CN104257840B - Pharmaceutical composition for treating eczema of infants and young children and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating eczema of infants and young children and preparation method of pharmaceutical composition Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating eczema of infants and young children and a preparation method of the pharmaceutical composition. The composition is prepared from radix arnebiae seu lithospermi, folium artemisiae argyi, honeysuckle, cortex fraxini, cortex phellodendri, radix scutellariae, herba houttuyniae, gypsum and borneol. The pharmaceutical composition for treating eczema of infants and young children has the characteristics of good effect, no toxic and side effects and the like, and is safe to use. Trials show that the composition is good in both hardness and skin touch feeling, and is suitable for external use for skins of the infants and young children.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition treating infant eczema and preparation method thereof, belong to medical science neck
Territory.
Background technology
Infant eczema is a kind of allergic skin disease, is common clinical, and the traditional Chinese medical science is referred to as tire leprosy, infantile eczema, erythroderma of newborn
Deng.Clinical symptoms, with local erythema, pimple, vesicle, has a juice etc., and with violent pruritus, heat, meets and wet all can make eczema
Performance is notable.Primary disease pruritus difficulty is delayed, and touching difficulty heals, and easily recurrent exerbation, makes infant emotion uneasy and affects sleep and diet, and
Secondary bacterial infection, hinders normal growth and grows and healthy.
At present this disease treat and general use the outer method of preventing and treating being coated with for oral administration to treat, and clinically medicine for external use often contains
Glucocorticoids medicine or histamine class antiallergic agent, side effect is more, is easily caused whole body or local untoward reaction, and treatment natural law
Can not be long.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of pharmaceutical composition treating infant eczema, should
Pharmaceutical composition is effective, it is safe and free of toxic and side effects to use.Present invention also offers the preparation method of this pharmaceutical composition.
Technical scheme is as follows:
A kind of pharmaceutical composition treating infant eczema, said composition is made up of the crude drug of following weight portion: Radix Arnebiae (Radix Lithospermi)
50-100 part, Folium Artemisiae Argyi 100-150 part, Flos Lonicerae 50-100 part, Cortex Fraxini 50-80 part, Cortex Phellodendri 20-40 part, Radix Scutellariae 20-40 part, fish
Raw meat grass 10-20 part, Gypsum Fibrosum 20-30 part, Borneolum Syntheticum 4-10 part.
Currently preferred, the pharmaceutical composition of above-mentioned treatment infant eczema, it is made up of the crude drug of following weight portion:
Radix Arnebiae (Radix Lithospermi) 80 parts, Folium Artemisiae Argyi 120 parts, Flos Lonicerae 70 parts, Cortex Fraxini 60 parts, Cortex Phellodendri 30 parts, Radix Scutellariae 25 parts, Herba Houttuyniae 15 parts, 25 parts of Gypsum Fibrosum,
Borneolum Syntheticum 5 parts.
Present invention also offers the preparation method of the pharmaceutical composition of this treatment infant eczema, step is as follows:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume
The ethanol extraction of percentage ratio 35-65% 2-3 time, the 6-10 times amount that ethanol volume is medical material weight every time added, extract every time
1-2h, extracting solution merges filtration and concentrates, dries, pulverizes, and get dry extract powder I；
Or: after Cortex Fraxini is ground into coarse powder together with Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder, by above-mentioned
Step prepares the dried cream powder II containing Cortex Fraxini；
2) oil immersion thing is prepared: Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, and adds the Semen Lini oil of 3-7 times of weight of medical material, refine Adeps Caprae seu ovis
Miscella soaks 3-10 day, then slow fire decocts 1-2h, filters while hot, obtains oil immersion thing I；
Or: by Cortex Fraxini together with Radix Arnebiae (Radix Lithospermi), prepare the oil immersion thing II containing Cortex Fraxini by above-mentioned steps；
3) mixing: take step 2) prepare the oil immersion thing II containing Cortex Fraxini, temperature is cooled to 50 DEG C, add step 1) prepare
The dried cream powder I without Cortex Fraxini, stir, and with colloid mill polish 2 times, be eventually adding Borneolum Syntheticum, mix homogeneously, i.e. get Ben Fa
Bright pharmaceutical composition；
Or: take step 2) the oil immersion thing without Cortex Fraxini I and the step 1 that prepare) dried cream powder II containing Cortex Fraxini for preparing, press
Above-mentioned steps prepares the pharmaceutical composition of the present invention.
Currently preferred, in the preparation method of described pharmaceutical composition, step 1) described in the side preparing dried cream powder
Method is: after described crude drug is ground into coarse powder, the ethanol extraction of addition percent by volume 50% 2 times, the ethanol every time added
Volume is 7 times amount of medical material weight, extracts 2h every time, and extracting solution merges to filter and also concentrates, dries, pulverizes, get dry extract powder I or
Ⅱ。
The present invention it is further preferred that described pharmaceutical composition preparation method in, step 2) described in preparation oil immersion
The method of thing is: described crude drug is ground into coarse powder, and adds the Semen Lini oil of 6 times of weight of medical material, the mixing of refine Adeps Caprae seu ovis
Oil immersion is steeped 5, then slow fire decocts 2h, filters while hot, obtains oil immersion thing I or II.
Further, in the preparation method of pharmaceutical composition of the present invention, step 2) described in Semen Lini oil, essence
The weight ratio of refining Adeps Caprae seu ovis miscella is 2:1.
Volume of the present invention is mL:g or L:kg with the unit corresponding relation of weight.
Beneficial effect: the present invention provide treatment infant eczema pharmaceutical composition, have effective, use safety,
The feature such as have no side effect.The present invention is found by experiment that, when the ratio of Semen Lini oil and refine Adeps Caprae seu ovis is 2: 1, gained mixes
Thing no matter hardness, contact skin sense or half way freezing point are all preferable, are suitable for infant external preparation for skin, and the extraction to Cortex Fraxini,
The effect of oil immersion is better than alcohol extraction.
Detailed description of the invention:
Below in conjunction with experimental example and embodiment, the present invention is further illustrated.
Experimental example 1, the selection of miscella
Adeps Caprae seu ovis is fine and smooth, contact skin sense is good, but freezing point is higher, is unfavorable for preparation；Semen Lini oil freezing point is relatively low, but skin
Skin contact is too greasy.Consider for this Radix Arnebiae (Radix Lithospermi) is extracted the two mixing, and select for index with contact skin sense and fusing point
The ratio of the two.
One, test material and sample
Refine Adeps Caprae seu ovis (He'nan Yisai Beef (Stock) Co., Ltd. produces, lot number 2013120908X), Semen Lini oil (Datong District
Huajian, city oils and fats Co., Ltd produces, lot number 20140211)
Two, test method
The miscella of differently configured part by weight, adds 8g Radix Arnebiae (Radix Lithospermi) coarse powder, 6g Cortex Fraxini coarse powder, soaks 5, then slow fire decocts
2h, filters while hot, adds embodiment 1 step 1) the dried cream powder 20g for preparing, colloid mill polishes 2 times, Slow cooling, writes down half way
Freezing point (has i.e. solidified the temperature of 1/2), is applied on skin by gained mixture after solidifying completely, hard according to mixture
Degree and giving a mark respectively with the contiguous sense of skin, hardness score value according to contact skin, suitable 5 points of soft or hard, cross soft or really up to the mark 3 points,
Too soft or the hardest 1 point；With the contiguous sense of skin marking score value: from exquisiteness lubrication non-greasy to greasy the dryest and the comfortableest, score value is respectively
It is 5～1.
Three, result of the test: be shown in Table 1.
The investigation of the different miscella ratio of table 1
According to upper table, when the ratio of Semen Lini oil and refine Adeps Caprae seu ovis is 2:1, gained mixture no matter hardness, skin connect
Sense of touch or half way freezing point are all preferable, are suitable for infant external preparation for skin.
Experimental example 2, clinical data
One, case selection
Choose 78 example infant eczema infants, male 38 examples, female 40 example；3 months ages～2 years old 8 months, 1 years old 3 mean age
Individual month, main clinical manifestation: face, cervical region and other area skin erythra of whole body, red pimple, erythema, vesicle and silly skin,
Ooze out, rotten to the corn, and with pruritus in various degree.
Two, prepared by sample
1, sample 1:
1) dried cream powder is prepared: by Folium Artemisiae Argyi 120g, Flos Lonicerae 70g, Cortex Phellodendri 30g, Radix Scutellariae 25g, Herba Houttuyniae 15g, Gypsum Fibrosum 25g powder
After being broken into coarse powder, the ethanol extraction of addition percent by volume 50% 2 times, ethanol volume is medical material weight 7 times every time added
Amount, extracts 2h every time, and extracting solution merges filtration and concentrates, dries, pulverizes, and get dry extract powder 23g；
2) prepare oil immersion thing: Radix Arnebiae (Radix Lithospermi), Cortex Fraxini are ground into coarse powder, and add 6 times of weight of medical material, weight ratio is the Asia of 2:1
Hemp seed oil, refine Adeps Caprae seu ovis miscella soak 5, then slow fire decocts 2h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum 5g, mix homogeneously, obtains sample 1.
2, sample 2:
By the preparation method of Cortex Fraxini from oil immersion become together with Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder by
Step 1) described method makes dried cream powder, and other preparation processes are with the preparation method of sample 1.
Three, Therapeutic Method
Above 78 example infant stochastic averagina are divided into 3 groups: matched group, treat 1 group and treatment 2 groups, wherein matched group use
999 baby's Radix Arnebiae (Radix Lithospermi) eczema ointments (three nine-day periods after the winter solstice Pharmaceutical, 20140122), smear affected part every day 3 times；Treat 1 group and use sample 1, treat 2 groups
Use sample 2, smear affected part 3 times equal every day.
With warm water, affected part is cleaned before medication, rubs affected part with the hands heat with hands, with cotton swab dip reference substance and sample 1, sample 2 is coated with
Put affected part on the skin, three times a day, within one week, be a course for the treatment of, continuously two courses for the treatment of of treatment, during treatment, disable other drug.
Four, criterion of therapeutical effect
1, cure: erythra, red pimple, erythema, little water scar, yellow squama and silly skin, ooze out, the clinical symptoms such as rotten to the corn whole
Disappear, physical rehabilitation；
2, effective: clinical symptom relief, improvement；
3, invalid: symptom nothing compared with before treatment is improved.
Five, therapeutic outcome
It is shown in Table 2, compares between group and check with ridit.
During test, matched group has 2 examples the worst, and 1 group and 2 groups of sample does not all observe untoward reaction.
Table 2, clinical effectiveness
| Cure (n/%) | Effectively (n/%) | Invalid (n/%) | Total effective rate (%) | Untoward reaction rate | |
| Matched group | 9(34.6) | 11(42.3) | 6(23.1) | 76.9 | 2 (7.7%) |
| 1 group of sample | 19(73.1) | 6(23.1) | 1(3.8) | 96.2** | —— |
| 2 groups of sample | 17(65.4) | 7(26.9) | 2(7.7) | 92.3* | —— |
Note: compare * P ＜ 0.05 with matched group；* P ＜ 0.01.
Six, brief summary
Clinical effectiveness shows, comparison medicine, sample 1 and sample 2 are respectively provided with good effect for infant eczema；Wherein
Cortex Fraxini oil immersion (sample 1) is more better than ethanol extraction (sample 2), compares have pole significant difference (P ＜ with compareing medicine
0.01)。
Following example all can realize the effect of described experimental example.
Embodiment 1, a kind of pharmaceutical composition treating infant eczema, its raw material composition includes the medicine of following weight portion
Material: Radix Arnebiae (Radix Lithospermi) 80g, Folium Artemisiae Argyi 120g, Flos Lonicerae 70g, Cortex Fraxini 60g, Cortex Phellodendri 30g, Radix Scutellariae 25g, Herba Houttuyniae 15g, Gypsum Fibrosum 25g, Borneolum Syntheticum
5g。
The preparation method of aforementioned pharmaceutical compositions, comprises the steps:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume
The ethanol extraction of percentage ratio 50% 2 times, 7 times amount that ethanol volume is medical material weight every time added, extract 2h, extracting solution every time
Merging and filter and concentrate, dry, pulverize, get dry extract powder 63.5g；
2) prepare oil immersion thing: Radix Arnebiae (Radix Lithospermi), Cortex Fraxini are ground into coarse powder, and add 6 times of weight of medical material, weight ratio is the Asia of 2:1
Hemp seed oil, refine Adeps Caprae seu ovis miscella soak 5, then slow fire decocts 2h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum, mix homogeneously, to obtain final product.
Embodiment 2, a kind of pharmaceutical composition treating infant eczema, its raw material forms and includes following medical material: Radix Arnebiae (Radix Lithospermi)
50g, Folium Artemisiae Argyi 100g, Flos Lonicerae 50g, Cortex Fraxini 50g, Cortex Phellodendri 20g, Radix Scutellariae 20g, Herba Houttuyniae 10g, Gypsum Fibrosum 20g, Borneolum Syntheticum 4g.
The preparation method of aforementioned pharmaceutical compositions, comprises the steps:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume
The ethanol extraction of percentage ratio 35% 2 times, 6 times amount that ethanol volume is medical material weight every time added, extract 1h, extracting solution every time
Merging and filter and concentrate, dry, pulverize, get dry extract powder 54.5g；
2) prepare oil immersion thing: Radix Arnebiae (Radix Lithospermi), Cortex Fraxini are ground into coarse powder, and add 3 times of weight of medical material, weight ratio is the Asia of 1:1
Hemp seed oil, refine Adeps Caprae seu ovis miscella soak 3, then slow fire decocts 1h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum, mix homogeneously, to obtain final product.
Embodiment 3, a kind of pharmaceutical composition treating infant eczema, its raw material forms and includes following medical material: Radix Arnebiae (Radix Lithospermi)
100g, Folium Artemisiae Argyi 150g, Flos Lonicerae 100g, Cortex Fraxini 80g, Cortex Phellodendri 40g, Radix Scutellariae 40g, Herba Houttuyniae 20g, Gypsum Fibrosum 30g, Borneolum Syntheticum 10g.
The preparation method of aforementioned pharmaceutical compositions, comprises the steps:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume
The ethanol extraction of percentage ratio 65% 3 times, 10 times amount that ethanol volume is medical material weight every time added, extract 2h every time, extract
Liquid merges filtration and concentrates, dries, pulverizes, and get dry extract powder 82.5g；
2) oil immersion thing is prepared: Radix Arnebiae (Radix Lithospermi), Cortex Fraxini are ground into coarse powder, and add the Semen Lini oil of 7 times of weight of medical material, refine sheep
Oil miscella (the two weight ratio 1:1) soaks 5, then slow fire decocts 2h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum, mix homogeneously, obtains the pharmaceutical composition of the present invention.
Embodiment 4, a kind of pharmaceutical composition treating infant eczema, its raw material forms and includes following medical material: Radix Arnebiae (Radix Lithospermi)
80g, Folium Artemisiae Argyi 100g, Flos Lonicerae 50g, Cortex Fraxini 80g, Cortex Phellodendri 30g, Radix Scutellariae 30g, Herba Houttuyniae 20g, Gypsum Fibrosum 30g, Borneolum Syntheticum 6g.
The preparation method of aforementioned pharmaceutical compositions, comprises the steps:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume
The ethanol extraction of percentage ratio 45% 3 times, 6 times amount that ethanol volume is medical material weight every time added, extract 2h, extracting solution every time
Merging and filter and concentrate, dry, pulverize, get dry extract powder 45.5g；
2) oil immersion thing is prepared: Radix Arnebiae (Radix Lithospermi), Cortex Fraxini are ground into coarse powder, and add the Semen Lini oil of 6 times of weight of medical material, refine sheep
Oil miscella (the two weight ratio 3:1) soaks 7, then slow fire decocts 1h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum, mix homogeneously, obtains the pharmaceutical composition of the present invention.
Embodiment 5, a kind of pharmaceutical composition treating infant eczema, its raw material forms and includes following medical material: Radix Arnebiae (Radix Lithospermi)
80g, Folium Artemisiae Argyi 120g, Flos Lonicerae 70g, Cortex Fraxini 80g, Cortex Phellodendri 20g, Radix Scutellariae 20g, Herba Houttuyniae 10g, Gypsum Fibrosum 20g, Borneolum Syntheticum 5g.
The preparation method of aforementioned pharmaceutical compositions, comprises the steps
1) dried cream powder is prepared: after Cortex Fraxini, Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add
Enter the ethanol extraction 2 times of percent by volume 50%, 6 times amount that ethanol volume is medical material weight every time added, extract 1h every time,
Extracting solution merges filtration and concentrates, dries, pulverizes, and get dry extract powder 63.5g；
2) prepare oil immersion thing: Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, and add the Semen Lini oil of 5 times of weight of medical material, refine Adeps Caprae seu ovis mixes
Close oil (the two weight ratio 2:1) to soak 10, then slow fire decocts 1h, filters while hot, obtains oil immersion thing；
3) mixing: wait oil immersion thing temperature to be cooled to 50 DEG C and add steps 1) dried cream powder of gained, stir, and with colloid
Mill polishing 2 times, is eventually adding Borneolum Syntheticum, mix homogeneously, obtains the pharmaceutical composition of the present invention.
Embodiment of the present invention is merely illustrative of, and is not the restriction that the present invention makees other form, any familiar
Professional and technical personnel utilizes the same change that technology contents of the present invention is made, and still falls within the guarantor of technical solution of the present invention
Protect scope.
Claims (6)
1. the pharmaceutical composition treating infant eczema, it is characterised in that said composition is by the crude drug of following weight portion
Make: Radix Arnebiae (Radix Lithospermi) 50-100 part, Folium Artemisiae Argyi 100-150 part, Flos Lonicerae 50-100 part, Cortex Fraxini 50-80 part, Cortex Phellodendri 20-40 part, Radix Scutellariae
20-40 part, Herba Houttuyniae 10-20 part, Gypsum Fibrosum 20-30 part, Borneolum Syntheticum 4-10 part；Preparation method is as follows:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume basis
Ethanol extraction than 35-65% 2-3 time, the 6-10 times amount that ethanol volume is medical material weight every time added, extract 1-2h every time,
Extracting solution merges filtration and concentrates, dries, pulverizes, and get dry extract powder I；
Or: after Cortex Fraxini is ground into coarse powder together with Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum, by above-mentioned steps system
Must be containing the dried cream powder II of Cortex Fraxini；
2) oil immersion thing is prepared: Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, and adds the Semen Lini oil of 3-7 times of weight of medical material, the mixing of refine Adeps Caprae seu ovis
3-10 day is steeped in oil immersion, then slow fire decocts 1-2h, filters while hot, obtains oil immersion thing I；
Or: by Cortex Fraxini together with Radix Arnebiae (Radix Lithospermi), prepare the oil immersion thing II containing Cortex Fraxini by above-mentioned steps；
3) mixing: take step 2) prepare the oil immersion thing II containing Cortex Fraxini, temperature is cooled to 50 DEG C, add step 1) prepare not
Dried cream powder I containing Cortex Fraxini, stirs, and polishes 2 times with colloid mill, is eventually adding Borneolum Syntheticum, mix homogeneously, obtains described medicine
Compositions；
Or: take step 2) dried cream powder II containing Cortex Fraxini for preparing with step 1) of the oil immersion thing without Cortex Fraxini I for preparing, by above-mentioned
Step prepares described pharmaceutical composition；
Volume described in this method is mL: g or L: kg with the unit corresponding relation of weight.
The pharmaceutical composition for the treatment of infant eczema the most according to claim 1, it is characterised in that said composition is by following
The crude drug of weight portion is made: Radix Arnebiae (Radix Lithospermi) 80 parts, Folium Artemisiae Argyi 120 parts, Flos Lonicerae 70 parts, Cortex Fraxini 60 parts, Cortex Phellodendri 30 parts, Radix Scutellariae 25 parts,
Herba Houttuyniae 15 parts, 25 parts of Gypsum Fibrosum, Borneolum Syntheticum 5 parts.
3. a preparation method for the pharmaceutical composition of the treatment infant eczema described in claim 1 or 2, step is as follows:
1) prepare dried cream powder: after Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum powder are broken into coarse powder, add volume basis
Ethanol extraction than 35-65% 2-3 time, the 6-10 times amount that ethanol volume is medical material weight every time added, extract 1-2h every time,
Extracting solution merges filtration and concentrates, dries, pulverizes, and get dry extract powder I；
Or: after Cortex Fraxini is ground into coarse powder together with Folium Artemisiae Argyi, Flos Lonicerae, Cortex Phellodendri, Radix Scutellariae, Herba Houttuyniae, Gypsum Fibrosum, by above-mentioned steps system
Must be containing the dried cream powder II of Cortex Fraxini；
2) oil immersion thing is prepared: Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, and adds the Semen Lini oil of 3-7 times of weight of medical material, the mixing of refine Adeps Caprae seu ovis
3-10 day is steeped in oil immersion, then slow fire decocts 1-2h, filters while hot, obtains oil immersion thing I；
Or: by Cortex Fraxini together with Radix Arnebiae (Radix Lithospermi), prepare the oil immersion thing II containing Cortex Fraxini by above-mentioned steps；
3) mixing: take step 2) prepare the oil immersion thing II containing Cortex Fraxini, temperature is cooled to 50 DEG C, add step 1) prepare not
Dried cream powder I containing Cortex Fraxini, stirs, and polishes 2 times with colloid mill, is eventually adding Borneolum Syntheticum, mix homogeneously, obtains described medicine
Compositions；
Or: take step 2) dried cream powder II containing Cortex Fraxini for preparing with step 1) of the oil immersion thing without Cortex Fraxini I for preparing, by above-mentioned
Step prepares described pharmaceutical composition；
Volume described in this method is mL: g or L: kg with the unit corresponding relation of weight.
The preparation method of the pharmaceutical composition for the treatment of infant eczema the most according to claim 3, it is characterised in that step
1) method preparing dried cream powder described in is: after described crude drug is ground into coarse powder, and the ethanol adding percent by volume 50% carries
Taking 2 times, 7 times amount that ethanol volume is medical material weight every time added, extract 2h every time, extracting solution merges filtration and concentrates, dries
Dry, pulverizing, get dry extract powder I or II.
The preparation method of the pharmaceutical composition for the treatment of infant eczema the most according to claim 3, it is characterised in that step
2) method of the preparation oil immersion thing described in is: described crude drug is ground into coarse powder, and adds the Semen Lini of 6 times of weight of medical material
Oil, refine Adeps Caprae seu ovis miscella soak 5, then slow fire decocts 2h, filters while hot, obtains oil immersion thing I or II.
6. according to the preparation method of the pharmaceutical composition treating infant eczema described in any one of claim 3-5, its feature
Be, step 2) described in Semen Lini oil, the weight ratio of refine Adeps Caprae seu ovis miscella be 2: 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101757387A (en) * | 2010-02-08 | 2010-06-30 | 张昌生 | Preparation method of traditional Chinese medicine for treating subcutaneous acute cellulitis |
| CN102973770A (en) * | 2012-11-13 | 2013-03-20 | 黄文珍 | Varicella-curing Chinese medicine combination and preparing method thereof |
| CN103055193A (en) * | 2012-12-03 | 2013-04-24 | 展继军 | Chinese medicinal composition for treating eczema |
| CN103784773A (en) * | 2012-10-30 | 2014-05-14 | 蔡田湉 | Health-care product for treating eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101757387A (en) * | 2010-02-08 | 2010-06-30 | 张昌生 | Preparation method of traditional Chinese medicine for treating subcutaneous acute cellulitis |
| CN103784773A (en) * | 2012-10-30 | 2014-05-14 | 蔡田湉 | Health-care product for treating eczema |
| CN102973770A (en) * | 2012-11-13 | 2013-03-20 | 黄文珍 | Varicella-curing Chinese medicine combination and preparing method thereof |
| CN103055193A (en) * | 2012-12-03 | 2013-04-24 | 展继军 | Chinese medicinal composition for treating eczema |
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