CN110604765A - Traditional Chinese medicine composition for treating diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating diarrhea and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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Abstract
A traditional Chinese medicine composition for treating diarrhea comprises 10-20 parts of coptis chinensis, 1100 parts of white pepper 900-. Compared with the conventional traditional Chinese medicine composition for treating diarrhea, the traditional Chinese medicine composition for treating diarrhea has the characteristics of short administration period, good curative effect, no side effect and the like when being applied to treating diarrhea diseases. The coptis and the white pepper are used as monarch drugs, the long pepper, the camphor and the yellow lead are used as assistants, and the drugs are combined to complement each other, so that the cost is low and the curative effect is remarkable.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diarrhea and a preparation method thereof.
Background
Diarrhea is a common symptom, commonly called as diarrhea, and means that the frequency of defecation obviously exceeds the frequency of ordinary daily habit, the stool quality is thin, the water content is increased, the daily defecation amount exceeds 200g, or the diarrhea contains undigested food or bloody pus and mucus. Diarrhea is often accompanied by symptoms such as a sense of urgency, anal discomfort, incontinence, etc. About 9L of liquid enters the gastrointestinal tract of normal people every day, and the moisture is absorbed through the intestinal tract, so that the final moisture in the excrement is only about 100-200 ml. If the amount of fluid entering the colon exceeds the absorption capacity of the colon or/and the absorption capacity of the colon is reduced, this results in increased water excretion from the stool and diarrhea. Clinically, diarrhea is classified into acute and chronic types according to the length of the disease course. Acute diarrhea is acute, the course of disease is within 2-3 weeks, and most of the disease is caused by infection. Chronic diarrhea refers to recurrent diarrhea with a course of more than two months or in a rest period of 2-4 weeks, and the cause of the disease is more complex and can be caused by infectious or non-infectious factors. Both etiological and symptomatic treatments are important. Before the etiology is not clear, pain-relieving herbs and anti-diarrhea herbs should be used with cautions to avoid covering symptoms and delaying the disease. The conventional western medicines for treating diarrhea are more, but side effects exist mostly, the traditional Chinese medicine for treating diarrhea is not general, and the traditional Chinese medicine for treating diarrhea has different causes and different treatment effects. Therefore, there is a need to develop a new Chinese medicinal composition for treating diarrhea caused by various reasons.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine composition for treating diarrhea and a preparation method thereof, and the traditional Chinese medicine composition has the characteristics of quick response, high curative effect, easy acceptance by children patients, no toxic or side effect, safety and convenience.
The technical scheme adopted by the invention to solve the problems is as follows: a Chinese medicinal composition for treating diarrhea comprises Coptidis rhizoma, fructus Piperis Longi, Camphora, and Plumbum Preparatium.
In the invention, preferably, the traditional Chinese medicine composition comprises 10-20 parts by weight of coptis chinensis, 1100 parts by weight of white pepper 900-.
In the invention, preferably, the traditional Chinese medicine composition comprises 13-17 parts by weight of coptis chinensis, 1050 parts by weight of white pepper 950-.
In the invention, preferably, the traditional Chinese medicine composition comprises 15 parts by weight of coptis chinensis, 1000 parts by weight of white pepper, 100 parts by weight of long pepper, 150 parts by weight of camphor and 15 parts by weight of yellow lead.
In the invention, preferably, the traditional Chinese medicine composition comprises 14 parts by weight of coptis chinensis, 980 parts by weight of white pepper, 110 parts by weight of long pepper, 130 parts by weight of camphor and 16 parts by weight of yellow lead.
In the invention, preferably, the traditional Chinese medicine composition comprises 18 parts of coptis chinensis, 1100 parts of white pepper, 107 parts of long pepper, 165 parts of camphor and 19 parts of yellow lead according to parts by weight.
In the invention, preferably, the traditional Chinese medicine composition further comprises 8-12 parts of purslane by weight.
In the invention, preferably, the traditional Chinese medicine composition further comprises 4-8 parts of radix bupleuri according to parts by weight.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 100-300 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and granulating the mixed powder to obtain the traditional Chinese medicine composition with the particle size of 3-5 mm, thus obtaining the traditional Chinese medicine composition for treating diarrhea.
In the present invention, preferably, the drying manner of the crushed Chinese herbal medicine in the step (2) is freeze drying or vacuum drying.
Huang Lian is cold in nature and bitter in taste. The liver meridian, the gallbladder meridian, and the large intestine meridian; heat-clearing and dampness-drying herbs, fire-purging and toxicity-removing belong to the category of heat-clearing herbs.
White pepper, warm in nature and good at warming the middle-jiao to dispel cold, has good relieving effect on stomach and abdomen psychroalgia and borborygmus diarrhea caused by stomach cold, can promote sweating, and can be added into mutton soup for treating wind-cold type common cold and lung cold with excessive phlegm to warm lung and reduce phlegm. Long Pepper, warming the middle-jiao and descending qi, tonifying waist and feet, killing fishy smell, promoting digestion, and removing stomach cold, scrotal hernia and chest and abdominal pain. It can be used for treating cholera, heart pain, blood and qi, diarrhea due to water retention, dysentery, emesis, sour regurgitation, puerperal dysentery, abdominal pain, emesis, sour water, diarrhea, coronary heart disease, angina pectoris, nervous headache, and toothache due to stomach cold.
Camphor, pungent in flavor, hot in nature and slightly toxic; it enters heart and spleen meridians and is fragrant and strongly ventilating. Inducing resuscitation and refreshing mind, removing filth and benefiting qi, relieving swelling and pain, killing parasites and relieving itching. It is used to treat fever with coma, sudden collapse, summer-heat, dampness, vomiting and diarrhea.
Huangdan, also called Guangdan pill. Pungent, slightly cold and toxic. Enter heart, spleen and liver meridians. External use: removing toxic substance, promoting granulation, killing parasites and relieving itching; oral administration: phlegm-resolving and convulsion-relieving, toxic pathogen-counteracting and malaria-checking.
Compared with the prior art, the invention has the following beneficial effects:
compared with the conventional traditional Chinese medicine composition for treating diarrhea, the traditional Chinese medicine composition for treating diarrhea has the characteristics of short administration period, good curative effect, no side effect and the like when being applied to treating diarrhea diseases. The coptis and the white pepper are used as monarch drugs, the long pepper, the camphor and the yellow lead are used as assistants, and the drugs are combined to complement each other, so that the cost is low and the curative effect is remarkable.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments. It is to be understood that the described embodiments are part of the invention and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the described embodiments of the invention, belong to the scope of protection of the invention.
Example 1:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 10 parts of coptis chinensis, 900 parts of white pepper, 90 parts of long pepper, 130 parts of camphor and 10 parts of yellow lead.
According to the parts by weight, the traditional Chinese medicine composition also comprises 8 parts of purslane.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicinal composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 100 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 3 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying.
Example 2:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 20 parts of coptis chinensis, 1100 parts of white pepper, 110 parts of long pepper, 170 parts of camphor and 20 parts of yellow lead.
The traditional Chinese medicine composition also comprises 8 parts of radix bupleuri according to parts by weight.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 300 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 5 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying.
Example 3:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 13 parts of coptis chinensis, 950 parts of white pepper, 95 parts of long pepper, 140 parts of camphor and 13 parts of yellow lead.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicinal composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 100 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 3 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying.
Example 4:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 17 parts of coptis chinensis, 1050 parts of white pepper, 105 parts of long pepper, 160 parts of camphor and 17 parts of yellow lead.
According to the parts by weight, the traditional Chinese medicine composition also comprises 8 parts of purslane.
The traditional Chinese medicine composition also comprises 4 parts of radix bupleuri according to parts by weight.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 300 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 5 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying.
Example 5:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 15 parts of coptis chinensis, 1000 parts of white pepper, 100 parts of long pepper, 150 parts of camphor and 15 parts of yellow lead.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 200 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder, and obtaining the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 2 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying.
Example 6:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 14 parts of coptis chinensis, 980 parts of white pepper, 110 parts of long pepper, 130 parts of camphor and 16 parts of yellow lead.
The traditional Chinese medicine composition also comprises 4 parts of radix bupleuri according to parts by weight.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 200 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 4 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is vacuum drying.
Example 7:
a traditional Chinese medicine composition for treating diarrhea comprises, by weight, 18 parts of coptis chinensis, 1100 parts of white pepper, 107 parts of long pepper, 165 parts of camphor and 19 parts of yellow lead.
According to the parts by weight, the traditional Chinese medicine composition also comprises 10 parts of purslane.
The traditional Chinese medicine composition also comprises 6 parts of radix bupleuri according to parts by weight.
A preparation method of a traditional Chinese medicine composition for treating diarrhea comprises the following steps:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 200 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and (4) granulating the mixed powder to obtain the traditional Chinese medicine composition for treating the diarrhea, wherein the particle size of the granules is 4 mm.
The drying mode of the crushed Chinese medicinal materials in the step (2) is vacuum drying.
The use method of the traditional Chinese medicine composition provided by the invention comprises the following steps:
the composition powder 1g is applied to the Shenque acupoint (navel) via medical adhesive tape, and the application lasts ten hours once and twice a day.
Clinical demonstration:
in order to verify the effect of the traditional Chinese medicine composition, 90 diarrhea patients are randomly selected in outpatient clinics from 7 months to 11 months in 2017, and the curative effect of the traditional Chinese medicine composition is clinically observed.
The treatment method comprises the following steps:
applied topically.
And (3) evaluating the curative effect:
and finally evaluating the conclusion of healing, effectiveness and ineffectiveness as a distinction, wherein the definitions of healing, effectiveness and ineffectiveness are as follows:
and (3) curing: within 2 days of treatment, the frequency of diarrhea is reduced to be within 3 times, the total amount of diarrhea is less than 150ml, the shape and the frequency of the excrement are recovered to be normal within 3 days, and the general symptoms disappear.
The method has the following advantages: within 2 days after the medicine is taken, the diarrhea frequency is reduced to be within 5 times, the total diarrhea amount is less than 250ml, the shape and the frequency of the excrement are obviously improved within 3 days, and the general symptoms are obviously improved.
And (4) invalidation: within 2 days of administration, the frequency of diarrhea is still more than 5 times, the total amount of diarrhea is more than 300ml, and the shape, frequency and general symptoms of the feces are not obviously improved to worsen within 3 days.
The final treatment results were as follows:
the clinical treatment results of 90 diarrhea patients are that the number of cured patients is 59 and accounts for 65.6 percent of the total number of patients, the number of effective patients is 27 and accounts for 30 percent of the total number of patients, and the number of ineffective patients is 4 and accounts for 4.4 percent of the total number of patients; the total effective cure rate reaches 95.6 percent.
The cure rate can also show that the traditional Chinese medicine composition has high cure rate and obvious treatment effect.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating diarrhea is characterized in that: the Chinese medicinal composition comprises Coptidis rhizoma, fructus Piperis Longi, Camphora, and Plumbum Preparatium.
2. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition comprises, by weight, 10-20 parts of coptis chinensis, 900-1100 parts of white pepper, 90-110 parts of long pepper, 130-170 parts of camphor and 10-20 parts of yellow lead.
3. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition comprises, by weight, 13-17 parts of coptis chinensis, 1050 parts of white pepper 950-.
4. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition comprises 15 parts by weight of coptis chinensis, 1000 parts by weight of white pepper, 100 parts by weight of long pepper, 150 parts by weight of camphor and 15 parts by weight of yellow lead.
5. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition comprises 14 parts by weight of coptis chinensis, 980 parts by weight of white pepper, 110 parts by weight of long pepper, 130 parts by weight of camphor and 16 parts by weight of yellow lead.
6. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition comprises 18 parts by weight of coptis chinensis, 1100 parts by weight of white pepper, 107 parts by weight of long pepper, 165 parts by weight of camphor and 19 parts by weight of yellow lead.
7. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition also comprises 8-12 parts of purslane according to parts by weight.
8. The traditional Chinese medicine composition for treating diarrhea according to claim 1, wherein: the traditional Chinese medicine composition also comprises 4-8 parts of radix bupleuri according to parts by weight.
9. The method for preparing a Chinese medicinal composition for treating diarrhea according to any one of claims 1 to 9, comprising the steps of:
(1) weighing the traditional Chinese medicinal materials for preparing the traditional Chinese medicine composition for treating diarrhea according to a formula, uniformly mixing the traditional Chinese medicinal materials, and crushing the traditional Chinese medicinal materials into 100-300 meshes to obtain mixed powder;
(2) drying the mixed powder to obtain dry mixed powder;
(3) and granulating the mixed powder to obtain the traditional Chinese medicine composition with the particle size of 3-5 mm, thus obtaining the traditional Chinese medicine composition for treating diarrhea.
10. The method for preparing a Chinese medicinal composition for treating diarrhea according to claim 9, wherein: the drying mode of the crushed Chinese medicinal materials in the step (2) is freeze drying or vacuum drying.
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Application publication date: 20191224 |