CN104352779B - Chinese medicine composition containing cordyceps sinensis and preparation method thereof - Google Patents

Chinese medicine composition containing cordyceps sinensis and preparation method thereof Download PDF

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Publication number
CN104352779B
CN104352779B CN201410533592.3A CN201410533592A CN104352779B CN 104352779 B CN104352779 B CN 104352779B CN 201410533592 A CN201410533592 A CN 201410533592A CN 104352779 B CN104352779 B CN 104352779B
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cordyceps sinensis
parts
chinese medicine
safflower
medicine composition
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CN104352779A (en
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尼玛次仁
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TIBET CAILUN TIBETAN MEDICINE Co Ltd
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TIBET CAILUN TIBETAN MEDICINE Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/41Crassulaceae (Stonecrop family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of Chinese medicine composition containing cordyceps sinensis and preparation method thereof, belong to traditional Chinese medicine health care product field.It is mainly prepared from by cordyceps sinensis, safflower, sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root by certain mass proportioning.It can be made into any conventional internal dosage form.Function of the present invention with Yishen Jianpi, nourishing heart tonifying lung, liver protection of invigorating blood circulation, treats all consumptive disease damages, impotence and seminal emission, chest impediment and cardialgia and other effects good.

Description

Chinese medicine composition containing cordyceps sinensis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition containing cordyceps sinensis and preparation method thereof, belong to traditional Chinese medicine health care product field.
Background technology
Cordyceps sinensis also known as Cordyceps sinensis, cordyceps sinensis,《Herbal justice》There is speech:" cordyceps sinensis, first appeared in Wu Shi《Book on Chinese herbal medicine from Newly》, claim its sweet flat, protect lung, kidney-nourishing mends marrow, hemostasis and phlegm, overstrain cough.”《Modern Practical Chinese medicinal》Carry:" it is applied to lung knot The weak chronic cough moral of core, old man is breathed heavily, spitted blood, night sweat, spontaneous perspiration etc.;It is used for anaemia weakness seminal emission again, old man's chilly, tears are more The diseases such as lacrimation." it is the traditional rare traditional Chinese medicine of the traditional Chinese medical science.
Modern pharmacological research shows(Select from《Dictionary of medicinal plant》Second edition P1056-1058), cordyceps sinensis is at least below Effect:1st, there is enhancing or the dual regulation weakened to immunologic function;2nd, antitumaous effect;3rd, cardiac muscle, decompression, the anti-heart are protected Rate is not normal to wait effect;4th, mitigate the pathological change of kidney, promote the reparation of nephridial tissue;5th, there are protective effect, and energy to hepatic injury Prevent and treat liver fibrosis;6th, PFT is improved;7th, there are androgen-like action, controllability dysfunction;8th, liver courage can be suppressed to consolidate Alcohol synthesis, reduction hyperlipidemia mouse serum TC and TG content;9th, anti-aging;10:It is antifatigue;11st, anti-inflammatory;12nd, calm, It is anticonvulsion;It is 13 antibacterials, antiviral;14th, radioresistance etc..It may be said that cordyceps sinensis meets need of the modern to health multi-facetedly Ask, people to cordyceps sinensis to chase after rod also lasting:" cordyceps sinensis " is inputted in Baidu can obtain result 100,000,000 It is individual, and input traditional Chinese medical science common medicine radix glycyrrhizae later and get only correlated results 62,900,000(2014-9-5 16:45PM).
But, related cordyceps sinensis product is generally single in the market, rarely has compound.There is no its work(of effective compatibility Effect can not be played preferably, caused the waste of valuable ingredient of traditional Chinese medicine, also do not reached preferable health-care effect.On August 28th, 2013, Chinese invention patent application CN103263019 A disclose a kind of invigorating qi and refreshing, the composition of strengthen immunity, including following Group composition and content:10~15 grams of 30~40 grams of ginseng, cordyceps sinensis or river in Zhejiang Province cordyceps sinensis, 2~3 grams of lycopene, ganoderma lucidum 10~15 Gram, 10~15 grams of Morinda officinalis, 10~15 grams of the fruit of Chinese wolfberry, the microgram of Organic Selenium 50~70, the microgram of vitamin A 550~650, vitamin The microgram of B125~6,130~140 milligrams of vitamin C, 5~8 grams of remaining auxiliary material.The invention have invigorating qi and refreshing, strengthen immunity, Function in terms of anti-oxidant, anti-aging, alleviation physical fatigue, auxiliary improvement of memory, kidney tonifying.But the invention only using tonifying Qi as It is main, do not reach the purpose of conditioning the five internal organs balance.
The content of the invention
The technical problems to be solved by the invention are to overcome prior art defect to mend there is provided a kind of Yishen Jianpi, nourishing heart Lung, promoting blood circulation liver protection, comprehensive can effectively nurse one's health Chinese medicine composition containing cordyceps sinensis that the five internal organs are balanced and preparation method thereof.
The present invention is combined from cordyceps sinensis, safflower, sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root.Wherein cordyceps sinensis Gan Wen, return lung kidney channel;Tonifying lung solid table, tonifying kidney and benefiting sperm;Cure mainly cough due to deficiency of the lung, phthisical cough phlegm blood, spontaneous sweating, deficiency of the kidney impotence, seminal emission, Soreness of waist and knee joint.Sealwort:Gan Ping, returns spleen lung kidney channel;Yin nourishing and lung moistening, invigorate the spleen and benefit qi, Zishen fill fine.The two is altogether monarch drug in a prescription, is made successively It must mend and all empty must solve.Safflower pungent-warm, thoughts of returning home Liver Channel;Invigorate blood circulation, stasis-dispelling and pain-killing;Cure mainly Amenorrhea, dysmenorrhoea, postpartum stasis abdomen Bitterly, chest impediment and cardialgia, a lump in the abdomen causing distension and pain, traumatic injury, arthralgia, macula.Ganoderma lucidum:Gan Ping, thoughts of returning home spleen and lung warp;QI invigorating is strong, supports Heart and tranquilizing mind;Cure mainly thin and weak consumptive disease, poor appetite, palpitaition, insomnia, dizziness, spiritlessness and weakness, chronic cough asthma, hypertension, coronary heart disease, Silicosis, hyperlipemia, also be used for tumor chemoradiotherapy after it is physically weak.Conic gymnadenia tuber:Gan Ping, return lung taste warp;Benefiting qi and nourishing blood, kidney-nourishing are good for Spleen, promoting blood circulation and stopping pain.Deficiency syndrome of the lung cough and asthma is cured mainly, consumptive disease is become thin, neurasthenia, lassitude in loin and legs, impotence, involuntary emission, frequent micturition, chronic hepatitis, Chronic diarrhea, loses blood, the few traumatic injury of band breast.Ganoderma lucidum, conic gymnadenia tuber help two taste monarchs drug in a prescription with qi-restoratives, and safflower is invigorated blood circulation and hemostasis is dispelled new blood Must be raw, three is ministerial drug altogether.Rhodiola root;It is sweet puckery cold, return lung warp;Clearing lung-heat is stopped blooding, eliminating stasis to subdue swelling;Cure mainly cough with lung heat, spitting of blood, chest Numbness is pained, to the temperature of cordyceps sinensis processed, safflower, is adjuvant.
The consumption of drug component of the present invention is summarized with great concentration by inventor to be drawn, each component consumption is in following mass parts In the range of have good therapeutic effect:
1~3 part of cordyceps sinensis, 1~5 part of safflower, 80~100 parts of sealwort, 60~80 parts of conic gymnadenia tuber, 40~60 parts of ganoderma lucidum, 80~100 parts of rhodiola root.
Preferably:2 parts of cordyceps sinensis, 3 parts of safflower, 90 parts of sealwort, 70 parts of conic gymnadenia tuber, 50 parts of ganoderma lucidum, 90 parts of rhodiola root.
The preferred safflower of safflower in the present invention.
Medicine of the present invention can be prepared into any conventional internal dosage form, such as ball using the conventional method of Chinese medicine preparation Agent, powder, tablet, decoction, capsule, oral liquid, paste, medicinal tea etc., the present invention preferably capsule and tablet.
The preparation method of Chinese medicinal composition capsules agent of the present invention comprises the following steps:
1), weigh each bulk drug cordyceps sinensis, safflower, sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root, it is standby;
2), cordyceps sinensis, safflower individually crushed, cross 200 mesh sieves, it is standby;
3), sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, collecting decoction, filtration, filtrate concentration Relative density 1.05 is surveyed to 80~90 DEG C, is stood, Aspirate supernatant is concentrated into thick paste;
4), by step 2)Gained cordyceps sinensis, saffron powder add step 3)In gained thick paste, mix, particle is made.
5), wherein by step 4)Obtained particle loads capsule, and capsule is made.
The 1 of this preparation method)、2)、3)The adjustment of step sequencing is prepared with not influenceing the formulation.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition tablet, comprise the following steps:
1), weigh each bulk drug cordyceps sinensis, safflower, sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root, it is standby;
2), cordyceps sinensis, safflower individually crushed, cross 200 mesh sieves, it is standby;
3), sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, collecting decoction, filtration, filtrate concentration To relative density 1.05(Surveyed at 80~90 DEG C), stand, Aspirate supernatant is concentrated into thick paste;
4), by step 2)Gained cordyceps sinensis, saffron powder add step 3)In gained thick paste, mix, particle is made.
5), by step 4)Obtained particle adds lubricant, mixes, and tablet is made in tabletting, sugar coating.
The 1 of this preparation method)、2)、3)The sequencing of step is adjustable.
The beneficial effects of the present invention are:
(1)The present composition has Yishen Jianpi, nourishing heart tonifying lung, the function for liver protection of invigorating blood circulation, and treats all consumptive disease damages, impotence Seminal emission, chest impediment and cardialgia and other effects are good.
(2)The present invention is not limited only to more than conditioning all disease, all to be applicable this therapy person through Chinese medical discrimination and can use it, such as tumour After patient's chemicotherapy it is deficient, women's postpartum is deficient etc..
(3)Bulk drug utilization rate of the present invention is high, and composition formed thereby carries, convenient to take.
Embodiment
The clinical observation of the present invention
1st, general information
Out-patient totally 36 is accepted for medical treatment, wherein man 16, female 20.20~30 years old age 5,31~40 years old 10,41 ~50 years old 15, more than 50 years old person 6.Patient 8 wherein after tumor chemoradiotherapy, postpartum deficient patient 3, because of other reasonses body Empty person 25.
2nd, treatment method
2 parts of cordyceps sinensis, 3 parts of safflower, 90 parts of sealwort, 70 parts of conic gymnadenia tuber, 50 parts of ganoderma lucidum, 90 parts of rhodiola root are selected, by implementation 3 Capsule is made, 0.5g/, takes day 3 times, 5 every time, one month is a course for the treatment of, and two courses for the treatment of are used in conjunction.
3rd, efficacy assessment standard
1)It is effective:Subjective symptoms disappears;
2)Take a turn for the better:Subjective symptoms mitigates;
3)It is invalid:Symptom is learnt by oneself without change.
4th, treatment results
Effective person 19, accounts for 53%;Improvement person 13, accounts for 36%;Nonresponder 4, accounts for 11%.Total effective rate is up to 89%.
It is expanded on further the preparation method of medicine of the present invention by the following examples.
The preparation of [embodiment 1] capsule of the present invention
1)Weigh each bulk drug, 1 kilogram of cordyceps sinensis, 1 kilogram of safflower, 80 kilograms of sealwort, 60 kilograms of conic gymnadenia tuber, ganoderma lucidum 40 Kilogram, 80 kilograms of rhodiola root it is standby;
2)1 kilogram of cordyceps sinensis, 1 kilogram of safflower are individually crushed with micronizer respectively, 200 mesh sieves are crossed, it is standby;
3)80 kilograms of 80 kilograms of sealwort, 60 kilograms of conic gymnadenia tuber, 40 kilograms of ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, Collecting decoction, filtration, filtrate is concentrated into relative density 1.05(Surveyed at 80~90 DEG C), stand, Aspirate supernatant is concentrated into thick Cream;
4), by step 2)Gained cordyceps sinensis, saffron powder add step 3)In gained thick paste, mix, particle is made.
5), wherein by step 4)Obtained particle loads capsule, and capsule is made.
The preparation of [embodiment 2] Tablets
1)Weigh each 3 kilograms of bulk drug cordyceps sinensis, 5 kilograms of safflower, sealwort double centner, 80 kilograms of conic gymnadenia tuber, ganoderma lucidum 60 Kilogram, rhodiola root double centner, it is standby;
2)3 kilograms of cordyceps sinensis, 5 kilograms of safflower are individually crushed with micronizer respectively, 200 mesh sieves are crossed, it is standby;
3)By sealwort double centner, 80 kilograms of conic gymnadenia tuber, 60 kilograms of ganoderma lucidum and rhodiola root double centner water boiling and extraction two Secondary, collecting decoction, filtration, filtrate is concentrated into relative density 1.05(Surveyed at 80~90 DEG C), stand, Aspirate supernatant is concentrated into Thick paste;
4)By 2)Gained powder adds 3)In gained thick paste, mix, particle is made.
5)By step 4)Obtained particle adds lubricant, mixes, and tablet is made in tabletting, sugar coating..
The preparation of [embodiment 3] capsule of the present invention
1)Weigh each 2 kilograms of bulk drug cordyceps sinensis, 3 kilograms of safflower, 90 kilograms of sealwort, 70 kilograms of conic gymnadenia tuber, ganoderma lucidum 50 Kilogram, 90 kilograms of rhodiola root, it is standby;
2)2 kilograms of cordyceps sinensis, 3 kilograms of safflower are individually crushed with micronizer respectively, 200 mesh sieves are crossed, it is standby;
3)90 kilograms of 90 kilograms of sealwort, 70 kilograms of conic gymnadenia tuber, 50 kilograms of ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, Collecting decoction, filtration, filtrate is concentrated into relative density 1.05(Surveyed at 80~90 DEG C), stand, Aspirate supernatant is concentrated into thick Cream;
4), by step 2)Gained cordyceps sinensis, saffron powder add step 3)In gained thick paste, mix, particle is made.
5), wherein by step 4)Obtained particle loads capsule, and capsule is made.
The preparation of [embodiment 4] Tablets
1)Weigh each 2 kilograms of bulk drug cordyceps sinensis, 3 kilograms of safflower, 90 kilograms of sealwort, 70 kilograms of conic gymnadenia tuber, ganoderma lucidum 50 Kilogram, 90 kilograms of rhodiola root, it is standby;
2)90 kilograms of 90 kilograms of sealwort, 70 kilograms of conic gymnadenia tuber, 50 kilograms of ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, Collecting decoction, filtration, filtrate is concentrated into relative density 1.05(Surveyed at 80~90 DEG C), stand, Aspirate supernatant is concentrated into thick Cream;
3)2 kilograms of cordyceps sinensis, 3 kilograms of safflower are individually crushed with micronizer respectively, 200 mesh sieves are crossed, it is standby;
4)By 2)Gained powder adds 3)In gained thick paste, mix, particle is made.
5)By step 4)Obtained particle adds lubricant, mixes, and tablet is made in tabletting, sugar coating.

Claims (6)

1. a kind of Chinese medicine composition containing cordyceps sinensis, is made up of the Chinese medicine material of following quality proportionings:1~3 part of cordyceps sinensis, 1~5 part of safflower, 80~100 parts of sealwort, 60~80 parts of conic gymnadenia tuber, 40~60 parts of ganoderma lucidum, 80~100 parts of rhodiola root.
2. the Chinese medicine composition according to claim 1 containing cordyceps sinensis, wherein the quality proportioning of each bulk drug is:Winter worm 2 parts of summer grass, 3 parts of safflower, 90 parts of sealwort, 70 parts of conic gymnadenia tuber, 50 parts of ganoderma lucidum, 90 parts of rhodiola root.
3. the Chinese medicine composition according to claim 1 or 2 containing cordyceps sinensis, it is characterised in that the safflower is safranine Flower.
4. the preparation method of the Chinese medicine composition containing cordyceps sinensis described in claim 1 or 2, it is characterised in that including following step Suddenly:
1) each bulk drug cordyceps sinensis, safflower, sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root, are weighed, it is standby;
2), cordyceps sinensis, safflower are individually crushed, 200 mesh sieves are crossed, it is standby;
3), that sealwort, conic gymnadenia tuber, ganoderma lucidum and rhodiola root is secondary with water boiling and extraction, collecting decoction, filtration, filtrate is concentrated into phase To surveying 1.05 at 80~90 DEG C of density, standing, Aspirate supernatant is concentrated into thick paste;
4), by step 2) gained cordyceps sinensis, saffron powder add step 3) gained thick paste in, mix, particle is made.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that by step 4) made from particle load Capsule, is made capsule.
6. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that by step 4) made from particle add profit Lubrication prescription, is mixed, and tablet is made in tabletting, sugar coating.
CN201410533592.3A 2014-10-11 2014-10-11 Chinese medicine composition containing cordyceps sinensis and preparation method thereof Active CN104352779B (en)

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CN103627610A (en) * 2013-12-10 2014-03-12 尹治华 Compound rhodiola wine and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1480206A (en) * 2002-09-02 2004-03-10 成都浦泓生物科技开发有限公司 Combination of gadol and Chinese caterpillar fungus as well as preparing method
CN1593226A (en) * 2004-06-30 2005-03-16 虞泓 Health food
CN101721615A (en) * 2008-10-30 2010-06-09 周世明 Superfine powdery Chinese herbal medicine solid preparation for treating impotence and premature ejaculation and resisting senility
CN103627610A (en) * 2013-12-10 2014-03-12 尹治华 Compound rhodiola wine and preparation method thereof

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Title
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