CN104288652B - 具有解酒保健功效的中药组合物及其制备方法和应用 - Google Patents
具有解酒保健功效的中药组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开一种具有解酒保健功效的中药组合物及其制备方法和应用。所述中药组合物,其有效成分主要由如下重量份的原料制备而成:枳椇子5‑15份,葛根5‑15份,葛花0.5‑7.5份,陈皮0.5‑7.5份,神曲1‑10份,麦芽1‑10份,焦山楂1‑10份,柞木根5‑15份,砂仁0.4‑7份,莱菔子0.8‑9份,茯苓1‑10份。本发明所述中药组合物,原料采用纯中药,按照君臣佐使的中药理论配伍而成,具有解酒毒,止渴除烦,健脾和胃、疏肝行气,利水渗湿,宁心的功效。经实验验证,本发明所述具有解酒保健功效的中药组合物,能够有效延长醉酒潜伏期,缩短醉酒后昏睡时间,提高乙醇脱氢酶和乙醛脱氢酶活性。
Description
技术领域
本发明涉及保健食品领域,特别是涉及一种具有解酒保健功效的中药组合物及其制备方法和应用。
背景技术
中国的酒文化历史悠久,饮酒有几千年的传统历史,有近五亿酒民。酒的主要成份是酒精,化学名叫乙醇。乙醇进入人体,能产生多方面的破坏作用。血液中的乙醇浓度达到0.05%时,出现兴奋和欣快感;当血中乙醇浓度达到0.1%时,人就会失去自制能力;如达到0.2%时,人已到了酩酊大醉的地步;达到0.4%时,人就可失去知觉,昏迷不醒,甚至有生命危险。酒精对人中枢神经系统、肝脏系统和生殖系统具有较大的危害。可导致多发性神经炎、心肌病变、脑病变、造血功能障碍、胰腺炎、胃炎和溃疡病、酒精肝硬化、高血压、喉癌、消化道癌、生殖能力下降等病症。
目前,解酒药大体可以分为化学药品和中药制剂,化学药品会对肝脏、肾脏造成代谢负担,副作用较大,而中药制剂虽副作用小,但见效缓慢,疗效不甚明显。
发明内容
基于此,本发明的目的在于克服现有技术的缺陷,提供一种具有解酒保健功效的中药组合物及其制备方法和应用。
为实现上述目的,本发明采取以下技术方案:
一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子5-15份,葛根5-15份,葛花0.5-7.5份,陈皮0.5-7.5份,神曲1-10份,麦芽1-10份,焦山楂1-10份,柞木根5-15份,砂仁0.4-7份,莱菔子0.8-9份,茯苓1-10份。
在其中一个实施例中,其有效成分主要由如下重量份的原料制备而成:
枳椇子7-13份,葛根7-13份,葛花0.5-5.5份,陈皮0.5-5.5份,神曲2-8份,麦芽2-8份,焦山楂2-8份,柞木根7-13份,砂仁0.4-5份,莱菔子1-7份,茯苓2-8份。
在其中一个实施例中,其有效成分主要由如下重量份的原料制备而成:
枳椇子9-11份,葛根9-11份,葛花2-3份,陈皮2-3份,神曲4-6份,麦芽4-6份,焦山楂4-6份,柞木根9-11份,砂仁1-3份,莱菔子3-5份,茯苓4-6份。
本发明还提供所述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,混合;
置于提取罐中,加入乙醇或水提取;或,
粉碎后,置于超声提取器中,加入水或乙醇超声提取;
收集提取液,过滤,所得滤液浓缩后,干燥,得干膏,即得所述具有解酒保健功效的中药组合物。
在其中一个实施例中,将所述干膏加入药学上可接受的载体制成常规制剂,即得所述具有解酒保健功效的中药组合物。
在其中一个实施例中,所述加入水提取的方法为加入所述原料重量5-7倍的水煎煮提取1-3次。
在其中一个实施例中,所述加入乙醇提取的方法为加入所述原料重量5-7倍的体积浓度为20-45%的乙醇溶液提取1-3次。
在其中一个实施例中,所述加入水或乙醇超声提取的方法为加入所述原料重量5-7倍的水或体积浓度为40-50%的乙醇溶液超声1-3次,每次0.5-1小时。
在其中一个实施例中,所述浓缩的方法为将所述滤液于55℃~65℃浓缩至相对密度为1.05-1.25。
本发明还提供上述具有解酒保健功效的中药组合物在制备具有解酒保健功效的保健品中的应用。
本发明的原理及优点如下:
本发明所采用的原料药理如下:
枳椇子:解酒毒,止渴除烦,止呕,利大小便。用于醉酒,饭客,呕吐,二便不利。现代研究表明枳椇子具有抑制中枢神经,降血压和阻止乙醇所致的肝脏丙二醇升高和谷胱肽的下降,并能对抗乙醇所致的胆固醇、三油酸甘油酯增高,减轻肝脏胶原纤维增生程度。
葛根:生津止渴,升阳止泻,通经活络,解酒毒。用于头痛,项背强痛,口渴,泄泻,眩晕头痛,胸痹心痛,酒毒伤中。
葛花:治头晕,解酒醒脾,酒痢,饮食不思。
陈皮:理气健脾,燥湿化痰。用于食少吐泻。
麦芽:行气消食,健脾和胃,疏肝行气,用于食积不消,脘腹胀痛,脾虚食少,肝郁胁痛,肝胃气痛。同时有研究表明麦芽可刺激生殖性腺轴从而提高性腺激素水平,增强繁殖能力。麦芽纤维可明显改善溃疡性结肠炎小鼠结肠炎的发展。
焦山楂:消食健胃,行气散瘀,化浊降脂。用于肉食积滞,泻痢不爽。
砂仁:湿开胃,温脾止泻,理气,消积食。用于湿浊中阻,脘痞不饥,脾胃虚寒,呕吐泄泻。
莱菔子:辛、甘、平。消食除胀,降气化痰。用于饮食停滞,脘腹胀痛,大便秘结,积滞泻痢。
茯苓:利水渗湿,健脾,宁心。用于水肿尿少,脾虚食少,便溏泄泻,心神不安,惊悸失眠。同时有研究表明,茯苓对肝癌具有抗增殖和促凋亡作用,茯苓水煎剂还具有改善糖代谢和肾功能,保护肾脏的作用。
柞木根:解毒,利湿,散瘀,消肿止痛。
神曲:健脾和胃,消食调中,其功专于消化谷麦酒积。
本发明所述具有解酒保健功效的中药组合物,采用上述纯中药为原料,按照君臣佐使的中药理论配伍而成,克服了单味药效果单一的不足,增强药效,多方面调控,以达到解酒保健之功效:以枳椇子、葛根、葛花为君药,具有清热利尿,止咳除烦,解酒毒之功效;添加陈皮、神曲、麦芽、焦山楂为臣药,理气健脾、消积食、化浊降脂;添加柞木根为佐药,具有解毒散瘀之功效;以茯苓、砂仁、莱菔子为使药,利水渗湿、宁心行气。诸药合用,共筑解酒保健之功效。
与现有技术相比,本发明具有以下有益效果:
1、本发明所述具有解酒保健功效的中药组合物,原料采用枳椇子,葛根,葛花,陈皮,神曲,麦芽,焦山楂,柞木根,砂仁,莱菔子,茯苓等中药材,按照君臣佐使的中药理论配伍而成,具有解酒毒,止渴除烦,健脾和胃、疏肝行气,利水渗湿,宁心的功效。经药效实验验证,本发明所述具有解酒保健功效的中药组合物,能够有效延长醉酒潜伏期,缩短醉酒后昏睡时间,提高乙醇脱氢酶和乙醛脱氢酶活性,具有显著的解酒功效。
2、本发明所述具有解酒保健功效的中药组合物的制备方法,简单易操作。
具体实施方式
以下结合具体的实施例对本发明所述具有解酒保健功效的中药组合物及其制备方法和应用作进一步说明。
实施例1
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子10份,葛根10份,葛花2.5份,陈皮2.5份,神曲5份,麦芽5份,焦山楂5份,柞木根10份,砂仁2份,莱菔子4份,茯苓5份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合;
置于提取罐中,加入所述原料重量6倍的水煎煮提取2次;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例2
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子15份,葛根15份,葛花7.5份,陈皮7.5份,神曲10份,麦芽10份,焦山楂10份,柞木根15份,砂仁7份,莱菔子8份,茯苓10份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合;
置于提取罐中,加入所述原料重量5倍的水煎煮提取3次;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例3
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子5份,葛根5份,葛花0.5份,陈皮0.5份,神曲1份,麦芽1份,焦山楂1份,柞木根5份,砂仁0.4份,莱菔子0.8份,茯苓1份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合;
置于提取罐中,加入所述原料重量7倍的水煎煮提取1次;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例4
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子10份,葛根10份,葛花2.5份,陈皮2.5份,神曲5份,麦芽5份,焦山楂5份,柞木根10份,砂仁2份,莱菔子4份,茯苓5份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合;
置于提取罐中,加入所述原料重量6倍的体积浓度为30%的乙醇溶液提取2次;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例5
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子10份,葛根10份,葛花2.5份,陈皮2.5份,神曲5份,麦芽5份,焦山楂5份,柞木根10份,砂仁2份,莱菔子4份,茯苓5份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合,粉碎成粗粉;
置于超声提取器中,加入所述原料重量6倍的水超声2次,每次为0.5小时;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例6
本实施例一种具有解酒保健功效的中药组合物,其有效成分主要由如下重量份的原料制备而成:
枳椇子10份,葛根10份,葛花2.5份,陈皮2.5份,神曲5份,麦芽5份,焦山楂5份,柞木根10份,砂仁2份,莱菔子4份,茯苓5份。
上述具有解酒保健功效的中药组合物的制备方法,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,充分混合,粉碎成粗粉;
置于超声提取器中,加入所述原料重量6倍量45%乙醇超声2次,每次为1小时;
收集提取液,过滤,所得滤液于55℃-65℃浓缩至相对密度为1.05-1.25(测量温度55℃-65℃),干燥得干膏,即得所述具有解酒保健功效的中药组合物。
实施例7
将实施例1所述具有解酒保健功效的中药组合物加入乳糖、淀粉和倍他环糊精,制成颗粒剂。
实施例8
实施例7所述颗粒剂的翻正反射实验。
实验方案:
分组:将50只ICR雄性小鼠随机平均分为A-空白对照组、B-模型对照组、C-高剂量组、D-中剂量组和E-高剂量组。
处理:试验前,所有小鼠禁食一夜(12h),不禁水。然后,A组不做处理,B组灌胃生理盐水0.2mL/20g,C-E组灌胃药物(根据小鼠体重,按高剂量4945.65mg/kg、中剂量3709.24mg/kg、低剂量2472.83mg/kg将实施例7所述颗粒剂溶解于纯水分别配成药液,进行灌胃),30min后,B-E组小鼠灌胃56度红星二锅头0.3mL/20g,以小鼠翻正反射消失为观察指标,即将小鼠背向下轻轻放在动物笼里,若仰位姿势保持30s以上,则认为翻正反射消失。
实验期间,A组小鼠活动正常,B-E组小鼠从灌酒到翻正反射消失的潜伏时间(T1)和翻正反射恢复时间(T2)如表1所示。
表1
结果表明,与模型对照组比较,高、中、低剂量组的小鼠潜伏时间(T1)和翻正反射恢复时间(T2)分别被显著推迟和缩短,由此说明本发明所述具有解酒保健功效的中药组合物显著推迟了小鼠醉倒时间,缩短了小鼠昏睡时间。
实施例9
实施例7所述颗粒剂的药效实验。
实验方案:
分组:130只ICR小鼠随机分组如下:
模型对照组A:分为A1-A3,3个小组,每小组10只;
样本试验组B:分为B1-B3,3个小组,每小组30只,分别均分为高、中、低剂量组,每组10只;
空白对照组10只。
处理:空白对照组不作处理,A组灌胃生理盐水,0.2mL/20g,B组灌胃药物(根据小鼠体重,将实施例7所述颗粒剂溶解于纯水分别配成药液,按高剂量4945.65mg/kg、中剂量3709.24mg/kg、低剂量2472.83mg/kg体重,进行灌胃)。30min后,A组和B组灌胃酒精,A1和B1组小鼠于灌酒后1h摘眼球取血,同时取肝脏;A2和B2组小鼠于灌酒后2h摘眼球取血,同时取肝脏;A3和B3组小鼠于灌酒后3h取肝脏。
(1)小鼠血液中乙醇含量测定:
两次取血均于1.5mL离心管中,加肝素钠抗凝,于37℃水浴静置15min,3000r/min离心15min,得血浆。按照血液乙醇测定试剂盒(长春汇力生物技术有限公司提供)的要求用全自动生化分析仪测定小鼠血液中的乙醇含量。用spss分析软件比较分析模型对照组A与样本试验组B小鼠的血液乙醇体积浓度差异,结果如表2所示。
表2
实验结果表明,与模型对照组比较,本发明所述具有解酒保健功效的中药组合物的高剂量和中剂量能够显著降低酒后两小时内血液乙醇含量。
(2)小鼠肝脏组织中乙醇脱氢酶与乙醛脱氢酶的总活性测定:
三次取肝脏组织,分别制备10%匀浆液,按照乙醇脱氢酶(ADH酶)与乙醛脱氢酶(ALDH酶)的总活性比色法定量检测试剂盒的要求,进行乙醇脱氢酶与乙醛脱氢酶的总活性检测,结果如表3所示。
表3
实验结果表明,与模型对照组比较,本发明所述具有解酒保健功效的中药组合物的高剂量能够显著提高乙醇脱氢酶(第一酶)活性,最大提高16.77%;中剂量能够显著提高乙醛脱氢酶(第二酶)活性,最大提高32.39%。
综上所述,本发明所述具有解酒保健功效的中药组合物可以显著延长醉酒潜伏期,缩短醉酒后昏睡时间,并显著降低酒后两小时内血液乙醇含量;能够有效提高乙醇脱氢酶与乙醛脱氢酶的总活性,具有显著的解酒保健功效。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (10)
1.一种具有解酒保健功效的中药组合物,其特征在于,其有效成分由如下重量份的原料制备而成:
枳椇子5-15份,葛根5-15份,葛花0.5-7.5份,陈皮0.5-7.5份,神曲1-10份,麦芽1-10份,焦山楂1-10份,柞木根5-15份,砂仁0.4-7份,莱菔子0.8-9份,茯苓1-10份。
2.根据权利要求1所述的具有解酒保健功效的中药组合物,其特征在于,其有效成分由如下重量份的原料制备而成:
枳椇子7-13份,葛根7-13份,葛花0.5-5.5份,陈皮0.5-5.5份,神曲2-8份,麦芽2-8份,焦山楂2-8份,柞木根7-13份,砂仁0.4-5份,莱菔子1-7份,茯苓2-8份。
3.根据权利要求2所述的具有解酒保健功效的中药组合物,其特征在于,其有效成分由如下重量份的原料制备而成:
枳椇子9-11份,葛根9-11份,葛花2-3份,陈皮2-3份,神曲4-6份,麦芽4-6份,焦山楂4-6份,柞木根9-11份,砂仁1-3份,莱菔子3-5份,茯苓4-6份。
4.权利要求1-3任一项所述具有解酒保健功效的中药组合物的制备方法,其特征在于,包括如下步骤:
称取所述重量份的枳椇子、葛根、葛花、陈皮、神曲、麦芽、焦山楂、柞木根、砂仁、莱菔子和茯苓,混合;
置于提取罐中,加入乙醇或水提取;或,
粉碎后,置于超声提取器中,加入水或乙醇超声提取;
收集提取液,过滤,所得滤液浓缩后,干燥,得干膏,即得所述具有解酒保健功效的中药组合物。
5.根据权利要求4所述的具有解酒保健功效的中药组合物的制备方法,其特征在于,将所述干膏加入药学上可接受的载体制成常规制剂,即得所述具有解酒保健功效的中药组合物。
6.根据权利要求4所述的具有解酒保健功效的中药组合物的制备方法,其特征在于,所述加入水提取的方法为加入所述原料重量5-7倍的水煎煮提取1-3次。
7.根据权利要求4所述的具有解酒保健功效的中药组合物的制备方法,其特征在于,所述加入乙醇提取的方法为加入所述原料重量5-7倍的体积浓度为20-45%的乙醇溶液提取1-3次。
8.根据权利要求4所述的具有解酒保健功效的中药组合物的制备方法,其特征在于,所述加入水或乙醇超声提取的方法为加入所述原料重量5-7倍的水或体积浓度为40-50%的乙醇溶液超声1-3次,每次0.5-1小时。
9.根据权利要求4-8任一项所述的具有解酒保健功效的中药组合物的制备方法,其特征在于,所述浓缩的方法为将所述滤液于55℃~65℃浓缩至相对密度为1.05-1.25。
10.权利要求1-3任一项所述具有解酒保健功效的中药组合物在制备具有解酒保健功效的保健品中的应用。
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