetes mice hyperglycemia is good; And during mice administration and front and back have no adverse reaction, the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
And matched group 1 successive administration is after 10 days, mouse blood sugar concentration is 415.4 ± 88.7mg/dL, about 31mg/dL lower than the mouse blood sugar concentration 446.3 ± 38.2mg/dL of model group; Than statistical value height about the 23mg/dL of medicine group mouse blood sugar concentration of the present invention; And the statistical result of matched group 1 is relative to the statistical result P > 0.05 of model group, there was no significant difference.Therefore learn, the blood sugar lowering therapeutic effect of Chinese medicine composition to alloxan diabetes mice hyperglycemia prepared by comparative example is poor.
To sum up, the present invention treats the Chinese medicine composition of diabetes, good, the instant effect for the treatment of diabetes curative effect and having no side effect to health, and 6 taste medicinal raw materials press after formula proportion combines, and have Synergistic function; Lack any component, the curative effect of traditional Chinese medicine composition for treating diabetes all can obviously reduce, as in above-mentioned pharmacodynamics test, the therapeutic effect of matched group 1 obviously reduces relative to the curative effect of medicine group of the present invention, and the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
Claims (10)
1., containing a Chinese medicine composition for the treatment diabetes of linum, it is characterized in that: it is made up of the medicinal raw material of following weight proportion: Stigma Maydis 15 ~ 35 parts, Radix Ranunculi Ternati 4 ~ 12 parts, Rhizoma Chuanxiong 2 ~ 7 parts, Herba Dracocephali 2 ~ 9 parts, linum 2 ~ 9 parts, 1 ~ 5 part, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Stigma Maydis is 20 ~ 30 parts.
3. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Radix Ranunculi Ternati is 6 ~ 10 parts.
4. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Rhizoma Chuanxiong is 4 ~ 6 parts.
5. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Herba Dracocephali is 4 ~ 7 parts.
6. the Chinese medicine composition for the treatment of diabetes according to claim 5, is characterized in that: part by weight shared by Herba Dracocephali is 6 parts.
7. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by linum is 4 ~ 7 parts.
8. the Chinese medicine composition for the treatment of diabetes according to claim 7, is characterized in that: part by weight shared by linum is 6 parts.
9. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.
10. the Chinese medicine composition for the treatment of diabetes according to claim 9, is characterized in that: part by weight shared by Radix Glycyrrhizae is 3 parts.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306171A (en) * | 2008-05-10 | 2008-11-19 | 王跃进 | Traditional Chinese medicine capsule for repairing dysinsulinism function to balance blood sugar |
| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
| CN102940757A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating diabetic foot |
| CN103386015A (en) * | 2013-07-15 | 2013-11-13 | 通辽东北六药业有限公司 | A traditional Mongolian medicine for the treatment of diabetes |
-
2014
- 2014-11-11 CN CN201410633256.6A patent/CN104352861A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306171A (en) * | 2008-05-10 | 2008-11-19 | 王跃进 | Traditional Chinese medicine capsule for repairing dysinsulinism function to balance blood sugar |
| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
| CN102940757A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating diabetic foot |
| CN103386015A (en) * | 2013-07-15 | 2013-11-13 | 通辽东北六药业有限公司 | A traditional Mongolian medicine for the treatment of diabetes |
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Application publication date: 20150218 |