CN104304687B - A kind of pig's feed degrading mold toxin adsorbent and application thereof - Google Patents
A kind of pig's feed degrading mold toxin adsorbent and application thereof Download PDFInfo
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Abstract
The invention discloses a kind of degrading mold toxin adsorbent, be made up of bacillus subtilis, Lactobacillus plantarum, Lactobacillus acidophilus, leuconostoc lactis, Deshi Lactobacillus, Lactobacillus fermenti, Lactobacillus salivarius, vitamin C, vitamin E, the Radix Astragali, zinc methionine, potassium chloride, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli, Herba Artemisiae Scopariae, Folium Artemisiae Argyi, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Semen Plantaginis, yeast cell wall and phytase.Described degrading mold toxin adsorbent is respectively provided with suppression and produces, degrade and adsorb multiple action common mycotoxin multiple in feedstuff, also can improve Swinery immunity power, the excretion of promotion poisonous substance, there is comprehensive premium properties, weaned piglets is had significant effect, sickness rate can be reduced, improve daily gain, improve feed digestibility, reduce feedstuff-meat ratio.And usage amount is low and effective, to medicine and other nutrient substance without adsorption, can be biodegradable after discharge, itself, without pollutant, has good using value for aquaculture.
Description
Technical field
The invention belongs to field of feed additive technology.More particularly, to a kind of pig's feed degrading mold toxin adsorbent and application thereof.
Background technology
Mycotoxin is present in the antinutritional factor in feedstuff and mixed feed, they are two grades of poisonous metabolites produced by the fungus by different generics, specifically include that aflatoxin, ochracin, T-2 toxin, snakelike mycin (Diaeetoxyscirpenol, DAS), the rotten sickle mykol (Deoxynivalenol of deoxidation snow, DON, vomitoxin, fumonisin and 6-(10-hydroxy-6-oxo-trans-1-undecenyl)-.beta.-resorcylic acid lactone etc..Mycotoxin almost affects each organ of health, particularly liver, kidney, oral cavity, gastrointestinal tract, spleen and nervous system.Affect feed intake and the body weight gains of pig, make feed conversion rate reduce.Cause that vaginal orifice swelling, lactogenic is unusual, infertile, miscarriage, rectum and vagina hang down de-, and cause pulmonary edema, neurological disorders and the susceptibility to disease that have increase.The mould toxin of the most single-ended spore such as T-2 toxin, DAS, DON main harm oral cavity, gastrointestinal tract, immunity and nervous system, they are by playing toxic action at ribosome level suppression protein synthesis.This type of mycotoxin adds the animal susceptibility to disease by destroying immune system, thus causes the secondary infection of virosis, bacterial disease and parasitic disease, brings great economic loss to pig farm.The significant damage that China's pig industry is caused by mycotoxin is reported the most in a large number.From the point of view of clinical manifestation, in the middle of nearly 2 years many provinces gram popular hyperpyrexia disease disease pigs of China, having many similar to the symptom of mycotoxicosis, this time epidemic disease causes a large amount of pig dead, and is once causing many people's fears.Therefore, finding suitable effective method and be controlled mycotoxin is the task of top priority of animal husbandry development.
Owing to mycotoxin is affected by many factors to the toxicity of animal, the kind etc. of age kind, environment and disease condition, nutrition and the mycotoxin of such as animal.Therefore, mycotoxin contamination thing to be given determines that a level of security is impossible.The adverse effect of mycotoxin and control its potential danger that food safety and human health are constituted in animal feed to be controlled, it is desirable to have a multi-faceted consideration.Control strategy includes: Feed Manufacturing strategy, farm management strategy and to by feedstuff or the control etc. of complete feedstuff of mycotoxin contamination.It is said that in general, mycotoxin is often more stable compound, but their stability and content can method handled differently impacts.At present detoxicating mycotoxin is processed and mainly have: the methods such as machinery detoxification, biological detoxication, chemical detoxication and physical absorption detoxification.Wherein, physics detoxification, chemical detoxication effectively cannot use because of trivial operations, with high costs, self problem such as detoxification technology defect and chemical residues in production practices；Adsorbent detoxicity method is mainly by adding various adsorbent in feedstuff or corn, reduce or eliminate mycotoxin and absorb at gastrointestinal, i.e. add in feedstuff and toxin can be made not to be absorbed by animals through animal intestinal with the material of absorbing mycotoxin, be expelled directly out outside animal body.This is a kind of detoxicating mycotoxin method the most ripe and more feasible on current feed market, it is contemplated that the multiformity of mycotoxin structure, specificity and unicity, the limitation of common adsorbents material, any single, conventional adsorbent material all can not effectively solve pollution and the harm problem of multiple mycotoxin.The most widely studied mold toxin sorbent includes clay class adsorbent or organic polymer, but from the point of view of the situation with regard to current Clinical practice, effect is the most undesirable.
Biological detoxication is a kind of novel detoxicating mycotoxin mode, mainly has enzymatic isolation method and microbe fermentation method.Enzymatic isolation method mainly selects some enzyme, utilizes its degraded or destroys toxin.But this type of method is more due to mycotoxin kind, it is desirable to enzyme system is complicated complete, and is easily affected by animal digestion organ dysfunction；Thermo-labile and easily inactivate during feed manufacturing and relatively costly additionally, due to enzyme, it is also difficult to promote the use of in actual production.Use fermentable to remove mycotoxin and have many reports, as being other product by AFB1 microbe conversion, but this conversion is typically the most slowly, and is incomplete, and the safety of converted product there is no final conclusion, can play a role in actual production and also need to make the research of system perfecting.Therefore, research one safely, effectively, can be effectively reduced the mycotoxin harm to animal, not adversely affect growth of animal, to medicine and other nutrient substance without adsorbing degrading mold toxin adsorbent, it it is the research topic of a great prospect.
Summary of the invention
The technical problem to be solved in the present invention is defect and the technical deficiency overcoming existing mold toxin sorbent, there is provided a kind of common mycotoxin multiple in feedstuff to be respectively provided with suppression generation, degrade and adsorbs multiple action, and to improving Swinery immunity power, promoting that the excretion of poisonous substance all has the mold toxin sorbent of remarkable result.
It is an object of the invention to provide a kind of degrading mold toxin adsorbent.
Another object of the present invention is to provide the application of described degrading mold toxin adsorbent.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The invention provides a kind of degrading mold toxin adsorbent, be made up of probiotic bacteria, vitamin, mineral, Chinese herbal medicine, yeast cell wall and phytase；
Described probiotic bacteria be bacillus subtilis (Bacillus subtilis), Lactobacillus plantarum (Lactobacillus
plantarum), Lactobacillus acidophilus (Lactobacillus
acidophilus), leuconostoc lactis (Leuconostoc lactis), Deshi Lactobacillus (Lactobacillus delbrueckii), Lactobacillus fermenti (lactobacillus fermentum) and Lactobacillus salivarius (Lactobacillus salivarius) mixture；
Described vitamin is the mixture of vitamin C and vitamin E；
Described mineral is the mixture of zinc methionine and potassium chloride；
Described Chinese herbal medicine is the mixture of the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli, Herba Artemisiae Scopariae, Folium Artemisiae Argyi, Herba Artemisiae Annuae, Flos Chrysanthemi Indici and Semen Plantaginis.
Preferably, to account for the mass ratio range of gross weight, above-mentioned degrading mold toxin adsorbent is grouped into by the one-tenth of following weight meter:
Bacillus subtilis (YB4) 15～25 parts, Lactobacillus plantarum (R1) 10～20 parts, Lactobacillus acidophilus (R4) 10～20 parts, leuconostoc lactis 5～15 parts, Deshi Lactobacillus 5～15 parts, Lactobacillus fermenti 5～15 parts, Lactobacillus salivarius 5～15 parts, vitamin C 10～20 parts, vitamin E 10～20 parts, the Radix Astragali 20～30 parts, zinc methionine 10～20 parts, potassium chloride 20～30 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 20～30 parts, Flos Caryophylli 10～20 parts, Herba Artemisiae Scopariae 15～25 parts, Folium Artemisiae Argyi 20～30 parts, Herba Artemisiae Annuae 10～20 parts, Flos Chrysanthemi Indici 20～30 parts, Semen Plantaginis 15～25 parts, yeast cell wall 30～50 parts and phytase 20000U/g.
It is highly preferred that to account for the mass ratio range of gross weight, above-mentioned degrading mold toxin adsorbent is grouped into by the one-tenth of following weight meter:
Bacillus subtilis (YB4) 20 ~ 25 parts, Lactobacillus plantarum (R1) 15 ~ 20 parts, Lactobacillus acidophilus (R4) 15 ~ 20 parts, leuconostoc lactis 10 ~ 15 parts, Deshi Lactobacillus 10 ~ 15 parts, Lactobacillus fermenti 10 ~ 15 parts and Lactobacillus salivarius 10 ~ 15 parts, vitamin C 15 ~ 20 parts, vitamin E 15 ~ 20 parts, the Radix Astragali 25 ~ 30 parts, zinc methionine 15 ~ 20 parts, 25 ~ 30 parts of potassium chloride, 25 ~ 30 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 15 ~ 20 parts, Herba Artemisiae Scopariae 20 ~ 25 parts, Folium Artemisiae Argyi 25 ~ 30 parts, Herba Artemisiae Annuae 15 ~ 20 parts, Flos Chrysanthemi Indici 25 ~ 30 parts, Semen Plantaginis 20 ~ 25 parts, yeast cell wall 40 ~ 50 parts and phytase 20000U/g.
If no special instructions, strict restriction is not the most done in source to all above raw material, can be commercial.
The most preferably, described leuconostoc lactis, Deshi Lactobacillus, Lactobacillus fermenti and Lactobacillus salivarius are chicken intestinal normal flora, are to be separated amplification extraction by chicken intestinal content and obtain.
Present invention also offers above-mentioned degrading mold toxin adsorbent as the application in terms of feed additive；Preferably, described feedstuff is pig's feed.
The invention also discloses the pig's feed of a kind of improvement, be in pig normal feedstuff, to add the present invention above-mentioned degrading mold toxin adsorbent obtain.Described pig is not cooked strict restriction of normal feedstuff, and the most conventional raising all feeds used by pig is the most applicable.
The most preferably, the addition of described degrading mold toxin adsorbent is 1～10g/kg normal feedstuff, preferably 2
G/kg normal feedstuff.
The preparation method of degrading mold toxin adsorbent of the present invention does not do strict restriction, universal for, according to formula proportion, by all raw material pulverizing, mixing (or many step processing granulations, expanded), be vacuum-packed,.
The raw materials used health of the present invention, have no side effect.Bacillus subtilis (YB4): bacillus subtilis can consume rapidly the free oxygen in digestive tract in environment, form intestinal low-oxygen environment, promote that useful anaerobe grows, and produce the organic acids such as lactic acid, reduce gut pH, indirectly suppress the growth of other pathogenic bacterium；Bacillus subtilis thalline self can synthesize digestibility enzyme, such as protease, amylase, lipase, cellulase etc., jointly plays a role with endogenous enzymes in digestive tract, improves feed digestibility.
Lactobacillus plantarum (R1) and Lactobacillus acidophilus (R4): produce lactic acid and acetic acid, energy extracellular proteinase, promote digesting and assimilating of protein.The predigestion of gastric food can be improved, improve calcium, phosphorus, the utilization rate of ferrum and the absorption of vitamin D；Also can produce antibiotics, such as acidophilin, acidolin and lactocidin.The a large amount of vitamin B group energys produced promote the growth of neurocyte.
Chicken intestinal normal flora (leuconostoc lactis, Deshi Lactobacillus, Lactobacillus fermenti and Lactobacillus salivarius): being separated amplification extraction by chicken intestinal content and obtain, its adsorption mechanism mainly has: the physisorption of (1) cell wall.Heating and acid treatment can increase the adsorption of cell contratoxin and (heat or acid treatment makes the polysaccharide of wall and the general key of sugar of skin polysaccharide or skin bond fission, discharge monomer, cell wall is thinning, aperture increases, toxin can be adsorbed by cell wall and plasmalemma component simultaneously): the absorption of toxin is the hydrophobic interaction of non-covalent bond, being reversible (washing and organic solvent extraction can discharge toxin again), adsorption effect is relevant with cell concentration.(2) some protein analogues or extracellular polysaccharide block or delay the biosynthesis of toxin.As ring skin can suppress transcribing of Virulence-associated genes, thus suppress the generation of toxin；This effect of ring skin is relevant with its circulus, and must just show antibacterial activity containing proline and hydrophobic amino acid in ring skin.(3) intracellular and exoenzyme are degraded into toxin that toxicity is less or non-toxic substance.
Vitamin C: be most important antioxidant in extracellular fluid; biomembrane can be protected from the infringement of lipid peroxidation, reduce tocopherol radicals, thus the free radical recovering vitamin E purifies activity; the impact that body stress be caused by alleviation, and employ immunoreation and come anti-stress.
Vitamin E: protective tissue is not attacked by lipid free radical, thus prevent the peroxidating of fat in cell membrane and a series of infringements caused therefrom, weaken superoxide anion and the activity of hydrogen peroxide in phagocyte, thus extend the life of cell.
The Radix Astragali: by improving the content of lipid peroxy compound, great booster immunization organ dysfunction in the immune organ such as spleen and thymus, making body produce more lymphocyte, antibody tormation increases, inducement interferon Y and produce the ability of antiviral etc..
Zinc methionine: organic zinc has assosting effect to strengthening Swinery immunity power.
Potassium chloride: potassium, chloride ion are provided, it is ensured that the normal physiological function of poultry during mycotoxin infringement.
Cortex cinnamomi japonici (Ramulus Cinnamomi): cinnamic aldehyde (CA) is the ethereal oil refined in Cortex cinnamomi japonici (Ramulus Cinnamomi), and cinnamic aldehyde all has antibacterial action to multiple mycete.
Flos Caryophylli: Oleum Caryophylli (CO) is respectively provided with antibacterial action to the various moulding fungi such as 27 strain mycetes such as penicillium sp, aspergillosis, Trichoderma spp., rhizopus.Basis of microscopic observation: Flos Caryophylli volatile oil can destroy rapidly mold structures, makes mycete embrace son and comes off, decomposes thus play and kill mycete, and suppress it to breed.
Herba Artemisiae Scopariae, Folium Artemisiae Argyi, Herba Artemisiae Annuae: spongy body character, adsorption feed excessive moisture and the toxin of generation thereof, have anti-abortional effect to female animal, removes hidden danger of going mouldy from root.
Flos Chrysanthemi Indici: protect the liver and protect kidney good medicine.
Semen Plantaginis: have and good press down mould detoxicating effect, female animal metritis, mastitis are prevented effect.
Phytase: increase profitable strain quantity in poultry body, reduces harmful mycete vivosphere, by the toxicity of enzyme preparation degraded mycotoxin.
Yeast cell wall (glucomannan class): esterification glucomannan (EGM) is extracted by yeast cell wall, can effectively adsorb different types of mycotoxin.Owing to EGM has porous feature, its surface area is relatively big, is conducive to the most rapidly and efficiently absorbing mycotoxin, and therefore addition is low, is that a kind of usage amount is relatively low and the most natural mold toxin sorbent of effect.
Those skilled in the art's general knowledge, combination and the Chinese medicine of Chinese medicine has the most complicated rigorous compatibility effect and theory with the combination of other material compositions, may exist between each component mutual reinforcement between, make mutually, be multiplied, the mutual inhibition, contrary, mutual restraint between two drugs, the relation such as the mutual-detoxication.Even, the content ratio of each component is also the factor of non-the normally off key, and effect of compositions can produce the impact of matter.Therefore, the formulating of a Chinese medicine composition with effect, is a complexity and unordered exploration problem.The present invention is through substantial amounts of exploration and research, with the traditional Chinese medical science, Chinese veterinarian's medicine theory is foundation, make full use of modern medicine, the achievement of veterinary's scientific development, draw modern physics, chemistry, information science advantage, based on the mechanism of action of the compatibility of medicines in a prescription and the science of Compatibility Law of TCM Prescriptions, sum up the reasonable compatibility ratio obtaining each component further, draw the formula of above-mentioned degrading mold toxin adsorbent, not only common mycotoxin multiple in feedstuff is respectively provided with significantly degraded and adsorption dual effect, overcome the problem that existing mold toxin sorbent can only adsorb single kind mycotoxin, and to improving Swinery immunity power, the excretion promoting poisonous substance all has significant effect, weaned piglets is had significant effect, sickness rate can be reduced, improve daily gain, reduce feedstuff-meat ratio.
The method have the advantages that
nullThe invention provides a kind of degrading mold toxin adsorbent，Contain degraded and adsorb the probiotic bacteria of multiple mycotoxin、Vitamin、Mineral、Chinese herbal medicine and enzyme preparation etc.，With the traditional Chinese medical science、Chinese veterinarian's medicine theory is foundation，Make full use of modern medicine、The achievement of veterinary's scientific development，Draw modern physics、Chemistry、Information science advantage，Based on the mechanism of action of the compatibility of medicines in a prescription and the science of Compatibility Law of TCM Prescriptions，Sum up the reasonable compatibility ratio obtaining each component further，Obtained degrading mold toxin adsorbent overcomes the problem that existing mold toxin sorbent can only adsorb single kind mycotoxin，Common mycotoxin multiple in feedstuff is respectively provided with suppression produce、Degraded and absorption multiple action，Especially there is significantly degraded and adsorption dual effect，Enterprise can be effectively helped to reduce the disease harm and economic loss caused because of mycotoxin.
Simultaneously, the degrading mold toxin adsorbent of the present invention is also to improving Swinery immunity power, promoting that the excretion of poisonous substance all has remarkable result, there is comprehensive premium properties, not only it is effectively reduced the elimination mycotoxin harm to animal, growth of animal is not adversely affected, to medicine and other nutrient substance without adsorption.
And, in the degrading mold toxin adsorbent of the present invention, being rich in nutrition property additive, probiotic bacteria etc., have significant effect to weaned piglets, can reduce sickness rate, improves daily gain, improves feed digestibility, reduces feedstuff-meat ratio.
The more important thing is, the degrading mold toxin adsorbent usage amount of the present invention is low and effective, rapidly and evenly can mix in feedstuff；Processing pelletize, expanded, store during have stronger stability；To vitamin, trace element；Having higher stability in the range of wide pH, can be biodegradable after discharge, itself, without pollutant, has good using value for aquaculture.
Detailed description of the invention
Further illustrate the present invention below in conjunction with specific embodiment, but the present invention is not limited in any form by embodiment.Unless stated otherwise, the present invention uses reagent, method and apparatus are the art conventional reagent, method and apparatus.
Unless stated otherwise, agents useful for same of the present invention and material are commercial.
Embodiment
1
1, to prepare the formula of degrading mold toxin adsorbent as follows for the present embodiment:
Each component is respectively as follows: bacillus subtilis (YB4) 15 grams by weight, Lactobacillus plantarum (R1) 10 grams, Lactobacillus acidophilus (R4) 10 grams, leuconostoc lactis 5 grams, Deshi Lactobacillus 5 grams, Lactobacillus fermenti 5 grams and Lactobacillus salivarius 5 grams, vitamin C 10 grams, vitamin E 10 grams, the Radix Astragali 20 grams, zinc methionine 10 grams, 20 grams of potassium chloride, 20 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 10 grams, Herba Artemisiae Scopariae 15 grams, Folium Artemisiae Argyi 20 grams, Herba Artemisiae Annuae 10 grams, Flos Chrysanthemi Indici 20 grams, Semen Plantaginis 15 grams, yeast cell wall 30 grams, phytase 1 gram (content 20000U/g).
2, preparation method: according to formula proportion, by all raw material pulverizing, mixes, is vacuum-packed.
3, using method: degrading mold toxin adsorbent is additionally added in complete feed by 0.2% and (adds 2g degrading mold toxin adsorbent in i.e. every kg feedstuff), the same matched group of feeding and management.
Embodiment
2
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 20 grams by weight, Lactobacillus plantarum (R1) 15 grams, Lactobacillus acidophilus (R4) 15 grams, leuconostoc lactis 10 grams, Deshi Lactobacillus 10 grams, Lactobacillus fermenti 10 grams and Lactobacillus salivarius 10 grams, vitamin C 15 grams, vitamin E 15 grams, the Radix Astragali 25 grams, zinc methionine 15 grams, 25 grams of potassium chloride, 25 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 15 grams, Herba Artemisiae Scopariae 20 grams, Folium Artemisiae Argyi 25 grams, Herba Artemisiae Annuae 15 grams, Flos Chrysanthemi Indici 25 grams, Semen Plantaginis 20 grams, yeast cell wall 40 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
3
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 25 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 20 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 20 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 30 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 50 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
4
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 15 grams by weight, Lactobacillus plantarum (R1) 15 grams, Lactobacillus acidophilus (R4) 15 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 10 grams, vitamin E 20 grams, the Radix Astragali 25 grams, zinc methionine 15 grams, 25 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 10 grams, Herba Artemisiae Scopariae 15 grams, Folium Artemisiae Argyi 25 grams, Herba Artemisiae Annuae 15 grams, Flos Chrysanthemi Indici 25 grams, Semen Plantaginis 25 grams, yeast cell wall 45 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
5
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 20 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 20 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 15 grams, vitamin E 10 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 28 grams of potassium chloride, 28 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 18 grams, Herba Artemisiae Scopariae 18 grams, Folium Artemisiae Argyi 28 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 25 grams, Semen Plantaginis 25 grams, yeast cell wall 35 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
6
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 25 grams by weight, Lactobacillus plantarum (R1) 10 grams, Lactobacillus acidophilus (R4) 10 grams, leuconostoc lactis 5 grams, Deshi Lactobacillus 5 grams, Lactobacillus fermenti 5 grams and Lactobacillus salivarius 5 grams, vitamin C 18 grams, vitamin E 18 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 25 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 25 grams, Semen Plantaginis 25 grams, yeast cell wall 50 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
7
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 18 grams by weight, Lactobacillus plantarum (R1) 18 grams, Lactobacillus acidophilus (R4) 18 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 10 grams, vitamin E 10 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 25 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 25 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 50 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
8
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 22 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 15 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 10 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 5 grams, vitamin C 10 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 28 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 20 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 50 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
9
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 19 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 10 grams, leuconostoc lactis 5 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 5 grams, vitamin C 18 grams, vitamin E 10 grams, the Radix Astragali 26 grams, zinc methionine 16 grams, 30 grams of potassium chloride, 24 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 38 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
10
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 24 grams by weight, Lactobacillus plantarum (R1) 19 grams, Lactobacillus acidophilus (R4) 17 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 10 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 20 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 18 grams, 30 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 18 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 22 grams, Semen Plantaginis 25 grams, yeast cell wall 50 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
11
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 16 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 18 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 20 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 30 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 30 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
12
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 25 grams by weight, Lactobacillus plantarum (R1) 10 grams, Lactobacillus acidophilus (R4) 20 grams, leuconostoc lactis 5 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 10 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 30 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 30 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
13
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 15 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 20 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 20 grams, vitamin E 20 grams, the Radix Astragali 30 grams, zinc methionine 20 grams, 30 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 20 grams, Semen Plantaginis 25 grams, yeast cell wall 48 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
14
The formula that the present embodiment prepares degrading mold toxin adsorbent is as follows:
Each component is respectively as follows: bacillus subtilis (YB4) 20 grams by weight, Lactobacillus plantarum (R1) 20 grams, Lactobacillus acidophilus (R4) 20 grams, leuconostoc lactis 15 grams, Deshi Lactobacillus 15 grams, Lactobacillus fermenti 15 grams and Lactobacillus salivarius 15 grams, vitamin C 20 grams, vitamin E 20 grams, the Radix Astragali 20 grams, zinc methionine 20 grams, 10 grams of potassium chloride, 30 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 20 grams, Herba Artemisiae Scopariae 25 grams, Folium Artemisiae Argyi 30 grams, Herba Artemisiae Annuae 20 grams, Flos Chrysanthemi Indici 30 grams, Semen Plantaginis 25 grams, yeast cell wall 40 grams, phytase 1 gram (content 20000U/g).
Preparation method and using method, with embodiment 1, repeat no more.
Embodiment
15
Degrading mold toxin adsorbent of the present invention adds feedstuff
Test
Substantial amounts of exploration and confirmatory experiment all show, can apply to feedstuff according to the degrading mold toxin adsorbent prepared by the formula of the present invention and add, six kinds of mycotoxins common in pig starter feed are had significant elimination effect；And weaned piglets is had significant effect, sickness rate can be reduced, improve daily gain, reduce feedstuff-meat ratio.Presented below go out part data (embodiment 1,2,3) to support this effect.
1, experimental design
In order to verify the detoxification efficiency of degrading mold toxin adsorbent of the present invention, applicant has carried out the feeding experiment of 7 days by a definite date in April, 2012 on pig farm.
(1) packet: test uses the design of single factor test contrast test, and 120 30 age in days piglets are randomly divided into 3 test group and 1 matched group, and often group includes 30 piglets.
Matched group: basal diet；
Test group (i.e. embodiment group): the degrading mold toxin adsorbent of embodiment 1,2,3, as additive, adds in the basal diet identical with matched group；Addition is 2g/kg.
(2) method: the 8th day morning fed front blood, and separated plasma is cooked efficient liquid phase Mass Spectrometer Method.The production performance of piglet is added up from 30 ages in days to 60 ages in days.Results contrast is carried out with biological statistical method.
2, result of the test shows:
(1) as shown in table 1, compared with matched group, add degrading mold toxin adsorbent of the present invention, six kinds of mycotoxins common in pig starter feed are had significant elimination effect.
It addition, embodiment 2,3 groups has pole significant difference compared with matched group, there were significant differences with matched group for embodiment 1, and embodiment 2 groups is not significantly different from embodiment 3 groups.
Comparatively speaking, the effect of embodiment 3 is compared with more preferable (difference is the most notable) of embodiment 2, it is contemplated that composite factors such as costs, the most preferably select in actual application is the formula of embodiment 2 groups.
Table 1 uses the impact (ng/mL) of mold toxin sorbent feedstuff mycotoxin common on piglet blood plasma
Note: with column data shoulder mark same letter or not notable (P ＞ 0.05) without letter representation difference, different letter representation significant differences (P ＜ 0.05).
(2) as shown in table 2, relatively each test group is visible with matched group weaned piglets, and the feedstuff adding degrading mold toxin adsorbent of the present invention has significant effect to weaned piglets, can reduce sickness rate, improves daily gain, reduces feedstuff-meat ratio.
Wherein embodiment 2,3 groups has pole significant difference, embodiment 2 groups to be not significantly different from embodiment 3 groups compared with matched group.
Comparatively speaking, the effect of embodiment 3 is compared with more preferable (difference is the most notable) of embodiment 2, it is contemplated that composite factors such as costs, the most preferably select in actual application is the formula of embodiment 2 groups.
Table 2 uses the mildew-doffing agent feedstuff impact on weaned piglets
Note: with column data shoulder mark same letter or not notable (P ＞ 0.05) without letter representation difference, different letter representation significant differences (P ＜ 0.05).
Claims (9)
1. a degrading mold toxin adsorbent, it is characterised in that be made up of probiotic bacteria, vitamin, mineral, Chinese herbal medicine, yeast cell wall and phytase；
Described probiotic bacteria be bacillus subtilis (Bacillus subtilis), Lactobacillus plantarum (Lactobacillus plantarum), Lactobacillus acidophilus (Lactobacillus acidophilus), leuconostoc lactis (Leuconostoc lactis), Deshi Lactobacillus (Lactobacillus delbrueckii), Lactobacillus fermenti (lactobacillus fermentum) and Lactobacillus salivarius (Lactobacillus salivarius) mixture；
Described vitamin is the mixture of vitamin C and vitamin E；Described mineral is the mixture of zinc methionine and potassium chloride；Described Chinese herbal medicine is the mixture of the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli, Herba Artemisiae Scopariae, Folium Artemisiae Argyi, Herba Artemisiae Annuae, Flos Chrysanthemi Indici and Semen Plantaginis.
The most according to claim 1, degrading mold toxin adsorbent, it is characterised in that to account for the mass ratio range of gross weight, be grouped into by the one-tenth of following weight meter:
Bacillus subtilis 15～25 parts, Lactobacillus plantarum 10～20 parts, Lactobacillus acidophilus 10～20 parts, leuconostoc lactis 5～15 parts, Deshi Lactobacillus 5～15 parts, Lactobacillus fermenti 5～15 parts, Lactobacillus salivarius 5～15 parts, vitamin C 10～20 parts, vitamin E 10～20 parts, the Radix Astragali 20～30 parts, zinc methionine 10～20 parts, potassium chloride 20～30 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 20～30 parts, Flos Caryophylli 10～20 parts, Herba Artemisiae Scopariae 15～25 parts, Folium Artemisiae Argyi 20～30 parts, Herba Artemisiae Annuae 10～20 parts, Flos Chrysanthemi Indici 20～30 parts, Semen Plantaginis 15～25 parts, yeast cell wall 30～50 parts and phytase 20000U/g；
Wherein, described bacillus subtilis is YB4, and described Lactobacillus plantarum is R1, and described Lactobacillus acidophilus is R4.
The most according to claim 1, degrading mold toxin adsorbent, it is characterised in that to account for the mass ratio range of gross weight, be grouped into by the one-tenth of following weight meter:
Bacillus subtilis 20 ~ 25 parts, Lactobacillus plantarum 15 ~ 20 parts, Lactobacillus acidophilus 15 ~ 20 parts, leuconostoc lactis 10 ~ 15 parts, Deshi Lactobacillus 10 ~ 15 parts, Lactobacillus fermenti 10 ~ 15 parts and Lactobacillus salivarius 10 ~ 15 parts, vitamin C 15 ~ 20 parts, vitamin E 15 ~ 20 parts, the Radix Astragali 25 ~ 30 parts, zinc methionine 15 ~ 20 parts, 25 ~ 30 parts of potassium chloride, 25 ~ 30 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Caryophylli 15 ~ 20 parts, Herba Artemisiae Scopariae 20 ~ 25 parts, Folium Artemisiae Argyi 25 ~ 30 parts, Herba Artemisiae Annuae 15 ~ 20 parts, Flos Chrysanthemi Indici 25 ~ 30 parts, Semen Plantaginis 20 ~ 25 parts, yeast cell wall 40 ~ 50 parts and phytase 20000U/g；
Wherein, described bacillus subtilis is YB4, and described Lactobacillus plantarum is R1, and described Lactobacillus acidophilus is R4.
4., according to the arbitrary described degrading mold toxin adsorbent of claims 1 to 3, it is characterised in that described leuconostoc lactis, Deshi Lactobacillus, Lactobacillus fermenti and Lactobacillus salivarius are chicken intestinal normal flora, it is to be separated amplification extraction by chicken intestinal content and obtain.
5. the arbitrary described degrading mold toxin adsorbent of claims 1 to 3 is as the application in terms of feed additive.
Apply the most according to claim 5, it is characterised in that described feedstuff is pig's feed.
7. an improvement pig's feed, it is characterised in that be to add the arbitrary described degrading mold toxin adsorbent of claims 1 to 3 in pig normal feedstuff to obtain.
Improve pig's feed the most according to claim 7, it is characterised in that the addition of described degrading mold toxin adsorbent is 1～10g/kg normal feedstuff.
Improve pig's feed the most according to claim 8, it is characterised in that the addition of described degrading mold toxin adsorbent is 2g/kg normal feedstuff.
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