CN104288415A - Traditional Chinese medicine composition for treating phthisis as well as preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating phthisis as well as preparation method and application thereof Download PDF

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CN104288415A
CN104288415A CN201410554542.3A CN201410554542A CN104288415A CN 104288415 A CN104288415 A CN 104288415A CN 201410554542 A CN201410554542 A CN 201410554542A CN 104288415 A CN104288415 A CN 104288415A
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herba
chinese medicine
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李正梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Abstract

The invention provides a traditional Chinese medicine composition for treating phthisis. The traditional Chinese medicine composition is prepared from the following materials in parts by weight: 14 parts of cluster mallow fruit, 11 parts of emblic leafflower fruit, 15 parts of rhizome panacis majoris, 10 parts of entada phaseoloides, 12 parts of beefwood-like clubmoss herb, 14 parts of phoenix tail fern, 15 parts of caulophyllum robustum, 12 parts of Chinese alpine rush, 15 parts of Japanese violet herb or root, 9 parts of clerodendrum trichotomum, 11 parts of erodium stephanianum willd, 14 parts of lrkutsk anemone rhizome, 11 parts of evodia lepta, 13 parts of callicarpa macrophylla, 9 parts of hybridum linn, 12 parts of flying bandit, 14 parts of euphorbia hypericifolia, 14 parts of desmodium microphyllum, 16 parts of red psychotria leaf, 11 parts of Japanese snake gourd root, 6 parts of libanotis buethorimensis, 13 parts of pagoda flower and 15 parts of pteris semipinnata. The traditional Chinese medicine composition can be used for treating phthisis.

Description

One treats phthisical Chinese medicine composition and preparation method and application
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to one and treat phthisical Chinese medicine composition and preparation method and application.
Background technology
Tuberculosis is the chronic infectious disease caused by mycobacterium tuberculosis, can invade and many internal organs, infects the most common with pulmonary Mycobacterium.Excreter is its important source of infection.Not necessarily fall ill after human infection tulase, when resistance reduces or cell-mediated allergy increases, just may cause clinical onset.If can diagnose in time, and give rational therapy, mostly clinical recovery can be obtained.Have closer tuberculosis contact history, onset can suddenly can be delayed, and mostly is low grade fever (afternoon for work), night sweat, weak, poor appetite, becomes thin, female menstrual disorder etc.; Respiratory symptom has cough, expectoration, spitting of blood, chest pain, in various degree uncomfortable in chest or dyspnea.Physical signs of lung is different and variant according to state of an illness weight, extent of disease, and tuberculosis in early days, among a small circle not easily finds positive sign, and the wider person's percussion of extent of disease be voiced sound, vocal fremitus enhancing, the low and moist rales of vesicular breathing sound.Late period, tuberculosis formed fibrosis, and local contraction makes pleura subside and mediastinal displacement.Have pleuritic rub in early days tuberculous pleuritis person, when forming a large amount of hydrothorax, thoracic wall is full, the turbid reality of percussion, and vocal fremitus and respiratory murmur lower or disappear.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide one to treat phthisical Chinese medicine composition and preparation method and application.
Technical scheme: the object of the invention is by following scheme realize:
One treats phthisical Chinese medicine composition, and it is prepared by the raw material of following parts by weight: Fructus Malvae 14 parts, Fructus Phyllanthi 11 parts, Rhizoma Panacis Majoris 15 parts, Caulis Entadae 10 parts, Lycopodium casuarinoides Spring 12 parts, Herba Pteridis Multifidae 14 parts, Radix Caulophylli 15 parts, large Herba Kylligac coloratae 12 parts, Herba Violae japonicae 15 parts, clerodendron trichotomum 9 parts, geranium 11 parts, Rhizoma Anemones Altaicae 14 parts, Foliumet Ramulus Evodiae 11 parts, Folium Callicarpae Macrophyllae 13 parts, great Ye Herba chenopodii 9 parts, Caulis cyatheae spinulosae 12 parts, logical Herba Euphorbiae Humifusae 14 parts, Herba desmodii microphylli 14 parts, Red Psychotria Leaf 16 parts, Radix Trichosanthis Cucumeroidis 11 parts, Radix Libanotidis buchotomensis 6 parts, pagoda spend 13 parts, Herba Pteridis Semipinnatae 15 parts.
The application of the phthisical Chinese medicine composition of described treatment in preparation treatment tuberculosis drugs.
In the present invention, Fructus Malvae is the dry mature fruit of Malvaceae plant Semen Abutili Malva verticillata L..Gather when summer, autumn two season fruit maturation, removing impurity, dries in the shade.Clearing away heat and promoting diuresis, detumescence.For urine retention, edema, thirsty; Urinary tract infection.
Fructus Phyllanthi is the dry mature fruit of Euphorbiaceae phyllanthus emblica platymiscium Fructus Phyllanthi Phyllanthus emblica L..Winter gathers to during secondary spring fruit maturation, removing impurity, dry.Clearing away heat and cooling blood, promoting digestion and invigorating the stomach, cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, liver-gallbladder disease, dyspepsia, stomachache, cough, laryngalgia, xerostomia.
Rhizoma Panacis Majoris derives from Araliaceae, Panax, the dry root stock of Panax pseudoginseng Wall. Subgenus Rhizoma Panacis Majoris Panax pseudoginseng Wall.var.major (Burkill) H.L.Li, tonifying the lung, and yin nourishing is active, hemostasis.For deficiency of both QI and YIN, dysphoria with smothery sensation is thirsty, cough due to consumptive disease, injury from falling down, arthralgia, hemoptysis, spits blood, traumatic hemorrhage.
Caulis Entadae is herb or the spore of lycopsid bar helictite, Latin plant name: Diphasiastrum complanatum (L.) Holub. [Lycopodium complanatum L., treatment summer-heat dysentery, Sunstroke generates heat; dysuria, acute toothache, infantile measles; External treatment sores ulceration of skin pyretic toxicity, erysipelas, flies infections skin ulcer, flies Serpentis ovum.The present invention is with all herbal medicine.
Lycopodium casuarinoides Spring, Latin literary fame: Lycopodiastrum casuarinoides (Spring) Holub ex Dixit.Belong to Lycopodiales, the large-scale autochthonal plant of Lycopodiaceae.The wooden rattan shape of stem on the ground, extends to climb up by holding on to and reaches several meters, cylindrical, leaf helical arrangement, adhesion, and ovum shape lanceolar is to boring shape, and summer, autumn gather, using fresh herb or dry.Under being born in the sylvan life of height above sea level 100-3100 rice, border, shrubbery or ditch Region In Yanbian, the Chinese East China that distributes, south China, Central China and southwestern most of provinces and regions are many.Relaxing muscles and tendons to promote blood circulation, wind-damp dispelling.For rheumatic arthritis, traumatic injury, menoxenia.The present invention is with all herbal medicine.
Herba Pteridis Multifidae is a kind of pteridophyta, belongs to Pteridaceae, Pteris.Formal name used at school Pteris multifda poir.Happiness growth is at concealment, moistening, warm place.Also drought-enduring, in southern winter, the plant arid in warp-February grown in crack of stone, still unlikely completely withered.The main product Yangtze river basin and on the south each province, district, the north Shaanxi, Hebei, Shandong etc. economize also have distribution.Tonifying blood and regulating menstruation, yin nourishing.For menoxenia, deficiency of YIN hectic fever, has a dizzy spell, women's asthenia.The present invention is with all herbal medicine.
Radix Caulophylli is the root and rhizome of Berberidaceae plant Radix Caulophylli Caulopyhllum robustum.Because its fibrous root is many carefully in aubergine, therefore obtain this name.Radix Caulophylli is perennial herb.Root stock is sturdy, horizontal walk, above the many aubergine fibrous roots of close life.Regulating QI to relieve pain, expelling wind and activating blood circulation.For menoxenia, stomach abdomen pain, traumatic injury, rheumatalgia.
Large Herba Kylligac coloratae is the herb of sedge Herba Rhynchosporae Rubrae.Latin plant animal mineral name: Rhynchospora rubra (Lour.) Makino., gathers and stores: summer, autumn gather, and cleans, dries.Wind and heat dispersing; Dampness removing is treating stranguria.Main anemopyretic cold; Cough; Headache; Stranguria with turbid discharge.
Herba Violae japonicae derives from viola inconspicua Blume V.inconspicua Blume, with all herbal medicine.Gather herb when Xia Qiu is bloomed, dry.Meridian distribution of property and flavor: bitter, micro-pungent, cold.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.
Clerodendron trichotomum, Latin is called Clerodendrum trichotomum Thunb. root, stem, leaf, spends and be used as medicine, remove rheumatism, blood pressure lowering.Root, leaf: rheumatic arthritis, hypertension, dysentery, malaria.Leaf: the tinea manuum is controlled in external, paddy-field dermatitis, eczema, hemorrhoid.The present invention is with all herbal medicine.
Geranium is the aerial parts of Niu Er Seedling section plant cattle Seedling ErodiumstephnaianumWilld., and summer and autumn gathers.Remove rheumatism.For rheumatic arthralgia.
Rhizoma Anemones Altaicae is the rhizome of Ranunculaceae herbaceos perennial anemone altaica (Anemone altaica Fisch.), has expectorant of having one's ideas straightened out, a function of being amusing of calming the nerves., inappetence vexed for calentura stupor, epilepsy, neurosis, Hiccough and deaf, breast abdominal distention.Carbuncle skin ulcer tinea is controlled in external.
Foliumet Ramulus Evodiae derives from Rutaceae Evodia plant Foliumet Ramulus Evodiae Evodia lepta (Spreng.) Merr., is used as medicine with root and leaf.The whole year can adopt, and root is cleaned, and section is dried for subsequent use; Leaf dries in the shade for subsequent use.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Control the diseases such as laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis, traumatic injury and worm venom.
Folium Callicarpae Macrophyllae is Herba Verbenae Callicarpa plant Folium Callicarpae Macrophyllae Callicarpa macrophylla Vahl, is used as medicine with root and leaf.Summer, autumn picking leaves, clean using fresh herb or dry and grind into powder for subsequent use; The whole year all can adopt root, and section, dries.Dissipating blood stasis stops blooding, reducing swelling and alleviating pain.Leaf: for spitting blood, spitting of blood, epistaxis, has blood in stool; External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.
Great Ye Herba chenopodii derives from Chenopodiaceae genus Chenopodium and mixes and join the herb of Herba chenopodii Chenopodium hybridum L., extracts wounded in the battle, fruit herb the 6-8 month, using fresh herb or chopping, regulating menstruation, hemostasis.For menoxenia, dysfunctional uterine hemorrhage, spits blood, epistaxis, spitting of blood, hematuria.
Caulis cyatheae spinulosae is Cyatheaceae Caulis cyatheae spinulosae platymiscium Caulis cyatheae spinulosae Cyathea spinulosa Wall., is used as medicine with trunk.The whole year can adopt, and the hard crust of trunk of pruning, section is dried.Expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, clearing and antitussive.For rheumatic arthritis, traumatic injury, chronic bronchitis, cough due to lung-heat, oedema due to nephritis, prevention influenza; Put on the skin outside juice in stem and control ringworm.
Logical Herba Euphorbiae Humifusae, formal name used at school: Euphorbia hypericifolia is the plant of Euphorbiaceae Euphorbia.Be distributed in the ground such as Hainan, Jiangxi, Sichuan, Guizhou, Hunan, Guangxi, Guangdong, Yunnan of the torrid zone, the island of Taiwan, subtropical zone and China's Mainland, be grown on height above sea level 30 meters to 2, the area of 100 meters, normal growth is in shrubbery, wasteland, wilderness, roadside or field, at present by artificial introducing and planting: clearing away heat-damp and promoting diuresis, restrain antipruritic.Bacillary dysentery, enteritis, diarrhea, bleeding hemorrhoids; Eczema is controlled in external, allergic dermatitis, skin pruritus.The present invention is with all herbal medicine.
Herba desmodii microphylli is pulse family, beggar-ticks, herbaceos perennial.Be born in the thick grass of wasteland or in spinney.Classification system: Desmodium microphyllum (Thunb.) DC. invigorating spleen to remove dampness, relieving cough and asthma, removing toxic substances and promoting subsidence of swelling.For infantile malnutrition, jaundice, dysentery, cough, asthma, bronchitis; Venom is controlled in external, and carbuncle skin ulcer is festered, dermatitis rhus, hemorrhoid.The present invention is with all herbal medicine.
Red Psychotria Leaf is Rubiaceae Psychotria rubra (Lour.) Poir. platymiscium Psychotria rubra (Lour.) Poir. Psychotria rubra (Lour.) Poir., is used as medicine with root, leaf.Annual collection, using fresh herb or clean section are dried.Heat-clearing and toxic substances removing, detumescence and drawing out poison.Root, leaf: diphtheria, tonsillitis, pharyngolaryngitis, dysentery, ileotyphus, stomachache, rheumatic ostalgia; Leaf: treating swelling and pain by traumatic injury is controlled in external, traumatic hemorrhage, venom, sore swollen toxin, ulcer of the lower limb.The present invention is with all herbal medicine.
Radix Trichosanthis Cucumeroidis is the root of cucurbitaceous plant Fructus Trichosanthis Cucumeroidis, heat-clearing and toxic substances removing, inducing diuresis to remove edema, eliminating stasis to stop pain.For venom, acute tonsillitis, pharyngolaryngitis, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysuria, stomachache.
Radix Libanotidis buchotomensis is the root of samphire rock wind, bar wind and gray wool rock wind, and perennial herb, normal Herb is by Lycoperdon polymorphum Vitt pubescence.Collar longizationer, upper end retains most withered sheath.Wooden in undershrub shape; Root can be used as medicine, and has relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, effect of dispelling, collateral-activating.Classification system: Libanotis spodotrichoma K.T.Fu, delivers cold expelling, dispelling, collateral-activating.For flu, cough, headache, toothache, Fengshi Guanjie pain, traumatic injury.The present invention is with all herbal medicine.
Pagoda flower is the herb of labiate C. gracile Clinopodium gracile (Benth.) Matsumra.Dispelling wind to relieve the exterior syndrome, expelling phlegm for arresting cough, scattered silt pain relieving.For upper respiratory tract infection, pertussis, bronchitis, rheumatic arthritis, gastroenteritis, treating swelling and pain by traumatic injury, puerperal abdominalgia with blood stasis; Venom is controlled in external, eczema, skin itching.
Herba Pteridis Semipinnatae is one of plant in Pteridaceae Polypodiales.The uprightly short or tiltedly life of stem, tool scale, leafage is raw; The long 20-35 centimetre of petiole, bronzing; Petiole ovum shape lanceolar, long 20-40 centimetre, wide 8-18 centimetre, two times pinniform drastic cracks; The wide lanceolar of top accessory pinna, long 7-11 centimetre, wide 3-4 centimetre, pinniform drastic crack; Side accessory pinna 3-7 couple, the full edge in upside to irregular plumage splits, the pinniform drastic crack of downside in rule; Sliver is linear, edge sawtooth shape; Sporangiorus is along accessory pinna marginal distribution.Classification system: Pteris semipinnata L., heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For bacillary dysentery, acute enteritis, icterohepatitis, conjunctivitis; Traumatic injury is controlled in external, traumatic hemorrhage, skin infection furuncle and phyma, eczema, venom.The present invention is with all herbal medicine.
Beneficial effect: the medicine that the present invention obtains can safe and effective treatment pulmonary tuberculosis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: take Fructus Malvae 14g, Fructus Phyllanthi 11g, Rhizoma Panacis Majoris 15g, Caulis Entadae 10g, Lycopodium casuarinoides Spring 12g, Herba Pteridis Multifidae 14g, Radix Caulophylli 15g, large Herba Kylligac coloratae 12g, Herba Violae japonicae 15g, clerodendron trichotomum 9g, geranium 11g, Rhizoma Anemones Altaicae 14g, Foliumet Ramulus Evodiae 11g, Folium Callicarpae Macrophyllae 13g, great Ye Herba chenopodii 9g, Caulis cyatheae spinulosae 12g, logical Herba Euphorbiae Humifusae 14g, Herba desmodii microphylli 14g, Red Psychotria Leaf 16g, Radix Trichosanthis Cucumeroidis 11g, Radix Libanotidis buchotomensis 6g, pagoda flower 13g, Herba Pteridis Semipinnatae 15g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of pulmonary tuberculosis.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take Fructus Malvae 14g, Fructus Phyllanthi 11g, Rhizoma Panacis Majoris 15g, Caulis Entadae 10g, Lycopodium casuarinoides Spring 12g, Herba Pteridis Multifidae 14g, Radix Caulophylli 15g, large Herba Kylligac coloratae 12g, Herba Violae japonicae 15g, clerodendron trichotomum 9g, geranium 11g, Rhizoma Anemones Altaicae 14g, Foliumet Ramulus Evodiae 11g, Folium Callicarpae Macrophyllae 13g, great Ye Herba chenopodii 9g, Caulis cyatheae spinulosae 12g, logical Herba Euphorbiae Humifusae 14g, Herba desmodii microphylli 14g, Red Psychotria Leaf 16g, Radix Trichosanthis Cucumeroidis 11g, Radix Libanotidis buchotomensis 6g, pagoda flower 13g, Herba Pteridis Semipinnatae 15g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of pulmonary tuberculosis.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take Fructus Malvae 14g, Fructus Phyllanthi 11g, Rhizoma Panacis Majoris 15g, Caulis Entadae 10g, Lycopodium casuarinoides Spring 12g, Herba Pteridis Multifidae 14g, Radix Caulophylli 15g, large Herba Kylligac coloratae 12g, Herba Violae japonicae 15g, clerodendron trichotomum 9g, geranium 11g, Rhizoma Anemones Altaicae 14g, Foliumet Ramulus Evodiae 11g, Folium Callicarpae Macrophyllae 13g, great Ye Herba chenopodii 9g, Caulis cyatheae spinulosae 12g, logical Herba Euphorbiae Humifusae 14g, Herba desmodii microphylli 14g, Red Psychotria Leaf 16g, Radix Trichosanthis Cucumeroidis 11g, Radix Libanotidis buchotomensis 6g, pagoda flower 13g, Herba Pteridis Semipinnatae 15g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of pulmonary tuberculosis.Oral, every bu is taken for twice sooner or later.
4, the present invention is to phthisical clinical research
4.1, physical data: inventor collects 60 routine phthisical out-patients between in October ,-2012 in August, 2010 altogether, age 19-48 year, course of disease 1-5.Be divided at random: treatment group 40 example, blank group 20 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: (1) sputum examination for tubercle bacillus positive (comprising smear or cultivation).(2) spit negative, chest X-ray has typical active tuberculosis pathological changes to show.(3) pulmonary lesion specimen, pathological diagnosis are tuberculosis.(4) suspected tuberculosis person, after following up a case by regular visits to, observing, can get rid of other pulmonary lesions through Clinical X line.(5) hydrothorax that other reasons causes has been got rid of clinically, diagnosable tuberculous pleuritis.Concrete reference: diagnosis of pulmonary tuberculosis standard (WS288-2008).
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 40 18 16 6 85
Blank group 20 1 1 18 10
Visible, the medicine that the present invention obtains can safe and effective treatment pulmonary tuberculosis.

Claims (2)

1. the phthisical Chinese medicine composition for the treatment of, it is characterized in that, it is prepared by the raw material of following parts by weight: Fructus Malvae 14 parts, Fructus Phyllanthi 11 parts, Rhizoma Panacis Majoris 15 parts, Caulis Entadae 10 parts, Lycopodium casuarinoides Spring 12 parts, Herba Pteridis Multifidae 14 parts, Radix Caulophylli 15 parts, large Herba Kylligac coloratae 12 parts, Herba Violae japonicae 15 parts, clerodendron trichotomum 9 parts, geranium 11 parts, Rhizoma Anemones Altaicae 14 parts, Foliumet Ramulus Evodiae 11 parts, Folium Callicarpae Macrophyllae 13 parts, great Ye Herba chenopodii 9 parts, Caulis cyatheae spinulosae 12 parts, logical Herba Euphorbiae Humifusae 14 parts, Herba desmodii microphylli 14 parts, Red Psychotria Leaf 16 parts, Radix Trichosanthis Cucumeroidis 11 parts, Radix Libanotidis buchotomensis 6 parts, pagoda spends 13 parts, Herba Pteridis Semipinnatae 15 parts.
2. treat the application of phthisical Chinese medicine composition in treatment tuberculosis drugs as claimed in claim 1.
CN201410554542.3A 2014-10-17 2014-10-17 Traditional Chinese medicine composition for treating phthisis as well as preparation method and application thereof Pending CN104288415A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009051741A (en) * 2007-08-23 2009-03-12 Kao Corp Nfat signal inhibitor and nfat signal inhibition method
CN101491632A (en) * 2007-11-27 2009-07-29 李求才 Traditional Chinese medicine for treating phthisis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009051741A (en) * 2007-08-23 2009-03-12 Kao Corp Nfat signal inhibitor and nfat signal inhibition method
CN101491632A (en) * 2007-11-27 2009-07-29 李求才 Traditional Chinese medicine for treating phthisis

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