CN104306769A - Traditional Chinese medicine composition for treating primary hypotension - Google Patents

Traditional Chinese medicine composition for treating primary hypotension Download PDF

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CN104306769A
CN104306769A CN201410559694.2A CN201410559694A CN104306769A CN 104306769 A CN104306769 A CN 104306769A CN 201410559694 A CN201410559694 A CN 201410559694A CN 104306769 A CN104306769 A CN 104306769A
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chinese medicine
parts
medicine composition
hypotension
powder
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张俊刚
刘金玲
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张俊刚
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Abstract

The invention relates to a traditional Chinese medicine composition for treating primary hypotension. By combining the traditional Chinese herbs such as white-stemmed scorzonera roots, eisenocher powder, tylorrhynchus, ventilago leiocarpa benth, fir, herb of gold stargrass, gorgon fruits, winged yam rhizome, conic gymnadenia tuber, dog bone, Mangnolia coco, mint, vine of multiflower knotweed, rhizoma phragmitis, cabbage mustard, sagina japonica, cinnamon, radix polygonati officinalis, vitamin B12, folic acid, vitamin C, nicotinamide (vitamin PP), bee milk, spirulina tablets, iron folic acid tablet protein powder, ferrous fumarate and the like, the traditional Chinese medicine is not only capable of nourishing the spleen, enhancing the digestion, tonifying the Qi and tonifying the blood, but also capable of improving the metabolic function of the brain tissue, improving the immunity, gradually improving the hypotension, definite in drug effect, remarkable in effect, stable and reliable in curative effect and capable of avoiding side effect.

Description

A kind of Chinese medicine composition for the treatment of essential hypotension
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of essential hypotension.
Background technology
Hypotension is the subnormal general name of systemic arterial pressure.In general measurement method routinely, when recording adult's brachial arterial pressure lower than 90/60mmHg (12.0/0.8kPa), can be described as hypotension.Hypopiesi can be divided into: essential hypotension and secondary hypotension disease.Essential hypotension refers to the hypotension state without obvious cause, as physiological hypotension (constitutional hypotension) and pathologic hypotension (hypopiesi).Secondary hypotension disease refers to that the blood pressure caused by disease of a certain organ of human body or system reduces, and this hypotension can occur rapidly in a short time, so that occurs the sign of collapse and shock, is called acute hypotension.
Essential hypotension mainly contains following performance: (1) is tired, unable; (2) headache, dizziness; (3) pareordia dull pain or discomfort; (4) delayed ischemic neurological deficits; (5) hypocrine phenomenon; (6) other: inappetence, abdominal discomfort, dyspepsia can be shown as, and erythrocyte increases, leukopenia, resistance reduce easily cause the signs such as infection.
Western medical treatment hypertension, if the depressor of overdose can make hypertension become hypotension, because be at stimulation nervus centralis.And in medical be the method for rebuilding one's physical constitution, hypertension can be made to reduce, and---return to normal level, hypotension is raised---returns to normal level.
Essential hypotension is equivalent to the traditional Chinese medical science " dizzy ", " asthenia " demonstrate,proves category, and clinical main manifestations is dizziness headache, fatigue and asthenia, nervous, lazy speech of breathing hard, and hypomnesis, easily catches a cold, aggravation etc. after tired.Young women patient is many with menoxenia, and hypomenorrhea is light red through color.
The traditional Chinese medical science thinks hypopiesi mainly heart deficiency of spleen-YANG, and YANG QI deficiency, caused by blood is weak.Chronic primary hypopiesi because mostly being innate deficiency, deficiency of qi and blood, in addition impairment caused by overstrain and sending out.Heart governing blood and vessels, insufficiency of heart-QI then sering is unfavorable, and run unable, have palpitation as seen, breathe hard, blood pressure is lower, thready pulse without strength; Deficiency of heart-blood, can not go up flourish in brain, then occur the vertigo, insomnia and dreamful sleep, hypomnesis etc.The normal transporting that QI and blood derives from taste is transferred.If dysfunction of the spleen in transportation, raw cloudy blood can not be changed, then affect the biochemistry of QI and blood, occur fatigue and asthenia, inappetence, disharmony of nutrient QI with defensive QI, fear of cold sweating, and then facilitate QI and blood all empty.
The patent for the treatment of essential hypotension in prior art is also few, and medicine used is substantially similar, and curative effect is remarkable not.And the traditional Chinese medical science is of extensive knowledge and profound scholarship, Chinese crude drug is many countless especially, furthers investigate, allot a kind of drug regimen for the treatment of essential hypotension evident in efficacy so necessary to motherland's Chinese medicine.
Summary of the invention
According to above-described problem, the invention provides a kind of Chinese medicine composition for the treatment of essential hypotension.The details of various aspects of the present invention is able to detailed description by chapters and sections subsequently.By hereafter and the description of claim, feature of the present invention, object and advantage will be more obvious.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for essential hypotension, it obtains through following steps with the raw material of Chinese medicine of following parts by weight and adjuvant:
Raw material of Chinese medicine: Radix Scorzonerae Albicaulis 43 ~ 65 parts, Magnetite 10 ~ 20 parts, Tylorrhynchus heterochaeta Quatrefages 15 ~ 25 parts, Radix seu Caulis Verntilaginis Leiocarpae 60 ~ 90 parts, 20 ~ 100 parts, China fir tower, Herba hypoxis aureae 32 ~ 86 parts, Semen Euryales 45 ~ 75 parts, Rhizoma Dioscoreae Alatae 36 ~ 60 parts, Rhizoma Gymnadeniae 28 ~ 50 parts, Os Canitis 9 ~ 15 parts, Flos Magnoliae Cocinis 12 ~ 38 parts, Herba Ziziphorae clinopodioidis 25 ~ 39 parts, Caulis Polygoni Multiflori 36 ~ 74 parts, Rhizoma Phragmitis 38 ~ 70 parts, cabbage mustard 45 ~ 75 parts, rod rod grass 26 ~ 50 parts, 8 ~ 20 parts, Nan Yu osmanthus, Rhizoma Polygonati Odorati 24 ~ 48 parts;
Adjuvant: vitamin B12 0.01 ~ 0.02 part, 0.008 ~ 0.014 part, folic acid, vitamin C 0.05 ~ 0.15 part, nicotiamide 0.03 ~ 0.04 part, spiral algae sheet 0.3 ~ 0.5 part, Lac regis apis 8 ~ 20 parts, protein powder 2 ~ 4 parts;
The property of medicine and effect of described each raw material of Chinese medicine are: Radix Scorzonerae Albicaulis [nature and flavor]: sweet in the mouth, warm in nature.[function cures mainly] expelling wind and removing dampness, vital energy regualting and blood circulation-promoting.Control affection of exogenous wind-cold, fever and headache, year of a specified duration asthma, rheumatic arthralgia, women's vicarious menstruation, traumatic injury, furuncle.Magnetite [nature and flavor] is salty; Flat; Nontoxic.[return through] heart; Liver; Kidney channel.[function cures mainly] nourishing blood to tranquillize the mind; Checking hyperfunction of the liver for relieving convulsion; Removing toxic substances and promoting subsidence of swelling.Main blood deficiency and yellow complexion; Palpitation with fear; Demented; Forgetful; Proctoptosis; Anal fistula.Tylorrhynchus heterochaeta Quatrefages [nature and flavor] sweet in the mouth; Warm in nature.[return through] spleen; Stomach warp.[function cures mainly] tonifying the spleen and stomach; Replenishing QI and blood; Inducing diuresis to remove edema.Main weakness of the spleen and stomach; Have loose bowels; Anemia; Edema.Radix seu Caulis Verntilaginis Leiocarpae [nature and flavor] is sweet; Temperature.[return through] lung; Spleen channel.[function cures mainly] fills blood; Bone and muscle strengthening; Relax meridians.Main deficient qi and blood; Have through uncomfortable; Blood deficiency amenorrhea; Rheumatalgia; Traumatic injury; Lumbar muscle strain.Shan Ta [nature and flavor] is pungent; Slightly warm in nature.[function cures mainly] warming the kidney to invigorate YANG; Parasite killing detoxifies; Mind calming; Cough-relieving.Main seminal emission; Sexual impotence; Vitiligo; Acute mastitis; Cardiopalmus; Cough.Herba hypoxis aureae [nature and flavor] is sweet, micro-pungent, warm.[function cures mainly] warming the kidney to invigorate YANG; Regulating QI to relieve pain.Main lumbago due to renal deficiency; Sexual impotence; Insomnia; Colic of cold type is suffered from abdominal pain.Semen Euryales [nature and flavor] is sweet, puckery, flat.[return through] returns spleen, kidney channel.[function cures mainly] supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.Rhizoma Dioscoreae Alatae [nature and flavor] is sweet; Micro-puckery; Flat.[return through] spleen; Lung; Kidney channel.[function cures mainly] spleen reinforcing lung, arresting seminal emission gas, detumescence, pain relieving.Invigorating the spleen to arrest diarrhea; Lung benefiting nourishing kidney; Removing toxic substances sore.Rhizoma Gymnadeniae [nature and flavor] is sweet; Flat.[return through] lung; Spleen; Stomach warp.[function cures mainly] relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.Os Canitis [nature and flavor] is pungent, salty, temperature.[return through] spleen; Liver; Kidney channel.[function cures mainly] main tonify deficiency, spleen invigorating and network, blood activating and promoting tissue regeneration.Dispelling the wind and dampness pathogens pain, waist skelasthenia, numb limbs and tense tendons, chronic dysentery, skin ulcer fistula, chilblain.Sleep not good enough: Flos Magnoliae Cocinis [nature and flavor] is pungent; Warm in nature.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.[function cures mainly] circulation of qi promoting blood stasis dispelling, insomnia.Herba Ziziphorae clinopodioidis [function cures mainly] " Chinese Herbal Medicine in Xinjiang handbook ": " control insomnia, nervous, osteomalacia, sexual impotence." Caulis Polygoni Multiflori [nature and flavor] is sweet, flat.[return through] GUIXIN, Liver Channel.[function cures mainly] nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; External treatment skin pruritus.Rhizoma Phragmitis [nature and flavor] is sweet; Cold.[return through] lung; Stomach; Bladder.[function cures mainly] clearing away heat and promoting production of body fluid; Relieve restlessness and prevent vomiting; Dryness of the tongue and Tianjin few.Cabbage mustard [nature and flavor] sweet in the mouth; Pungent; Cool in nature; [return through] lung meridian.[function cures mainly] sore-throat relieving; Pleasant.Rod rod grass [nature and flavor] is sweet; Bitter; Tepor.[function cures mainly] tonifying the lung; Spleen invigorating; YIN nourishing and the production of body fluid promoting.Main cough due to deficiency of the lung; Insufficiency of the spleen lack of appetite; Cardiopalmus spontaneous perspiration; Tired out weak; Xerostomia.Nan Yugui [nature and flavor] is pungent, sweet, hot greatly.[return through] returns kidney, spleen, the heart, Liver Channel.It is supporing yang that [function cures mainly] mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency.Rhizoma Polygonati Odorati [nature and flavor] is sweet, is slightly cold.[return through] attaches to the lung and stomach meridians.[pharmacological action] is on the impact of blood pressure: blood pressure can be made slowly to increase.
Step one: Magnetite, Os Canitis, Nan Yugui ball milling refiner superfine powder is for subsequent use after being broken into fine powder;
Step 2: by Tylorrhynchus heterochaeta Quatrefages, Radix seu Caulis Verntilaginis Leiocarpae, Shan Ta, Herba hypoxis aureae, Semen Euryales, Rhizoma Dioscoreae Alatae, Flos Magnoliae Cocinis, Herba Ziziphorae clinopodioidis, Caulis Polygoni Multiflori, Rhizoma Phragmitis, cabbage mustard, excellent grass is pulverized respectively, mix homogeneously, obtain Chinese medicine powder, Chinese medicine powder is loaded gauze pocket, be tamping opening, put into boiler, add the pure water of Chinese medicine powder 8 ~ 10 times of weight, 20min is extracted with continuing to decoct after the high-temperature heatings of 150 ~ 170 DEG C to boiling, again according to the cooling rate of 20 DEG C/min, cool the temperature to 100 ~ 120 DEG C, continue to decoct and extract 30min, obtain a traditional Chinese medicine liquid and Chinese medicine granulated slag, Chinese medicine granulated slag adds the pure water of 3 ~ 7 times of weight again, carry out second time to extract, extraction time is 20 ~ 30min, obtain secondary traditional Chinese medicine liquid, merge twice traditional Chinese medicine liquid, cooling, slowly ethanol is added according to 1:1 Capacity Ratio, limit edged at the uniform velocity stirs, Keep agitation 10 ~ 20 minutes, gained mixed liquor is left standstill 2 ~ 4 hours, abundant precipitation to be precipitated, remove a small amount of impurity of bottom, obtain pure filtrate, stand-by together with Chinese medicine granulated slag,
Step 3: Radix Scorzonerae Albicaulis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati are pulverized, mixing, is placed in medicinal cupping, adds and soak 48 ~ 60h at normal temperatures relative to the ethanol of mixture 5 ~ 8 times amount, filters, by the homogenate of gained filtrate, centrifugal, obtains centrifugal liquid and centrifugal slag, stand-by;
Step 4: the Chinese medicine granulated slag of step 2 is mixed with the centrifugal slag of step 3, be placed in vacuum drier, be dry under the condition of 0.5MPa in vacuum, then be placed in pulverizer and be crushed to 200 orders, the fine powder obtained with step one mixes, add protein powder according to weight again, stir, obtain Chinese medicine mixed powder; The immunity of described protein powder energy enhancing body, the hemopoietic function of enhancing body, recovers the elasticity of blood vessel wall;
Step 5: the filtrate of step 2 mixed with the centrifugal liquid of step 3, adds vitamin B12, folic acid, vitamin C, nicotiamide, spiral algae sheet according to described weight, stirring to dissolving completely, obtaining admixing medical solutions, be concentrated into 10 ~ 60%; Folic acid and vitamin B12 manufacture the necessary nutrient of blood; Vitamin C can promote absorption and the utilization of irony in body, promotes that folic acid utilizes; Spirulina contains very abundant irony and chlorophyll, to adjustment blood pressure Be very effective;
Step 6: semi-finished product step 4 and step 5 obtained, after mixing, add Lac regis apis according to certain ratio, traditionally the processing technology preparation of medicament, obtains the Chinese medicine composition for the treatment of essential hypotension of the present invention.Described Lac regis apis can two-ways regulation blood pressure, enhancing immunity, life lengthening.
Further, in described step 2, its determining alcohol of ethanol used is 75%, can remove the impurity in extracting solution with ethanol.
Further, in described step 3, its alcoholic strength of ethanol used is 40 ~ 62%, and ethanol soak at room temperature by the extracts active ingredients in medical material out, and can ensure that effective ingredient is not destroyed.
Further, in described step 6, mixed proportion is 1 ~ 5: 1 ~ 5, and the size of this ratio can regulate by the preparation type prepared by the later stage.
Further, the preparation of described Chinese medicine composition is tablet, oral liquid.
Wherein, described tablet, its preparation method is:
In step 5, gained admixing medical solutions is concentrated into 10 ~ 25%, in step 6, by the semi-finished product that step 4 and step 5 obtain, after ratio according to 3 ~ 4: 1 mixes, add Lac regis apis, and traditionally prepared by the processing technology of tablet, add pregelatinized Starch 12-15 part, maltodextrin 2-4 part, granulate, tabletting, namely obtains the tablet of the Chinese medicine composition for the treatment of essential hypotension of the present invention.
Wherein, described oral liquid, its preparation method is:
In step 5, gained admixing medical solutions is concentrated into 25 ~ 60%, in step 6, by the semi-finished product that step 4 and step 5 obtain, after ratio according to 1: 3 ~ 5 mixes, add Lac regis apis, and traditionally prepared by the processing technology of oral liquid, adds 5-8 part sucrose, 0.012-0.02 part potassium sorbate, tinning, obtains the oral liquid of the Chinese medicine composition for the treatment of essential hypotension of the present invention.Described sucrose can improve the taste of oral liquid, and described potassium sorbate can play antisepsis.
Usage and consumption: tablet: 2-4g/ time, three times/day; Oral liquid: 5-10ml/ time, three times/day; Three take after the meal.
To take medicine points for attention: note striking a proper balance between work and rest, strengthen physical training, health invigorating, eat fresh vegetables, fruit, every morning and noon drink a little coffee, cocoa or strong tea, and period in a medicine is drunk less, quit smoking, and avoid strenuous exercise as far as possible more.
The invention has the beneficial effects as follows: the Chinese medicine composition for the treatment of essential hypotension of the present invention activates yang primarily of temperature compensation, mend spleen health movement, strengthen digest and assimilate, the Chinese herbal medicine composition of supplementing QI and nourishing YIN and blood vessels, be aided with the adjuvant containing essential nutrients again, to help improve brain tissue metabolism function, enhancing body improves immunity, improve hypostension gradually, drug effect is clear and definite, Be very effective, stable curative effect is reliable, without any side effect.
Detailed description of the invention
Below, be described in detail in conjunction with the details of detailed description of the invention to each side of the present invention, to embody feature of the present invention, object and advantage better.
Embodiment 1:
Treat a Chinese medicine composition for essential hypotension, it obtains through following steps with the raw material of Chinese medicine of following parts by weight and adjuvant:
Raw material of Chinese medicine: Radix Scorzonerae Albicaulis 43 parts, Magnetite 10 parts, Tylorrhynchus heterochaeta Quatrefages 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 60 parts, 20 parts, China fir tower, Herba hypoxis aureae 32 parts, Semen Euryales 45 parts, Rhizoma Dioscoreae Alatae 36 parts, Rhizoma Gymnadeniae 28 parts, Os Canitis 9 parts, Flos Magnoliae Cocinis 12 parts, Herba Ziziphorae clinopodioidis 25 parts, Caulis Polygoni Multiflori 36 parts, Rhizoma Phragmitis 38 parts, cabbage mustard 45 parts, rod rod grass 26 parts, 8 parts, Nan Yu osmanthus, Rhizoma Polygonati Odorati 24 parts;
Adjuvant: vitamin B12 0.01 part, 0.008 part, folic acid, vitamin C 0.05 part, nicotiamide 0.03 part, spiral algae sheet 0.3, Lac regis apis 8 parts, protein powder 2 parts;
Step one: Magnetite, Os Canitis, Nan Yugui ball milling refiner superfine powder is for subsequent use after being broken into fine powder;
Step 2: by Tylorrhynchus heterochaeta Quatrefages, Radix seu Caulis Verntilaginis Leiocarpae, Shan Ta, Herba hypoxis aureae, Semen Euryales, Rhizoma Dioscoreae Alatae, Flos Magnoliae Cocinis, Herba Ziziphorae clinopodioidis, Caulis Polygoni Multiflori, Rhizoma Phragmitis, cabbage mustard, excellent grass is pulverized respectively, mix homogeneously, obtain Chinese medicine powder, Chinese medicine powder is loaded gauze pocket, be tamping opening, put into boiler, add the pure water of Chinese medicine powder 8 times of weight, 20min is extracted with continuing to decoct after the high-temperature heatings of 150 DEG C to boiling, again according to the cooling rate of 20 DEG C/min, cool the temperature to 100 DEG C, continue to decoct and extract 30min, obtain a traditional Chinese medicine liquid and Chinese medicine granulated slag, Chinese medicine granulated slag adds the pure water of 3 times of weight again, carry out second time to extract, extraction time is 20min, obtain secondary traditional Chinese medicine liquid, merge twice traditional Chinese medicine liquid, cooling, the ethanol that determining alcohol is 75% is slowly added according to 1:1 Capacity Ratio, the impurity in extracting solution can be removed with ethanol, limit edged at the uniform velocity stirs, Keep agitation 10 minutes, gained mixed liquor is left standstill 2 hours, abundant precipitation to be precipitated, remove a small amount of impurity of bottom, obtain pure filtrate, stand-by together with Chinese medicine granulated slag,
Step 3: Radix Scorzonerae Albicaulis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati are pulverized, mixing, be placed in medicinal cupping, the ethanol that to add relative to the alcoholic strength of mixture 5 times amount be 40% soaks 48h at normal temperatures, and ethanol soak at room temperature can by the extracts active ingredients in medical material out, and ensure that effective ingredient is not destroyed, filter, by the homogenate of gained filtrate, centrifugal, obtain centrifugal liquid and centrifugal slag, stand-by;
Step 4: the Chinese medicine granulated slag of step 2 is mixed with the centrifugal slag of step 3, be placed in vacuum drier, be dry under the condition of 0.5MPa in vacuum, then be placed in pulverizer and be crushed to 200 orders, the fine powder obtained with step one mixes, add protein powder according to weight again, stir, obtain Chinese medicine mixed powder; The immunity of described protein powder energy enhancing body, the hemopoietic function of enhancing body, recovers the elasticity of blood vessel wall;
Step 5: the filtrate of step 2 mixed with the centrifugal liquid of step 3, adds vitamin B12, folic acid, vitamin C, nicotiamide, spiral algae sheet according to described weight, stirring to dissolving completely, obtaining admixing medical solutions, be concentrated into 10%; Folic acid and vitamin B12 manufacture the necessary nutrient of blood; Vitamin C can promote absorption and the utilization of irony in body, promotes that folic acid utilizes; Spirulina contains very abundant irony and chlorophyll, to adjustment blood pressure Be very effective;
Step 6: the semi-finished product that step 4 and step 5 are obtained, after ratio according to 3: 1 mixes, add Lac regis apis, described Lac regis apis can two-ways regulation blood pressure, enhancing immunity, life lengthening, and traditionally prepared by the processing technology of tablet, adds pregelatinized Starch 12 parts, maltodextrin 2 parts, granulates, tabletting, namely obtains the tablet of the Chinese medicine composition for the treatment of essential hypotension of the present invention.
Usage and consumption: 4g/ time, three times/day, three take after the meal.
To take medicine points for attention: note striking a proper balance between work and rest, strengthen physical training, health invigorating, eat fresh vegetables, fruit, every morning and noon drink a little coffee, cocoa or strong tea, and period in a medicine is drunk less, quit smoking, and avoid strenuous exercise as far as possible more.
Embodiment 2: a kind of Chinese medicine composition for the treatment of essential hypotension, it obtains through following steps with the raw material of Chinese medicine of following parts by weight and adjuvant:
Raw material of Chinese medicine: Radix Scorzonerae Albicaulis 54 parts, Magnetite 15 parts, Tylorrhynchus heterochaeta Quatrefages 20 parts, Radix seu Caulis Verntilaginis Leiocarpae 75 parts, 60 parts, China fir tower, Herba hypoxis aureae 59 parts, Semen Euryales 60 parts, Rhizoma Dioscoreae Alatae 48 parts, Rhizoma Gymnadeniae 39 parts, Os Canitis 12 parts, Flos Magnoliae Cocinis 25 parts, Herba Ziziphorae clinopodioidis 32 parts, Caulis Polygoni Multiflori 55 parts, Rhizoma Phragmitis 54 parts, cabbage mustard 60 parts, rod rod grass 38 parts, 14 parts, Nan Yu osmanthus, Rhizoma Polygonati Odorati 36 parts;
Adjuvant: vitamin B12 0.015 part, 0.011 part, folic acid, vitamin C 0.10 part, nicotiamide 0.035 part, spiral algae sheet 0.4 part, Lac regis apis 14 parts, protein powder 3 parts;
Step one: Magnetite, Os Canitis, Nan Yugui ball milling refiner superfine powder is for subsequent use after being broken into fine powder;
Step 2: by Tylorrhynchus heterochaeta Quatrefages, Radix seu Caulis Verntilaginis Leiocarpae, Shan Ta, Herba hypoxis aureae, Semen Euryales, Rhizoma Dioscoreae Alatae, Flos Magnoliae Cocinis, Herba Ziziphorae clinopodioidis, Caulis Polygoni Multiflori, Rhizoma Phragmitis, cabbage mustard, excellent grass is pulverized respectively, mix homogeneously, obtain Chinese medicine powder, Chinese medicine powder is loaded gauze pocket, be tamping opening, put into boiler, add the pure water of Chinese medicine powder 9 times of weight, 20min is extracted with continuing to decoct after the high-temperature heatings of 160 DEG C to boiling, again according to the cooling rate of 20 DEG C/min, cool the temperature to 110 DEG C, continue to decoct and extract 30min, obtain a traditional Chinese medicine liquid and Chinese medicine granulated slag, Chinese medicine granulated slag adds the pure water of 5 times of weight again, carry out second time to extract, extraction time is 25min, obtain secondary traditional Chinese medicine liquid, merge twice traditional Chinese medicine liquid, cooling, the ethanol that determining alcohol is 75% is slowly added according to 1:1 Capacity Ratio, the impurity in extracting solution can be removed with ethanol, limit edged at the uniform velocity stirs, Keep agitation 15 minutes, gained mixed liquor is left standstill 3 hours, abundant precipitation to be precipitated, remove a small amount of impurity of bottom, obtain pure filtrate, stand-by together with Chinese medicine granulated slag,
Step 3: Radix Scorzonerae Albicaulis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati are pulverized, mixing, be placed in medicinal cupping, the ethanol that to add relative to the alcoholic strength of mixture 6.5 times amount be 51% soaks 54h at normal temperatures, and ethanol soak at room temperature can by the extracts active ingredients in medical material out, and ensure that effective ingredient is not destroyed, filter, by the homogenate of gained filtrate, centrifugal, obtain centrifugal liquid and centrifugal slag, stand-by;
Step 4: the Chinese medicine granulated slag of step 2 is mixed with the centrifugal slag of step 3, be placed in vacuum drier, be dry under the condition of 0.5MPa in vacuum, then be placed in pulverizer and be crushed to 200 orders, the fine powder obtained with step one mixes, add protein powder according to weight again, stir, obtain Chinese medicine mixed powder; The immunity of described protein powder energy enhancing body, the hemopoietic function of enhancing body, recovers the elasticity of blood vessel wall;
Step 5: the filtrate of step 2 mixed with the centrifugal liquid of step 3, adds vitamin B12, folic acid, vitamin C, nicotiamide, spiral algae sheet according to described weight, stirring to dissolving completely, obtaining admixing medical solutions, be concentrated into 25%; Folic acid and vitamin B12 manufacture the necessary nutrient of blood; Vitamin C can promote absorption and the utilization of irony in body, promotes that folic acid utilizes; Spirulina contains very abundant irony and chlorophyll, to adjustment blood pressure Be very effective;
Step 6: the semi-finished product that step 4 and step 5 are obtained, after mixing according to the ratio according to 4: 1, add Lac regis apis, described Lac regis apis can two-ways regulation blood pressure, enhancing immunity, life lengthening, and traditionally prepared by the processing technology of tablet, adds pregelatinized Starch 15 parts, maltodextrin 4 parts, granulates, tabletting, namely obtains the tablet of the Chinese medicine composition for the treatment of essential hypotension of the present invention.
Usage and consumption: tablet: 2g/ time, three times/day, three take after the meal.
To take medicine points for attention: note striking a proper balance between work and rest, strengthen physical training, health invigorating, eat fresh vegetables, fruit, every morning and noon drink a little coffee, cocoa or strong tea, and period in a medicine is drunk less, quit smoking, and avoid strenuous exercise as far as possible more.
Embodiment 3:
Treat a Chinese medicine composition for essential hypotension, it obtains through following steps with the raw material of Chinese medicine of following parts by weight and adjuvant:
Raw material of Chinese medicine: Radix Scorzonerae Albicaulis 65 parts, Magnetite 20 parts, Tylorrhynchus heterochaeta Quatrefages 25 parts, Radix seu Caulis Verntilaginis Leiocarpae 90 parts, 100 parts, China fir tower, Herba hypoxis aureae 86 parts, Semen Euryales 75 parts, Rhizoma Dioscoreae Alatae 60 parts, Rhizoma Gymnadeniae 50 parts, Os Canitis 15 parts, Flos Magnoliae Cocinis 38 parts, Herba Ziziphorae clinopodioidis 39 parts, Caulis Polygoni Multiflori 74 parts, Rhizoma Phragmitis 70 parts, cabbage mustard 75 parts, rod rod grass 50 parts, 20 parts, Nan Yu osmanthus, Rhizoma Polygonati Odorati 48 parts;
Adjuvant: vitamin B12 0.02 part, folic acid .014 part, vitamin C 0.15 part, nicotiamide 0.04 part, spiral algae sheet 0.5 part, Lac regis apis 20 parts, protein powder 4 parts;
Step one: Magnetite, Os Canitis, Nan Yugui ball milling refiner superfine powder is for subsequent use after being broken into fine powder;
Step 2: by Tylorrhynchus heterochaeta Quatrefages, Radix seu Caulis Verntilaginis Leiocarpae, Shan Ta, Herba hypoxis aureae, Semen Euryales, Rhizoma Dioscoreae Alatae, Flos Magnoliae Cocinis, Herba Ziziphorae clinopodioidis, Caulis Polygoni Multiflori, Rhizoma Phragmitis, cabbage mustard, excellent grass is pulverized respectively, mix homogeneously, obtain Chinese medicine powder, Chinese medicine powder is loaded gauze pocket, be tamping opening, put into boiler, add the pure water of Chinese medicine powder 10 times of weight, 20min is extracted with continuing to decoct after the high-temperature heatings of 170 DEG C to boiling, again according to the cooling rate of 20 DEG C/min, cool the temperature to 120 DEG C, continue to decoct and extract 30min, obtain a traditional Chinese medicine liquid and Chinese medicine granulated slag, Chinese medicine granulated slag adds the pure water of 7 times of weight again, carry out second time to extract, extraction time is 30min, obtain secondary traditional Chinese medicine liquid, merge twice traditional Chinese medicine liquid, cooling, the ethanol that determining alcohol is 75% is slowly added according to 1:1 Capacity Ratio, the impurity in extracting solution can be removed with ethanol, limit edged at the uniform velocity stirs, Keep agitation 20 minutes, gained mixed liquor is left standstill 4 hours, abundant precipitation to be precipitated, remove a small amount of impurity of bottom, obtain pure filtrate, stand-by together with Chinese medicine granulated slag,
Step 3: Radix Scorzonerae Albicaulis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati are pulverized, mixing, be placed in medicinal cupping, the ethanol that to add relative to the alcoholic strength of mixture 8 times amount be 62% soaks 60h at normal temperatures, and ethanol soak at room temperature can by the extracts active ingredients in medical material out, and ensure that effective ingredient is not destroyed, filter, by the homogenate of gained filtrate, centrifugal, obtain centrifugal liquid and centrifugal slag, stand-by;
Step 4: the Chinese medicine granulated slag of step 2 is mixed with the centrifugal slag of step 3, be placed in vacuum drier, be dry under the condition of 0.5MPa in vacuum, then be placed in pulverizer and be crushed to 200 orders, the fine powder obtained with step one mixes, add protein powder according to weight again, stir, obtain Chinese medicine mixed powder; The immunity of described protein powder energy enhancing body, the hemopoietic function of enhancing body, recovers the elasticity of blood vessel wall;
Step 5: the filtrate of step 2 mixed with the centrifugal liquid of step 3, adds vitamin B12, folic acid, vitamin C, nicotiamide, spiral algae sheet according to described weight, stirring to dissolving completely, obtaining admixing medical solutions, be concentrated into 60%; Folic acid and vitamin B12 manufacture the necessary nutrient of blood; Vitamin C can promote absorption and the utilization of irony in body, promotes that folic acid utilizes; Spirulina contains very abundant irony and chlorophyll, to adjustment blood pressure Be very effective;
Step 6: the semi-finished product that step 4 and step 5 are obtained, according to 1: after the ratio of (3 ~ 5) mixes, add Lac regis apis, described Lac regis apis can two-ways regulation blood pressure, enhancing immunity, life lengthening, and traditionally prepared by the processing technology of oral liquid, add 5-8 part sucrose, 0.012-0.02 part potassium sorbate, tinning, obtain the oral liquid of the Chinese medicine composition for the treatment of essential hypotension of the present invention.Described sucrose can improve the taste of oral liquid, and described potassium sorbate can play antisepsis.
Usage and consumption: 5ml/ time, three times/day, three take after the meal.
To take medicine points for attention: note striking a proper balance between work and rest, strengthen physical training, health invigorating, eat fresh vegetables, fruit, every morning and noon drink a little coffee, cocoa or strong tea, and period in a medicine is drunk less, quit smoking, and avoid strenuous exercise as far as possible more.
Clinical verification
(1) object choice:
Choose in April, 2012 ~ 2013 clinical essential hypotension patient 180 example of seeing and treating patients in year April, age distribution, at 30 ~ 70 years old, is divided into 5 groups at random, often organizes each 36 people, is experimental group one, experimental group two, experimental group three, matched group one, matched group two respectively.
Wherein, the choice criteria of above-mentioned case is: 1. continuous measurement 3d brachial arterial pressure is lower than 90/60mmHg (12/8kPa); 2. clinically there is chest pain, abnormal food appetite, dizzy, headache, pale complexion, shortness of breath and palpitation, lassitude, depressed, the symptom such as aversion to cold and cold limbs, abdominal distention after meal; 3. check without organ diseases such as liver, spleen, lung, kidneys, meet above-mentioned 3 conditions, can essential hypotension be diagnosed as.
(2) Therapeutic Method:
Experimental group one, experimental group two, experimental group three take the medicine of the embodiment of the present invention 1, embodiment 2, embodiment 3 preparation respectively, and usage to specifications and consumption carry out oral, are used in conjunction 5 weeks; Matched group one takes common pressor agent, and usage to specifications and consumption carry out oral, are used in conjunction 5 weeks, and matched group two does not temporarily take any medicine.Regular weekly all patients to be checked, observe the symptoms, blood pressure, heart rate and hemodynamic change.Every example all in treatment start and at the end of, carry out Doppler echocardiography inspection, measure heart output (CO), cardiac index (CL), the hematodinamics index such as ejection fraction (EF).
(3) efficacy assessment standard:
Effective: clinical symptom disappearance after treatment, blood pressure recovers normal substantially, blood pressure > 100/70mmHg; Effective: clinical symptom relief or disappearance after treatment, blood pressure makes moderate progress than before treatment, but does not recover normal, blood pressure > 90/60mmHg; Invalid: clinical symptoms without improvement, blood pressure < 90/60mmHg.
(4) data statistics is treated: in table 1
Table 1-each group efficacy result statistics
(5) results and analysis:
The result of being added up from table 1, medicine prepared by the embodiment of the present invention 1,2,3 is along with the prolongation of medicine time, effective percentage is more and more higher, total effective rate after five weeks is respectively 94.4%, 91.7%, 100%, and matched group a dose of medicine two weeks effective percentage just reach 44.4%, but along with the prolongation of medicine time, its effective percentage starts to rise to some extent, but but started afterwards to decline, as can be seen here, its curative effect is not as drug substance stable of the present invention, and final effective percentage is also significantly less than the effective percentage of medicine of the present invention.
(6) conclusion:
According to the data of table 1 and above-mentioned analysis visible, medicine prepared by the present invention is in treatment essential hypotension, and therapeutic effect and stability are all better than matched group, is very applicable to clinical application.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (7)

1. treat a Chinese medicine composition for essential hypotension, it is characterized in that, it obtains through following steps with the raw material of Chinese medicine of following parts by weight and adjuvant:
Raw material of Chinese medicine: Radix Scorzonerae Albicaulis 43 ~ 65 parts, Magnetite 10 ~ 20 parts, Tylorrhynchus heterochaeta Quatrefages 15 ~ 25 parts, Radix seu Caulis Verntilaginis Leiocarpae 60 ~ 90 parts, 20 ~ 100 parts, China fir tower, Herba hypoxis aureae 32 ~ 86 parts, Semen Euryales 45 ~ 75 parts, Rhizoma Dioscoreae Alatae 36 ~ 60 parts, Rhizoma Gymnadeniae 28 ~ 50 parts, Os Canitis 9 ~ 15 parts, Flos Magnoliae Cocinis 12 ~ 38 parts, Herba Ziziphorae clinopodioidis 25 ~ 39 parts, Caulis Polygoni Multiflori 36 ~ 74 parts, Rhizoma Phragmitis 38 ~ 70 parts, cabbage mustard 45 ~ 75 parts, rod rod grass 26 ~ 50 parts, 8 ~ 20 parts, Nan Yu osmanthus, Rhizoma Polygonati Odorati 24 ~ 48 parts;
Adjuvant: vitamin B12 0.01 ~ 0.02 part, 0.008 ~ 0.014 part, folic acid, vitamin C 0.05 ~ 0.15 part, nicotiamide 0.03 ~ 0.04 part, spiral algae sheet 0.3 ~ 0.5 part, Lac regis apis 8 ~ 20 parts, protein powder 2 ~ 4 parts;
Step one: Magnetite, Os Canitis, Nan Yu osmanthus superfine powder is for subsequent use after being broken into fine powder;
Step 2: by Tylorrhynchus heterochaeta Quatrefages, Radix seu Caulis Verntilaginis Leiocarpae, Shan Ta, Herba hypoxis aureae, Semen Euryales, Rhizoma Dioscoreae Alatae, Flos Magnoliae Cocinis, Herba Ziziphorae clinopodioidis, Caulis Polygoni Multiflori, Rhizoma Phragmitis, cabbage mustard, excellent grass is pulverized respectively, mix homogeneously, obtain Chinese medicine powder, Chinese medicine powder is loaded gauze pocket, be tamping opening, put into boiler, add the pure water of Chinese medicine powder 8 ~ 10 times of weight, , 20min is extracted with continuing to decoct after the high-temperature heatings of 150 ~ 170 DEG C to boiling, again according to the cooling rate of 20 DEG C/min, cool the temperature to 100 ~ 120 DEG C, continue to decoct and extract 30min, obtain a traditional Chinese medicine liquid and Chinese medicine granulated slag, Chinese medicine granulated slag adds the pure water of 3 ~ 7 times of weight again, carry out second time to extract, obtain secondary traditional Chinese medicine liquid, merge twice traditional Chinese medicine liquid, cooling, slowly ethanol is added according to 1:1 Capacity Ratio, limit edged at the uniform velocity stirs, gained mixed liquor is left standstill 2 ~ 4 hours, abundant precipitation to be precipitated, remove a small amount of impurity of bottom, obtain pure filtrate, stand-by together with Chinese medicine granulated slag,
Step 3: Radix Scorzonerae Albicaulis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati are pulverized, mixing, adds and soak 48 ~ 60h at normal temperatures relative to the ethanol of mixture 5 ~ 8 times amount, filters, by the homogenate of gained filtrate, centrifugal, obtains centrifugal liquid and centrifugal slag, stand-by;
Step 4: the Chinese medicine granulated slag of step 2 is mixed with the centrifugal slag of step 3, is placed in vacuum drier, dry, then be placed in pulverizer and be crushed to 200 orders, the fine powder obtained with step one mixes, then adds protein powder according to weight, stir, obtain Chinese medicine mixed powder;
Step 5: the filtrate of step 2 mixed with the centrifugal liquid of step 3, adds vitamin B12, folic acid, vitamin C, nicotiamide, spiral algae sheet according to described weight, stirring to dissolving completely, obtaining admixing medical solutions, be concentrated into 10 ~ 60%;
Step 6: semi-finished product step 4 and step 5 obtained, after mixing, add Lac regis apis according to certain ratio, traditionally the processing technology preparation of medicament, obtains the Chinese medicine composition for the treatment of essential hypotension of the present invention.
2. the Chinese medicine composition for the treatment of essential hypotension as claimed in claim 1, it is characterized in that, in described step 2, its determining alcohol of ethanol used is 75%.
3. the Chinese medicine composition for the treatment of essential hypotension as claimed in claim 1, it is characterized in that, in described step 3, its alcoholic strength of ethanol used is 40 ~ 62%.
4. the Chinese medicine composition for the treatment of essential hypotension as claimed in claim 1, it is characterized in that, in described step 6, mixed proportion is 1 ~ 5: 1 ~ 5.
5. the Chinese medicine composition of the treatment essential hypotension as described in Claims 1 to 4, is characterized in that, the preparation of described Chinese medicine composition is tablet, oral liquid.
6. the Chinese medicine composition for the treatment of essential hypotension as claimed in claim 5, it is characterized in that, described tablet, its preparation method is:
In step 5, gained admixing medical solutions is concentrated into 10 ~ 25%, in step 6, by the semi-finished product that step 4 and step 5 obtain, after ratio according to 3 ~ 4: 1 mixes, add Lac regis apis, and traditionally prepared by the processing technology of tablet, compacting, obtains the tablet of the Chinese medicine composition for the treatment of essential hypotension of the present invention.
7. the Chinese medicine composition for the treatment of essential hypotension as claimed in claim 5, it is characterized in that, described oral liquid, its preparation method is:
In step 5, gained admixing medical solutions is concentrated into 25 ~ 60%, in step 6, by the semi-finished product that step 4 and step 5 obtain, after ratio according to 1: 3 ~ 5 mixes, add Lac regis apis, and traditionally prepared by the processing technology of oral liquid, tinning, obtains the oral liquid of the Chinese medicine composition for the treatment of essential hypotension of the present invention.
CN201410559694.2A 2014-10-20 2014-10-20 Traditional Chinese medicine composition for treating primary hypotension Pending CN104306769A (en)

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