CN104334275B - 加载液体样品的系统和方法 - Google Patents

加载液体样品的系统和方法 Download PDF

Info

Publication number
CN104334275B
CN104334275B CN201380023088.2A CN201380023088A CN104334275B CN 104334275 B CN104334275 B CN 104334275B CN 201380023088 A CN201380023088 A CN 201380023088A CN 104334275 B CN104334275 B CN 104334275B
Authority
CN
China
Prior art keywords
sample
chip
loader
liquid sample
reaction sites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380023088.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN104334275A (zh
Inventor
迈克尔·C·帕拉斯
詹姆士·讷尔斯
加里·利姆
西奥多·斯特劳博
埃文·福斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Publication of CN104334275A publication Critical patent/CN104334275A/zh
Application granted granted Critical
Publication of CN104334275B publication Critical patent/CN104334275B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5088—Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0038—Drawing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201380023088.2A 2012-03-16 2013-03-15 加载液体样品的系统和方法 Active CN104334275B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261612008P 2012-03-16 2012-03-16
US201261612087P 2012-03-16 2012-03-16
US201261612005P 2012-03-16 2012-03-16
US61/612,005 2012-03-16
US61/612,008 2012-03-16
US61/612,087 2012-03-16
US201261723759P 2012-11-07 2012-11-07
US201261723658P 2012-11-07 2012-11-07
US201261723738P 2012-11-07 2012-11-07
US61/723,759 2012-11-07
US61/723,738 2012-11-07
US61/723,658 2012-11-07
PCT/US2013/032107 WO2013138724A2 (en) 2012-03-16 2013-03-15 Systems and methods for loading liquid samples

Publications (2)

Publication Number Publication Date
CN104334275A CN104334275A (zh) 2015-02-04
CN104334275B true CN104334275B (zh) 2016-08-24

Family

ID=48014373

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380023088.2A Active CN104334275B (zh) 2012-03-16 2013-03-15 加载液体样品的系统和方法
CN201380023031.2A Expired - Fee Related CN104334273B (zh) 2012-03-16 2013-03-15 用于生物反应系统的包被的基底

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380023031.2A Expired - Fee Related CN104334273B (zh) 2012-03-16 2013-03-15 用于生物反应系统的包被的基底

Country Status (10)

Country Link
US (4) US10627420B2 (cg-RX-API-DMAC7.html)
EP (2) EP2825311B1 (cg-RX-API-DMAC7.html)
JP (2) JP2015512508A (cg-RX-API-DMAC7.html)
KR (2) KR20150022751A (cg-RX-API-DMAC7.html)
CN (2) CN104334275B (cg-RX-API-DMAC7.html)
AU (2) AU2013231955A1 (cg-RX-API-DMAC7.html)
IN (2) IN2014DN08136A (cg-RX-API-DMAC7.html)
RU (2) RU2014141634A (cg-RX-API-DMAC7.html)
SG (2) SG11201405788UA (cg-RX-API-DMAC7.html)
WO (2) WO2013138724A2 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015511015A (ja) * 2012-03-16 2015-04-13 ライフ テクノロジーズ コーポレーション 生体試料を収容するためのシステム及び方法
CA2915475A1 (en) 2013-05-24 2014-11-27 Life Technologies Corporation Case and case holder for biological samples and corresponding method of use
CN106061611A (zh) * 2013-11-18 2016-10-26 生命技术公司 用于装载液体样品的系统和方法
JP6560054B2 (ja) * 2015-08-05 2019-08-14 株式会社古河電工アドバンストエンジニアリング 検体導入部材、ウェルへの検体導入方法
WO2017038682A1 (ja) * 2015-08-28 2017-03-09 国立研究開発法人理化学研究所 鋳型核酸の分析方法、標的物質の分析方法、鋳型核酸または標的物質の分析用キット、および鋳型核酸または標的物質の分析用装置
CN105543064B (zh) * 2015-12-29 2018-04-17 西安交通大学 一种数字pcr芯片及其使用方法
WO2017123626A1 (en) * 2016-01-11 2017-07-20 Advandx, Inc. Device for capillary force sample loading and improved assay performance
CN106111220A (zh) * 2016-06-20 2016-11-16 北京领宇科技有限公司 一种用于生物/化学反应体系的反应装置及其制备方法和应用
EP3551745A4 (en) 2016-12-12 2020-07-15 Xcella Biosciences, Inc. SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CN110382439B (zh) 2016-12-30 2026-07-21 埃克切拉生物科学公司 多级样品回收系统
CN108660068B (zh) * 2018-02-13 2022-04-05 臻准生物工程(山西)有限公司 生物反应芯片及其制备方法
DK3890876T3 (da) 2018-12-06 2024-07-22 Xcella Biosciences Inc Lateral påfyldning af mikrokapillære arrays
CA3156776A1 (en) 2019-11-08 2021-05-14 xCella Biosciences, Inc. Apparatus and methods for laser-based single cell recovery from microcapillary arrays
DE102019220017A1 (de) * 2019-12-18 2021-06-24 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmeeinheit zum Aufnehmen eines Fluids, Verfahren und Vorrichtung zum Herstellen einer Aufnahmeeinheit, Verfahren und Vorrichtung zum Betreiben einer Aufnahmeeinheit und Aufnahmeeinrichtung
US20230347349A1 (en) * 2020-09-10 2023-11-02 Nuclera Nucleics Ltd Composite top plate for magnetic and temperature control in a digital microfluidic device
CN114985023B (zh) * 2021-10-27 2024-01-05 北京擎科生物科技股份有限公司 微阵列芯片和包括其的寡核苷酸合成装置
EP4433796A4 (en) * 2021-11-19 2025-10-22 Univ Cornell OMNIPHOBIC TILES (DOTS) WITH SURFACE PATTERNS, ASSOCIATED MANUFACTURE, LOADING AND USE
CN114414811B (zh) * 2021-12-15 2024-12-31 中核同辐（长春）辐射技术有限公司 一种羟基改性蛋白质芯片的制备方法
KR20230138571A (ko) 2022-03-23 2023-10-05 삼성전자주식회사 바이오 입자 검출 장치 및 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086624A1 (en) * 2008-01-04 2009-07-16 The Royal Institution For The Advancement Of Learning/Mcgill University Microfluidic microarray system and method for the multiplexed analysis of biomolecules

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110555A (en) * 1989-09-18 1992-05-05 Miles Inc. Capillary flow apparatus for inoculation of a test substrate
JPH04301608A (ja) * 1991-03-29 1992-10-26 Hitachi Cable Ltd 合成樹脂光伝送体の製造方法
JPH05126716A (ja) * 1991-11-06 1993-05-21 Dainippon Printing Co Ltd 前進及び後退接触角測定方法
WO1997006890A1 (en) 1995-08-11 1997-02-27 Robbins Scientific Corporation Compartmentalized multi-well container
DE19740806C2 (de) * 1997-09-17 1999-10-07 Schott Glas Mikrotiterplatte aus Kunststoff
US5972176A (en) * 1997-10-03 1999-10-26 3M Innovative Properties Company Corona treatment of polymers
US6027873A (en) * 1999-03-19 2000-02-22 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
JP2000271525A (ja) * 1999-03-26 2000-10-03 Mitsubishi Paper Mills Ltd 塗布装置
US7332271B2 (en) * 2000-02-18 2008-02-19 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
JP2004517175A (ja) * 2000-12-29 2004-06-10 エヌ・ケー・ティー リサーチ アンド イノベーション アクティーゼルスカブ 化合物を固定する基質の調製方法、その基質およびその使用方法
JP2002214232A (ja) * 2001-01-12 2002-07-31 Toray Ind Inc 選択結合性物質固定化フィルム及びそれを用いた被検物質の測定方法
AU2002306862A1 (en) * 2001-03-23 2002-11-05 Children's Medical Center Corporation Selective deposition of materials on contoured surfaces
JP2002335960A (ja) * 2001-05-15 2002-11-26 Moritex Corp Ｐｃｒ用マイクロプレート及びそれを用いたｐｃｒ法
CA2451201A1 (en) * 2001-06-20 2003-01-03 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
US6734436B2 (en) * 2001-08-07 2004-05-11 Sri International Optical microfluidic devices and methods
NL1019378C2 (nl) * 2001-11-16 2003-05-20 Univ Delft Tech Werkwijze voor het vullen van een putje in een substraat.
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
WO2003100421A1 (en) * 2002-05-28 2003-12-04 Bio Strand, Inc. Specimen distributing device, coating part manufacturing method, specimen distributing method, and substrate activating device
JP2004109107A (ja) * 2002-07-25 2004-04-08 Nippon Sheet Glass Co Ltd 生化学用容器
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
JP2004184100A (ja) * 2002-11-29 2004-07-02 I Design:Kk 分析用具、それを用いた分析方法及び、分析用具の製造方法
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
EP1583950B1 (en) * 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
ATE357977T1 (de) * 2003-03-31 2007-04-15 Eidgenoess Tech Hochschule Kontrolierte oberflächen-stoffgradienten
EP1656202A1 (en) * 2003-07-14 2006-05-17 Qiagen Sciences, Inc. Sample presentation device with differing wettability
US20060233671A1 (en) 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7291362B2 (en) * 2004-01-20 2007-11-06 3M Innovative Properties Company Method and apparatus for controlling coating width
WO2005089945A1 (en) * 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
US7690325B2 (en) * 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
EP1782075B1 (en) * 2004-08-04 2023-10-04 Life Technologies Corporation Method for differentially coating a substrate
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7315019B2 (en) * 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
EP1693337A1 (de) * 2005-02-18 2006-08-23 Infineon Technologies AG Makroporöser Träger für chemische Amplifikationsreaktionen
US7682816B2 (en) * 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
CN1996009B (zh) * 2007-01-10 2010-05-19 博奥生物有限公司 一种用于多样品分析的微流体器件和使用方法
JP5095247B2 (ja) * 2007-03-22 2012-12-12 株式会社城北精工所 コーティングダイ
FI20105692A0 (fi) * 2010-06-15 2010-06-15 Aabo Akademi University Menetelmä arkkimaisen reaktiolevyn valmistamiseksi, reaktiolevy ja sen käyttö
CN106443039B (zh) 2010-06-28 2018-04-24 生命科技公司 用于转移液体样品的系统和方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086624A1 (en) * 2008-01-04 2009-07-16 The Royal Institution For The Advancement Of Learning/Mcgill University Microfluidic microarray system and method for the multiplexed analysis of biomolecules

Also Published As

Publication number Publication date
US11493526B2 (en) 2022-11-08
US10627420B2 (en) 2020-04-21
EP2825312A2 (en) 2015-01-21
SG11201405788UA (en) 2014-11-27
KR20150022751A (ko) 2015-03-04
EP2825311B1 (en) 2020-07-29
US20150072897A1 (en) 2015-03-12
US20200319221A1 (en) 2020-10-08
CN104334273B (zh) 2016-12-07
US20150051118A1 (en) 2015-02-19
WO2013138724A3 (en) 2014-04-24
IN2014DN08164A (cg-RX-API-DMAC7.html) 2015-05-01
US10627421B2 (en) 2020-04-21
KR20150003737A (ko) 2015-01-09
WO2013138746A1 (en) 2013-09-19
RU2014141635A (ru) 2016-05-10
IN2014DN08136A (cg-RX-API-DMAC7.html) 2015-05-01
CN104334275A (zh) 2015-02-04
JP2015511016A (ja) 2015-04-13
AU2013231955A1 (en) 2014-10-30
WO2013138724A2 (en) 2013-09-19
JP2015512508A (ja) 2015-04-27
RU2014141634A (ru) 2016-05-10
EP2825312B1 (en) 2020-04-29
US20230030218A1 (en) 2023-02-02
CN104334273A (zh) 2015-02-04
AU2013231889A1 (en) 2014-10-30
SG11201405787SA (en) 2014-11-27
EP2825311A1 (en) 2015-01-21

Similar Documents

Publication Publication Date Title
CN104334275A (zh) 加载液体样品的系统和方法
US20160271604A1 (en) Systems and Methods for Loading Liquid Samples
EP1608952B1 (en) Assay apparatus and method using microfluidic arrays
US7351379B2 (en) Fluid containment structure
US20110105356A1 (en) Compositions and methods for providing substances to and from an array
US20030231985A1 (en) Form in place gaskets for assays
US20030231989A1 (en) Multiple array format
US20060094108A1 (en) Thermal cycler for microfluidic array assays
US20040235036A1 (en) Devices and methods for detecting genetic sequences
US10415084B2 (en) Multiplex slide plate device and operation method thereof
US9724692B2 (en) Multiplex slide plate
US20230017412A1 (en) Receiving Unit for Receiving a Fluid, Method and Apparatus for Producing a Receiving Unit, Method and Apparatus for Operating a Receiving Unit, and Receiving Device
HK1214200A1 (zh) 從阱提取受抑制液體
JP2009528037A (ja) 核酸増幅用基材
CN107709959B (zh) 蒸发微毛细管中的液体的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant