CN104271160B - 包含基于有机硅的赋形剂以将活性物质递送到基底的局部用制剂组合物 - Google Patents

包含基于有机硅的赋形剂以将活性物质递送到基底的局部用制剂组合物 Download PDF

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Publication number
CN104271160B
CN104271160B CN201380021411.2A CN201380021411A CN104271160B CN 104271160 B CN104271160 B CN 104271160B CN 201380021411 A CN201380021411 A CN 201380021411A CN 104271160 B CN104271160 B CN 104271160B
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formulation
examples
formulations
skin
silicone
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Chinese (zh)
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CN104271160A (zh
Inventor
海德·艾力亚尔
R·O·胡伯
盖瑞·L·劳伯特
杰拉尔德·K·沙劳
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Dow Silicones Corp
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Dow Corning Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380021411.2A 2012-04-27 2013-03-11 包含基于有机硅的赋形剂以将活性物质递送到基底的局部用制剂组合物 Active CN104271160B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639611P 2012-04-27 2012-04-27
US61/639,611 2012-04-27
PCT/US2013/030212 WO2013162723A1 (en) 2012-04-27 2013-03-11 Topical formulation compositions containing silicone based excipients to deliver actives to a substrate

Publications (2)

Publication Number Publication Date
CN104271160A CN104271160A (zh) 2015-01-07
CN104271160B true CN104271160B (zh) 2017-08-08

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CN201380021411.2A Active CN104271160B (zh) 2012-04-27 2013-03-11 包含基于有机硅的赋形剂以将活性物质递送到基底的局部用制剂组合物

Country Status (6)

Country Link
US (1) US20150141389A1 (enExample)
EP (1) EP2841106A1 (enExample)
JP (1) JP6093007B2 (enExample)
CN (1) CN104271160B (enExample)
IN (1) IN2014DN09817A (enExample)
WO (1) WO2013162723A1 (enExample)

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CN105012228B (zh) * 2015-08-17 2018-04-20 郑州和济生物科技股份有限公司 防止疤痕形成及早期修复的玻尿酸硅凝胶组合物及制备方法
GB201616223D0 (en) * 2016-09-23 2016-11-09 University College Cardiff Consultants Limited Topical treatment patch
AU2018221889A1 (en) * 2017-02-15 2019-09-05 Botanix Pharmaceuticals Ltd Compositions for treating acne
CA3082286A1 (en) 2017-12-04 2019-06-13 Johnson & Johnson Consumer Inc. Topical emulsion composition containing nonsteroidal anti-inflammatory drug
BR112020014955A2 (pt) * 2018-01-24 2020-12-22 Botanix Pharmaceuticals Ltd Regime de dosagem de canabinoides para acne
US20190224137A1 (en) * 2018-01-24 2019-07-25 Botanix Pharmaceuticals Ltd. Cannabinoid Dosing Regime for Acne
AT521126A2 (de) * 2018-03-29 2019-10-15 Bcsk Biocid Gmbh Sprühpflasterzusammensetzung
WO2019213142A1 (en) * 2018-04-30 2019-11-07 Eleblend Llc Cosmetic compositions
US11304416B2 (en) * 2018-09-24 2022-04-19 Relevo Labs, Llc Cyclopentasiloxane and cationic biocide as a formulation additive to enhance persistent sanitizing and miscibility
CA3138194A1 (en) 2019-04-30 2020-11-05 Bayer Healthcare Llc Topical analgesic gel compositions
US12097186B2 (en) 2019-04-30 2024-09-24 Bayer Healthcare Llc Topical analgesic compositions
TWI691343B (zh) * 2019-05-02 2020-04-21 邵明遠 液體繃帶組成物之用途
WO2021061913A1 (en) * 2019-09-27 2021-04-01 Encube Ethicals, Pvt. Ltd. Diclofenac sodium topical solution
EP4251196A4 (en) * 2020-11-25 2024-10-02 Topix Pharmaceuticals, Inc. Scar treatment composition
WO2023007275A1 (en) * 2021-07-29 2023-02-02 3M Innovative Properties Company Film-forming compositions comprising salicylic acid and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101193629A (zh) * 2005-03-24 2008-06-04 位相转换有限公司 局部用组合物及其应用
US20100184714A1 (en) * 2007-07-11 2010-07-22 Victor Albert Raul Compositions For Delivering A Drug

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000063267A (ja) * 1998-08-21 2000-02-29 Senju Pharmaceut Co Ltd 経皮吸収貼付剤
FR2867682B1 (fr) * 2004-03-22 2009-06-05 Galderma Res & Dev Composition pharmaceutique anhydre associant un agent silicone et un principe actif solubilise.
BRPI0511398A (pt) * 2004-06-17 2007-12-04 Galderma Sa composição farmacêutica anidra para o tratamento da psorìase e uso de um agente siliconado
FR2871699A1 (fr) * 2004-06-17 2005-12-23 Galderma Sa Composition de type emulsion inverse contenant du calcitrol et du 17-propionate de clobetasol, et ses utilisations en cosmetiques et en dermatologie
US20070207107A1 (en) * 2006-03-03 2007-09-06 Gareth Winckle Silicone based emulsions for topical drug delivery
CA2669918C (en) * 2006-11-15 2020-03-10 Arthritis Relief Plus Ltd Topical formulation comprising comfrey and tannic acid, and uses thereof
US20100092408A1 (en) * 2008-10-14 2010-04-15 Laurie Ellen Breyfogle Resilient personal care composition comprising polyalkyl ether containing siloxane elastomers
US20100099766A1 (en) * 2008-10-16 2010-04-22 Novartis Ag Topical NSAID compositions having sensate component
JP2012532889A (ja) * 2009-07-09 2012-12-20 クレッシェンド セラピューティクス、エルエルシー 創傷治療方法及び傷跡変性方法
WO2011113000A1 (en) * 2010-03-11 2011-09-15 Chemsmart, Llc Novel ester containing compositions and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101193629A (zh) * 2005-03-24 2008-06-04 位相转换有限公司 局部用组合物及其应用
US20100184714A1 (en) * 2007-07-11 2010-07-22 Victor Albert Raul Compositions For Delivering A Drug

Also Published As

Publication number Publication date
CN104271160A (zh) 2015-01-07
JP6093007B2 (ja) 2017-03-08
EP2841106A1 (en) 2015-03-04
US20150141389A1 (en) 2015-05-21
JP2015514801A (ja) 2015-05-21
IN2014DN09817A (enExample) 2015-07-31
WO2013162723A1 (en) 2013-10-31

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