CN104338041A - Traditional Chinese medicine for treating acute cystitis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating acute cystitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating acute cystitis and a preparation method thereof. The traditional Chinese medicine comprises the raw medicinal materials of galium verum, serissa serissoides, blumea, Salvinia natans, Streptocaulon griffithii Hook., Hippochaete debilis, Japanese climbing fern spore, japan clover herb, longtube ground ivy herb, Heliotropium indicum, Hemsleya macrosperma, climbing fig, sensitive joint vetch wood, palmate maidenhair, Melica scabrosa Trin., Phymatopsis hastate and all-grass of nakedcaule groundsel. The traditional Chinese medicine has a definite curative effect on acute cystitis, small toxic and side effects and a low adverse reaction rate.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine for the treatment of acute cystitis and preparation method thereof.
Background technology
Acute cystitis is the acute inflammation caused by escherichia coli etc., and pathogenic bacteria often per urethram goes upward to bladder this disease caused, and women is more than male.The cause of disease of cystitis is a lot, but great majority are pyogenic baeceria infection, and inducement has calculus, foreign body, tumor or obstructive pulmonary disease, comprises because nervous system disease produces urinary dysfunction etc.
Western medical treatment acute cystitis many employings levofloxacin magnitude broad spectrum antibiotic, though there is good therapeutic effect, but injury in various degree can be caused to nervous system, digestive system, blood vessel etc., cause many patients to take and can occur the malaise symptoms such as Nausea and vomiting, headache, dizziness, thus Patient drug's tolerance level is reduced, be unfavorable for treatment.
Acute cystitis belongs to the traditional Chinese medical science " stranguria " category.The cause of disease is many pents up bladder by invade in damp and hot or damp-heat in middle-JIAO is betted, cause functioning of bladder can not, the gas difficulty in urination, and occur the diseases such as urine urgency-frequency, scorching hot twinge, lumbago tenderness, urine red complexion be yellow.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine for the treatment of acute cystitis and preparation method thereof, and Chinese medicine of the present invention has definite curative effect to acute cystitis, and toxic and side effects is little, and untoward reaction rate is low.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of acute cystitis, its raw medicinal material comprises: Herba Violae dissectae, Radix Serissae, Herba Blumeae Lacerae, Herba salviniae natantis, Radix Streptocauli Griffithii, Herba Psychotriae Siamicae, Spora Lygodii, Herba Kummerowiae Striatae, Herba Glechomae, Herba Heliotroph, Radix Hemsleyae Macrospermae, Caulis fici pumilae (Fructus Fici Pumilae), Folium Aeschynomense indicae, Herba adianti pedati, Melica scabrosa Trin., Herba Lysimachiae Fortunei and Radix Semiaquilegiae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Violae dissectae 20 ~ 30 parts, Radix Serissae 5 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Herba salviniae natantis 20 ~ 30 parts, Radix Streptocauli Griffithii 5 ~ 15 parts, Herba Psychotriae Siamicae 15 ~ 25 parts, Spora Lygodii 30 ~ 40 parts, Herba Kummerowiae Striatae 10 ~ 20 parts, Herba Glechomae 30 ~ 40 parts, Herba Heliotroph 5 ~ 15 parts, Radix Hemsleyae Macrospermae 5 ~ 15 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 20 parts, Folium Aeschynomense indicae 15 ~ 25 parts, 15 ~ 25 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 20 parts, Herba Lysimachiae Fortunei 10 ~ 20 parts and Radix Semiaquilegiae 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Violae dissectae 20 ~ 25 parts, Radix Serissae 5 ~ 10 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Herba salviniae natantis 20 ~ 25 parts, Radix Streptocauli Griffithii 5 ~ 10 parts, Herba Psychotriae Siamicae 15 ~ 20 parts, Spora Lygodii 30 ~ 35 parts, Herba Kummerowiae Striatae 10 ~ 15 parts, Herba Glechomae 30 ~ 35 parts, Herba Heliotroph 5 ~ 10 parts, Radix Hemsleyae Macrospermae 5 ~ 10 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 15 parts, Folium Aeschynomense indicae 15 ~ 20 parts, 15 ~ 20 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 15 parts, Herba Lysimachiae Fortunei 10 ~ 15 parts and Radix Semiaquilegiae 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Violae dissectae 24 parts, Radix Serissae 6 parts, Herba Blumeae Lacerae 7 parts, Herba salviniae natantis 22 parts, Radix Streptocauli Griffithii 8 parts, Herba Psychotriae Siamicae 17 parts, Spora Lygodii 34 parts, Herba Kummerowiae Striatae 12 parts, Herba Glechomae 31 parts, Herba Heliotroph 8 parts, Radix Hemsleyae Macrospermae 6 parts, Caulis fici pumilae (Fructus Fici Pumilae) 14 parts, Folium Aeschynomense indicae 18 parts, 16 parts, Herba adianti pedati, Melica scabrosa Trin. 12 parts, Herba Lysimachiae Fortunei 13 parts and Radix Semiaquilegiae 8 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Violae dissectae 22 parts, Radix Serissae 8 parts, Herba Blumeae Lacerae 6 parts, Herba salviniae natantis 24 parts, Radix Streptocauli Griffithii 7 parts, Herba Psychotriae Siamicae 16 parts, Spora Lygodii 31 parts, Herba Kummerowiae Striatae 14 parts, Herba Glechomae 33 parts, Herba Heliotroph 6 parts, Radix Hemsleyae Macrospermae 8 parts, Caulis fici pumilae (Fructus Fici Pumilae) 12 parts, Folium Aeschynomense indicae 16 parts, 18 parts, Herba adianti pedati, Melica scabrosa Trin. 14 parts, Herba Lysimachiae Fortunei 11 parts and Radix Semiaquilegiae 6 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.01 ~ 0.1 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.001 ~ 0.01 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature 170 ~ 180 DEG C of spray dryer, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to acute cystitis, and toxic and side effects is little, untoward reaction rate is low.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of acute cystitis, its raw medicinal material comprises: Herba Violae dissectae, Radix Serissae, Herba Blumeae Lacerae, Herba salviniae natantis, Radix Streptocauli Griffithii, Herba Psychotriae Siamicae, Spora Lygodii, Herba Kummerowiae Striatae, Herba Glechomae, Herba Heliotroph, Radix Hemsleyae Macrospermae, Caulis fici pumilae (Fructus Fici Pumilae), Folium Aeschynomense indicae, Herba adianti pedati, Melica scabrosa Trin., Herba Lysimachiae Fortunei and Radix Semiaquilegiae.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Violae dissectae: be the Herb of Violaceae plant decomposite leaf common violet.Bitter in the mouth, cold in nature.GUIXIN, gallbladder, spleen, Liver Channel.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Main furuncle swelling toxin, measles pyretic toxicity, pneumonia, pleuritis, stranguria with turbid discharge, leucorrhea, nephritis.
Radix Serissae: be the herb of Maguireothamnus speciosus Radix Serissae or Serissa foetida.Hardship, pungent, cool.Return liver, spleen channel.Expelling wind and removing dampness, heat-clearing and toxic substances removing.Main flu, icterohepatitis, oedema due to nephritis, cough, laryngalgia, keratitis, enteritis, dysentery, lumbago and skelalgia, hemoptysis, hematuria, women's amenorrhea, leucorrhea, infantile malnutrition, infantile convulsion, acute toothache, swollen ulcer drug, traumatic injury.
Herba Blumeae Lacerae: Compositae Herba Blumeae Balsamiferae platymiscium is shown in the herb of white yellow Blumea laceraDC..Cold, bitter.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia, carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.
Herba salviniae natantis: this product is the herb of Salviniaceae (Saliviniaceae) plant Japanese pagodatree leaf duckweed.Latin plant animal mineral name: Salvinia nutans (L) All. [Marsileanutans L.].Miao ethnic group's medicine name: Benx ndenb benl basin is to spray (Guizhou pine Fructus Persicae), and Buax ninx duckweed manages (the south of Guizhou Province, Guizhou).Pungent, bitter, cold in nature.Clearing away heat and expelling pathogen in the exterior, inducing diuresis to remove edema, removing toxic substances.Main anemopyretic cold, measles without adequate eruption, edema, pyretic stranguria, dysuria, hematodiarrhoea, hemorrhoid, carbuncle treats skin ulcer, erysipelas, parotitis, eczema, burn and scald.
Radix Streptocauli Griffithii: trailing plants rattan Ke Malian saddle platymiscium horse connects saddle Streptoculon griffithii Hook.f. and is used as medicine with root.Hardship, micro-sweet, cool.Heat-clearing and toxic substances removing.Control and have loose bowels, dysentery, malaria, flu, stomachache, stranguria with turbid discharge.
Herba Psychotriae Siamicae: be the Herb of Maguireothamnus speciosus floral leaf Psychotria rubra (Lour.) Poir. wood.Hardship, cool, sweet.Return lung, liver, spleen, large intestine channel.Improving eyesight, heat clearing away, dampness removing, hemostasis.The red distending pain of argument, gonorrhea, icterohepatitis, hematuria, metrorrhagia.
Spora Lygodii: be the drying and ripening spore of Lygodiaceae plant sea golden Lygodiumjaponicum (Thunb.) sw..Sweet, light, cold.Return small intestinal, urinary bladder channel.Heat-clearing and toxic substances removing, relieving stranguria by diuresis.Control urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.
Herba Kummerowiae Striatae: this product is that pulse family Herba Kummerowiae Striatae platymiscium Herba Kummerowiae Striatae Kummerowia striata (Thunb.) Schindl. is with all herbal medicine.Sweet, light, be slightly cold.Heat-clearing and toxic substances removing, invigorates blood circulation, dampness removing antidiarrheal.For gastroenteritis, dysentery, hepatitis, nyctalopia, urinary system infection, traumatic injury, furuncle furuncle and phyma.
Herba Glechomae: the dry aerial parts of labiate HUOXUEDAN Glechoma longituba (Nakai) Kupr..Pungent, micro-hardship, is slightly cold.Return liver, kidney, urinary bladder channel.Dampness removing is treating stranguria, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pyretic stranguria, stranguria caused by urinary stone, jaundice due to damp-heat, sore, carbuncle and painful swelling, injury from falling down.
Herba Heliotroph: Boraginaceae heliotrope Herba Heliotroph Heliotropium indicumL., with all herbal medicine.Hardship, flat.Return lung, urinary bladder channel.Diuresis, detumescence, removing toxic substances.Main pneumonia, empyema, pharyngalgia, oral erosion, vesical calculus, too fat to move.
Radix Hemsleyae Macrospermae: the tuber of cucurbitaceous plant China Radix Hemsleyae Macrospermae, lovely Radix Hemsleyae Macrospermae and large seed Radix Hemsleyae Macrospermae.Bitter in the mouth, cold in nature.GUIXIN, stomach, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema, analgesic hemostatic.Main laryngopharynx swelling and pain, toothache, conjunctival congestion and swelling pain; Stomachache, bacillary dysentery, enteritis, hepatitis, urinary tract infection, prostatitis, hemorrhoid, cervicitis, carbuncle furuncle, traumatic hemorrhage.
Caulis fici pumilae (Fructus Fici Pumilae): be stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae).Acid, flat.Dispel the wind, dampness removing, invigorates blood circulation, removing toxic substances.Control phoenix pain of dampness syndrome, dysentery, gonorrhea, traumatic injury, carbuncle furuncle.
Folium Aeschynomense indicae: be the xylem of leguminous plant Herba Aeschynonenes Indicae stem.Light, flat, micro-hardship.Heat clearing away, dampness removing, treating stranguria, stimulating milk secretion.Harness the river swollen, pyretic stranguria, calentura excessive thirst, hot urination, agalactia.
Herba adianti pedati: be the Herb of adiantaceae plant maidenhair.Sweet in the mouth, micro-puckery, bitter, property is put down.Diuretic, dehumidifying, treating stranguria, regulating menstruation, pain relieving.Control dysuria, stranguria, hematuria, dysentery, rheumatism swells and ache, menoxenia, metrorrhagia, leucorrhea, toothache.
Melica scabrosa Trin.: grass family Melica scabrosa Trin. Melica scabrosa Trin., all herbal medicine.Sweet, cool.Inducing diuresis for treating stranguria syndrome, heat clearing away jaundice eliminating.Main urinary tract infection, oedema due to nephritis, cold, fever, icterohepatitis, diabetes.
Herba Lysimachiae Fortunei: false close net Cyclosorus plant Herba Lysimachiae Fortunei Phymatopsis hastata (Thunb.) Kitag. of Polypodiaceae, with all herbal medicine.Sweet, micro-hardship, micro-pungent, cool.Heat-clearing and toxic substances removing, wind dispelling is relieving convulsion, relieving stranguria by diuresis.Main fever caused by exogenous pathogenic factors, cough due to lung-heat, laryngopharynx swelling and pain, infantile convulsion, carbuncle sore tumefacting virus, snake bite and insect sting, burn due to hot liquid or fire, dysentery, has loose bowels, stranguria with turbid discharge.
Radix Semiaquilegiae: the herb of ranunculaceae plant Radix Semiaquilegiae.Micro-hardship, cold nature.Removing toxic substances and promoting subsidence of swelling, relieving stranguria by diuresis.Main scrofula carbuncle, snake bite and insect sting, hernia, urine leaching pain.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Violae dissectae 20 ~ 30 parts, Radix Serissae 5 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Herba salviniae natantis 20 ~ 30 parts, Radix Streptocauli Griffithii 5 ~ 15 parts, Herba Psychotriae Siamicae 15 ~ 25 parts, Spora Lygodii 30 ~ 40 parts, Herba Kummerowiae Striatae 10 ~ 20 parts, Herba Glechomae 30 ~ 40 parts, Herba Heliotroph 5 ~ 15 parts, Radix Hemsleyae Macrospermae 5 ~ 15 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 20 parts, Folium Aeschynomense indicae 15 ~ 25 parts, 15 ~ 25 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 20 parts, Herba Lysimachiae Fortunei 10 ~ 20 parts and Radix Semiaquilegiae 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Violae dissectae 20 ~ 25 parts, Radix Serissae 5 ~ 10 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Herba salviniae natantis 20 ~ 25 parts, Radix Streptocauli Griffithii 5 ~ 10 parts, Herba Psychotriae Siamicae 15 ~ 20 parts, Spora Lygodii 30 ~ 35 parts, Herba Kummerowiae Striatae 10 ~ 15 parts, Herba Glechomae 30 ~ 35 parts, Herba Heliotroph 5 ~ 10 parts, Radix Hemsleyae Macrospermae 5 ~ 10 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 15 parts, Folium Aeschynomense indicae 15 ~ 20 parts, 15 ~ 20 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 15 parts, Herba Lysimachiae Fortunei 10 ~ 15 parts and Radix Semiaquilegiae 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Violae dissectae 24 parts, Radix Serissae 6 parts, Herba Blumeae Lacerae 7 parts, Herba salviniae natantis 22 parts, Radix Streptocauli Griffithii 8 parts, Herba Psychotriae Siamicae 17 parts, Spora Lygodii 34 parts, Herba Kummerowiae Striatae 12 parts, Herba Glechomae 31 parts, Herba Heliotroph 8 parts, Radix Hemsleyae Macrospermae 6 parts, Caulis fici pumilae (Fructus Fici Pumilae) 14 parts, Folium Aeschynomense indicae 18 parts, 16 parts, Herba adianti pedati, Melica scabrosa Trin. 12 parts, Herba Lysimachiae Fortunei 13 parts and Radix Semiaquilegiae 8 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Violae dissectae 22 parts, Radix Serissae 8 parts, Herba Blumeae Lacerae 6 parts, Herba salviniae natantis 24 parts, Radix Streptocauli Griffithii 7 parts, Herba Psychotriae Siamicae 16 parts, Spora Lygodii 31 parts, Herba Kummerowiae Striatae 14 parts, Herba Glechomae 33 parts, Herba Heliotroph 6 parts, Radix Hemsleyae Macrospermae 8 parts, Caulis fici pumilae (Fructus Fici Pumilae) 12 parts, Folium Aeschynomense indicae 16 parts, 18 parts, Herba adianti pedati, Melica scabrosa Trin. 14 parts, Herba Lysimachiae Fortunei 11 parts and Radix Semiaquilegiae 6 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.01 ~ 0.1 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.001 ~ 0.01 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature 170 ~ 180 DEG C of spray dryer, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1 tablet
Get Herba Violae dissectae 240g, Radix Serissae 60g, Herba Blumeae Lacerae 70g, Herba salviniae natantis 220g, Radix Streptocauli Griffithii 80g, Herba Psychotriae Siamicae 170g, Spora Lygodii 340g, Herba Kummerowiae Striatae 120g, Herba Glechomae 310g, Herba Heliotroph 80g, Radix Hemsleyae Macrospermae 60g, Caulis fici pumilae (Fructus Fici Pumilae) 140g, Folium Aeschynomense indicae 180g, Herba adianti pedati 160g, Melica scabrosa Trin. 120g, Herba Lysimachiae Fortunei 130g and Radix Semiaquilegiae 80g;
Prepare according to the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize and sieve acquisition 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.005 times, granulate, tabletting, makes.
Embodiment 2 granule
Get Herba Violae dissectae 220g, Radix Serissae 80g, Herba Blumeae Lacerae 60g, Herba salviniae natantis 240g, Radix Streptocauli Griffithii 70g, Herba Psychotriae Siamicae 160g, Spora Lygodii 310g, Herba Kummerowiae Striatae 140g, Herba Glechomae 330g, Herba Heliotroph 60g, Radix Hemsleyae Macrospermae 80g, Caulis fici pumilae (Fructus Fici Pumilae) 120g, Folium Aeschynomense indicae 160g, Herba adianti pedati 180g, Melica scabrosa Trin. 140g, Herba Lysimachiae Fortunei 110g and Radix Semiaquilegiae 60g;
Prepare according to the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 95%, be heated to boiling reflux 2 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 70 DEG C subsequently under vacuum 0.05Mpa, relative density is the mastic of 1.00, spraying dry, the inlet temperature 180 DEG C of spray dryer, leaving air temp 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.3 times in the dried cream powder obtained, makes granule, in 60 DEG C of dryings, obtains granule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.34g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>41.7 crude drug/kg, every day, maximum dosage-feeding was 83.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 583 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 13.55,22.85 and 42.23g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 90 routine cases are my Out-patient Department patient in May, 2010 ~ in June, 2013.Patient is divided into treatment group and matched group at random, wherein treatment group 50 people, male 5 people, women 45 people, 20 ~ 65 years old age; Matched group 40 people, male 4 people, women 36 people, 22 ~ 63 years old age.Get rid of object: (1) makes a definite diagnosis chronic cystitis patient (2) with other serious conditions person.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: cardinal symptom is frequent micturition, urgent micturition, dysurea, similar urinary incontinence time serious, the discomforts such as companion's lower abdominal pain, urine routine: leukocyte (+), erythrocyte (+), urine positive bacterial culture.
Therapeutic Method:
Matched group: oral Levofloxacin M. S. A 0.2g/ time, every day 2 times.7 days courses for the treatment of.
Treatment group: oral each 5 of Chinese medicine embodiment 1 tablet of the present invention, every day 3 times.7 days courses for the treatment of.
Curative effect judging standard: clinical cure: Clinical symptom and sign disappears, routine urianlysis recovers normal for 2 times, urine Bacterial Negative, and is feminine gender in the 2nd, 6 week check urine thin bacterium.Effective: clinical symptom disappearance or substantially disappear, routine urinalysis is normal or close to normal, urine Bacterial Negative.Take a turn for the better: clinical symptom relief, routine urinalysis significantly improves, and urine antibacterial culturing is even the positive.Invalid: clinical symptoms and routine urianlysis obviously do not improve, urine bacterioscopy is still positive, or urine thin bacterium is still positive when check in the 2nd, 6 week, and is same strain.
Therapeutic outcome: treat 1 course for the treatment of and through the 2nd, 6 week check after, statistical result sees the following form.
| Group | n | Clinical cure | Effective | Take a turn for the better | Invalid | Effectively total |
| Treatment group | 50 | 40 | 5 | 3 | 2 | 48(96.00％) |
| Matched group | 40 | 19 | 7 | 8 | 6 | 34(85.00％) |
Untoward reaction: feeling sick appears in treatment group 1 example, transference cure after drug withdrawal, feeling sick appears in matched group 4 example, 2 examples occur dizzy, and disappear after drug withdrawal, the untoward reaction rate for the treatment of group is 2%, the untoward reaction rate of matched group is 15%, and treatment group untoward reaction rate is starkly lower than matched group.
Concrete case: appoint certain, female, 33 years old.Because of frequent micturition, urgent micturition, dysurea is gone to a doctor, companion's lower abdominal pain, urine routine: leukocyte (+), and urine bacterioscopy is positive.Be diagnosed as acute cystitis.Give each 5 of Chinese medicine embodiment 1 tablet of the present invention, every day 3 times, treat 1 the course for the treatment of clinical cure.2nd, within 6 weeks, check urine thin bacterium is feminine gender.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat a Chinese medicine for acute cystitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Violae dissectae, Radix Serissae, Herba Blumeae Lacerae, Herba salviniae natantis, Radix Streptocauli Griffithii, Herba Psychotriae Siamicae, Spora Lygodii, Herba Kummerowiae Striatae, Herba Glechomae, Herba Heliotroph, Radix Hemsleyae Macrospermae, Caulis fici pumilae (Fructus Fici Pumilae), Folium Aeschynomense indicae, Herba adianti pedati, Melica scabrosa Trin., Herba Lysimachiae Fortunei and Radix Semiaquilegiae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Violae dissectae 20 ~ 30 parts, Radix Serissae 5 ~ 15 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Herba salviniae natantis 20 ~ 30 parts, Radix Streptocauli Griffithii 5 ~ 15 parts, Herba Psychotriae Siamicae 15 ~ 25 parts, Spora Lygodii 30 ~ 40 parts, Herba Kummerowiae Striatae 10 ~ 20 parts, Herba Glechomae 30 ~ 40 parts, Herba Heliotroph 5 ~ 15 parts, Radix Hemsleyae Macrospermae 5 ~ 15 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 20 parts, Folium Aeschynomense indicae 15 ~ 25 parts, 15 ~ 25 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 20 parts, Herba Lysimachiae Fortunei 10 ~ 20 parts and Radix Semiaquilegiae 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Violae dissectae 20 ~ 25 parts, Radix Serissae 5 ~ 10 parts, Herba Blumeae Lacerae 5 ~ 10 parts, Herba salviniae natantis 20 ~ 25 parts, Radix Streptocauli Griffithii 5 ~ 10 parts, Herba Psychotriae Siamicae 15 ~ 20 parts, Spora Lygodii 30 ~ 35 parts, Herba Kummerowiae Striatae 10 ~ 15 parts, Herba Glechomae 30 ~ 35 parts, Herba Heliotroph 5 ~ 10 parts, Radix Hemsleyae Macrospermae 5 ~ 10 parts, Caulis fici pumilae (Fructus Fici Pumilae) 10 ~ 15 parts, Folium Aeschynomense indicae 15 ~ 20 parts, 15 ~ 20 parts, Herba adianti pedati, Melica scabrosa Trin. 10 ~ 15 parts, Herba Lysimachiae Fortunei 10 ~ 15 parts and Radix Semiaquilegiae 5 ~ 10 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Violae dissectae 24 parts, Radix Serissae 6 parts, Herba Blumeae Lacerae 7 parts, Herba salviniae natantis 22 parts, Radix Streptocauli Griffithii 8 parts, Herba Psychotriae Siamicae 17 parts, Spora Lygodii 34 parts, Herba Kummerowiae Striatae 12 parts, Herba Glechomae 31 parts, Herba Heliotroph 8 parts, Radix Hemsleyae Macrospermae 6 parts, Caulis fici pumilae (Fructus Fici Pumilae) 14 parts, Folium Aeschynomense indicae 18 parts, 16 parts, Herba adianti pedati, Melica scabrosa Trin. 12 parts, Herba Lysimachiae Fortunei 13 parts and Radix Semiaquilegiae 8 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Violae dissectae 22 parts, Radix Serissae 8 parts, Herba Blumeae Lacerae 6 parts, Herba salviniae natantis 24 parts, Radix Streptocauli Griffithii 7 parts, Herba Psychotriae Siamicae 16 parts, Spora Lygodii 31 parts, Herba Kummerowiae Striatae 14 parts, Herba Glechomae 33 parts, Herba Heliotroph 6 parts, Radix Hemsleyae Macrospermae 8 parts, Caulis fici pumilae (Fructus Fici Pumilae) 12 parts, Folium Aeschynomense indicae 16 parts, 18 parts, Herba adianti pedati, Melica scabrosa Trin. 14 parts, Herba Lysimachiae Fortunei 11 parts and Radix Semiaquilegiae 6 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.01 ~ 0.1 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.001 ~ 0.01 times, granulate, tabletting, makes.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature 170 ~ 180 DEG C of spray dryer, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.01 ~ 0.1 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.001 ~ 0.01 times, granulate, tabletting, makes.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature 170 ~ 180 DEG C of spray dryer, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
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| CN101032586A (en) * | 2007-04-04 | 2007-09-12 | 侯雪云 | Chinese traditional medicine composition to be taken orally for curing acute cystitis |
| CN101574446A (en) * | 2008-05-10 | 2009-11-11 | 史战勇 | Chinese medicament for treating acute cystitis |
| CN102670806A (en) * | 2012-05-17 | 2012-09-19 | 宋协勘 | Traditional Chinese medicine for treating acute cystitis |
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