CN104288313A - Method for extracting flavone from longan seeds - Google Patents
Method for extracting flavone from longan seeds Download PDFInfo
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- CN104288313A CN104288313A CN201410605537.0A CN201410605537A CN104288313A CN 104288313 A CN104288313 A CN 104288313A CN 201410605537 A CN201410605537 A CN 201410605537A CN 104288313 A CN104288313 A CN 104288313A
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- Prior art keywords
- seed
- arillus longan
- flavone
- extract
- extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a method for extracting flavone from longan seeds. The method is characterized by comprising the following steps: selecting the longan seeds which are uniform in color and luster without suffering diseases and pests, smashing the longan seeds, and drying the longan seeds through a screen with 40-60 meshes; adding a propyl alcohol extractant with the concentration of 50%-70% and the liquor ratio of 1: 30, and placing the mixture in a constant-temperature digital readout water bath kettle at the temperature of 65-75 DEG C for reflux extraction for 2-3 h; filtering after extraction is finished, evaporating, concentrating and drying. According to the invention, the flavone is extracted from the longan seeds through the reflux extraction method, so that maximum resource waste can be avoided, and the comprehensive utilization value of the longan seeds is improved; the method is simple, convenient and fast and easy to operate and popularize, the extraction rate and the purity of the flavones can be higher, and the method is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of extracting method of flavone, be specifically related to a kind of method extracting flavone from seed of Arillus Longan.
Background technology
Flavone also claims flavone, is the general name of flavone compound, is extensively present in nature, particularly in plant, because the flavone compound found at first all has a ketone carbonyl group structure, again in yellow or faint yellow, therefore claims flavone.Flavone has multiple biological activity, its physiological action extremely people's concern always.Much research is verified, and flavone has the effect such as antioxidation, antibacterial and resisting fatigue, scavenging free radicals, blood fat reducing, blood sugar lowering, and it can have broad application prospects at medicine, field of food.
Seed of Arillus Longan is the seed of longan fruit, and weight accounts for 17% of fruit fresh weight, and its bitter in the mouth, puckery, property are put down, and have significant nutrition and health care effect.Show, containing a large amount of pyrite isoreactivity material in seed of Arillus Longan, to there is value of exploiting and utilizing widely after deliberation.At present, for the exploitation mainly Arillus Longan of longan fruit, seed of Arillus Longan abandons as waste material in the course of processing, and the annual discarded seed of Arillus Longan in the whole nation, up to hundreds of thousands ton, causes resource to waste greatly.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind ofly avoid the wasting of resources, improve longan fruit comprehensive utilization value, the method for flavone in extraction seed of Arillus Longan that extraction ratio is high.
In order to achieve the above object, the technical scheme that the present invention takes is:
From seed of Arillus Longan, extract a method for flavone, comprise the following steps:
(1) select the seed of Arillus Longan of uniform color, anosis worm, be placed in high speed machine pulverizer and pulverize rear dry, dried seed of Arillus Longan powder is crossed 40 ~ 60 mesh sieves;
(2) the seed of Arillus Longan powder after screening is added by solid-liquid ratio 1:30 the propanol extraction agent that concentration is 50% ~ 70%, be placed in constant temperature digital display water-bath reflux, extract, 2 ~ 3h that temperature is 65 DEG C ~ 75 DEG C;
(3) after extraction time, filter extracting solution immediately, get supernatant and be placed in Rotary Evaporators evaporation and concentration, can flavone be obtained by after concentrated extract drying.
As optimal technical scheme, in order to extract at optimum extraction conditions as far as possible, to improve extraction ratio and the purity of flavone, in described step (2) powder in constant temperature digital display water-bath reflux, extract, preferably the time is 2.5h.
As optimal technical scheme, in order to allow the flavone in seed of Arillus Longan be dissolved in improve the extraction ratio of flavone in organic solvent-acetone as far as possible, in described step (2), the concentration of extractant acetone is preferably 60%.
As optimal technical scheme, in order to extract at optimum extraction conditions as far as possible, to improve extraction ratio and the purity of flavone, the middle constant temperature digital display water-bath reflux, extract, of described step (2) preferably temperature is 70 DEG C.
As optimal technical scheme, in order to the sophistication pulverizing powder in rear seed of Arillus Longan is suitable, to improve the dissolubility of powder in extractant, dried seed of Arillus Longan powder better mistake 50 mesh sieve in described step (1).
The beneficial effect that the present invention has: adopt the flavone in reflux extraction extraction seed of Arillus Longan, improve Arillus Longan comprehensive utilization value while avoiding resource significant wastage; According to the impact of extraction conditions on flavone in seed of Arillus Longan, take the best extraction conditions such as extraction time, Extractant concentration, Extracting temperature, solid-liquid ratio, thus ensure that higher extraction ratio and purity; This method is simple and convenient, be easy to operation and promote, and is applicable to suitability for industrialized production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment 1
From seed of Arillus Longan, extract a method for flavone, comprise the following steps:
(1) select the seed of Arillus Longan of uniform color, anosis worm, be placed in high speed machine pulverizer and pulverize rear dry, dried seed of Arillus Longan powder is crossed 40 mesh sieves;
(2) the seed of Arillus Longan powder after screening is added by solid-liquid ratio 1:30 the propanol extraction agent that concentration is 50% ~ 70%, be placed in the constant temperature digital display water-bath reflux, extract, 2 ~ 3 that temperature is 65 DEG C ~ 75 DEG C;
(3) after extraction time, filter extracting solution immediately, get supernatant and be placed in Rotary Evaporators evaporation and concentration, can flavone be obtained by after concentrated extract drying.
Embodiment 2
From seed of Arillus Longan, extract a method for flavone, comprise the following steps:
(1) select the seed of Arillus Longan of uniform color, anosis worm, be placed in high speed machine pulverizer and pulverize rear dry, dried seed of Arillus Longan powder is crossed 50 mesh sieves;
(2) the seed of Arillus Longan powder after screening is added by solid-liquid ratio 1:30 the propanol extraction agent that concentration is 50% ~ 70%, be placed in constant temperature digital display water-bath reflux, extract, 2 ~ 3h that temperature is 65 DEG C ~ 75 DEG C;
(3) after extraction time, filter extracting solution immediately, get supernatant and be placed in Rotary Evaporators evaporation and concentration, can flavone be obtained by after concentrated extract drying.
Embodiment 3
From seed of Arillus Longan, extract a method for flavone, comprise the following steps:
(1) select the seed of Arillus Longan of uniform color, anosis worm, be placed in high speed machine pulverizer and pulverize rear dry, dried seed of Arillus Longan powder is crossed 60 mesh sieves;
(2) the seed of Arillus Longan powder after screening is added by solid-liquid ratio 1:30 the propanol extraction agent that concentration is 50% ~ 70%, be placed in constant temperature digital display water-bath reflux, extract, 2 ~ 3h that temperature is 65 DEG C ~ 75 DEG C;
(3) after extraction time, filter extracting solution immediately, get supernatant and be placed in Rotary Evaporators evaporation and concentration, can flavone be obtained by after concentrated extract drying.
It should be pointed out that above case is only the representational example of the present invention.Obviously, technical scheme of the present invention is not limited to above-described embodiment, can also have many degeneration.
Claims (5)
1. from seed of Arillus Longan, extract a method for flavone, it is characterized in that, comprise the following steps:
(1) select the seed of Arillus Longan of uniform color, anosis worm, be placed in high speed machine pulverizer and pulverize rear dry, dried seed of Arillus Longan powder is crossed 40 ~ 60 mesh sieves;
(2) the seed of Arillus Longan powder after screening is added by solid-liquid ratio 1:30 the propanol extraction agent that concentration is 50% ~ 70%, be placed in constant temperature digital display water-bath reflux, extract, 2 ~ 3h that temperature is 65 DEG C ~ 75 DEG C;
(3) after extraction time, filter extracting solution immediately, get supernatant and be placed in Rotary Evaporators evaporation and concentration, can flavone be obtained by after concentrated extract drying.
2. a kind of method extracting flavone from seed of Arillus Longan according to claim 1, is characterized in that: in described step (2) powder in constant temperature digital display water-bath reflux, extract, preferably the time is 2.5h.
3. a kind of method extracting flavone from seed of Arillus Longan according to claim 1, is characterized in that: in described step (2), the concentration of extractant acetone is preferably 60%.
4. a kind of method extracting flavone from seed of Arillus Longan according to claim 1, is characterized in that: in described step (2) constant temperature digital display water-bath reflux, extract, preferably temperature be 70 DEG C.
5. a kind of method extracting flavone from seed of Arillus Longan according to Claims 1 to 4 any one, is characterized in that: dried seed of Arillus Longan powder better mistake 50 mesh sieve in described step (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410605537.0A CN104288313A (en) | 2014-10-31 | 2014-10-31 | Method for extracting flavone from longan seeds |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410605537.0A CN104288313A (en) | 2014-10-31 | 2014-10-31 | Method for extracting flavone from longan seeds |
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| Publication Number | Publication Date |
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| CN104288313A true CN104288313A (en) | 2015-01-21 |
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| CN201410605537.0A Pending CN104288313A (en) | 2014-10-31 | 2014-10-31 | Method for extracting flavone from longan seeds |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326978A (en) * | 2015-11-13 | 2016-02-17 | 谢镜国 | Method for extracting longan seed flavone |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5835104A (en) * | 1981-08-27 | 1983-03-01 | Motoyasu Uehara | Herbicide |
| CN101744928A (en) * | 2008-12-12 | 2010-06-23 | 黄驰波 | Method for extracting active substance in longan seeds |
| CN102920830A (en) * | 2012-11-28 | 2013-02-13 | 华南师范大学 | Method for effectively extracting polyphenol from Longan seed |
| CN102961486A (en) * | 2012-12-24 | 2013-03-13 | 厦门大学 | Extraction method of longan seed polyphenol |
| CN103610821A (en) * | 2013-11-29 | 2014-03-05 | 南宁市百济生物工程有限公司 | Production method of longan seed extract oral liquid |
| CN103829240A (en) * | 2014-03-05 | 2014-06-04 | 兰州乐赛特食品饮料有限公司 | Eyesight-improving health-protection product containing longan shell and seed leach liquor and preparation method thereof |
| CN104000925A (en) * | 2014-05-27 | 2014-08-27 | 青岛市市立医院 | Pharmaceutical composition for treating thyromegaly and application thereof |
-
2014
- 2014-10-31 CN CN201410605537.0A patent/CN104288313A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5835104A (en) * | 1981-08-27 | 1983-03-01 | Motoyasu Uehara | Herbicide |
| CN101744928A (en) * | 2008-12-12 | 2010-06-23 | 黄驰波 | Method for extracting active substance in longan seeds |
| CN102920830A (en) * | 2012-11-28 | 2013-02-13 | 华南师范大学 | Method for effectively extracting polyphenol from Longan seed |
| CN102961486A (en) * | 2012-12-24 | 2013-03-13 | 厦门大学 | Extraction method of longan seed polyphenol |
| CN103610821A (en) * | 2013-11-29 | 2014-03-05 | 南宁市百济生物工程有限公司 | Production method of longan seed extract oral liquid |
| CN103829240A (en) * | 2014-03-05 | 2014-06-04 | 兰州乐赛特食品饮料有限公司 | Eyesight-improving health-protection product containing longan shell and seed leach liquor and preparation method thereof |
| CN104000925A (en) * | 2014-05-27 | 2014-08-27 | 青岛市市立医院 | Pharmaceutical composition for treating thyromegaly and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 关恺珍，等: "响应面法优化龙眼核中总黄酮的提取工艺", 《今日药学》 * |
| 梁志,等: "龙眼核中总黄酮含量测定及其抗氧化性研究", 《云南化工》 * |
| 陈颖峰，等: "正交法优化龙眼核中黄酮类物质提取条件的研究", 《广东化工》 * |
| 黄晓兵，等: "响应面法超声提取龙眼核黄酮工艺的优化", 《江西农业学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326978A (en) * | 2015-11-13 | 2016-02-17 | 谢镜国 | Method for extracting longan seed flavone |
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