CN104258026A - Blood fat-reducing traditional Chinese medicine composition and preparation method thereof - Google Patents
Blood fat-reducing traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blood fat-reducing traditional Chinese medicine composition and a preparation method thereof. The blood fat-reducing traditional Chinese medicine composition comprises the following components in parts by weight: 2-6 parts of sappanwood, 4-7 parts of lotus leaf, 4-9 parts of the root of red-rooted salvia, 2-4 parts of Rhodiola rosea, 7-12 parts of Kadsura Root-bark, 4-7 parts of Fritillaria thun-bergli and 5-8 parts of orange peel. The preparation method comprises the following steps: drying the sappanwood, the lotus leaf, the root of red-rooted salvia, the Rhodiola rosea, the Kadsura Root-bark, the Fritillaria thun-bergli and the orange peel, grinding each traditional Chinese medicine material into powder after drying, and mixing the powder, thereby obtaining the mixed traditional Chinese medicine composition. According to the traditional Chinese medicine composition prepared by the preparation method disclosed by the invention, the content of total cholesterol and triglyceride in blood fat can be obviously reduced.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine formula thing and preparation method thereof, particularly relate to a kind of Chinese medicine composition that can be used for blood fat reducing and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is being collectively referred to as of heart disease and angiopathy.Pressure value and the too high problem of blood fat value in most body in Patients with Cardiovascular/Cerebrovascular Diseases.Wherein, the lipids contents in patient body is too high, can cause its problem such as atherosclerosis, cardiovascular disease.The rising of the too high main manifestations of lipids contents total cholesterol level in vivo (TC), content of triglyceride (TG), low density cholesterol (LDL-C), lipids contents is too high, can cause the generation of various disease.
At the pharmaceutical preparations for the treatment of Hyperlipemia, mainly contain Western medicine and Chinese medicine.Wherein in Chinese medicine, the research of Fructus Lycii, Radix Notoginseng, Herb Gynostemmae Pentaphylli etc. is more, also has effect of certain reduction blood fat.Flavone in these Chinese medicine ingredients, triterpene, polysaccharide may have the function reducing blood fat.The function that single Chinese medicine ingredients reduces blood fat is not remarkable, number of patent application is the Chinese medicine formula describing a kind of blood fat reducing in the application of 2012102240585, Chinese medicine composition comprises Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Alismatis, Ampelopsis grossedentata, in this application, Chinese medicine constituent is less, and the efficacy result of its correspondence also needs further raising.
In sum, we need to grope Chinese medicine formula, explore the Chinese medicine formula of lipids contents in a kind of efficient reduction body, overcome the puzzlement that heart and brain blood disorders disease is brought to us.
Summary of the invention
The technical problem solved: along with the raising of people's living standard, the cardio-cerebralvascular diseases of people is also increasing, wherein hyperlipidemia is exactly a serious problem, need to effectively reduce the content of T-CHOL in blood, total triglyceride, therefore need Chinese medicine composition of a kind of blood fat reducing and preparation method thereof.
Technical scheme: for the problems referred to above, the invention discloses a kind of Chinese medicinal composition for reducing blood fat and preparation method thereof.
Described Chinese medicinal composition for reducing blood fat comprises following composition according to weight:
Lignum Sappan 2 ~ 6 parts,
4 ~ 7 parts, Folium Nelumbinis,
Radix Salviae Miltiorrhizae 4 ~ 9 parts,
Radix Rhodiolae 2 ~ 4 parts,
Cortex cercis chinensis 7 ~ 12 parts,
Bulbus Fritillariae Uninbracteatae 4 ~ 7 parts,
Pericarpium Citri tangerinae 5 ~ 8 parts.
Preferably, described a kind of Chinese medicinal composition for reducing blood fat, comprises following composition according to weight:
Lignum Sappan 2 ~ 6 parts,
4 ~ 7 parts, Folium Nelumbinis,
Radix Salviae Miltiorrhizae 4 ~ 9 parts,
Radix Rhodiolae 2 ~ 4 parts,
Cortex cercis chinensis 7 ~ 12 parts,
Bulbus Fritillariae Uninbracteatae 4 ~ 7 parts,
Pericarpium Citri tangerinae 5 ~ 8 parts,
Flos Caryophylli 4 ~ 7 parts,
Radix Bupleuri 8 ~ 12 parts,
Rhizoma Acori Graminei 4 ~ 7 parts.
Preferred further, described a kind of Chinese medicinal composition for reducing blood fat, comprises following composition according to weight:
Lignum Sappan 4 parts,
6 parts, Folium Nelumbinis,
Radix Salviae Miltiorrhizae 5 parts,
Radix Rhodiolae 4 parts,
Cortex cercis chinensis 9 parts,
Bulbus Fritillariae Uninbracteatae 5 parts,
Pericarpium Citri tangerinae 8 parts,
Flos Caryophylli 6 parts,
Radix Bupleuri 10 parts,
Rhizoma Acori Graminei 6 parts.
A kind of preparation method of Chinese medicinal composition for reducing blood fat, described preparation method is as follows: get according to weight that Lignum Sappan is 2 ~ 6 parts, Folium Nelumbinis is 4 ~ 7 parts, Radix Salviae Miltiorrhizae is 4 ~ 9 parts, Radix Rhodiolae is 2 ~ 4 parts, Cortex cercis chinensis is 7 ~ 12 parts, Bulbus Fritillariae Uninbracteatae is 4 ~ 7 parts, Pericarpium Citri tangerinae is 5 ~ 8 parts, Flos Caryophylli is 4 ~ 7 parts, Radix Bupleuri is 8 ~ 12 parts, Rhizoma Acori Graminei is 4 ~ 7 parts, Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, Rhizoma Acori Graminei is first dry, after drying, each Chinese crude drug being crushed into powder, is mixed Chinese medicine composition.
Preferably, the preparation method of described a kind of Chinese medicinal composition for reducing blood fat, described preparation method is as follows: get according to weight that Lignum Sappan is 4 parts, Folium Nelumbinis is 6 parts, Radix Salviae Miltiorrhizae is 5 parts, Radix Rhodiolae is 4 parts, Cortex cercis chinensis is 9 parts, Bulbus Fritillariae Uninbracteatae is 5 parts, Pericarpium Citri tangerinae is 8 parts, Flos Caryophylli is 6 parts, Radix Bupleuri is 10 parts, Rhizoma Acori Graminei is 6 parts, Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, Rhizoma Acori Graminei is first dry, after drying, each Chinese crude drug being crushed into powder, is mixed Chinese medicine composition.
In preparation method of the present invention, the characteristic of the Chinese crude drug adopted is all not identical, dissimilar Chinese crude drug is carried out composite after, the effect of the Chinese crude drug blood fat reducing prepared obtains maximum performance, this may be owing to having different active component in different Chinese crude drugs, the pharmacological action of some of them active component is also effectively confirmed, after therefore being combined by mentioned component, lipid-lowering effect obtains and manifests significantly.
Beneficial effect: after preparing Chinese medicinal composition for reducing blood fat of the present invention, determines the function of Chinese medicine composition blood fat reducing of the present invention.Get male rat to divide into groups, gavage carried out to male rat, gavage be Chinese medicine composition of the present invention decoct described decoction, feed after 10 days, determine total cholesterol level and the content of triglyceride of rat.Total cholesterol level in rat body is down to 3.44 to 3.69mmol/L from 4.63 to 4.85mmol/L, content of triglyceride in rat body is down to 0.77 to 0.93mmol/L from 1.35 to 1.48mmol/L, has the significant function reducing T-CHOL in rat body and content of triglyceride.
Detailed description of the invention
Embodiment 1
Getting Lignum Sappan according to weight is 4 parts, fresh Folium Nelumbinis is 6 parts, Radix Salviae Miltiorrhizae is 5 parts, Radix Rhodiolae is 4 parts, Cortex cercis chinensis is 9 parts, Bulbus Fritillariae Uninbracteatae is 5 parts, Pericarpium Citri tangerinae after harvesting is 8 parts, Flos Caryophylli is 6 parts, Radix Bupleuri is 10 parts, Rhizoma Acori Graminei is 6 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, first Rhizoma Acori Graminei puts into vacuum drying oven, be 70 DEG C in temperature and carry out vacuum drying, after vacuum drying to all fresh Chinese crude drugs are reduced to drying regime, again dried various Chinese crude drug is taken out, the large-scale pulverizer of each Chinese crude drug is pulverized, be crushed to traditional Chinese medicinal material raw materials and become powder, powder is the Chinese medicinal composition for reducing blood fat of preparation.
Embodiment 2
Getting Lignum Sappan according to weight is 2 parts, fresh Folium Nelumbinis is 7 parts, Radix Salviae Miltiorrhizae is 4 parts, Radix Rhodiolae is 3 parts, Cortex cercis chinensis is 12 parts, Bulbus Fritillariae Uninbracteatae is 4 parts, Pericarpium Citri tangerinae after harvesting is 7 parts, Flos Caryophylli is 4 parts, Radix Bupleuri is 12 parts, Rhizoma Acori Graminei is 4 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, first Rhizoma Acori Graminei puts into vacuum drying oven, be 70 DEG C in temperature and carry out vacuum drying, after vacuum drying to all fresh Chinese crude drugs are reduced to drying regime, again dried various Chinese crude drug is taken out, the large-scale pulverizer of each Chinese crude drug is pulverized, be crushed to traditional Chinese medicinal material raw materials and become powder, powder is the Chinese medicinal composition for reducing blood fat of preparation.
Embodiment 3
Getting Lignum Sappan according to weight is 6 parts, fresh Folium Nelumbinis is 4 parts, Radix Salviae Miltiorrhizae is 9 parts, Radix Rhodiolae is 2 parts, Cortex cercis chinensis is 7 parts, Bulbus Fritillariae Uninbracteatae is 7 parts, Pericarpium Citri tangerinae after harvesting is 5 parts, Flos Caryophylli is 7 parts, Radix Bupleuri is 8 parts, Rhizoma Acori Graminei is 7 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, first Rhizoma Acori Graminei puts into vacuum drying oven, be 70 DEG C in temperature and carry out vacuum drying, after vacuum drying to all fresh Chinese crude drugs are reduced to drying regime, again dried various Chinese crude drug is taken out, the large-scale pulverizer of each Chinese crude drug is pulverized, be crushed to traditional Chinese medicinal material raw materials and become powder, powder is the Chinese medicinal composition for reducing blood fat of preparation.
Embodiment 4
Getting Lignum Sappan according to weight is 2 parts, fresh Folium Nelumbinis is 7 parts, Radix Salviae Miltiorrhizae is 4 parts, Radix Rhodiolae is 3 parts, Cortex cercis chinensis is 12 parts, Bulbus Fritillariae Uninbracteatae is 4 parts, Pericarpium Citri tangerinae after harvesting is 7 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, first vacuum drying oven is put into, be 70 DEG C in temperature and carry out vacuum drying, after vacuum drying to all fresh Chinese crude drugs are reduced to drying regime, again dried various Chinese crude drug is taken out, the large-scale pulverizer of each Chinese crude drug is pulverized, be crushed to traditional Chinese medicinal material raw materials and become powder, powder is the Chinese medicinal composition for reducing blood fat of preparation.
Embodiment 5
Getting Lignum Sappan according to weight is 6 parts, fresh Folium Nelumbinis is 4 parts, Radix Salviae Miltiorrhizae is 9 parts, Radix Rhodiolae is 2 parts, Cortex cercis chinensis is 7 parts, Bulbus Fritillariae Uninbracteatae is 7 parts, Pericarpium Citri tangerinae after harvesting is 5 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, first vacuum drying oven is put into, be 70 DEG C in temperature and carry out vacuum drying, after vacuum drying to all fresh Chinese crude drugs are reduced to drying regime, again dried various Chinese crude drug is taken out, the large-scale pulverizer of each Chinese crude drug is pulverized, be crushed to traditional Chinese medicinal material raw materials and become powder, powder is the Chinese medicinal composition for reducing blood fat of preparation.
After preparing Chinese medicinal composition for reducing blood fat of the present invention, decocted by the Chinese medicine composition of embodiment 1 to 5, decocting temperature is 100 DEG C, and decocting time is 2h, and when decocting, solid-liquid ratio is 1:10, decocts rear cooling, filters the decoction obtaining Chinese medicinal composition for reducing blood fat.
Get male rat 5, respectively to 5 rat oral gavages, gavage is respectively the decoction of Chinese medicine composition of embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5.Given low is 0.5g/kg, and the gavage time is 10 days.Measure the total cholesterol level before and after gavage in rat body and content of triglyceride.The T-CHOL of male rat before and after gavage and content of triglyceride measurement result as follows.
Embodiment 1 measurement result
Male rat is by the Chinese medicine composition decoction gavage of embodiment 1 after 10 days, and the total cholesterol level in its body is down to 3.44 mmol/L from 4.85, and the content of triglyceride in rat body is down to 0.77 mmol/L from 1.48mmol/L.
Embodiment 2 measurement result
Male rat is by the Chinese medicine composition decoction gavage of embodiment 2 after 10 days, and the total cholesterol level in its body is down to 3.52 mmol/L from 4.81, and the content of triglyceride in rat body is down to 0.85 mmol/L from 1.42mmol/L.
Embodiment 3 measurement result
Male rat is by the Chinese medicine composition decoction gavage of embodiment 3 after 10 days, and the total cholesterol level in its body is down to 3.53 mmol/L from 4.82, and the content of triglyceride in rat body is down to 0.84 mmol/L from 1.43mmol/L.
Embodiment 4 measurement result
Male rat is by the Chinese medicine composition decoction gavage of embodiment 4 after 10 days, and the total cholesterol level in its body is down to 3.68 mmol/L from 4.63, and the content of triglyceride in rat body is down to 0.93mmol/L from 1.35mmol/L.
Embodiment 5 measurement result
Male rat is by the Chinese medicine composition decoction gavage of embodiment 5 after 10 days, and the total cholesterol level in its body is down to 3.69 mmol/L from 4.66, and the content of triglyceride in rat body is down to 0.92 mmol/L from 1.37mmol/L.
T-CHOL and the content of triglyceride measurement result of above rat show, Chinese medicine composition of the present invention has the effect of extraordinary reduction blood fat, the wherein best results of embodiment 1, embodiment 2 and embodiment 3 are taken second place, especially with the addition of Flos Caryophylli, Radix Bupleuri and Rhizoma Acori Graminei and after content optimizes further to its composition, the effect of its blood fat reducing is more remarkable.
Contrast experiment
The Chinese medicine formula of comparative example is Ampelopsis grossedentata 400g, Radix Salviae Miltiorrhizae is 150g, Rhizoma Alismatis is 200g, Fructus Crataegi is 200g.Decoct method identical with the method for taking dose and embodiment 1 to 5.Male rat took the Chinese medicine composition decoction gavage of comparative example after 10 days, and the total cholesterol level in its body is down to 4.33 mmol/L from 4.76, and the content of triglyceride in rat body is down to 1.39 mmol/L from 1.53mmol/L.The effect of blood fat reducing is not so good as the Be very effective of embodiments of the invention 1 to 5.
Claims (10)
1. a Chinese medicinal composition for reducing blood fat, is characterized in that described Chinese medicinal composition for reducing blood fat comprises following composition according to weight:
Lignum Sappan 2 ~ 6 parts,
4 ~ 7 parts, Folium Nelumbinis,
Radix Salviae Miltiorrhizae 4 ~ 9 parts,
Radix Rhodiolae 2 ~ 4 parts,
Cortex cercis chinensis 7 ~ 12 parts,
Bulbus Fritillariae Uninbracteatae 4 ~ 7 parts,
Pericarpium Citri tangerinae 5 ~ 8 parts.
2. a kind of Chinese medicinal composition for reducing blood fat according to claim 1, is characterized in that described Chinese medicinal composition for reducing blood fat comprises following composition according to weight:
Lignum Sappan 2 ~ 6 parts,
4 ~ 7 parts, Folium Nelumbinis,
Radix Salviae Miltiorrhizae 4 ~ 9 parts,
Radix Rhodiolae 2 ~ 4 parts,
Cortex cercis chinensis 7 ~ 12 parts,
Bulbus Fritillariae Uninbracteatae 4 ~ 7 parts,
Pericarpium Citri tangerinae 5 ~ 8 parts,
Flos Caryophylli 4 ~ 7 parts,
Radix Bupleuri 8 ~ 12 parts,
Rhizoma Acori Graminei 4 ~ 7 parts.
3. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Lignum Sappan weight described in described Chinese medicinal composition for reducing blood fat is 4 parts.
4. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Folium Nelumbinis weight described in described Chinese medicinal composition for reducing blood fat is 6 parts.
5. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Radix Salviae Miltiorrhizae weight described in described Chinese medicinal composition for reducing blood fat is 5 parts.
6. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Radix Rhodiolae weight described in described Chinese medicinal composition for reducing blood fat is 4 parts.
7. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Cortex cercis chinensis weight described in described Chinese medicinal composition for reducing blood fat is 9 parts.
8. a kind of Chinese medicinal composition for reducing blood fat according to claim 2, is characterized in that the Bulbus Fritillariae Uninbracteatae weight described in described Chinese medicinal composition for reducing blood fat is 5 parts, Pericarpium Citri tangerinae weight is 8 parts, Flos Caryophylli weight is 6 parts, Radix Bupleuri weight is 10 parts, Rhizoma Acori Graminei weight is 6 parts.
9. the preparation method of a kind of Chinese medicinal composition for reducing blood fat according to claim 2, it is characterized in that described preparation method is as follows: getting Lignum Sappan according to weight is 2 ~ 6 parts, Folium Nelumbinis is 4 ~ 7 parts, Radix Salviae Miltiorrhizae is 4 ~ 9 parts, Radix Rhodiolae is 2 ~ 4 parts, Cortex cercis chinensis is 7 ~ 12 parts, Bulbus Fritillariae Uninbracteatae is 4 ~ 7 parts, Pericarpium Citri tangerinae is 5 ~ 8 parts, Flos Caryophylli is 4 ~ 7 parts, Radix Bupleuri is 8 ~ 12 parts, Rhizoma Acori Graminei is 4 ~ 7 parts, by Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, Rhizoma Acori Graminei is first dry, after drying, each Chinese crude drug is crushed into powder, for mixed Chinese medicine composition.
10. the preparation method of a kind of Chinese medicinal composition for reducing blood fat according to claim 9, it is characterized in that described preparation method is as follows: get according to weight that Lignum Sappan is 4 parts, Folium Nelumbinis is 6 parts, Radix Salviae Miltiorrhizae is 5 parts, Radix Rhodiolae is 4 parts, Cortex cercis chinensis is 9 parts, Bulbus Fritillariae Uninbracteatae is 5 parts, Pericarpium Citri tangerinae is 8 parts, Flos Caryophylli is 6 parts, Radix Bupleuri is 10 parts, Rhizoma Acori Graminei is 6 parts, Lignum Sappan, Folium Nelumbinis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Cortex cercis chinensis, Bulbus Fritillariae Uninbracteatae, Pericarpium Citri tangerinae, Flos Caryophylli, Radix Bupleuri, Rhizoma Acori Graminei is first dry, after drying, each Chinese crude drug being crushed into powder, is mixed Chinese medicine composition.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105267431A (en) * | 2015-09-30 | 2016-01-27 | 李文 | Ready-to-drink traditional Chinese medicinal health product composition with blood fat lowering effect |
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| CN1537558A (en) * | 2003-04-14 | 2004-10-20 | 铁 于 | Traditional Chinese medicine for treating blood viscosity |
| CN1689603A (en) * | 2004-04-21 | 2005-11-02 | 色达县藏医院 | Pharmaceutical composition for treating hypertension and hyperlipemia and its preparation method |
| CN103301436A (en) * | 2013-06-21 | 2013-09-18 | 王燕华 | Medicine for loosing weight and reducing fat |
| CN103446426A (en) * | 2013-01-14 | 2013-12-18 | 贾晋科 | Chinese medicine tea capable of lowering blood pressure and reducing blood fat |
| CN103463426A (en) * | 2013-09-03 | 2013-12-25 | 陈柏林 | Traditional Chinese medicine pill for treating hyperlipidemia |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537558A (en) * | 2003-04-14 | 2004-10-20 | 铁 于 | Traditional Chinese medicine for treating blood viscosity |
| CN1689603A (en) * | 2004-04-21 | 2005-11-02 | 色达县藏医院 | Pharmaceutical composition for treating hypertension and hyperlipemia and its preparation method |
| CN103446426A (en) * | 2013-01-14 | 2013-12-18 | 贾晋科 | Chinese medicine tea capable of lowering blood pressure and reducing blood fat |
| CN103301436A (en) * | 2013-06-21 | 2013-09-18 | 王燕华 | Medicine for loosing weight and reducing fat |
| CN103463426A (en) * | 2013-09-03 | 2013-12-25 | 陈柏林 | Traditional Chinese medicine pill for treating hyperlipidemia |
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| 李秀才: "高脂血症的中医中药治疗", 《现代诊断与治疗》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267431A (en) * | 2015-09-30 | 2016-01-27 | 李文 | Ready-to-drink traditional Chinese medicinal health product composition with blood fat lowering effect |
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