CN105663416A - Traditional Chinese medicine composition for treating heart blood stasis type chest obstruction and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating heart blood stasis type chest obstruction and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a traditional Chinese medicine composition for treating heart blood stasis type chest obstruction.The traditional Chinese medicine composition is prepared from, by weight, 6-8 parts of rhizomes of chuanxiong, 10-12 parts of radix angelica sinensis, 13-14 parts of safflowers, 3-5 parts of radix paeoniae rubra, 6-8 parts of radix achyranthis bidentatae, 10-13 parts of roots of rehmannia, 3-4 parts of Chinese holly leaves and 1-3 parts of stiff silkworms.The invention further provides a preparation method of the traditional Chinese medicine composition for treating heart blood stasis type chest obstruction.The traditional Chinese medicine composition for treating heart blood stasis type chest obstruction has a good treatment effect on a patient with heart blood stasis type chest obstruction, the cure rate is 87.5%, the total effective rate is 96.9%, the prescription is simple, and no toxic or side effect is caused.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction and preparation method thereof.
Background technology
The thoracic obstruction refers to that, with suffocating pain over the chest, very then chest pain radiating to the back, failing to sleep due to dyspnea is a kind of disease of main manifestations, and the lighter feels uncomfortable in chest, breathes and owes smooth, and severe one then has chest pain, severe patient chest pain radiating to the back, backache radiating to the heart. Proposing the title of " thoracic obstruction " in Han dynasty Zhang Zhongjing " Medical Treasures of the Golden Chamber ", concluding pathogenesis is " weak pulse at YANG and stringy pulse at YIN ". Type of obstruction of heart-blood, stagnation of QI ambition type, the turbid impatency type of expectorant, cold coagulation heart arteries and veins type, type of deficiency of both QI and YIN, the heart can be divided intoDeficiency of the kidney yinType and the heartInsufficiency of kidney-YANGType. Wherein the main manifestations of type of obstruction of heart-blood is: the blood stasis of blood is stagnant, and breast sun numbness hinders, and heart arteries and veins does not freely cause ambition pain, such as thorn such as strand, localized pain, is very at nightfall, very then chest pain radiating to the back, backache radiating to the heart, or bitterly draw the shoulder back of the body, and with uncomfortable in chest, with the passing of time do not heal, can because of rage, tired aggravation. Purplish tongue, has ecchymosis, thin fur, stringy and hesitant pulse. At present, doctor trained in Western medicine mainly adopts the mode of analgesic drug product to treat for the thoracic obstruction, cures the symptoms, not the disease, and side effect is bigger.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction and preparation method thereof, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 6-8 part, Radix Angelicae Sinensis 10-12 part, Flos Carthami 13-14 part, Radix Paeoniae Rubra 3-5 part, Radix Achyranthis Bidentatae 6-8 part, Radix Rehmanniae 10-13 part, Folium Ilicis Cornutae 3-4 part, Bombyx Batryticatus 1-3 part.
As the further scheme of the present invention: be made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7-8 part, Radix Angelicae Sinensis 10-11 part, Flos Carthami 13-14 part, Radix Paeoniae Rubra 4-5 part, Radix Achyranthis Bidentatae 7-8 part, Radix Rehmanniae 11-12 part, Folium Ilicis Cornutae 3-4 part, Bombyx Batryticatus 2-3 part.
As the present invention further scheme: be made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 4 parts, Radix Achyranthis Bidentatae 7 parts, 11 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 4 parts, Bombyx Batryticatus 2 parts.
The preparation method of the Chinese medicine composition of the described treatment type of obstruction of heart-blood thoracic obstruction, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 13-15 times amount, heating and refluxing extraction 3-4h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 10-12 times amount, heating and refluxing extraction 1-2h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 13-15 times amount, soak 3-4h, decoct 3-4h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 8-10 times amount, soak 2-3h, decoct 2-3h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 5-6 times amount, decocts 0.5-1h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Above-mentioned Chinese medicine composition is for preparing the medicine of the treatment type of obstruction of heart-blood thoracic obstruction.
Compared with prior art, the invention has the beneficial effects as follows: the Chinese medicine composition that the present invention treats the type of obstruction of heart-blood thoracic obstruction is good to the therapeutic effect of type of obstruction of heart-blood thoracic obstruction patient, and cure rate is 87.5%, and total effective rate is 96.9%. The Chinese medicine composition prescription that the present invention treats the type of obstruction of heart-blood thoracic obstruction is simple, evident in efficacy, has no side effect, and adopts Folium Ilicis Cornutae, Bombyx Batryticatus and other medical material compatibilities the preparation method adopting the present invention, it is possible to effectively strengthen therapeutic effect.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 10 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 3 parts, Radix Achyranthis Bidentatae 6 parts, 10 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 3 parts, Bombyx Batryticatus 1 part.
The preparation method treating the Chinese medicine composition of the type of obstruction of heart-blood thoracic obstruction described in the present embodiment, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 13 times amount, heating and refluxing extraction 3h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 10 times amount, heating and refluxing extraction 1h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 13 times amount, soak 3h, decoct 3h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 8 times amount, soak 2h, decoct 2h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 5 times amount, decocts 0.5h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Embodiment 2
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 12 parts, 14 parts of Flos Carthami, Radix Paeoniae Rubra 5 parts, Radix Achyranthis Bidentatae 8 parts, 13 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 4 parts, Bombyx Batryticatus 3 parts.
The preparation method treating the Chinese medicine composition of the type of obstruction of heart-blood thoracic obstruction described in the present embodiment, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 15 times amount, heating and refluxing extraction 4h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 12 times amount, heating and refluxing extraction 2h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 15 times amount, soak 4h, decoct 4h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 10 times amount, soak 3h, decoct 3h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 6 times amount, decocts 1h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Embodiment 3
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 4 parts, Radix Achyranthis Bidentatae 7 parts, 11 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 4 parts, Bombyx Batryticatus 2 parts.
The preparation method treating the Chinese medicine composition of the type of obstruction of heart-blood thoracic obstruction described in the present embodiment, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 14 times amount, heating and refluxing extraction 3.5h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 11 times amount, heating and refluxing extraction 2h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 14 times amount, soak 3.5h, decoct 3.5h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 10 times amount, soak 2h, decoct 2h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 6 times amount, decocts 1h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Embodiment 4
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 12 parts, 14 parts of Flos Carthami, Radix Paeoniae Rubra 3 parts, Radix Achyranthis Bidentatae 7 parts, 13 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 4 parts, Bombyx Batryticatus 1 part.
The preparation method treating the Chinese medicine composition of the type of obstruction of heart-blood thoracic obstruction described in the present embodiment, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 15 times amount, heating and refluxing extraction 4h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 12 times amount, heating and refluxing extraction 2h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 14 times amount, soak 3h, decoct 3h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 10 times amount, soak 2.5h, decoct 2.5h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 5 times amount, decocts 0.5h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Embodiment 5
A kind of Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, is made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 5 parts, Radix Achyranthis Bidentatae 8 parts, 12 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 3 parts, Bombyx Batryticatus 3 parts.
The preparation method treating the Chinese medicine composition of the type of obstruction of heart-blood thoracic obstruction described in the present embodiment, step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 15 times amount, heating and refluxing extraction 3.5h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 12 times amount, heating and refluxing extraction 1.5h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 14 times amount, soak 3h, decoct 4h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 10 times amount, soak 3h, decoct 2h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 6 times amount, decocts 1h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
Comparative example 1
Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 4 parts, Radix Achyranthis Bidentatae 7 parts, 11 parts of the Radix Rehmanniae is weighed according to weight portion. Decoct patent medicine soup.
Comparative example 2
Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 4 parts, Radix Achyranthis Bidentatae 7 parts, 11 parts of the Radix Rehmanniae, Bombyx Batryticatus 2 parts is weighed according to weight portion. Decoct patent medicine soup.
Clinical trial
1, choose type of obstruction of heart-blood thoracic obstruction patient 96 example made a definite diagnosis, be randomly divided into three groups, respectively treatment group, contrast one group and contrast two groups, often organize 32 people. Treatment group takes the medicament of the Chinese medicine composition prepared by embodiment 3, every day two doses, oral, 8 days courses for the treatment of. Contrast one group and two groups of medicaments taken respectively prepared by comparative example 1 and comparative example 2 of contrast, every day two doses, 8 days courses for the treatment of. After three courses for the treatment of, it is judged that therapeutic effect.
Treatment group, contrast one group and contrast two groups, the age of these three groups of cases, the course of disease, degrees of symptoms no significant difference, there is comparability.
2, Disease Clinical performance
The blood stasis of blood is stagnant, and breast sun numbness hinders, and heart arteries and veins does not freely cause ambition pain, and if thorn is as twisted, localized pain, is very at nightfall, very then chest pain radiating to the back, backache radiating to the heart, or pain draws the shoulder back of the body, with uncomfortable in chest, does not with the passing of time heal, can because of rage, fatigue aggravation. Purplish tongue, has ecchymosis, thin fur, stringy and hesitant pulse.
3, curative effect determinate standard
Curing: transference cure, electrocardiogram check ST section and T ripple recover normal, and exercise test is transferred to feminine gender by the positive.
Effective: symptom makes moderate progress, electrocardiogram check ST section is low flat, and T ripple is inverted and is corrected to some extent.
Invalid: symptom is not improved, electrocardiogram is not improved.
4, therapeutic outcome
Treatment group: cure 28 examples, effective 3 examples, invalid 1 example. Cure rate is 87.5%, and total effective rate is 96.9%.
Contrast one group: cure 10 examples, effective 13 examples, no effect 9. Cure rate is 31.3%, and total effective rate is 71.9%.
Contrast two groups: cure 12 examples, effective 14 examples, invalid 6 examples. Cure rate is 37.5%, and total effective rate is 81.3%.
From therapeutic outcome it can be seen that the present invention Chinese medicine composition for the treatment of the type of obstruction of heart-blood thoracic obstruction is good to the therapeutic effect of type of obstruction of heart-blood thoracic obstruction patient, cure rate is 87.5%, and total effective rate is 96.9%. The Chinese medicine composition prescription that the present invention treats the type of obstruction of heart-blood thoracic obstruction is simple, evident in efficacy, has no side effect.
It addition, comparative example 1 compared with embodiment 3 without Folium Ilicis Cornutae and Bombyx Batryticatus, and adopt common decoction. Comparative example 2 without Folium Ilicis Cornutae, and adopts common decoction compared with embodiment 3. The therapeutic effect of comparative example 1 and comparative example 2 is all poor than embodiment 3, therefore may determine that Folium Ilicis Cornutae, Bombyx Batryticatus and other medical material compatibilities the preparation method adopting the present invention, it is possible to effectively strengthen therapeutic effect.
5, model case
1) Liu, female, 56 years old, left breast place angor is felt in patient's readme often, and with symptoms such as uncomfortable in chest, hypopnea, once took western medicine, poor effect, here is diagnosed as the type of obstruction of heart-blood thoracic obstruction, taking the medicament of the embodiment of the present invention 3 preparation, after the course for the treatment of, symptom is alleviated to some extent, continue to take recovery from illness after three curative effects, follow up a case by regular visits to after 1 year without recurrence.
2) journey, man, 53 years old, patient's readme, from before 3 years, was felt of short duration chest dull pain once in a while, and As time goes on, the state of an illness is increased the weight of gradually, engender the symptom such as cardiopalmus, pale complexion. Here is diagnosed as the type of obstruction of heart-blood thoracic obstruction, takes the medicament of the embodiment of the present invention 3 preparation, and after the course for the treatment of, symptom is alleviated to some extent, continues to take recovery from illness after five curative effects, follows up a case by regular visits to without recurrence after half a year.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, it is also possible under the premise without departing from this patent objective, make various change.
Claims (5)
1. the Chinese medicine composition treating the type of obstruction of heart-blood thoracic obstruction, it is characterized in that, be made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 6-8 part, Radix Angelicae Sinensis 10-12 part, Flos Carthami 13-14 part, Radix Paeoniae Rubra 3-5 part, Radix Achyranthis Bidentatae 6-8 part, Radix Rehmanniae 10-13 part, Folium Ilicis Cornutae 3-4 part, Bombyx Batryticatus 1-3 part.
2. the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction according to claim 1, it is characterized in that, be made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7-8 part, Radix Angelicae Sinensis 10-11 part, Flos Carthami 13-14 part, Radix Paeoniae Rubra 4-5 part, Radix Achyranthis Bidentatae 7-8 part, Radix Rehmanniae 11-12 part, Folium Ilicis Cornutae 3-4 part, Bombyx Batryticatus 2-3 part.
3. the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction according to claim 2, it is characterized in that, be made up of according to the raw material of weight portion following: Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 11 parts, 13 parts of Flos Carthami, Radix Paeoniae Rubra 4 parts, Radix Achyranthis Bidentatae 7 parts, 11 parts of the Radix Rehmanniae, Folium Ilicis Cornutae 4 parts, Bombyx Batryticatus 2 parts.
4. one kind as arbitrary in claim 1-3 as described in the preparation method of Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction, it is characterised in that step is as follows:
1) weigh Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Folium Ilicis Cornutae, add the edible ethanol of 13-15 times amount, heating and refluxing extraction 3-4h, obtain an extracting solution and a residue, collect an extracting solution, residue is added again the edible ethanol of 10-12 times amount, heating and refluxing extraction 1-2h, obtain secondary raffinate and secondary residual, collect secondary raffinate, an extracting solution and secondary raffinate are merged, filters, obtain reflux extracting liquid, standby;
2) weigh Flos Carthami, Radix Achyranthis Bidentatae and the Radix Rehmanniae, add the water of 13-15 times amount, soak 3-4h, decoct 3-4h, it is thus achieved that a decoction liquor and medicinal residues, medicinal residues are added again the water of 8-10 times amount, soak 2-3h, decoct 2-3h, it is thus achieved that secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added again the water of 5-6 times amount, decocts 0.5-1h, it is thus achieved that three decoction liquor and three medicinal residues, decoction liquor, secondary decoction liquor and three decoction liquor are merged, filter, it is thus achieved that decoct total liquid, standby;
3) weigh Bombyx Batryticatus, stir-fry to slightly yellow, pulverize as smalls, standby;
4) being merged with decocting total liquid by reflux extracting liquid, mix homogeneously, evaporation and concentration is thick paste;
5) thick paste quick-freezing is become powder, add Bombyx Batryticatus smalls, after mix homogeneously, namely obtain the Chinese medicine composition of the treatment type of obstruction of heart-blood thoracic obstruction.
5. the purposes in preparation treatment type of obstruction of heart-blood thoracic obstruction medicine of the Chinese medicine composition as described in as arbitrary in claim 1-3.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902727A (en) * | 2016-06-28 | 2016-08-31 | 卿小艳 | Medicine for treating stagnation of heart-blood |
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Application publication date: 20160615 |