CN105232912A

CN105232912A - Compound rhubarb capsules for treating acne

Info

Publication number: CN105232912A
Application number: CN201510751491.8A
Authority: CN
Inventors: 赵银香
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-09
Filing date: 2015-11-09
Publication date: 2016-01-13

Abstract

The invention discloses a Chinese herbal compound rhubarb for treating facial acne and a preparation method for capsules of the compound rhubarb. The capsules are prepared from rhubarb, coptis chinensis, scutellaria baicalensis, phellodendron chinense schneid, rhizoma anemarrhenae, prunella vulgaris, spina gleditsiae, moutan bark, chrysanthemum, honeysuckle, and fructus forsythiae. By means of a decoction method, water-soluble active ingredients are extracted, the auxiliary materials of dextrin (diluent), croscarmellose sodium (disintegrant), magnesium stearate (lubricant), and water (adhesive) are added to prepare particles, packing and weighing are conducted, and capsules are manufactured. The defects that the Chinese herbal medicine is inconvenient to take and poor in taste and smell are overcome, and the unpleasant smell of the Chinese herbal medicine is concealed.

Description

A kind of compound rubarb capsule being used for the treatment of acne

Technical field

The invention belongs to field of medicaments, be specifically related to a kind ofly treat the Radix Et Rhizoma Rhei Chinese medicine compound of facial acne and the preparation method of its capsule.

Background technology

Acne, is commonly called as comedo, acne, skin sore, is dermatology common disease, frequently-occurring disease.Acne, often from pubarche morbidity, the flourishing position of sebaceous gland such as to be apt to occur between face, breast, omoplate, to show as blackhead, inflamed papules, Secondary cases pustule or tuberosity, cyst.The traditional Chinese medical science thinks that the cause of disease mostly is inhibited pulmonary QI, hold concurrently sense wind and cold, wind heat, rheumatism etc., so that hair key closes, and fills in strongly fragrant fire-transformation of a specified duration, caused by the expectorant blood coagulation stasis of blood

Radix Et Rhizoma Rhei is cold in nature, bitter in the mouth, returns stomach, large intestine, liver, spleen channel.Have and attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, effect of removing toxic substances, has certain effect to acne.

Modern diagnosis and treatment acne is by facial inflammation treatment, and medicine used often containing 17-hydroxy-11-dehydrocorticosterone AID, can not be nursed one's health from inside, and side effect is large, and the state of an illness easily repeatedly.External, containing hormones anti-inflammatory agent, easily forms steroid-dependent dermatitis on the contrary.

The present invention uses tcm clinical practice theoretical as instructing, and reasonable compatibility, prepares Chinese patent medicine acne to certain effect.Take inconvenience for improving Chinese herbal medicine, the defects such as mouthfeel, abnormal smells from the patient difference, are designed to capsule, taking convenience, and can cover Chinese medicine bad smell preferably by this product.

Summary of the invention

The object of the invention is to openly a kind of acne that is used for the treatment of, the preparation method of Chinese herb rhubarb compound recipe and capsule thereof, provide a kind of active constituent content high, without the compound Chinese medicinal preparation of the Acne treatment of bad smell.

Pharmaceutical formulation is as follows:

This compound medicine group component mobility scale is comparatively large, and the present invention recommends a representative formula: Radix Et Rhizoma Rhei 10 parts, Rhizoma Coptidis 10 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 10 parts, the Rhizoma Anemarrhenae 10 parts, Spica Prunellae 15 parts, Spina Gleditsiae 10 parts, Cortex Moutan 10 parts, Flos Chrysanthemi 20 parts, Fructus Forsythiae 12 parts, Flos Lonicerae 10 parts.

A kind of compound rubarb gel preparation course being used for the treatment of acne is as follows:

1, crude drug is taken by said ratio, crude drug sterilized water is soaked 30 ~ 60min, and then decoct, amount of water each when decoction is is 6 ~ 8 times of medical material, slow fire is changed into after medical material boils, each decoction 1 ~ 2h, decocts 2 ~ 3 times, will decoct medicinal liquid several times and merge, ultracentrifugation removing impurity, by decoction by revolving steaming, concentrated, drying is also polished into powder.

2, glue capsule: after being mixed with adjuvant by dry powder drug, is prepared as satisfactory granule, can incapsulate, and select No. 1 capsule (volume 0.55ml), load-carrying 0.5g loading amount, concrete operations are as follows.

1) granulate

Be equivalent to primary dose 1.5g by every capsules contained drug effective ingredient and carry out loading amount.

Crude drug is extracted dry powder, mixes with adjuvant diluent, disintegrating agent, add suitable amount of adhesive, sieve, granulate, dry, be prepared as particulate matter.Add lubricant again, make granule be less than 45 ° angle of repose, it is qualified to be.Usual various supplementary product consumption is as shown in the table:

Diluent (50 ~ 80%)

Disintegrating agent (3 ~ 15%)

Binding agent (consumption adds in right amount by soft material)

Lubricant (1 ~ 3%)

2) loading amount: made particle inspection is qualified, with hard capsule filling machine loading amount and conjunction capsule cap, makes finished product.

A kind of beneficial effect being used for the treatment of the compound rubarb capsule of acne prepared by present embodiment is internally taken good care of from traditional Chinese medical science angle, and therapeutic effect is good, and side reaction is low, and medicine does not have bad smell, and patient is acceptant, compares Chinese medicine more convenient, health.Than external Western medicine, side reaction is low.

Specific embodiments

Take raw medicinal herbs Radix Et Rhizoma Rhei 10g Rhizoma Coptidis 10g by recommended amounts, Radix Scutellariae 10g, Cortex Phellodendri 10g, Rhizoma Anemarrhenae 10g, Spica Prunellae 10g part, Spina Gleditsiae 10g, Cortex Moutan 10g, Flos Chrysanthemi 20g, Fructus Forsythiae 12g, Flos Lonicerae 10g, crude drug amount is 122g.

Crude drug sterilized water is soaked 30 ~ 60min, then decoct, amount of water each when decoction is is 6 ~ 8 times of medical material, changes slow fire into after medical material boils, each decoction 1 ~ 2h, decoct 2 ~ 3 times, medicinal liquid will be decocted several times and merge, ultracentrifugation removing impurity, by decoction by revolving steaming, concentrated, drying is also polished into powder, obtains medicated powder 18.044g (extraction ratio 14.79%).

Crude drug is extracted 19.154g dry powder (45.75%), mix with adjuvant dextrin 20g (40%), cross-linking sodium carboxymethyl cellulose 6g (15%), add suitable quantity of water, sieve, granulate, dry, be prepared as particulate matter.Add magnesium stearate 0.4g (1%) again, make granule be less than 45 ° angle of repose, it is qualified to be.

By hard capsule filling machine loading amount and close capsule cap, be prepared into weight differential and disintegration qualified capsule preparations.

Claims

1. be used for the treatment of a Radix Et Rhizoma Rhei Herbal compound capsule agent for facial acne, it is characterized in that this compound recipe is by following group component compatibility:

Radix Et Rhizoma Rhei 5-20 part, Rhizoma Coptidis 5-20 part, Radix Scutellariae 5-20 part, Cortex Phellodendri 5-20 part, Rhizoma Anemarrhenae 5-20 part, Spica Prunellae 10-30 part, Spina Gleditsiae 5-20 part, Cortex Moutan 5-20 part, Flos Chrysanthemi 10-30 part, Flos Lonicerae 5-20 part, Fructus Forsythiae 10-18 part.

2. be used for the treatment of a Radix Et Rhizoma Rhei Herbal compound capsule agent for facial acne, it is characterized in that preparing by following process:

Crude drug is taken by proportioning according to claim 1, crude drug sterilized water is soaked 30 ~ 60min, and then decoct, amount of water each during decoction is 6 ~ 8 times of medical material, slow fire is changed into after medical material boils, each decoction 1 ~ 2h, decocts 2 ~ 3 times, will decoct medicinal liquid several times and merge, ultracentrifugation removing impurity, by decoction by revolving steaming, concentrated, drying is also polished into powder;

Glue capsule: by dry powder drug with mix after, mix with adjuvant diluent, disintegrating agent, add suitable amount of adhesive, through granulate, dry, be prepared as particulate matter.Add lubricant again, make granule be less than 45 ° angle of repose, made particle inspection is qualified, with hard capsule filling machine loading amount and conjunction capsule cap, makes capsule.

3. be a kind ofly as claimed in claim 1 used for the treatment of the Radix Et Rhizoma Rhei Chinese medicine compound of facial acne and the preparation method of its capsule, it is characterized in that the adjuvant diluent that capsule adds is starch, dextrin, one or more in cellulose; Lubricant is one or more in magnesium stearate, Pulvis Talci, micropowder silica gel; Disintegrating agent is dried starch, low-substituted hydroxypropyl methylcellulose, one or more in cross-linking sodium carboxymethyl cellulose; Binding agent is water, ethanol, one or more in starch slurry.