CN104258336A

CN104258336A - Traditional Chinese medicine powder for treating senile hypertension via application

Info

Publication number: CN104258336A
Application number: CN201410498889.0A
Authority: CN
Inventors: 张泽
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-26
Filing date: 2014-09-26
Publication date: 2015-01-07
Anticipated expiration: 2034-09-26
Also published as: CN104258336B

Abstract

The invention discloses traditional Chinese medicine powder for treating senile hypertension via application. The traditional Chinese medicine powder comprises the following traditional Chinese medicinal ingredients in parts by weight: 1.5-3 parts of harlequin glorybower leaves, 1-5 parts of fructus evodiae, 1.5-8 parts of rhizoma zingiberis, 0.5-3 parts of ligusticum wallichii, 2.5-8 parts of orange peel, 2.5-5 parts of fructus alpiniae oxyphyllae, 3-10 parts of hawthorns, 2-10 parts of agelica sinensis, 1.5-5 parts of selfheal, 2.5-8 parts of cassia twig, 2-8 parts of seed of feather cockscomb, 1.5-3 part of sutellaria baicalensis and 2-5 parts of uncaria. The preparation process of the traditional Chinese medicine powder comprises the following steps: grinding the traditional Chinese medicinal ingredients into powder, mixing uniformly and preparing the powder into paste by a mixed solvent of vinegar and clean water. The traditional Chinese medicine powder is pasted to the Yongquan acupoint to stimulate and permeate in the meridian points, so as to effectively treat diseases; being matched with antihypertensive drugs, the traditional Chinese medicine powder can be used for treating the senile hypertension, so that the dosage of the antihypertensive drugs is effectively decreased, the untoward effects of the drugs are decreased and the living quality of the senile hypertension patients is improved.

Description

A kind of Chinese powder medicine for application treatment senile hypertension

Technical field

The invention belongs to technical field of Chinese medicines, specifically, relate to a kind of for aged patients with hypertension, what have hypotensive effect sticks Chinese powder medicine.

Background technology

Along with the aggravation of world population ages, gerontal patient occupies increasing ratio in total patient groups, has highlighted geratologous particularity.The treatment of senile hypertension is problem important in cardiovascular field, is also current social problem.Epidemiological study shows, along with aged tendency of population is accelerated, senile hypertension prevalence does not only reduce, on the rise on the contrary.In China's elderly population, hyperpietic is more than more than 8,000 ten thousand, 1 people is just had to suffer from hypertension in about every 2 old peoples, separately there is research display, the Prevalence of Hypertension of urban elderly population is greater than 60% even higher, and the problem of preventing and treating of senile hypertension is one of matter of utmost importance of Medical circle research.

The features such as senile hypertension has himself feature, as high in isolated systolic hypertension prevalence, diastolic pressure level is on the low side, pulse pressure increases, undulatory property is large, the remarkable and complication of peak height blood pressure phenomenon in morning is many.Therefore, the more young hypertension of senile hypertension treatment is more complicated, also more difficult.How according to the feature of old cardiovascular disease, formulating practicable therapeutic scheme is the key subjects of pendulum in face of each medical personnel.In recent years, along with medical science develops rapidly, senile hypertension basic research and clinical practice deepen continuously, and a large amount of evidence-based medical emerges in an endless stream, and make aged patients with hypertension obtain good treatment, and the controlling of blood pressure rate of patient declines to some extent.

But as everyone knows, old people is a special colony.Because infirmities of age has many diseases, clinical manifestation concealment is not true to type, and development is rapid, sudden death rate is high, adverse effect is many, the features such as complication is many, affect significantly by intelligence, psychology, Nervous and Mental Factors especially over the course for the treatment of, and the compliance of its treatment is poorer compared with other crowd.Therefore, the universality rule of Diagnosing Hypertension and treatment is applied to it old people, certainly will may brings the careless omission of diagnosis and treatment scheme, treatment falls flat, or occur the situations such as multi-medicament reaction.

External treatment of tcm is conceived to integrally-regulated, improves symptom successful, effectively can improve patients ' life quality; Simultaneously operation have " letter, just, test, honest and clean " etc. advantage, substantially increase the compliance of patient.Acupoint application treatment is a kind of conventional external treatment of Chinese medicine.Under the guidance of Chinese medicine meridian theory, relevant medicine is placed in acupuncture point skin locally by the feature according to acupuncture point and medicine, the function of meridional point is combined with the pharmacological action of medicine, the curative effect that it produces is the result of medicine pharmacological action, also be that meridians and acupuncture points on the human body embody human body regulatory function, thus YIN and YANG balance regulating, strengthening vital QI to eliminate pathogenic factors, dredging the meridian, reach the object of disease therapy, and the resistance against diseases of adjustment and raising body.Yongquan acupoint be positioned at vola first three/recess of, the well cave of kidney meridian, leads to again in the twelve regular channels and eight extra-channel, has good therapeutical effect.

In sum, a kind ofly having blood pressure lowering new formulation steady, esy to use, safe and reliable for senile hypertension if can research and develop, will be serious hope and the Gospel of extensive patients, also be the problem that urgent clinical needs solve.

Summary of the invention

The object of the present invention is to provide a kind of Chinese powder medicine for application treatment senile hypertension, Yongquan acupoint is affixed on after being allocated by Chinese powder medicine, stimulation and osmosis are produced to meridian point, plays hypotensive effect by " medicine cave economic benefits and social benefits ", thus effective disease therapy.

For realizing above-mentioned purpose of the present invention, the present invention adopts following technical scheme.

The present invention is made up of the Chinese medicine ingredients of following parts by weight: Folium et Ramulus Clerodendri Trichotomi 1.5-3 part, Fructus Evodiae 1-5 part, Rhizoma Zingiberis 1.5-8 part, Rhizoma Chuanxiong 0.5-3 part, Pericarpium Citri Reticulatae 2.5-8 part, Fructus Alpiniae Oxyphyllae 2.5-5 part, Fructus Crataegi 3-10 part, Radix Angelicae Sinensis 2-10 part, Spica Prunellae 1.5-5 part, Ramulus Cinnamomi 2.5-8 part, Semen Celosiae 2-8 part, Radix Scutellariae 1.5-3 part, Ramulus Uncariae Cum Uncis 2-5 part.

The present invention is used for the preparation process of the Chinese powder medicine of application treatment senile hypertension: described Chinese medicine ingredients ground as powder mixing, with the mixed solvent such as vinegar and clear water furnishing pasty state, wherein the usage ratio of vinegar, water and Chinese medicinal powder is 2:1:1.

The present invention is used for the using method of the Chinese powder medicine of application treatment senile hypertension: fully have a rest before 1. pasting cave; 2. patient gets dorsal position; 3. adhesive plaster is cut into 3cm × 3cm blockage, sticks Chinese powder medicine by hypertensive for treatment to be attached to adhesive plaster central authorities for subsequent use; 4. with 75% cotton ball soaked in alcohol sterilization spring acupuncture point, the adhesive plaster posting Chinese powder medicine is aimed at spring acupuncture points sticking; Each course for the treatment of is 4 weeks.

In prescription of the present invention.

Folium et Ramulus Clerodendri Trichotomi, Gui Jing: Liver Channel.Flavour of a drug: pungent, bitter, the property of medicine: cool.Get its efficacy effect: expelling wind and removing dampness blood pressure lowering.

Fructus Evodiae, Gui Jing: Liver Channel, spleen channel, stomach warp, flavour of a drug: pungent, bitter, the property of medicine: temperature.Get its efficacy effect: dispersing cold for relieving pain.

Rhizoma Zingiberis, Gui Jing: stomach warp, lung meridian, spleen channel, flavour of a drug: pungent, the property of medicine: heat.Get its efficacy effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation.

Rhizoma Chuanxiong, Gui Jing: gallbladder meridian, Liver Channel, flavour of a drug: pungent, the property of medicine: temperature.Get its efficacy effect: blood-activating and qi-promoting, wind-expelling pain-stopping.

Pericarpium Citri Reticulatae, Gui Jing: lung meridian, spleen channel, flavour of a drug: pungent, bitter, the property of medicine: temperature.Get its efficacy effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Fructus Alpiniae Oxyphyllae, Gui Jing: spleen channel, kidney channel, flavour of a drug: pungent, the property of medicine: temperature.Get its efficacy effect: warming the spleen, warming the kidney.

Fructus Crataegi, Gui Jing: stomach warp, spleen channel, Liver Channel, flavour of a drug: sour, sweet, the property of medicine: temperature.Get its efficacy effect: help digestion long-pending, change the stagnant stasis of blood.

Radix Angelicae Sinensis, Gui Jing: Liver Channel, heart channel, spleen channel, flavour of a drug: sweet, pungent, the property of medicine: temperature.Get its efficacy effect: enrich blood and invigorate blood circulation, loosening bowel to relieve constipation.

Spica Prunellae, Gui Jing: gallbladder meridian, Liver Channel, flavour of a drug: pungent, bitter, the property of medicine: cold.Get its efficacy effect: liver heat removing and eyesight improving; Powder detoxifcation.

Radix Scutellariae, Gui Jing: lung meridian, gallbladder meridian, stomach warp, large intestine channel, flavour of a drug: bitter, the property of medicine: cold.Get its efficacy effect: heat clearing and damp drying.

Ramulus Uncariae Cum Uncis, Gui Jing: Liver Channel, pericardium channel, flavour of a drug: sweet, the property of medicine: be slightly cold.Get its efficacy effect: removing heat from the liver, suppressing the hyperactive liver sun.

Prescription compatibility of the present invention lexical or textual analysis: Folium et Ramulus Clerodendri Trichotomi, Fructus Evodiae are monarch drug, and the traditional Chinese medical science is thought, liver belongs to wood, and hypertension is the too high Sheng of irritability, and Fructus Evodiae is soothing the liver good medicine.Folium et Ramulus Clerodendri Trichotomi expelling wind and removing dampness blood pressure lowering.Simultaneously Fructus Evodiae compatibility Rhizoma Zingiberis: Fructus Evodiae warming the middle warmer and descending qi and sending down the abnormal ascending QI; Rhizoma Zingiberis warming spleen and stomach for dispelling cold, Papillary has mutual reinforcement between effect.Fructus Evodiae compatibility Radix Angelicae Sinensis: Fructus Evodiae obtains the Radix Angelicae Sinensis then loose and not impairment of YIN blood of temperature, and Radix Angelicae Sinensis obtains Fructus Evodiae and then enriches blood and do not stagnate.Spica Prunellae is used for the treatment of headache, dizzy, and pharmacological research has hypotensive activity, and modern clinic, in order to Hypertension, helps blood pressure lowering.Radix Scutellariae: removing damp-heat, eliminating fire and detoxication, for the hypertension of Liver Channel excess-heat, has and eliminates dizzy, headache, bitter taste, vexed effect.Ramulus Uncariae Cum Uncis: suppressing the hyperactive liver stops working heat clearing away, can be used for the diseases such as dizzy, the headache caused by excessive rising of liver-YANG, conjunctival congestion.

Compared with prior art beneficial effect of the present invention.

The invention provides a kind of Chinese powder medicine for application treatment senile hypertension, 13 taste drug matching rules of prescription are based on basic theory of tcm, its formula hits tcm causa morbi, the pathogenesis of senile hypertension, by Chinese powder medicine is applied to Yongquan acupoint, stimulation and osmosis are produced to meridian point, and then played a role by " medicine cave economic benefits and social benefits ", thus reach the object of disease therapy.This Chinese powder medicine coordinates the conbined usage of antihypertensive drugs to treat aged hypertensives, effectively reduces the dosage of antihypertensive drugs, thus alleviates the untoward reaction of medicine, improves the quality of life of aged patients with hypertension.

Detailed description of the invention

Embodiment 1.

The present embodiment provides a kind of Chinese powder medicine for application treatment senile hypertension, is made up of following Chinese medicine ingredients: Folium et Ramulus Clerodendri Trichotomi 8 grams, Fructus Evodiae 12 grams, Rhizoma Zingiberis 15 grams, Rhizoma Chuanxiong 6 grams, Pericarpium Citri Reticulatae 25 grams, Fructus Alpiniae Oxyphyllae 18 grams, Fructus Crataegi 25 grams, Radix Angelicae Sinensis 12 grams, Spica Prunellae 9 grams, Ramulus Cinnamomi 15 grams, Semen Celosiae 12 grams, Radix Scutellariae 6 grams, Ramulus Uncariae Cum Uncis 10 grams.Namely raw material of Chinese medicine parts by weight are: Folium et Ramulus Clerodendri Trichotomi 2 parts, Fructus Evodiae 3 parts, Rhizoma Zingiberis 3.75 parts, Rhizoma Chuanxiong 1.5 parts, Pericarpium Citri Reticulatae 6.25 parts, Fructus Alpiniae Oxyphyllae 4.5 parts, Fructus Crataegi 6.25 parts, Radix Angelicae Sinensis 3 parts, Spica Prunellae 2.25 parts, Ramulus Cinnamomi 3.75 parts, Semen Celosiae 3 parts, Radix Scutellariae 1.5 parts, Ramulus Uncariae Cum Uncis 2.5 parts.

The present embodiment is used for the preparation process of the Chinese powder medicine of application treatment senile hypertension: described Chinese medicine ingredients ground as powder mixing, with the mixed solvent such as vinegar and clear water furnishing pasty state, wherein the usage ratio of vinegar, water and Chinese medicinal powder is 2:1:1.

1. clinical data.

1.1 physical data.

61 routine cases are Geriatrics Dept. inpatient, are divided into two groups at random, i.e. matched group and stick group.Matched group 31 example, wherein man 16 example, female 15 example; 60 years old-83 years old age, average 76.3 years old; The course of disease 5 months-32 years, average 12.5 years.Stick group 30 example, wherein man 15 example, female 15 example; 61 years old-84 years old age, average 77.1 years old; The course of disease 6 months-30 years, average 13.2 years.Two groups of patients through statistical analysis there was no significant difference, have comparability in age, sex, the course of disease etc.

1.2 case selection.

Inclusive criteria is with reference to " Chinese hypertension prevention and control guide " and " senile hypertension Clinics and Practices China Consensus of experts ": 1. previously have clear and definite essential hypertension history; 2. age 60-85 year; 3. do not treat or treat below standard 1 grade and 2 grades of hypertension: non-ly measure right upper extremity sitting systolic blood pressure >=140mmHg but < 180mmHg on the same day, and (or) right upper extremity SiDBP >=90mmHg but < 110mmHg; 4. can voluntary participation cooperating with doctor.

Exclusion standard: 1. clear and definite secondary hypertension, malignant hypertension and other diseases that heart output increase and SBP may be caused to raise are as aortic insufficiency, aortic sinus fistula, anemia, hyperthyroidism etc.; 2. severe pulmonary insufficiency; 3. serious hepatic renal dysfunction and disease of hematopoietic system; 4. 3 grades of hypertension; 5. allergic constitution person, can not resistance to receptor to medicine in therapeutic process.

2. Therapeutic Method.

2.1 stick group: adopt levo-amlodipine 2.5mg, once a day, oral; Adopt that the treatment of the present embodiment is hypertensive sticks Chinese powder medicine point-application Yongquan acupoint, once a day simultaneously.

2.2 matched groups: adopt levo-amlodipine 2.5mg, once a day, oral.

2.3 observation items: 1. quality of life: measure the scoring of Du Shi hypertension quality of life scale, are responsible for composing to scale dividing by special messenger after training; 2. blood pressure level: 30 minutes every mornings 9 .-9, patient measures brachial arterial pressure level by special messenger after having a rest 10 minutes, sphygomanometer is through calibration; 3. safety indexes: hematuria is conventional, hepatic and renal function just, is checked and check by clinical laboratory's uniform machinery.

2.4 statistical methods: use SPSS10.0 statistical software, two groups of diversityes compare uses X 2 test.

3. curative effect determinate standard and therapeutic outcome.

3.1 curative effect determinate standard.

3.1.1. Evaluation on quality of life.

Must standard be divided into Du Shi hypertension quality of life scale, evaluate the quality of life after hypertension human therapy and improve situation.Total score × 100% before improvement rate (%)=(before treatment the rear total score of total score-treatment)/treatment.Evaluation criteria: improvement rate >=50% is effective; Improvement rate >=25% is effective; Improvement rate < 25% is invalid.

3.1.2. efficacy of antihypertensive treatment evaluation.

Follow up a case by regular visits to 4 weeks, at the end of following up a case by regular visits to, measure the scoring of Du Shi hypertension quality of life scale, brachial arterial pressure decreasing value.Statistical procedures is carried out to the therapeutic effect of two groups.

With reference to the standard of " new Chinese medicine Hypertension guideline of clinical investigations " in 1993 " new Chinese medicine guideline of clinical investigations ".Effective: diastolic pressure decline 10mmHg or more, and reach normal range; Or diastolic pressure decline 20mmHg or more; Effective: diastolic pressure declines not as good as 10mmHg but reaches normal range; Or the 10 ~ 19mmHg that declines, but do not reach normal range; Invalid: not reach above standard.

The comparison (see table 1) of 3.2 liang of group brachial arterial pressure change: stick effective 12 examples of group, effective 15 examples, invalid 3 examples, total effective rate 90.00%; Effective 10 examples of matched group, effective 14 examples, invalid 7 examples, total effective rate 77.42%.Through statistical procedures, stick group total effective rate and be better than matched group (P<0.05).

Table 1: the comparison of two groups of brachial arterial pressure changes.

?	Case number	Effective	Effectively	Invalid	Total effective rate (%)
						Stick group	30	12	15	3	90.00
Matched group	31	10	14	7	77.42

Note: matched group with to stick group more variant, P < 0.05.

As can be seen here, two groups of patients are after treatment, and the brachial arterial pressure reduction level sticking group is better than matched group (P<0.05).

The quality of lifes improvement of 3.3 liang of groups is compared (see table 2): stick effective 11 examples of group, effective 17 examples, invalid 2 examples, total effective rate 93.33%; Effective 9 examples of matched group, effective 16 examples, invalid 6 examples, total effective rate 80.65%.Through statistical procedures, stick group total effective rate and be better than matched group (P<0.05).

Table 2: the scoring of Du Shi hypertension quality of life scale is compared.

?	Case number	Effective	Effectively	Invalid	Total effective rate (%)
						Stick group	30	11	17	2	93.33
Matched group	31	9	16	6	80.65

Note: matched group with to stick group more variant, P < 0.05.

As can be seen here, after two groups of patient treatments, the Du Shi hypertension quality of life scale scoring improvement level sticking group is better than matched group (P<0.05).

See table 1, also associative list 2 is known, and the Chinese powder medicine of spring point-application the present embodiment, sticks group and be better than matched group.

3.4 untoward reaction: before and after two groups of treatments, just routine, hepatic and renal function have no significant clinical exception to hematuria.

Conclusion: the Chinese powder medicine treatment aged hypertensives of spring point-application the present embodiment has good curative effect, not only can reduce blood pressure further, obviously can also improve the life quality of patient.

Embodiment 2.

The present embodiment provides a kind of Chinese powder medicine for application treatment senile hypertension, is made up of the Chinese medicine ingredients of following parts by weight: Folium et Ramulus Clerodendri Trichotomi 2.5 parts, Fructus Evodiae 4 parts, Rhizoma Zingiberis 5 parts, Rhizoma Chuanxiong 1 part, Pericarpium Citri Reticulatae 2.5 parts, Fructus Alpiniae Oxyphyllae 3 parts, Fructus Crataegi 3 parts, Radix Angelicae Sinensis 6 parts, Spica Prunellae 3 parts, Ramulus Cinnamomi 6 parts, Semen Celosiae 5 parts, Radix Scutellariae 2 parts, Ramulus Uncariae Cum Uncis 3 parts.

Embodiment 3.

The present embodiment provides a kind of Chinese powder medicine for application treatment senile hypertension, is made up of the Chinese medicine ingredients of following parts by weight: Folium et Ramulus Clerodendri Trichotomi 3 parts, Fructus Evodiae 5 parts, Rhizoma Zingiberis 6 parts, Rhizoma Chuanxiong 2 parts, Pericarpium Citri Reticulatae 5 parts, Fructus Alpiniae Oxyphyllae 3.5 parts, Fructus Crataegi 9 parts, Radix Angelicae Sinensis 8 parts, Spica Prunellae 3.5 parts, Ramulus Cinnamomi 5 parts, Semen Celosiae 4 parts, Radix Scutellariae 3 parts, Ramulus Uncariae Cum Uncis 4 parts.

Claims

1. for a Chinese powder medicine for application treatment senile hypertension, it is characterized in that: the present invention includes following composition: Folium et Ramulus Clerodendri Trichotomi 1.5-3 part, Fructus Evodiae 1-5 part, Rhizoma Zingiberis 1.5-8 part, Rhizoma Chuanxiong 0.5-3 part, Pericarpium Citri Reticulatae 2.5-8 part, Fructus Alpiniae Oxyphyllae 2.5-5 part, Fructus Crataegi 3-10 part, Radix Angelicae Sinensis 2-10 part, Spica Prunellae 1.5-5 part, Ramulus Cinnamomi 2.5-8 part, Semen Celosiae 2-8 part, Radix Scutellariae 1.5-3 part, Ramulus Uncariae Cum Uncis 2-5 part.

2., as claimed in claim 1 for the Chinese powder medicine of application treatment senile hypertension, it is characterized in that: the present invention is made up of following Chinese medicine ingredients: Folium et Ramulus Clerodendri Trichotomi 2 parts, Fructus Evodiae 3 parts, Rhizoma Zingiberis 3.75 parts, Rhizoma Chuanxiong 1.5 parts, Pericarpium Citri Reticulatae 6.25 parts, Fructus Alpiniae Oxyphyllae 4.5 parts, Fructus Crataegi 6.25 parts, Radix Angelicae Sinensis 3 parts, Spica Prunellae 2.25 parts, Ramulus Cinnamomi 3.75 parts, Semen Celosiae 3 parts, Radix Scutellariae 1.5 parts, Ramulus Uncariae Cum Uncis 5.5 parts.

3., as claimed in claim 2 for the Chinese powder medicine of application treatment senile hypertension, it is characterized in that: the present invention is made up of the Chinese medicine ingredients of following parts by weight: Folium et Ramulus Clerodendri Trichotomi 2.5 parts, Fructus Evodiae 4 parts, Rhizoma Zingiberis 5 parts, Rhizoma Chuanxiong 1 part, Pericarpium Citri Reticulatae 2.5 parts, Fructus Alpiniae Oxyphyllae 3 parts, Fructus Crataegi 3 parts, Radix Angelicae Sinensis 6 parts, Spica Prunellae 3 parts, Ramulus Cinnamomi 6 parts, Semen Celosiae 5 parts, Radix Scutellariae 1 part, Ramulus Uncariae Cum Uncis 3 parts.

4., as claimed in claim 3 for the Chinese powder medicine of application treatment senile hypertension, it is characterized in that: the present invention is made up of the Chinese medicine ingredients of following parts by weight: Folium et Ramulus Clerodendri Trichotomi 3 parts, Fructus Evodiae 5 parts, Rhizoma Zingiberis 6 parts, Rhizoma Chuanxiong 2 parts, Pericarpium Citri Reticulatae 5 parts, Fructus Alpiniae Oxyphyllae 3.5 parts, Fructus Crataegi 9 parts, Radix Angelicae Sinensis 8 parts, hay 3.5 parts, Ramulus Cinnamomi 5 parts, Semen Celosiae 4 parts, Radix Scutellariae 3 parts, Ramulus Uncariae Cum Uncis 4 parts.

5. claim 1 is for the using method of the Chinese powder medicine of application treatment senile hypertension, it is characterized in that: fully have a rest before pasting cave; Patient gets dorsal position; Adhesive plaster is cut into 3cm × 3cm blockage, sticks Chinese powder medicine by hypertensive for treatment to be attached to adhesive plaster central authorities for subsequent use; With 75% cotton ball soaked in alcohol sterilization spring acupuncture point, the adhesive plaster posting Chinese powder medicine is aimed at spring acupuncture points sticking; Each course for the treatment of is 14 weeks.

6. claim 5 is for the preparation process of the Chinese powder medicine of application treatment senile hypertension, it is characterized in that: described Chinese medicine ingredients ground as powder mixing, with vinegar and clear water mixed solvent furnishing pasty state.