CN104257916A - Medicament for treating allergic conjunctivitis - Google Patents
Medicament for treating allergic conjunctivitis Download PDFInfo
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- CN104257916A CN104257916A CN201410588004.6A CN201410588004A CN104257916A CN 104257916 A CN104257916 A CN 104257916A CN 201410588004 A CN201410588004 A CN 201410588004A CN 104257916 A CN104257916 A CN 104257916A
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- radix
- herba
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention provides a medicament for treating allergic conjunctivitis. The medicament comprises the following medical raw materials: wild chrysanthemum flowers, trollflowers, callicarpa macrophylla, burdock, herba schizonepetae, rheum officinale, jasmines, honeysuckles, fructus polygoni orientalis, sophora flavescens, mints, divaricate saposhnikovia roots, spatholobus suberctu, mimosa pudica, elephantopus scaber, viola philippica, garden euphorbia herb, white peony root and liquorice. Due to a treatment mode of the matching of ultrasonic atomization and eyedrop dripping, the medicament has an outstanding treating effect on the allergic conjunctivitis; the course of diseases is shortened, the long-term eyedrop dripping frequency is reduced, irritation is prevented, the cost is low, and side effects and drug resistance are avoided.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of medicine being used for the treatment of anaphylaxis conjunctivitis.
Background technology
In recent years, because air pollution is day by day serious, increasing the weight of of local pollution control, the sickness rate of the factor anaphylactic diseases such as the frequent use of cosmetics and contact lens rises year by year, and anaphylaxis conjunctivitis has also become one of modal disease of ophthalmology.This disease is after Body contact anaphylactogen, the immediate hypersensitivity disease showed with the form be inflamed at the conjunctiva of eyes, and normal and allergic rhinitis accompanies.Most typical feature is that eyes are very itched, and is difficult to stand.Visible conjunctival congestion in addition, edema, eyelid is red and swollen, has mucus secretions, sheds tears more than.The phenomenons such as ophthalmologic examination palpebral conjunctiva nipple follicle hypertrophy.At present, the treatment of this disease is based on local application, effective to desensitization therapy, but most of patients can not find definite anaphylactogen, thus effectively can not avoid anaphylactogen, causes this sick recurrent exerbation, not easily thoroughly cures.
Treatment anaphylaxis conjunctivitis is with eye local application, and main purpose is mitigation symptoms and avoids sequela occurs, and local application can be the drug level that diseased region provides higher, rapid-action, effective, and can avoid the side effect that systemic administration causes.Antihistaminic, vasoconstrictor, mast cell stabilizers, NSAID (non-steroidal anti-inflammatory drug), glucocorticoid etc. are the common drug of topical therapeutic anaphylaxis conjunctivitis in recent years.
Described in motherland's medical science has in TCM Document the understanding of anaphylaxis conjunctivitis, think that it belongs to the category of " recurrence of disease at the same time next year disease ", " eye itching disease ", " extremeitching with formication ", " pruritus of the eye disease ", its pathogeneticing characteristic is: the strange duckweed of eyes unbearably, scorching hot hypodynia, photophobia are shed tears, hyperemia of the bulbar conjunctiva, send out to the phase, in periodic flare.Its Etiological pathogenesis can be divided into following some: 1, lung is defended solid, invades, upper criminal's white of the eye, be to and between born of the same parents' eyelid skin space between skin and muscles outside wind heat; 2, accumulate in damp-heat in the spleen and stomach, feel ailment said due to cold or exposure again, rheumatism pathogenic heat is fought mutually, stagnant in born of the same parents' eyelid, white of the eye; 3, deficiency of liver-blood, stirring-up of pathogenic wind in the interior resulting from deficiency, on violate in order.This sick etiology and pathogenesis not exogenous wind, heat, wet, empty, lung meridian is by evil, and liver and gall wind heat, causes wind heat and violate order; Weakness of the spleen and stomach, damp is stagnated, strongly fragrant and heat-transformation, damp and hot accumulate stagnant fine in vain; Deficiency of liver-blood, wind syndrome due to blood-deficiency, wind syndrome caused by deficiency violates order.In treatment, should dehumidify with expelling wind and clearing away heat, nourishing blood to expel wind is principle.
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of anaphylaxis conjunctivitis, the therapeutic modality of eye drop is coordinated by ultrasonic atomizatio, evident in efficacy in treatment anaphylaxis conjunctivitis, shorten the course of disease, reduce long-term Local eye drop number of times, prevent from causing stimulation, cheap, have no adverse reaction and drug resistance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of anaphylaxis conjunctivitis, the therapeutic modality of eye drop is coordinated by ultrasonic atomizatio, evident in efficacy in treatment anaphylaxis conjunctivitis, shorten the course of disease, reduce long-term Local eye drop number of times, prevent from causing stimulation, cheap, have no adverse reaction and drug resistance.
For solving the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of anaphylaxis conjunctivitis, its crude drug comprises: Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Arctii, Herba Schizonepetae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Flos Lonicerae, Fructus Polygoni Orientalis, Radix Sophorae Flavescentis, Herba Menthae, Radix Saposhnikoviae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., Herba Violae, Ramulus et Folium Bauhiniae Faberi, the Radix Paeoniae Alba and Radix Glycyrrhizae.
Wherein, in described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 20g ~ 30g, Flos Trollii 25g ~ 35g, Folium Callicarpae Macrophyllae 30g ~ 40g, Fructus Arctii 15g ~ 25g, Herba Schizonepetae 20g ~ 30g, Radix Et Rhizoma Rhei 20g ~ 30g, Fructus Gardeniae 35g ~ 45g, Flos Lonicerae 50g ~ 60g, Fructus Polygoni Orientalis 25g ~ 35g, Radix Sophorae Flavescentis 30g ~ 40g, Herba Menthae 20g ~ 30g, Radix Saposhnikoviae 25g ~ 35g, Caulis Spatholobi 30g ~ 40g, Herba Mimosae Pudicae 25g ~ 35g, Elephantopus scaber L. 30g ~ 40g, Herba Violae 25g ~ 35g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Radix Paeoniae Alba 15g ~ 25g and Radix Glycyrrhizae 20g ~ 30g.
Wherein, in described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 23g ~ 27g, Flos Trollii 28g ~ 32g, Folium Callicarpae Macrophyllae 33g ~ 37g, Fructus Arctii 18g ~ 22g, Herba Schizonepetae 23g ~ 27g, Radix Et Rhizoma Rhei 23g ~ 27g, Fructus Gardeniae 38g ~ 42g, Flos Lonicerae 53g ~ 57g, Fructus Polygoni Orientalis 28g ~ 32g, Radix Sophorae Flavescentis 33g ~ 37g, Herba Menthae 23g ~ 27g, Radix Saposhnikoviae 28g ~ 32g, Caulis Spatholobi 33g ~ 37g, Herba Mimosae Pudicae 28g ~ 32g, Elephantopus scaber L. 33g ~ 37g, Herba Violae 28g ~ 32g, Ramulus et Folium Bauhiniae Faberi 23g ~ 27g, Radix Paeoniae Alba 18g ~ 22g and Radix Glycyrrhizae 23g ~ 27g.
Wherein, in described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 25g, Flos Trollii 30g, Folium Callicarpae Macrophyllae 35g, Fructus Arctii 20g, Herba Schizonepetae 25g, Radix Et Rhizoma Rhei 25g, Fructus Gardeniae 40g, Flos Lonicerae 55g, Fructus Polygoni Orientalis 30g, Radix Sophorae Flavescentis 35g, Herba Menthae 25g, Radix Saposhnikoviae 30g, Caulis Spatholobi 35g, Herba Mimosae Pudicae 30g, Elephantopus scaber L. 35g, Herba Violae 30g, Ramulus et Folium Bauhiniae Faberi 25g, Radix Paeoniae Alba 20g and Radix Glycyrrhizae 25g.
Wherein, described medicine can be prepared into decoction liquor and eye drop.
Present invention also offers the preparation method of said medicine, when prepared medicine is decoction liquor, be specially: each crude drug component is pulverized respectively, put into blender to be uniformly mixed, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decocts 2 ~ 4 hours, and decoction liquor is filtered, twice decoction liquor is merged, obtains decoction liquor.
Present invention also offers the preparation method of said medicine, when prepared medicine is eye drop, be specially:
The first step, by Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Gardeniae, Flos Lonicerae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., the Radix Paeoniae Alba and Radix Glycyrrhizae are by above-mentioned weight mixing, with the alcohol reflux 2 times ~ 4 times that determining alcohol is 80% ~ 90%, the amount of the ethanol added is the mixture quality 4 ~ 6 times that this step obtains, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.15 ~ 1.20, add the water dissolution relative to mastic quality 3 ~ 5 times amount subsequently, add relative to mass percentage concentration 5% ~ 10% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7 ~ 8, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate reduced in volume obtains and gets dry extract, be ground into 50 order ~ 100 object powder,
Second step, by remaining components by above-mentioned weight mixing, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object powder, the powder that this powder and the first step obtain is mixed, obtain fine powder,
3rd step, by the sodium chloride of 1g ~ 2g, 0.5g ~ 1g mannitol, 0.03g ~ 0.06g hydroxy benzenes ethyl ester, add in appropriate sterilized water for injection, stir, add the fine powder that second step obtains subsequently, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition.
Beneficial effect of the present invention:
The medicine being used for the treatment of anaphylaxis conjunctivitis provided by the invention, coordinates the therapeutic modality of eye drop by ultrasonic atomizatio, evident in efficacy in treatment anaphylaxis conjunctivitis, shorten the course of disease, reduce long-term Local eye drop number of times, prevent from causing stimulation, cheap, have no adverse reaction and drug resistance.
Detailed description of the invention
The invention provides a kind of medicine being used for the treatment of anaphylaxis conjunctivitis, its crude drug comprises: Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Arctii, Herba Schizonepetae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Flos Lonicerae, Fructus Polygoni Orientalis, Radix Sophorae Flavescentis, Herba Menthae, Radix Saposhnikoviae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., Herba Violae, Ramulus et Folium Bauhiniae Faberi, the Radix Paeoniae Alba and Radix Glycyrrhizae.
Further, described medicine is only made up of above-mentioned raw materials medicine.
In described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 20g ~ 30g, Flos Trollii 25g ~ 35g, Folium Callicarpae Macrophyllae 30g ~ 40g, Fructus Arctii 15g ~ 25g, Herba Schizonepetae 20g ~ 30g, Radix Et Rhizoma Rhei 20g ~ 30g, Fructus Gardeniae 35g ~ 45g, Flos Lonicerae 50g ~ 60g, Fructus Polygoni Orientalis 25g ~ 35g, Radix Sophorae Flavescentis 30g ~ 40g, Herba Menthae 20g ~ 30g, Radix Saposhnikoviae 25g ~ 35g, Caulis Spatholobi 30g ~ 40g, Herba Mimosae Pudicae 25g ~ 35g, Elephantopus scaber L. 30g ~ 40g, Herba Violae 25g ~ 35g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Radix Paeoniae Alba 15g ~ 25g and Radix Glycyrrhizae 20g ~ 30g.
Further preferably, in described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 23g ~ 27g, Flos Trollii 28g ~ 32g, Folium Callicarpae Macrophyllae 33g ~ 37g, Fructus Arctii 18g ~ 22g, Herba Schizonepetae 23g ~ 27g, Radix Et Rhizoma Rhei 23g ~ 27g, Fructus Gardeniae 38g ~ 42g, Flos Lonicerae 53g ~ 57g, Fructus Polygoni Orientalis 28g ~ 32g, Radix Sophorae Flavescentis 33g ~ 37g, Herba Menthae 23g ~ 27g, Radix Saposhnikoviae 28g ~ 32g, Caulis Spatholobi 33g ~ 37g, Herba Mimosae Pudicae 28g ~ 32g, Elephantopus scaber L. 33g ~ 37g, Herba Violae 28g ~ 32g, Ramulus et Folium Bauhiniae Faberi 23g ~ 27g, Radix Paeoniae Alba 18g ~ 22g and Radix Glycyrrhizae 23g ~ 27g.
Most preferably, in described medicine, the weight of each crude drug is respectively Flos Chrysanthemi Indici 25g, Flos Trollii 30g, Folium Callicarpae Macrophyllae 35g, Fructus Arctii 20g, Herba Schizonepetae 25g, Radix Et Rhizoma Rhei 25g, Fructus Gardeniae 40g, Flos Lonicerae 55g, Fructus Polygoni Orientalis 30g, Radix Sophorae Flavescentis 35g, Herba Menthae 25g, Radix Saposhnikoviae 30g, Caulis Spatholobi 35g, Herba Mimosae Pudicae 30g, Elephantopus scaber L. 35g, Herba Violae 30g, Ramulus et Folium Bauhiniae Faberi 25g, Radix Paeoniae Alba 20g and Radix Glycyrrhizae 25g.
Described medicine is prepared into eye drop and decoction liquor, and decoction liquor is treated patient by ultrasonic atomizatio.
Present invention also offers the preparation method of said medicine, when prepared medicine is decoction liquor, be specially: each crude drug component is pulverized respectively, put into blender to be uniformly mixed, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decocts 2 ~ 4 hours, and decoction liquor is filtered, twice decoction liquor is merged, obtains decoction liquor.
Present invention also offers the preparation method of said medicine, when prepared medicine is eye drop, be specially:
The first step, by Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Gardeniae, Flos Lonicerae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., the Radix Paeoniae Alba and Radix Glycyrrhizae are by above-mentioned weight mixing, with the alcohol reflux 2 times ~ 4 times that determining alcohol is 80% ~ 90%, the amount of the ethanol added is the mixture quality 4 ~ 6 times that this step obtains, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.15 ~ 1.20, add the water dissolution relative to mastic quality 3 ~ 5 times amount subsequently, add relative to mass percentage concentration 5% ~ 10% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7 ~ 8, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate reduced in volume obtains and gets dry extract, be ground into 50 order ~ 100 object powder,
Second step, by remaining components by above-mentioned weight mixing, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object powder, the powder that this powder and the first step obtain is mixed, obtain fine powder,
3rd step, by the sodium chloride of 1g ~ 2g, 0.5g ~ 1g mannitol, 0.03g ~ 0.06g hydroxy benzenes ethyl ester, add in appropriate sterilized water for injection, stir, add the fine powder that second step obtains subsequently, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition.
In treatment epidemic hemorrhagic conjunctivitis, during general conventional eye drip treatment, medicine is low at conjunctival sac distributed density, action time is not long, and absorbs slow, poor permeability.And current more eye drop is irritant, after eye drop enters conjunctival sac, lacrimal secretion is caused to increase, before medicine not yet enters tissue, very easily diluted by tear, affect pharmaceutically-active performance, but, it is advantageous that and can use at any time, for patient treatment is provided convenience.Ultrasonic atomizatio is that aerosol trickle for medicinal atomized one-tenth is acted on focus by using ultrasound ripple, at local reachability to higher effective treatment concentration and persistent period, nebulae inhalation can make medicine contact eye table better, also have hot-wet compress effect to promote the absorption of inflammation, fumigating by air-flow, can accelerate local blood circulation simultaneously, disperse exopathogen, pass unimpeded QI and blood, but its Therapeutic Method is comparatively complicated, not easily uses at any time.
During atomization, medical liquid atomizing becomes micro particles to directly act on affected part, can make medicinal liquid local reach valid density and and continue for some time, diagonal angle conjunctiva plays direct osmosis, is conducive to angle conjunctiva to drug absorption; 2. stifling, the impact of air-flow can make a local blood circulation increase, and have stronger suppression and killing action to pathogen; 3. during atomization, steam can dilute antigen in tear, in and pH of tears, can the symptom of very fast reduction of patient.
It is carrier that the using method of described decoction liquor is specially with ultrasound atomizer, by in the prepared decoction liquor nebulizer container of falling people, plastic nozzle is connected by mist pipe, nozzle is just to trouble eye, patient opens eyelid and accepts treatment, and make medicinal liquid form atomization molecule by supersonic vibration and arrive bulbar conjunctiva and cornea, distance is 20cm, start timing 20 minutes, is atomized the clean napkin of complete use and dries.
Each crude drug pharmacology is as follows:
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent, return lung, Liver Channel, there is effect of heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver, cure mainly furuncle, carbuncle, scrofula, erysipelas, eczema, scabies, anemopyretic cold, laryngopharynx swelling and pain, dizziness and headache, the cards such as conjunctival congestion burning pain, Flos Chrysanthemi Indici, to staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all has inhibitory action.
Flos Trollii: latin name Trollius chinensis, bitter in the mouth, cool in nature, there is effect of heat-clearing and toxic substances removing, cure mainly acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, the cards such as acute lymphangitis.
Folium Callicarpae Macrophyllae: acrid in the mouth, hardship, property is put down, and returns liver, lung, stomach warp, has effect of dissipating blood stasis hemostasis, reducing swelling and alleviating pain, cures mainly hemoptysis, spits blood, has blood in stool, traumatic hemorrhage, falls cards such as flutterring pain.
Fructus Arctii: acrid in the mouth is bitter; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, and lung qi dispersing sore-throat relieving falls apart swollen effect, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.
Herba Schizonepetae: acrid in the mouth, slightly warm in nature, enters lung, Liver Channel, has relieving the exterior syndrome by diaphoresis, declares malicious rash, and the effect of blood hemostasis, is mainly used in the fever and headache that affection of exogenous wind-cold wind heat is caused, no matter has antiperspirant lossless, all can apply; The headache that wind heat is attacked is dizzy, and rash goes out not saturating; Puerperal blood faints apoplexy, the cards such as discharging fresh blood stool.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, there is effect of purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention; dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting; spit blood, spitting of blood, epistaxis, has blood in stool, hematuria; blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury; pyretic toxicity carbuncle and ulcer, erysipelas, and the cards such as scald, Radix Et Rhizoma Rhei has the effect of broad-spectrum antiseptic, can control the infection of wound surface.
Fructus Gardeniae: latin name gardeniae fructus, bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in the vexed uneasiness of epidemic febrile disease heat stagnation breast gastral cavity, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The cards such as the abdominal distention of qi depression to blood stasis.
Flos Trollii: latin name Trollius chinensis, bitter in the mouth, cool in nature, there is effect of heat-clearing and toxic substances removing, cure mainly acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, the cards such as acute lymphangitis.
Fructus Polygoni Orientalis: taste becomes, and cold nature, returns liver, stomach warp, have effect of promoting flow of QI and blood, hard masses softening and resolving, cure mainly chronic hepatitis, cirrhotic ascites, the tuberculosis of cervical lymph nodes, splenomegaly, dyspepsia, abdomen amine is had a stomachache, food stagnation of child, the cards such as conjunctivitis.
Radix Sophorae Flavescentis: latin name Sophorae Flavescentis Radix, bitter in the mouth; Cold in nature, enter liver; Kidney; Large intestine; Small intestinal; Bladder; Heart channel, has heat clearing and damp drying, parasite killing, and effect of diuresis, cures mainly hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, the cards such as scabies leprosy.
Herba Menthae: latin name Menthae Haplocalycis Herba, acrid in the mouth, cool in nature, return lung, Liver Channel, there is dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of dispersing the stagnated live-QI to relieve the stagnation of QI, cures mainly affection due to external wind and heat, epidemic febrile disease is shown in heating, micro-evil pain from the beginning of, disease, headache, cough, headache due to pathogenic wind-heat, the many tear of conjunctival congestion, the cards such as laryngopharynx swelling and pain.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature, returns bladder, liver, spleen channel, has expelling pathogenic wind from the body surface, removing dampness to relieve pain, and effect that relieving convulsion is jerked surely cures mainly diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, the cards such as tetanus.
Caulis Spatholobi: latin name spatholobi caulis, bitter in the mouth, sweet, warm in nature, return liver, kidney channel, have blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cure mainly the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.
Herba Mimosae Pudicae: sweet in the mouth, puckery, micro-hardship, cold nature, returns spleen, kidney two warp, have removing pathogenic heat from blood and toxic substance from the body, clearing away heat-damp and promoting diuresis, effect of tranquillizing and allaying excitement, cures mainly flu, infantile hyperpyrexia, bronchitis, hepatitis, gastritis, conjunctivitis, urinary system calculus, edema, hemoptysis, hematuria, neurasthenia, insomnia, sore swollen toxin, herpes zoster, the cards such as traumatic injury.
Elephantopus scaber L.: cold in nature, bitter in the mouth is pungent, has heat-clearing and toxic substances removing, and effect of inducing diuresis to remove edema, cures mainly flu, acute tonsillitis, pharyngolaryngitis, eye conjunctivitis, epidemic encephalitis type B, pertussis, acute icterohepatitis, cirrhotic ascites, acute and chronic nephritis, furuncle and phyma, the cards such as eczema.
Herba Violae: bitter in the mouth, pungent, cold in nature, enter the heart, Liver Channel, there is the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, be mainly used in the treatment for the treatment of furuncle carbuncle furuncle, also have good therapeutic effect to acute conjunctivitis, hordeolum etc., Herba Violae has inhibitory action in various degree to Staphyloccocus aureus, pneumobacillus, escherichia coli, alpha streptococcus, group B streptococcus, hemophilus influenza, diphtheria corynebacterium, bacillus pyocyaneus, white grapes sugar coccus, Candida albicans.
Ramulus et Folium Bauhiniae Faberi: latin name Euphorbiae Hirate Herba, mildly bitter flavor, micro-acid, cool in nature, there is heat-clearing and toxic substances removing, effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.
The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior card.
Radix Glycyrrhizae: sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 decoction liquor 1
By Flos Chrysanthemi Indici 25g, Flos Trollii 30g, Folium Callicarpae Macrophyllae 35g, Fructus Arctii 20g, Herba Schizonepetae 25g, Radix Et Rhizoma Rhei 25g, Fructus Gardeniae 40g, Flos Lonicerae 55g, Fructus Polygoni Orientalis 30g, Radix Sophorae Flavescentis 35g, Herba Menthae 25g, Radix Saposhnikoviae 30g, Caulis Spatholobi 35g, Herba Mimosae Pudicae 30g, Elephantopus scaber L. 35g, Herba Violae 30g, Ramulus et Folium Bauhiniae Faberi 25g, Radix Paeoniae Alba 20g and Radix Glycyrrhizae 25g pulverizes respectively, put into blender to be uniformly mixed, obtain mixture, add the water of 1.8kg, decoct 4 hours, decoction liquor is filtered, filtering residue adds the water of 1.8kg again, decoct 3 hours, decoction liquor is filtered, twice decoction liquor is merged, obtain decoction liquor 1.
Embodiment 2 decoction liquor 2
By Flos Chrysanthemi Indici 23g, Flos Trollii 28g, Folium Callicarpae Macrophyllae 33g, Fructus Arctii 18g, Herba Schizonepetae 23g, Radix Et Rhizoma Rhei 23g, Fructus Gardeniae 38g, Flos Lonicerae 53g, Fructus Polygoni Orientalis 28g, Radix Sophorae Flavescentis 33g, Herba Menthae 23g, Radix Saposhnikoviae 28g, Caulis Spatholobi 33g, Herba Mimosae Pudicae 28g, Elephantopus scaber L. 33g, Herba Violae 28g, Ramulus et Folium Bauhiniae Faberi 23g, Radix Paeoniae Alba 18g and Radix Glycyrrhizae 23g pulverizes respectively, put into blender to be uniformly mixed, obtain mixture, add the water of 1.8kg, decoct 4 hours, decoction liquor is filtered, filtering residue adds the water of 1.8kg again, decoct 3 hours, decoction liquor is filtered, twice decoction liquor is merged, obtain decoction liquor 2.
Embodiment 3 decoction liquor 3
By Flos Chrysanthemi Indici 27g, Flos Trollii 32g, Folium Callicarpae Macrophyllae 37g, Fructus Arctii 22g, Herba Schizonepetae 27g, Radix Et Rhizoma Rhei 27g, Fructus Gardeniae 42g, Flos Lonicerae 57g, Fructus Polygoni Orientalis 32g, Radix Sophorae Flavescentis 37g, Herba Menthae 27g, Radix Saposhnikoviae 32g, Caulis Spatholobi 37g, Herba Mimosae Pudicae 32, Elephantopus scaber L. 37g, Herba Violae 32g, Ramulus et Folium Bauhiniae Faberi 27g, Radix Paeoniae Alba 22g and Radix Glycyrrhizae 27g pulverizes respectively, put into blender to be uniformly mixed, obtain mixture, add the water of 1.8kg, decoct 4 hours, decoction liquor is filtered, filtering residue adds the water of 1.8kg again, decoct 3 hours, decoction liquor is filtered, twice decoction liquor is merged, obtain decoction liquor 3.
Embodiment 4 eye drop 1
By Flos Chrysanthemi Indici 25g, Flos Trollii 30g, Folium Callicarpae Macrophyllae 35g, Fructus Gardeniae 40g, Flos Lonicerae 55g, Caulis Spatholobi 35g, Herba Mimosae Pudicae 30g, Elephantopus scaber L. 35g, Radix Paeoniae Alba 20g and Radix Glycyrrhizae 25g mixes, with the alcohol reflux 3 times that 1.5kg determining alcohol is 90%, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.20, adds the water dissolution relative to mastic quality 4 times amount subsequently, adds relative to mass percentage concentration 5% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate reduced in volume obtains and gets dry extract, and is ground into 100 object powder, by Fructus Arctii 20g, Herba Schizonepetae 25g, Radix Et Rhizoma Rhei 25g, Fructus Polygoni Orientalis 30g, Radix Sophorae Flavescentis 35g, Herba Menthae 25g, Radix Saposhnikoviae 30g, Herba Violae 30g, Ramulus et Folium Bauhiniae Faberi 25g mixes, and obtains mixture, adds the water of 800g, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 800g again, decocts 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object powder subsequently, this powder is mixed with the powder obtained above, obtains fine powder, by the sodium chloride of 2g, 1g mannitol, 00.06g hydroxy benzenes ethyl ester, adds in appropriate sterilized water for injection, stir, add the fine powder obtained subsequently above, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition, obtain eye drop 1.
Embodiment 5 eye drop 2
By Flos Chrysanthemi Indici 23g, Flos Trollii 28g, Folium Callicarpae Macrophyllae 33g, Fructus Gardeniae 38g, Flos Lonicerae 53g, Caulis Spatholobi 33g, Herba Mimosae Pudicae 28g, Elephantopus scaber L. 33g, Radix Paeoniae Alba 18g and Radix Glycyrrhizae 23g mixes, with the alcohol reflux 3 times that 1.5kg determining alcohol is 90%, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.20, adds the water dissolution relative to mastic quality 4 times amount subsequently, adds relative to mass percentage concentration 5% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate reduced in volume obtains and gets dry extract, and is ground into 100 object powder, by Fructus Arctii 18g, Herba Schizonepetae 23g, Radix Et Rhizoma Rhei 23g, Fructus Polygoni Orientalis 28g, Radix Sophorae Flavescentis 33g, Herba Menthae 23g, Radix Saposhnikoviae 28g, Herba Violae 28g, Ramulus et Folium Bauhiniae Faberi 23g mixes, and obtains mixture, adds the water of 800g, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 800g again, decocts 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object powder subsequently, this powder is mixed with the powder obtained above, obtains fine powder, by the sodium chloride of 2g, 1g mannitol, 00.06g hydroxy benzenes ethyl ester, adds in appropriate sterilized water for injection, stir, add the fine powder obtained subsequently above, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition, obtain eye drop 2.
Embodiment 6 eye drop 3
By Flos Chrysanthemi Indici 27g, Flos Trollii 32g, Folium Callicarpae Macrophyllae 37g, Fructus Gardeniae 42g, Flos Lonicerae 57g, Caulis Spatholobi 37g, Herba Mimosae Pudicae 32g, Elephantopus scaber L. 37g, Radix Paeoniae Alba 22g and Radix Glycyrrhizae 27g mixes, with the alcohol reflux 3 times that 1.5kg determining alcohol is 90%, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.20, adds the water dissolution relative to mastic quality 4 times amount subsequently, adds relative to mass percentage concentration 5% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7, filter, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate reduced in volume obtains and gets dry extract, and is ground into 100 object powder, by Fructus Arctii 22g, Herba Schizonepetae 27g, Radix Et Rhizoma Rhei 27g, Fructus Polygoni Orientalis 32g, Radix Sophorae Flavescentis 37g, Herba Menthae 27g, Radix Saposhnikoviae 32g, Herba Violae 32g, Ramulus et Folium Bauhiniae Faberi 27g mixes, and obtains mixture, adds the water of 800g, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 800g again, decocts 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3, static 3 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object powder subsequently, this powder is mixed with the powder obtained above, obtains fine powder, by the sodium chloride of 2g, 1g mannitol, 00.06g hydroxy benzenes ethyl ester, adds in appropriate sterilized water for injection, stir, add the fine powder obtained subsequently above, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition, obtain eye drop 3.
Embodiment 7 toxicology test
Its mouse oral is tested
Select Kunming kind body weight 18 ~ 22g regular grade mice 60, random point 3 groups, often organize 20, male and female half and half.Matched group adopts routine feeding, tests 1 group of decoction liquor 1 that on the basis of routine feeding prepared by gavage embodiment 1, tests 2 groups of eye drops 1 that on the basis of routine feeding prepared by gavage embodiment 4.Fasting 12h, presses 0.4ml/10g (body weight) disposable gastric infusion to each group of mice.Viewing test animal poisoning manifestations and death condition after administration, Continuous Observation 14d.Calculate LD value.Result of the test shows, chmice acute Oral toxicity is tested, and presses once method to greatest extent, the equal > 10g/kg of LD, true border non-toxic type.
An intact skin irritation test
By healthy adult white, man exempts from 12, body weight 2.5 ~ 2.7kg, male and female half and half, is divided into test 1 group and test 2 groups.By its spinal column both sides skin unhairing 3cm × 3cm, getting 2 pieces of 2.5cm × 2.5cm, bis-layers of gauze is immersed in the decoction liquor 1 of embodiment 1 preparation and the eye drop 1 of embodiment 4 preparation, be applied on test 1 group and test 2 groups of plucked skins in family's rabbit back side respectively, cover with one deck cellophane, fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares again.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, Chinese medicinal ointment provided by the invention 1 pair of rabbit skin wound repair integration is 0, and skin, without erythema, belongs to non-stimulated.
Embodiment 8 clinical data
In January, 2013 ~ 2014 year March, through being diagnosed as anaphylaxis conjunctivitis patient totally 173 examples, treatment group and matched group is divided at random according to medical odd numbers, treatment group 90 example, male 53 example, women 37 example, 19 ~ 66 years old age (average 35.8 years old) matched group 83 example, male 45 example, women 38 example, 17 ~ 65 years old age (average 34.9 years old).Two groups of physical data are through statistical procedures, and no significant difference (P > 0.05), has comparability.
Diagnosis basis
Diagnosis is main with reference to " Chinese ophthalmology ": 1, symptom: ophthalmic pruritus, shed tears, burning sensation, foreign body sensation, photophobia and secretions increases (mostly being mucus); 2, sign: conjunctival congestion, edema, palpebral conjunctiva nipple follicle hypertrophy.
Exclusion standard
Get rid of with eye patients such as keratitis, xerophthalmia, glaucomas; Get rid of nearly 1 month and execute ophthalmic surgery; Get rid of use may other hydryllin of influence research result, mast cell stabilizers and corticosteroid collyrium, nasal mist or systemic drug patient.Get rid of intentionally, brain, liver, the severe primary disease such as kidney and hemopoietic system patient.Get rid of not by regulation medication, the infull person of curative effect or data cannot be judged.
Therapeutic Method
Treatment group: first washout suffers from eye 5 minutes before the treatment.
Nebulae inhalation: by decoction liquor 1 nebulizer container of falling people prepared by embodiment 1, plastic nozzle is connected by mist pipe, nozzle is just to trouble eye, patient opens eyelid and accepts treatment, make medicinal liquid form atomization molecule by supersonic vibration and arrive bulbar conjunctiva and cornea, distance is 20cm, and start timing 20 minutes, is atomized the clean napkin of complete use and dries.
Eye drops in treatment: the eye drop 1 embodiment 4 prepared instills suffers from eye place, every day 3 times, each 1 time of morning, noon and afternoon, each 1 ~ 2.
Nebulae inhalation and eye drops in treatment carry out simultaneously, within 7 days, are a course for the treatment of.
Matched group: give normal saline washout and suffer from eye 5min, every day 1 time; (emedastine difumarate eye drop, 5mL:2.5mg/ props up Ai Meiding eye drop, and local eye dripping, each 1, every day 3 times 7 days is 1 course for the treatment of.
Within 1 week, carry out checking and following up a case by regular visits to after 3 days, 5 days, 7 days and drug withdrawal after the treatment respectively, record eye subjective symptom and slit lamp examination palpebra inferior, conjunctiva, cornea situation.
Parameters for observation on effect
Adopt " clinical characters of anaphylaxis conjunctivitis " symptom and sign standards of grading to evaluate: ophthalmic pruritus, shed tears, foreign body sensation, eyelid nipple, palpebral follicles, secretions, knot abdomen is congested, chemosis.And calculate symptom integral.
Curative effect determinate standard
Computing formula: total mark × 100% before total mark decline index=(before treatment the rear total mark of total mark-treatment)/treatment.Effective: integration reduces > 70%; Effective: integration reduces 30% ~ 70%; Invalid: integration reduces < 30%.
Statistical method
Measurement data adopts
represent, compare between group and adopt χ
2inspection, all data all adopt the process of SPSS12.0 statistical software.
Result
Two groups of comparitive study, the results are shown in Table 1.
Table 1 liang group comparitive study
Group | Number of cases | Effective | Effectively | Invalid | Total effective rate/% |
Treatment group | 90 | 63 | 25 | 2 | 97.8 |
Matched group | 83 | 27 | 45 | 11 | 86.7 |
As can be seen from Table 1, two groups of therapeutic effect significant differences, p < 0.05, adopts medication effect provided by the invention better.
Two groups of MAIN OUTCOME MEASURES compare, in table 2 recovery time.
A table 2 liang group MAIN OUTCOME MEASURES compares (d) recovery time
Group | Number of cases | Ophthalmic pruritus | Conjunctival congestion | Chemosis | Palpebral follicles | Eyelid nipple |
Treatment group | 90 | 2.13±0.21 | 3.09±0.17 | 3.25±0.30 | 3.19±0.37 | 3.22±0.51 |
Matched group | 83 | 5.73±0.33 | 5.16±0.29 | 5.93±0.62 | 4.53±0.72 | 4.61±0.39 |
As can be seen from Table 2, the recovery time of each observation index for the treatment of group obviously will be less than matched group, p < 0.05.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. be used for the treatment of a medicine for anaphylaxis conjunctivitis, it is characterized in that: crude drug comprises Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Arctii, Herba Schizonepetae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Flos Lonicerae, Fructus Polygoni Orientalis, Radix Sophorae Flavescentis, Herba Menthae, Radix Saposhnikoviae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., Herba Violae, Ramulus et Folium Bauhiniae Faberi, the Radix Paeoniae Alba and Radix Glycyrrhizae.
2. medicine as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Flos Chrysanthemi Indici 20g ~ 30g, Flos Trollii 25g ~ 35g, Folium Callicarpae Macrophyllae 30g ~ 40g, Fructus Arctii 15g ~ 25g, Herba Schizonepetae 20g ~ 30g, Radix Et Rhizoma Rhei 20g ~ 30g, Fructus Gardeniae 35g ~ 45g, Flos Lonicerae 50g ~ 60g, Fructus Polygoni Orientalis 25g ~ 35g, Radix Sophorae Flavescentis 30g ~ 40g, Herba Menthae 20g ~ 30g, Radix Saposhnikoviae 25g ~ 35g, Caulis Spatholobi 30g ~ 40g, Herba Mimosae Pudicae 25g ~ 35g, Elephantopus scaber L. 30g ~ 40g, Herba Violae 25g ~ 35g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Radix Paeoniae Alba 15g ~ 25g and Radix Glycyrrhizae 20g ~ 30g.
3. medicine as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Flos Chrysanthemi Indici 23g ~ 27g, Flos Trollii 28g ~ 32g, Folium Callicarpae Macrophyllae 33g ~ 37g, Fructus Arctii 18g ~ 22g, Herba Schizonepetae 23g ~ 27g, Radix Et Rhizoma Rhei 23g ~ 27g, Fructus Gardeniae 38g ~ 42g, Flos Lonicerae 53g ~ 57g, Fructus Polygoni Orientalis 28g ~ 32g, Radix Sophorae Flavescentis 33g ~ 37g, Herba Menthae 23g ~ 27g, Radix Saposhnikoviae 28g ~ 32g, Caulis Spatholobi 33g ~ 37g, Herba Mimosae Pudicae 28g ~ 32g, Elephantopus scaber L. 33g ~ 37g, Herba Violae 28g ~ 32g, Ramulus et Folium Bauhiniae Faberi 23g ~ 27g, Radix Paeoniae Alba 18g ~ 22g and Radix Glycyrrhizae 23g ~ 27g.
4. the medicine as described in claims 1 to 3, is characterized in that: the weight of each crude drug is respectively Flos Chrysanthemi Indici 25g, Flos Trollii 30g, Folium Callicarpae Macrophyllae 35g, Fructus Arctii 20g, Herba Schizonepetae 25g, Radix Et Rhizoma Rhei 25g, Fructus Gardeniae 40g, Flos Lonicerae 55g, Fructus Polygoni Orientalis 30g, Radix Sophorae Flavescentis 35g, Herba Menthae 25g, Radix Saposhnikoviae 30g, Caulis Spatholobi 35g, Herba Mimosae Pudicae 30g, Elephantopus scaber L. 35g, Herba Violae 30g, Ramulus et Folium Bauhiniae Faberi 25g, Radix Paeoniae Alba 20g and Radix Glycyrrhizae 25g.
5. the medicine as described in Claims 1-4, is characterized in that: described medicine can be prepared into decoction liquor and eye drop.
6. the preparation method of medicine described in claim 1 to 5, is characterized in that: when prepared medicine is decoction liquor, is specially and each crude drug component is pulverized respectively, put into blender to be uniformly mixed, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decocts 2 ~ 4 hours, and decoction liquor is filtered, twice decoction liquor is merged, obtains decoction liquor.
7. the preparation method of medicine described in claim 1 to 6, is characterized in that: when prepared medicine is eye drop, comprise,
The first step, by Flos Chrysanthemi Indici, Flos Trollii, Folium Callicarpae Macrophyllae, Fructus Gardeniae, Flos Lonicerae, Caulis Spatholobi, Herba Mimosae Pudicae, Elephantopus scaber L., the Radix Paeoniae Alba and Radix Glycyrrhizae are by above-mentioned weight mixing, with the alcohol reflux 2 times ~ 4 times that determining alcohol is 80% ~ 90%, the amount of the ethanol added is the mixture quality 4 ~ 6 times that this step obtains, filter, merging filtrate, be evaporated to, when 60 DEG C, relative density is the mastic of 1.15 ~ 1.20, add the water dissolution relative to mastic quality 3 ~ 5 times amount subsequently, add relative to mass percentage concentration 5% ~ 10% sodium hydrate aqueous solution hydrotropy under stirring, adjust ph is 7 ~ 8, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate reduced in volume obtains and gets dry extract, be ground into 50 order ~ 100 object powder,
Second step, by remaining components by above-mentioned weight mixing, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object powder, the powder that this powder and the first step obtain is mixed, obtain fine powder,
3rd step, by the sodium chloride of 1g ~ 2g, 0.5g ~ 1g mannitol, 0.03g ~ 0.06g hydroxy benzenes ethyl ester, add in appropriate sterilized water for injection, stir, add the fine powder that second step obtains subsequently, stirring and dissolving is complete, stir evenly, continue to add sterilized water for injection, to the crude drug concentration of eye drop is 1g/ml, after stirring, with filtering with microporous membrane, at 100 DEG C, use flowing steam sterilization 30min, subpackage under aseptic condition.
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Publication number | Priority date | Publication date | Assignee | Title |
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CN105031011A (en) * | 2015-08-20 | 2015-11-11 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine composition for treating allergic conjunctivitis |
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