CN104739946A - Health preserving microcapsule for preventing and treating hyperlipidemia, high blood pressure and high blood sugar - Google Patents

Abstract

The invention belongs to the traditional Chinese medicine field, and provides a health preserving microcapsule for preventing and treating hyperlipidemia, high blood pressure and high blood sugar. The health preserving microcapsule comprises the following raw materials: 280-300 parts of rheum officinale, 260-290 parts of red sage root and 10-30 parts of chitosan. The health preserving microcapsule has the advantages of convenient and rapid administration, has long-term treatment effect by short period administration, and is effectively used for preventing and treating hyperlipidemia, high blood pressure and high blood sugar; and can prevent generation of hyperlipidemia, high blood pressure and high blood sugar for disease prevention by continuous administration of the health preserving medicine microcapsule, so that effect that the health preserving microcapsule can cure yourself when ill and health care when well.

Description

A kind of health preserving control three-hypers microcapsule and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of health preserving control three-hypers microcapsule.

Background technology

Three-hypers disease refers to hypertension, hyperglycemia, hyperlipidemia, they be modern society derive from " affluenza ", possible individualism, also may be interrelated.Three-hypers disease can have no symptom in early days, also no abnormalities feel, and usually just find when doing physical examination, as found not in time, this ongoing disease can form serious disease to late period, even threat to life.

Drug microcapsule is the novel dosage forms developing out in the last few years, it is due to much outstanding advantage, as reduced volatility, reduce toxicity, improve the stability of material, T/A etc. that taste masking can control Release of core material and effect, make it have and well apply potential.We know that three-hypers disease needs long-term treatment, how to reach long-term curative effect in a short time, and this is present bottleneck medically, urgently to be resolved hurrily.

Summary of the invention

The present invention overcomes three-hypers disease in prior art needs the deficiency of long-term treatment, provides anti-three-hypers microcapsule of a kind of health preserving and preparation method thereof.

The technical solution adopted in the present invention is: described health preserving anti-three-hypers its component of microcapsule and parts by weight as follows: Radix Et Rhizoma Rhei 280 ~ 300 parts, Radix Salviae Miltiorrhizae 260 ~ 290 parts, chitosan 10 ~ 30 parts.

As preferably, its component and parts by weight as follows: Radix Et Rhizoma Rhei 290 parts, Radix Salviae Miltiorrhizae 280 parts and chitosan 20 parts.

The preparation method of above-mentioned health preserving control three-hypers microcapsule, is characterized in that:

(1) Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae is clean by clean water, and put into clear water and soak 30 ~ 50min;

(2) add the water of Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae quality 5 ~ 10 times in the medical material soaked to step (1), decoct 2 ~ 3h, filter to obtain decocting liquid;

(3) in medicinal residues, add the water heating decoction 1 ~ 1.5h of 4 ~ 6 times again, leaching decocting liquid, then the water adding 3 ~ 5 times in medicinal residues, heating decoction 40 ~ 60min, merges three gained filtrates after filtering;

(4) chitosan is dissolved in HAC-NaAC buffer solution, under stirring, the filtrate that step (3) merges is added in chitosan solution, reaction 3.5 ~ 5h;

(5) step (4) product is carried out spraying dry, namely obtain health preserving control three-hypers microcapsule.

Further, described chitosan molecule amount is 350 ~ 450kDa, N-deacetylation is 85% ~ 95%.

Beneficial effect of the present invention: microcapsule taking convenience of the present invention, quick, short-term is taken and can be reached long-term therapeutic effect, can effectively treat hypertension, hyperglycemia, hyperlipidemia, the generation that also effectively can prevent three-hypers is taken continuously when there is not three-hypers symptom, reach ill to cure the disease, the effect of anosis health preserving.

Detailed description of the invention

Embodiment 1

(1) Radix Et Rhizoma Rhei 300 parts and Radix Salviae Miltiorrhizae 160 parts is clean by clean water, and put into clear water and soak 30min;

(2) add the water of Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae quality 5 times in the medical material soaked to step (1), decoct 2h, filter to obtain decocting liquid;

(3) the water heating adding 6 times again in medicinal residues decocts 1.5h, leaching decocting liquid, then the water adding 3 times in medicinal residues, and heating decocts 40min, merges three gained filtrates after filtering;

(4) be 350kDa, N-deacetylation by molecular weight be that 95% chitosan 10 parts is dissolved in HAC-NaAC buffer solution, under stirring, the filtrate that step (3) merges added in chitosan solution, reaction 5h;

(5) step (4) product is carried out spraying dry, namely obtain health preserving control three-hypers microcapsule.

Embodiment 2

(1) by clean by clean water to Radix Et Rhizoma Rhei 280 parts and Radix Salviae Miltiorrhizae 190 parts, and clear water immersion 30 ~ 50min is put into;

(2) add the water of Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae quality 10 times in the medical material soaked to step (1), decoct 3h, filter to obtain decocting liquid;

(3) the water heating adding 4 times again in medicinal residues decocts 1h, leaching decocting liquid, then the water adding 5 times in medicinal residues, and heating decocts 60min, merges three gained filtrates after filtering;

(4) be 450kDa, N-deacetylation by molecular weight be that 85% chitosan 30 parts is dissolved in HAC-NaAC buffer solution, under stirring, the filtrate that step (3) merges added in chitosan solution, reaction 3.5h;

(5) step (4) product is carried out spraying dry, namely obtain health preserving control three-hypers microcapsule.

Embodiment 3

(1) by clean by clean water to Radix Et Rhizoma Rhei 290 parts and Radix Salviae Miltiorrhizae 280 parts, and clear water immersion 30 ~ 50min is put into;

(2) add the water of Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae quality 8 times in the medical material soaked to step (1), decoct 2.5h, filter to obtain decocting liquid;

(3) the water heating adding 5 times again in medicinal residues decocts 1.5h, leaching decocting liquid, then the water adding 4 times in medicinal residues, and heating decocts 50min, merges three gained filtrates after filtering;

(4) be 400kDa, N-deacetylation by molecular weight be that 90% chitosan 20 parts is dissolved in HAC-NaAC buffer solution, under stirring, the filtrate that step (3) merges added in chitosan solution, reaction 4h;

(5) step (4) product is carried out spraying dry, namely obtain health preserving control three-hypers microcapsule.

Therapeutic effect:

The control three-hypers microcapsule that above prepared by each embodiment is chosen patient 150 example respectively and is treated, wherein simple hyperlipemic patients 20 example, simple hypertension 15 example, simple hyperglycemic patients 20 example, complicated hypertension hyperglycemic patients 25 example, complicated hypertension hyperlipemic patients 25 example, merge hyperglycemia hyperlipemic patients 25 example, hyperlipidemia and hypertension hyperglycemia all has patient 20 example.Age all between 32 ~ 68 years old, 50 years old mean age.

When microcapsule of the present invention is used for the treatment of three-hypers disease, need patient sooner or later all to take 3g, two weeks is a course for the treatment of, can take throughout the year.Before taking and carry out the measurement of blood pressure, blood glucose and blood fat after taking two courses for the treatment of respectively, found that, weak on his pins, dizziness headache that after taking a course for the treatment of, patient causes because of three-hypers, blush conjunctival congestion, the symptom such as nervous uncomfortable in chest and all make moderate progress, suffer from hypertensive patients' blood substantially all lower than 140/90mmHg after taking two courses for the treatment of, effective percentage reaches more than 96.5%; Suffer from the patient of hyperlipidemia after taking two courses for the treatment of, cholesterol and triglyceride is substantially all in normal level, and effective percentage is all more than 97%; The patient's fasting glucose suffering from hyperglycemia after taking two courses for the treatment of is substantially all in 3.9 ~ 6.1mmol/L, and effective percentage is more than 98.6%.Healing person's follow-up investigation one is average annual without recurrence.

Preventive effect:

The microcapsule that above prepared by each embodiment chooses that 30 builds are partially fat respectively, the age all more than 30 years old, the people that is in sub-health state takes experiment.When microcapsule of the present invention is used for preventing three-hypers disease, patient is needed to take 3g every morning, the appearance of prevention three-hypers needs long-term taking (more than 5 years), regularly three-hypers health check-up is carried out in above 150 experiment volunteers, in during taking medicine of the present invention, (5 years experimental periods), all without the appearance of three-hypers symptom, health status also makes moderate progress; Drug withdrawal after 6 years also without the appearance of three-hypers symptom.Above experimental data illustrates that medicine prepared by the present invention effectively can prevent the appearance of three-hypers symptom.

Diagnostic criteria:

Hyperlipidemia: evaluate with reference to " new drug (Chinese medicine) guideline of clinical investigations " and " Blood Lipid Abnormality in Chinese Adults guideline of prevention and treatment " standard in 2007;

Hypertension: clinical diagnosis all meets World Health Organization (WHO) (WTO) specified standard, namely before treatment, basic blood pressure is more than or equal to 160/95mmHg:

Hyperglycemia: with reference to WT0T2DM diagnostic criteria in 1999, tcm diagnosis standard is with reference to the Standards of Chinese Medical Syndrome Differentiation of quenching one's thirst in " new drug (Chinese medicine) guideline of clinical investigations (trying) ".

Claims (4)

1. a health preserving control three-hypers microcapsule, is characterized in that: its component and parts by weight as follows: Radix Et Rhizoma Rhei 280 ~ 300 parts, Radix Salviae Miltiorrhizae 260 ~ 290 parts, chitosan 10 ~ 30 parts.

2. health preserving according to claim 1 control three-hypers microcapsule, is characterized in that: its component and parts by weight as follows: Radix Et Rhizoma Rhei 290 parts, Radix Salviae Miltiorrhizae 280 parts and chitosan 20 parts.

3. the preparation method of the health preserving control three-hypers microcapsule according to any one of claim 1 ~ 2, is characterized in that:

(1) Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae is clean by clean water, and put into clear water and soak 30 ~ 50min;

(2) add the water of Radix Et Rhizoma Rhei and Radix Salviae Miltiorrhizae quality 5 ~ 10 times in the medical material soaked to step (1), decoct 2 ~ 3h, filter to obtain decocting liquid;

(3) in medicinal residues, add the water heating decoction 1 ~ 1.5h of 4 ~ 6 times again, leaching decocting liquid, then the water adding 3 ~ 5 times in medicinal residues, heating decoction 40 ~ 60min, merges three gained filtrates after filtering;

(4) chitosan is dissolved in HAC-NaAC buffer solution, under stirring, the filtrate that step (3) merges is added in chitosan solution, reaction 3.5 ~ 5h;

(5) step (4) product is carried out spraying dry, namely obtain health preserving control three-hypers microcapsule.

4. the preparation method of health preserving control three-hypers microcapsule according to claim 3, is characterized in that: described chitosan molecule amount is 350 ~ 450kDa, N-deacetylation is 85% ~ 95%.