CN104352784B - It is a kind of to treat stomach and the Chinese patent drug of dudenal disease and preparation method thereof - Google Patents
It is a kind of to treat stomach and the Chinese patent drug of dudenal disease and preparation method thereof Download PDFInfo
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Abstract
Stomach and the Chinese patent drug of dudenal disease are treated the invention discloses a kind of, raw material includes the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand, a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease is disclosed in addition.Said preparation prescription is more reasonable, ingredients synergy, therapeutic action extensively, for caused by liver-stomach disharmony a variety of disease of stomach such as all diseases, acute or chronic gastritis, peptic ulcer it is evident in efficacy, have no side effect safely.And preparation method is simple to operation, substep mixing is more uniform, the medical value between each component is acted synergistically and plays more notable, so as to significantly improve the medical value of preparation.
Description
Technical field
The present invention relates to treatment stomach trouble Chinese medicine composition, more particularly to it is a kind of treat in stomach and dudenal disease into
Medicine and preparation method thereof.
Background technology
Stomach trouble is a variety of sick general designations, due to these disease have similar symptom, frequently even mutually with and cause simultaneously
Hair, makes patient's sup sorrow.The species for the huge stomach trouble of colony of falling ill is various, and pathogenesis differs, and corresponding treatment method is each
It is different.Common gastrointestinal inflammatory diseases include chronic gastritis, gastroduodenal ulcer, chronic colitis, ulcerative colitis
Deng.The medicine for being used to treat these stomach trouble on the market is more and more, but the radical cure of stomach trouble is relatively difficult.West traditional at present
In medicine, such as gastropine, Lei Niding, first nitre file, treatment of these medicines to stomach trouble can only all be played a part of controlling temporarily,
Recurrence is easier in short time, and side effect is larger, easily causes sense of having a stomach upset, and occurs the diseases such as nausea and vomiting dizziness what is more
Shape.Because western medicine side effect is larger, and price is costly, therefore can configure corresponding system to the ill using Chinese medicine preparation
Agent.Traditional Chinese medicine, has the advantages that to produce effects that rapid, radical-ability is strong, is difficult repeatedly, Small side effects, and highly patient selects.
When above stomach trouble is concurrent, light judges the species of stomach trouble with symptom and takes treatment method not accurate enough, no
It can guarantee that and treat stomach trouble in time.Treatment of the composition of Chinese medicine to disease is of great importance, and different Chinese medicine has different pharmacology,
It is correct between each taste Chinese medicine that beneficial synergy occurs with credit union.Influence of the deal of Chinese medicine to the state of an illness can not look down upon, therefore,
Safety is taken in exploitation, composition and deal are accurate, can effectively treat the stomach medicine of various stomach, wide market.
The content of the invention
Stomach and the Chinese patent drug of dudenal disease are treated it is an object of the invention to provide a kind of, and said preparation is in pure natural
Medicinal material is made, and prescription is more reasonable, ingredients synergy, therapeutic action extensively, for caused by liver-stomach disharmony all diseases,
A variety of disease of stomach such as acute or chronic gastritis, peptic ulcer are evident in efficacy, have no side effect safely.
Another object of the present invention is to provide a kind of preparation side for treating stomach and the Chinese patent drug of dudenal disease
Method, this method is simple to operation, and substep mixing is more uniform, the medical value between each component is acted synergistically and plays more aobvious
Write, so as to significantly improve the medical value of preparation.
In order to realize the above object the technical solution adopted by the present invention is:It is a kind of to treat in stomach and dudenal disease
Patent medicine, it is characterised in that:Raw material includes the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand, and above each component is with mass parts
Number meter is respectively 8-12 parts of the membrane of a chicken's gizzard, 12-18 parts of the bletilla striata, 10-15 parts of cuttlebone, 8-12 parts of pseudo-ginseng, 4-6 parts of rheum officinale, Buddha's hand 4-6
Part.
It is preferred that, each component is respectively in terms of mass fraction:10 parts of the membrane of a chicken's gizzard, 15 parts of the bletilla striata, 12 parts of cuttlebone, three
7 10 parts, 5 parts of rheum officinale, 5 parts of Buddha's hand.
The Chinese patent medicine preparation is powder, granule, tablet or capsule.
A kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease, it is characterised in that comprise the following steps:
S110 steps 1, pretreatment of raw material:Take the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand through cleaning, screening,
It is standby after cutting, drying;
S120 steps 2,8-12 parts of the membrane of a chicken's gizzard taken in step 1,12-18 parts of the bletilla striata, 10-15 parts of cuttlebone, pseudo-ginseng 8-12
Part, it is well mixed after ingredients is distinguished into size-reduced, 100 mesh sieves excessively;
S130 steps 3,4-6 parts of the rheum officinale taken in step 1,4-6 parts of Buddha's hand, by ingredients, 2 filterings are boiled in decocting respectively
Merging filtrate afterwards, the filtrate that above-mentioned merging is obtained is through being concentrated under reduced pressure to give annex solution;
S140 steps 4, the annex solution for obtaining mixing medicinal powder and step 3 that step 2 is obtained are mixed and stirred for uniformly,
Required preparation formulation is made as required.
It is preferred that, the drying condition in the step 1 is dry 12-20 hours under the conditions of 60-80 DEG C.
It is preferred that, amount of water when being decocted in the step 3 is 5-10 times of every taste medicinal material weight.
It is preferred that, the concentration condition in the step 3 is that to be concentrated under reduced pressure into relative density under the conditions of 80-90 DEG C be 1.1-
1.3。
The concrete operation method that powder is made in step 4 is:The mixing medicinal powder that step 2 is obtained is obtained with step 3
Annex solution be mixed and stirred for uniformly, dried under the conditions of 50-80 DEG C to moisture and reach crushing after less than 2%, grind to form smalls packing
Enter inner wrapping and produce powder.
The concrete operation method that granule is made in step 4 is:The mixing medicinal powder that step 2 is obtained is obtained with step 3
To annex solution be mixed and stirred for uniformly, dried under the conditions of 50-80 DEG C to moisture and reach crushing after less than 2%, crossing 100 mesh sieves is
Obtain granule.
The concrete operation method that tablet is made in step 4 is:The mixing medicinal powder that step 2 is obtained is obtained with step 3
Annex solution be mixed and stirred for uniformly, dried after being molded according to a conventional method under the conditions of 50-80 DEG C after reaching less than 2% to moisture i.e.
Obtain tablet.
Prescription is discussed below according to theory of traditional Chinese medical science:
Gastral cavilty turgor pain, is one of clinical most common symptom, though its sick position is based on stomach, and liver, spleen relation are most
Closely.Lid stomach is connected with spleen with film, and stomach life is received, digesting food, be reduced to it is suitable.The liver belonging to wood, is firm dirty, main catharsis, property happiness
Depression is disliked up to bar.If troubled thoughts are angry, feelings are not smooth, stagnation of QI due to depression of the liver, and catharsis dereliction of duty, perverse and unreasonable manner violates stomach, and stagnation of QI-blood is not all right, obstructed
Then pain, therefore gastral cavilty turgor pain.Gas disease walks to alter, and the side of body is with the dividing line of liver, therefore pain connects two sides of body.Depression of QI, it is stomach Qi rising, therefore see
Warm belch hiccup, noisy pantothenic acid.If heat resulting from stagnation of QI, then, it is seen that irritated, the disease such as dry.Its suiting measures to different conditions is with dispersing stagnated hepatoqi, harmonizing stomach and lowering adverse Qi
Based on.If topical ulcers, help and held back ulcer myogenic;Have hot and suffocating, the product that Yi Zuo expels the heat-evil concurrently.
The present invention is abided by above-mentioned theory of traditional Chinese medical science, prescription:The membrane of a chicken's gizzard:Promoting digestion and removing indigestion effect it is stronger, and can invigorating the spleen and stomach, therefore
It is widely used in various dyspepsia diseases.《Prescriptions worth thousand gold》In point out that private this product can control regurgitation and emesis caused by indigestion.Pharmacology is made
With showing:After oral powder, gastric secretion, acidity and eupepsy are shown in raising, and stomach motion function is remarkably reinforced;Experiment in vitro
Stomach cardia acid, pancreatic lipase activity can be strengthened.
The bletilla striata:Matter glues puckery, is the key medicine of astringing to arrest bleeding, can with all haemorrhages in inside and outside are controlled, because it is led into lung, stomach,
Especially it is suitable for the disease of the bleeding of lung stomach.The bletilla striata has astringing to arrest bleeding, effect of detumescence and promoting granulation.Pharmacological action shows:Bletilla striata decoction can
Substantially shorten bleeding and clotting time, have obvious therapeutic action to mucosal lesion, ulcer inhibition rate is up to 94.8%;Bletilla striata powder
There is obvious therapeutic action to experimental dog stomach and duodenum perforation, perforation can be blocked rapidly, prevent stomach and duodenum content
Beyond the region of objective existence leaks and increases the covering of nethike embrane.Patients w ith peptic ulcer disease because at its ulcer Mucosa Barrier be destroyed, the high viscosity of the bletilla striata easily exists
Certain thickness is formed in stomach, is attached on ulcer surface, prevents hydrochloric acid in gastric juice, pepsin and other chemical factors from entering ulcer surface
One step is attacked, and is conducive to the healing and reparation of ulcer surface, while playing its convergence, hemostasis, myogenic curative effect.The bletilla striata is to acute and chronic
Gastritis and stomach lining is downright bad and various gastric injuries have the effect substantially repaired and protective effect.
Cuttlebone:Stomach is salty and puckery, energy relieving haperacidity analgesic, and to treat the good merchantable brand of gastral cavity pain hyperhydrochloria, pharmacological action shows:Sea
The egg capsule of a mantis has anti-peptic ulcer, antitumor, the effect such as anti-radiation.Calcium carbonate contained by it can neutralize hydrochloric acid in gastric juice, change stomach content
Thing and pH value, reduce pepsin activity, promote ulcer surface healing.In addition, its conchiolin is acted on organic matter in stomach and gastric juice
Afterwards, diaphragm can be formed on ulcer surface, bleeding is tended to solidification.Therefore treatment gastric ulcer, elimination Tong pains are efficient, ulcer healing
Effect is notable.
Pseudo-ginseng:Sweet and slightly bitter taste is warm-natured, and enter liver is through blood system, the kind hemostasis of work(, and energy blood stasis dispersing and fresh blood promoting, has hemostasis not stay the stasis of blood, stagnation resolvation
The characteristics of not hindering positive, available for various bleedings in human body.《Book on Chinese herbal medicine is newly organized》:" Roots of Panax Notoginseng, god's medicine of stopping blooding, in no matter going up
Lower bleeding, all have an outer more person, private simply also to imitate." pseudo-ginseng can invigorate blood circulation analgesic therapy again, to control the good merchantable brand of all diseases of hemostasis, Buddha's hand it
The work(of promoting the circulation of qi, the work(of promoting blood circulation analgesic therapy more writes, for gastric ulcer, and the pains of Tong caused by gastrorrhagia have significant curative effect.Modern study shows, three
Seven can shorten bleeding and clotting time, can improve the microcirculation of chronic ulcer tissue, suppress a small amount of oozing of blood of ulcer surface, promote inflammatory water
The absorption of swollen and slough.
Rheum officinale:There is stronger discharge function, stomach can be cleansed, Chen Zhixin is pushed away, for the key medicine of the stagnant constipation for the treatment of, it has again
Lead damp and hot outgoing work(.Therefore available for gastrointestinal retention, constipation, belly turgor, pain with tenderness, the disease of damp and hot Yun knots.Rheum officinale
Purify the blood purging intense heat, the work(of cooling blood and hemostasis.For UGB, there is good therapeutic effect.Pharmacological action shows:Rheum officinale can increase intestines
Wriggle.Suppress enteral moisture absorption, promote defecation.Moreover it is possible to cholagogic and stomach invigorating.
Buddha's hand:It is pungent, bitter, warm-natured.Return liver, spleen, stomach, lung channel.The pungent row hardship of this product is let out, and is apt to soothing liver-qi stagnation, promoting qi circulation and relieving pain, is used for
Liver depression chest the lung-distension pain.Because of its fragrant odour, can be amusing qi-regulating, and in lead stagnant, dispelling dampness with bitter and warm-natured drugs, therefore for stagnation of the circulation of vital energy chamber abdomen Tong pains, food
Few hiccup.Buddha's hand promoting the circulation of qi is evident in efficacy, be difficult the characteristics of consumption hinders healthy tendency, available for various stagnation of the circulation of vital energy diseases.
More than all medicine compatibilities, altogether long memorial liver and qi and stomach and alleviating pain work(, and have concurrently and hold back ulcer, myogenic, hemostasis, relieve pain, control
Acid, the effect of expelling the heat-evil etc..Thus the major function of Chinese patent drug of the present invention is:Liver-smoothing, qi-regulating and stomach and alleviating pain, hold back ulcer myogenic;With
Epigastric distending pain or pain alter the vexed deficiency of food of two sides of body, gastral cavity, belch hiccup, noisy pantothenic acid etc. caused by liver-stomach disharmony, and acute or chronic gastritis,
Peptic ulcer, duodenal ulcer, stomach erosion etc..
Beneficial effects of the present invention are:(1)The present invention provide it is a kind of treat stomach and the Chinese patent drug of dudenal disease, its
Reasonable recipe, all taste Chinese medicine is combined according to traditional Chinese medical theory compatibility, and collection improves stomach function, liver-smoothing, qi-regulating and stomach and alleviating pain, promotes to burst
The multiple efficacies such as ulcer healing, convergence, hemostasis, myogenic further reconcile and improvement each side in one, complementarity and mutual benefit, interaction
The effect of, for caused by liver-stomach disharmony a variety of disease of stomach such as all diseases, acute or chronic gastritis, peptic ulcer it is evident in efficacy.
(2)For natural Chinese traditional medicines material preparation, have no side effect safely, the purpose treated both principal and secondary aspect of disease can be reached;And Component Source is wide
It is general, it is with low cost;With higher clinical value and market popularization value.
(3)A kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease that the present invention is provided, this method is simple
Easy to operate, substep mixing is more uniform, the medical value between each component is acted synergistically and plays more notable, so as to significantly carry
The medical value of high preparation.
Brief description of the drawings
Fig. 1 is a kind of process chart for the preparation method for treating stomach and the Chinese patent drug of dudenal disease.
Numeral mark described in Fig. 1 is expressed as:S110 is step 1;S120 is step 2;S130 is step 3;S140 is
Step 4.
Embodiment
In order to facilitate the understanding of the purposes, features and advantages of the present invention, below in conjunction with the accompanying drawings to the present invention
Embodiment elaborate.Many details are elaborated in the following description to fully understand this hair
It is bright.But the present invention can be implemented with being much different from other modes described here, those skilled in the art can be not
Similar improvement is done in the case of running counter to intension of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.
Embodiment 1
A kind of Chinese patent drug for treating stomach and 12 finger diseases, its component and content are respectively:The membrane of a chicken's gizzard 12g, bletilla striata 12g,
Cuttlebone 15g, pseudo-ginseng 8g, rheum officinale 4g, Buddha's hand 6g.
The Chinese patent medicine preparation is powder.
A kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease, comprises the following steps:
S110 steps 1, take the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand through clean, screening, cutting, 60 DEG C of bars
It is standby after being dried 20 hours under part;
S120 steps 2, the membrane of a chicken's gizzard 12g taken in step 1, bletilla striata 12g, cuttlebone 15g, pseudo-ginseng 8g, by ingredients point
It is well mixed after not size-reduced, 100 mesh sieves excessively;
S130 steps 3, the rheum officinale 4g taken in step 1, Buddha's hand 6g, ingredients is merged after 2 filterings are boiled in decocting respectively
Filtrate, the filtrate that above-mentioned merging is obtained is described to decoct through being concentrated under reduced pressure to give the annex solution that relative density is 1.1 under the conditions of 80 DEG C
Amount of water when boiling is 10 times of every taste medicinal material weight;
S140 steps 4, the annex solution for obtaining mixing medicinal powder and step 3 that step 2 is obtained are mixed and stirred for uniformly,
Dried under the conditions of 50 DEG C to moisture and reach crushing after less than 2%, ground to form smalls and be distributed into inner wrapping and produce powder.
Embodiment 2
A kind of to treat stomach and the Chinese patent drug of dudenal disease, its component and content are respectively:The membrane of a chicken's gizzard 8g, bletilla striata 18g,
Cuttlebone 10g, pseudo-ginseng 12g, rheum officinale 6g, Buddha's hand 4g.
The Chinese patent medicine preparation is tablet.
A kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease, comprises the following steps:
S110 steps 1, take the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand through clean, screening, cutting, 80 DEG C of bars
It is standby after being dried 12 hours under part;
S120 steps 2, the membrane of a chicken's gizzard 8g taken in step 1, bletilla striata 18g, cuttlebone 10g, pseudo-ginseng 12g, by ingredients point
It is well mixed after not size-reduced, 100 mesh sieves excessively;
S130 steps 3, the rheum officinale 6g taken in step 1, Buddha's hand 4g, ingredients is merged after 2 filterings are boiled in decocting respectively
Filtrate, the filtrate that above-mentioned merging is obtained is described to decoct through being concentrated under reduced pressure to give the annex solution that relative density is 1.3 under the conditions of 90 DEG C
Amount of water when boiling is 5 times of every taste medicinal material weight;
S140 steps 4, the annex solution for obtaining mixing medicinal powder and step 3 that step 2 is obtained are mixed and stirred for uniformly,
Dried after being molded according to a conventional method under the conditions of 80 DEG C and produce tablet after reaching less than 2% to moisture.
Embodiment 3
A kind of to treat stomach and Duodenitis and the Chinese patent drug of ulcer, its component and content are respectively:The membrane of a chicken's gizzard
10g, bletilla striata 15g, cuttlebone 12g, pseudo-ginseng 10g, rheum officinale 5g, Buddha's hand 5g.
The Chinese patent medicine preparation is granule.
A kind of preparation method for treating stomach and Duodenitis and the Chinese patent drug of ulcer, comprises the following steps:
S110 steps 1, take the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand through clean, screening, cutting, 70 DEG C of bars
It is standby after being dried 16 hours under part;
S120 steps 2, the membrane of a chicken's gizzard 10g taken in step 1, bletilla striata 15g cuttlebones 12g, pseudo-ginseng 10g, by ingredients point
It is well mixed after not size-reduced, 100 mesh sieves excessively;
S130 steps 3, the rheum officinale 5g taken in step 1, Buddha's hand 5g, ingredients is merged after 2 filterings are boiled in decocting respectively
Filtrate, the filtrate that above-mentioned merging is obtained is described to decoct through being concentrated under reduced pressure to give the annex solution that relative density is 1.2 under the conditions of 85 DEG C
Amount of water when boiling is 8 times of every taste medicinal material weight;
S140 steps 4, the annex solution for obtaining mixing medicinal powder and step 3 that step 2 is obtained are mixed and stirred for uniformly,
Crushing after reaching less than 2% to moisture is dried under the conditions of 60 DEG C, 100 mesh sieves is crossed and produces granule.
Specific discrimination process is as follows to be differentiated to the gained Chinese patent drug of embodiment 3:
Character:Chinese patent drug is brown granular obtained by the present embodiment, and gas is micro-, mildly bitter flavor.
Differentiate:1)This product is taken to be placed in micro- Microscopic observation, needle-like calcium oxalate crystal beam is present in big mucilage cell or everywhere
It is dispersed in, the long 18-88um of needle.Irregular transparent sheet, some elongated lines of tool.Calcium oxalate cluster crystal diameter 50-80um.Resin canal is broken
Piece secretion containing yellow.
2)This product 8g is taken, it is finely ground, plus 80% ethanol 40mL, put and 1h is heated to reflux in water-bath, let cool filtration, filtrate is placed in water
It is evaporated in bath, the residue 10mL that adds water makes dissolving, plus hydrochloric acid 1mL, is placed in water-bath and heats 30min;Cooling, with extracted by ether 2 times,
Each 20mL, merges ether solution, volatilizes, and residue chlorination, which imitates 1mL, makes dissolving, is used as need testing solution.Separately take rheum officinale control medicinal material
0.5g, is made in the same way of control medicinal material solution, takes rheum emodin reference substance, plus methanol that 1mg/mL solution is made, molten as reference substance
Liquid.According to thin-layered chromatography experiment, each 2uL of above-mentioned 3 kinds of solution is drawn, is put respectively on same silica gel g thin-layer plate, with petroleum ether
(30-60℃)- Ethyl formate-formic acid(15:5:1)Upper solution be solvent, deploy, take out, dry after be placed in ammonia
Smoke clear to spot development.In test sample chromatogram, on position corresponding with control medicinal material and reference substance chromatogram, show same color
Spot.
3)This product 6g is taken, it is finely ground, plus methanol 40mL, put and 1h is heated to reflux in water-bath, let cool filtration.Filtrate is placed in water-bath
It is evaporated, the residue 20mL that adds water makes dissolving, add diethyl ether extraction 2 times, and each 20mL discards ether solution, with water saturated n-butanol liquid
Extract 3 times, each 20mL, merge n-butanol liquid, washed with ammonia solution 2 times, each 20mL discards alkali lye, takes n-butanol liquid to put
In being evaporated in water-bath, residue adds methanol 1mL to make dissolving, is used as need testing solution.Pseudo-ginseng control medicinal material 0.5g separately is taken, is made in the same way of
Control medicinal material solution, takes notoginsenoside R reference substance, plus methanol that 1mg/mL solution is made, is used as reference substance solution.According to thin layer
Chromatography experiment, draws each 4uL of above-mentioned 3 kinds of solution, puts respectively on same silica gel g thin-layer plate, with chloroform-methanol-water(65:
35:10)10 DEG C of lower floor's solution for once placing 12h are solvent, deploy, take out, dry, spray with 10% ethanol solution of sulfuric acid,
105 DEG C to be dried to spot development clear.Inspected under daylight, in test sample chromatogram, corresponding with control medicinal material and reference substance chromatogram
On position, show the spot of same color.
Check:Melting:This product 10g is taken, 20 times of water is heated, stirs 5 minutes, in addition to suspension has fine medicinal material powder, must not have
The foreign matters such as breeze.
Remaining item all should meet every pertinent regulations of granule.Specific survey report result and preparation stability experiment
As a result respectively as shown in Table 1 and Table 2.
The Chinese patent drug sample survey of 1 embodiment of table 3 is reported
Table 2 embodiment, 3 doses of stability test results
From Tables 1 and 2, according to technical scheme of the present invention, the Chinese patent drug prepared meets quality inspection mark
Standard, stability has also reached requirement.
Clinical test is carried out using the gained Chinese patent drug of embodiment 3, specific process of the test is as follows:
Case overview:Clinical observation treatment is carried out to 60 patients, wherein man 31, female 29, the age is 18-60 year
Between, average age 33.2 years old, the course of disease most elder 28 years, most short person 3 months.Wherein chronic gastritis 38, peptic ulcer 22,
Symptomatology is made a definite diagnosis all in accordance with clinical symptoms, sign and fibergastroscopy.60 patients are pressed into gastritis, gastric ulcer half and half
It is divided into 2 groups, every group of 30 people, i.e. treatment group and control group.
Test reagent and usage and dosage:The by reagent for the treatment of group is the gained Chinese patent medicine preparation of embodiment 3,4 times a day, every time
4g, empty stomach warm boiled water 1 month is a course for the treatment of;The by reagent of control group is stagnation of the circulation of vital energy instant particle for gastrosis, 3 times a day, every time
5g, empty stomach warm boiled water 1 month is a course for the treatment of.
Curative effect judging standard:
1)Liver-stomach disharmony disease curative effect judging standard
Clinic control:Primary symptom integration reduces more than 91% before relatively treating after treatment;
It is effective:Primary symptom integration reduces 70~90.9% before relatively treating after treatment;
Effectively:Primary symptom integration reduces 36~69.9% before relatively treating after treatment;
It is invalid:Primary symptom integration is reduced before relatively treating after treatment is less than 36%.
2)Chronic superficial gastritis curative effect judging standard
Clinical recovery:Symptom, sign disappear;Gastrocopy, acute inflammation disappears, and chronic inflammation reaches slight, bile regurgitation
Disappear;
It is effective:Symptom, sign improve more than 2 grades;Gastrocopy, acute inflammation disappears, chronic inflammation degree improvement I
Degree, bile regurgitation reduces more than 2/3;
Effectively:Symptom, sign improve more than 1 grade;Gastrocopy, mucosa infection range shorter more than 1/2, acute inflammation
Degree mitigates I degree, and bile regurgitation reduces more than 1/2;
It is invalid:Effective standard or on the contrary deterioration person are not reached.
3)Peptic ulcer curative effect judging standard
Clinical recovery:Primary symptom all disappears with time disease;Gastrocopy, ulcer is wholly absent, local mild hyperaemia, without substantially
Oedema;
It is effective:Primary symptom has clear improvement with time disease;Gastrocopy, ulcer disappears substantially, still there is obvious inflammation;
Effectively:Primary symptom has improvement with time disease;Gastrocopy, ulcer area reduces more than 50%;
It is invalid:Effective standard or on the contrary deterioration person are not reached.
The Comparison of therapeutic result for the treatment of group and control group is as shown in Table 3-5.
The liver-stomach disharmony disease Comparison of therapeutic result of table 3
The chronic superficial gastritis Comparison of therapeutic result of table 4
The peptic ulcer Comparison of therapeutic result of table 5
From table 3- tables 5, present invention gained Chinese patent drug is compared with by reagent stagnation of the circulation of vital energy instant particle for gastrosis, and curative effect is preferable.Below
It is specific model case introduction.
Model case 1:
Liu, female, 42 years old;Stomach medical history 10 years;
Symptom:Gastral cavity have a dull ache glutted, ruffian it is vexed, noisy, feed more so, stomach have burning heat sensation;
Check:Gastroscope shows that atrophic gastritis erosion, antrum sheet are rotten to the corn;
Take 2 months symptoms of this medicine take a turn for the better, follow-up January.
Model case 2:
Just certain, male, 56 years old;Stomach medical history is aggravated 2 months for about 30 years, is had hypertension history, is now taken nitrendipine control;
Symptom:The thorough back of the body of gastral cavity distending pain, glutted, ruffian is vexed, have burning heat sensation, it is sour, swollen after the meal very, belch gas, stool 2-3 days 1 time;
Check:Gastroscope shows that chronic superficial gastritis ball is scorching;
This medicine is taken to be cured within 2 months.
Model case 3:
Luo, female, 36 years old;Stomach medical history 2 years;
Symptom:More so, acid, vomits clear water, pharyngeal to have foreign body sensation, si dol urg to take Western medicine for gastral cavity severe pain, empty stomach
Respite but it can not be cured repeatedly;
Check:Gastroscope shows multiple ulcers after duodenal bulb, and periphery is congested, and chronic superficial gastritis, antrum is shown in piece
Shape is rotten to the corn;
The improvement in 2 months of this medicine is taken, because of improper diet recurrence, follow-up January.
Model case 4:
It is remaining certain, female, 21 years old;Stomach medical history 6 months;
Symptom:Gastral cavity is swollen, ruffian is vexed.With feeling of repletion, creeping chill, feed is ice-cold more so, defecates dilute;
Check:Chronic superficial gastritis;
Take this medicine 2 months, it is reactionless that the tenth day during medication title of sending a telegram here eats ice lolly stomach.
Model case 5:
Flood certain, man, 40 years old;Stomach medical history 12 years;
Symptom:Jiangxi burst in way of going on business has a vomiting of stomach severe pain, pale complexion, the symptom such as stool pitch color, then nine
River examination in hospital gastrorrhagia, bleeding, which stops, after 3 days both goes home to see a doctor;
Take and check that stomach is burst intestines healing after this medicine March, last year sees that it claims not recur so far.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific detailed, but not
Therefore the limitation to the scope of the claims of the present invention can be interpreted as.It should be pointed out that to those skilled in the art,
Without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection model of the present invention
Enclose.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of treat stomach and the Chinese patent drug of dudenal disease, it is characterised in that:Raw material is the membrane of a chicken's gizzard, the bletilla striata, cuttlebone, three
7th, rheum officinale, Buddha's hand, above each component are respectively 8-12 parts of the membrane of a chicken's gizzard, 12-18 parts of the bletilla striata, cuttlebone 10-15 in terms of mass fraction
Part, 8-12 parts of pseudo-ginseng, 4-6 parts of rheum officinale, 4-6 parts of Buddha's hand.
A kind of stomach and the Chinese patent drug of dudenal disease are treated 2. according to claim 1, it is characterised in that:The each group
Divide and be respectively in terms of mass fraction:10 parts of the membrane of a chicken's gizzard, 15 parts of the bletilla striata, 12 parts of cuttlebone, 10 parts of pseudo-ginseng, 5 parts of rheum officinale, 5 parts of Buddha's hand.
A kind of stomach and the Chinese patent drug of dudenal disease are treated 3. according to claim 1 or 2, it is characterised in that:It is described
Chinese patent medicine preparation is powder, granule, tablet or capsule.
4. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease as claimed in claim 3, it is characterised in that
Comprise the following steps:
Step 1, pretreatment of raw material:The membrane of a chicken's gizzard, the bletilla striata, cuttlebone, pseudo-ginseng, rheum officinale, Buddha's hand are taken through clean, screening, cutting, drying
It is standby afterwards;
Step 2,8-12 parts of the membrane of a chicken's gizzard taken in step 1,12-18 parts of the bletilla striata, 10-15 parts of cuttlebone, 8-12 parts of pseudo-ginseng, by each taste
Medicinal material difference is size-reduced, it is well mixed after 100 mesh sieves to cross;
Step 3,4-6 parts of the rheum officinale taken in step 1,4-6 parts of Buddha's hand, merge filter after 2 filterings are boiled in decocting respectively by ingredients
Liquid, the filtrate that above-mentioned merging is obtained is through being concentrated under reduced pressure to give annex solution;
Step 4, the annex solution for obtaining mixing medicinal powder and step 3 that step 2 is obtained are mixed and stirred for uniformly, as required
Required preparation formulation is made.
5. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
In the drying condition in the step 1 is dry 12-20 hours under the conditions of 60-80 DEG C.
6. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
In amount of water when being decocted in the step 3 is 5-10 times of every taste medicinal material weight.
7. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
It is that to be concentrated under reduced pressure into relative density under the conditions of 80-90 DEG C be 1.1-1.3 in, the concentration condition in the step 3.
8. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
In the concrete operation method that powder is made in step 4 is:The addition that the mixing medicinal powder that step 2 is obtained is obtained with step 3
Liquid is mixed and stirred for uniformly, and crushing after reaching less than 2% to moisture is dried under the conditions of 50-80 DEG C, smalls is ground to form and is distributed into parcel
Dress produces powder.
9. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
In the concrete operation method that granule is made in step 4 is:By step 2 obtained mixing medicinal powder and adding that step 3 is obtained
Liquid feeding is mixed and stirred for uniformly, and crushing after reaching less than 2% to moisture is dried under the conditions of 50-80 DEG C, is crossed 100 mesh sieves and is produced particle
Agent.
10. a kind of preparation method for treating stomach and the Chinese patent drug of dudenal disease according to claim 4, its feature exists
In the concrete operation method that tablet is made in step 4 is:The addition that the mixing medicinal powder that step 2 is obtained is obtained with step 3
Liquid is mixed and stirred for uniformly, is dried after shaping under the conditions of 50-80 DEG C produce tablet after reaching less than 2% to moisture according to a conventional method.
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Citations (4)
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---|---|---|---|---|
CN1836719A (en) * | 2005-11-08 | 2006-09-27 | 许景连 | Pharmaceutical composition for treating gastritis, gastric ulcer and duodenal ulcer |
CN101002887A (en) * | 2007-01-22 | 2007-07-25 | 王正 | Traditional Chinese medicine for treating epigastric pain |
CN101791388A (en) * | 2010-04-12 | 2010-08-04 | 汤永顺 | Traditional Chinese medicine preparation for treating peptic ulcer |
WO2012040915A1 (en) * | 2010-09-29 | 2012-04-05 | 深圳市齐旺投资有限公司 | Chinese medicinal composition for treating stomach pain of hepatogastric stagnated heat type, preparing method thereof |
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2014
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1836719A (en) * | 2005-11-08 | 2006-09-27 | 许景连 | Pharmaceutical composition for treating gastritis, gastric ulcer and duodenal ulcer |
CN101002887A (en) * | 2007-01-22 | 2007-07-25 | 王正 | Traditional Chinese medicine for treating epigastric pain |
CN101791388A (en) * | 2010-04-12 | 2010-08-04 | 汤永顺 | Traditional Chinese medicine preparation for treating peptic ulcer |
WO2012040915A1 (en) * | 2010-09-29 | 2012-04-05 | 深圳市齐旺投资有限公司 | Chinese medicinal composition for treating stomach pain of hepatogastric stagnated heat type, preparing method thereof |
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