CN104284896B - 取代的咪唑并哒嗪 - Google Patents

取代的咪唑并哒嗪 Download PDF

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Publication number
CN104284896B
CN104284896B CN201380024787.9A CN201380024787A CN104284896B CN 104284896 B CN104284896 B CN 104284896B CN 201380024787 A CN201380024787 A CN 201380024787A CN 104284896 B CN104284896 B CN 104284896B
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CN
China
Prior art keywords
cyclopropyl
imidazo
amino
methylbenzamide
trifluoropropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380024787.9A
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English (en)
Chinese (zh)
Other versions
CN104284896A (zh
Inventor
M·科皮茨
U·克拉尔
A·M·温内尔
R·诺伊豪斯
G·西迈斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Bayer Intellectual Property GmbH
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Bayer Pharma AG
Bayer Intellectual Property GmbH
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Filing date
Publication date
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Publication of CN104284896A publication Critical patent/CN104284896A/zh
Application granted granted Critical
Publication of CN104284896B publication Critical patent/CN104284896B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380024787.9A 2012-03-14 2013-03-11 取代的咪唑并哒嗪 Expired - Fee Related CN104284896B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12159455.0 2012-03-14
EP12159455 2012-03-14
EP13154139 2013-02-06
EP13154139.3 2013-02-06
PCT/EP2013/054841 WO2013135612A1 (en) 2012-03-14 2013-03-11 Substituted imidazopyridazines

Publications (2)

Publication Number Publication Date
CN104284896A CN104284896A (zh) 2015-01-14
CN104284896B true CN104284896B (zh) 2016-06-01

Family

ID=47913379

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380024787.9A Expired - Fee Related CN104284896B (zh) 2012-03-14 2013-03-11 取代的咪唑并哒嗪

Country Status (9)

Country Link
US (1) US9512126B2 (https=)
EP (1) EP2825540B1 (https=)
JP (1) JP6166289B2 (https=)
CN (1) CN104284896B (https=)
AR (1) AR090323A1 (https=)
CA (1) CA2867061A1 (https=)
ES (1) ES2605946T3 (https=)
UY (1) UY34677A (https=)
WO (1) WO2013135612A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104284896B (zh) 2012-03-14 2016-06-01 拜耳知识产权有限责任公司 取代的咪唑并哒嗪
RS56034B1 (sr) 2013-06-11 2017-09-29 Bayer Pharma AG Derivati prolekova supstituisanih triazolopiridina
CN105392484A (zh) * 2013-06-13 2016-03-09 拜耳制药股份公司 咪唑并哒嗪衍生物与有丝分裂试剂的联用药用于治疗癌症
FI3283642T3 (fi) 2015-04-17 2024-01-11 Crossfire Oncology Holding B V Prognostisia biomarkkereita ttk-inhibiittorikemoterapiaan
ES2839880T3 (es) 2015-07-07 2021-07-06 Janssen Vaccines & Prevention Bv Vacuna contra el VRS
GB201907616D0 (en) * 2019-05-29 2019-07-10 Galapagos Nv Novel compounds and pharmaceutical compositons thereof for the treatment of diseases

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WO2012032031A1 (en) * 2010-09-10 2012-03-15 Bayer Pharma Aktiengesellschaft Substituted imidazopyridazines

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IL127566A0 (en) 1996-08-28 1999-10-28 Pfizer Substituted 6,5-hetero- bicyclic derivatives
DE69828607T2 (de) 1997-05-28 2006-01-05 Aventis Pharmaceuticals Inc. CHINOLIN- UND CHINOXALIN-VERBINDUNGEN DIE DEN VON BLUTPLÄTTCHEN ABSTAMMMENDEN WACHSTUMSFAKTOR UND/ODER PDGF- UND P56lck-TYROSIN-KINASE HEMMEN
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SG173610A1 (en) 2009-02-13 2011-09-29 Fovea Pharmaceuticals Sa [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors
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ES2530802T3 (es) 2010-12-17 2015-03-06 Bayer Ip Gmbh Imidazopirazinas 6-tiosustituidas para uso como inhibidores de MPS-1 y TKK en el tratamiento de trastornos hiperproliferativos
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EP2734205B1 (en) * 2011-07-21 2018-03-21 Tolero Pharmaceuticals, Inc. Heterocyclic protein kinase inhibitors
CN104284896B (zh) 2012-03-14 2016-06-01 拜耳知识产权有限责任公司 取代的咪唑并哒嗪

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120059162A1 (en) * 2009-07-30 2012-03-08 Oncotherapy Science, Inc. Fused imidazole derivative having ttk inhibitory action
WO2012032031A1 (en) * 2010-09-10 2012-03-15 Bayer Pharma Aktiengesellschaft Substituted imidazopyridazines

Also Published As

Publication number Publication date
EP2825540A1 (en) 2015-01-21
CN104284896A (zh) 2015-01-14
WO2013135612A1 (en) 2013-09-19
ES2605946T3 (es) 2017-03-17
CA2867061A1 (en) 2013-09-19
US20150104526A1 (en) 2015-04-16
AR090323A1 (es) 2014-11-05
JP6166289B2 (ja) 2017-07-19
HK1206022A1 (zh) 2015-12-31
UY34677A (es) 2013-10-31
JP2015513559A (ja) 2015-05-14
EP2825540B1 (en) 2016-09-14
US9512126B2 (en) 2016-12-06

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