CN106620544A

CN106620544A - Medicine for treating schizophrenia and preparation method of medicine

Info

Publication number: CN106620544A
Application number: CN201710130439.XA
Authority: CN
Inventors: 李子义
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-07
Filing date: 2017-03-07
Publication date: 2017-05-10

Abstract

The invention discloses a medicine for treating schizophrenia and a preparation method of the medicine. The medicine is prepared from radix bupleuri, scutellaria baicalensis, pinellia ternata, pericarpium citri reticulatae viride, fructus aurantii, concha haliotidis, caulis bambusae in taeniam, radix gentianae, jasmine, concha margaritiferallsta, lapis micae aureum, rhizoma acori graminei, polygala tenuifolia, concretio silicea pambusae, rhizoma arisaematis, peach kernel, flowers carthami, fructus perillae, cortex mori radicis, white paeony root, radix curcumae, musk, calculus bovis, cinnabar and amber according to a certain weight ratio. The medicine has the functions of inducing resuscitation, regulating qi, activating blood, tranquilizing the mind, promoting the intelligence, cooling the heart, arresting convulsion, promoting the circulation of qi and relieving exterior syndrome, and takes a quick response and is good in treating effect on treatment of the schizophrenia, and the schizophrenia does not reoccur.

Description

One kind treats schizoid medicine and preparation method thereof

Technical field

The present invention relates to one kind treats schizoid medicine and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Schizophrenia is the unknown mental disease of one group of cause of disease, clinical more between twenty and fifty slow or subacute onset On often show as the different syndrome of symptom, be related to many obstacles such as sensory perception, thinking, emotion and behavior and spirit Movable is uncoordinated.The general Clear consciousness of patient, intelligence is normal, but some patientss occur cognitive work(in lysis The infringement of energy.The course of disease is typically delayed, and in recurrent exerbation, is increased or is deteriorated, and decline and mental disorder finally occur in some patientss.By In western medicine large side effects, therefore there is great demand in people to the schizoid Chinese medicine of effectively treatment, so far Till, it has not been found that with regard to the relevant report of the present invention.

The content of the invention

The present inventor have found effectively treatment spirit finally according to the checking repeatedly of research and the clinical testing of theory of traditional Chinese medical science The medicine of Split disease, so as to complete the present invention.

It is an object of the invention to provide a kind of schizoid Chinese medicine composition of effectively treatment.

Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.

Medicine of the present invention is to select radix bupleuri, the root of large-flowered skullcap, the tuber of pinellia, rascal, Fructus Aurantii, the shell of seaear, caulis bambusae in taenian, rough gentian, cape jasmine, pearl Mother, Lapis Micae Aureus, grass-leaved sweetflag, polygala root, Tabasheer, rhizoma arisaematis, peach kernel, safflower, perilla seed, the root bark of white mulberry, the root of herbaceous peony, root tuber of aromatic turmeric, Moschus, ox Huang, cinnabar, amber are combined preparation, cause each efficacy of drugs to produce synergy these drug regimens such that it is able to Effectively treatment schizophrenia.Wherein it is because that its nature and flavor is bitter from radix bupleuri, cool, enter liver, gallbladder channel are soothing the liver in having and inducing sweat, rises The function of sun, controls fevers and chills alternate, and fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp prolapse of the anus, irregular menstruation, under uterus Hang down.Its nature and flavor bitter cold is because from the root of large-flowered skullcap, enters cardiopulmonary, courage, large intestine channel, had and rush down excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, Control high fever polydipsia, cough with lung heat.It is because that its nature and flavor is pungent from the tuber of pinellia, temperature is poisonous, enters spleen, stomach, there is eliminating dampness and eliminating phlegm, drops inverse Preventing or arresting vomiting, the function of dissolving lump and resolving mass controls wet phlegm and cold drink, vomiting, gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless, Outer subduing inflammation.Its nature and flavor toil is because from rascal, tepor, enter liver, gallbladder channel have soothing the liver relieving stagnant Qi, and the function of dissipating bind dissolving phlegm is controlled Chest side of body gastral cavity pain, hernia, dyspepsia, breast is swollen, newborn core, chronic malaria addiction block.Be because its nature and flavor toil from Fructus Aurantii, it is cool, enter lung, Spleen, large intestine channel, there is a relieving stagnant Qi, row phlegm, and disappear long-pending function, control that chest diaphragm phlegm is stagnant, and the feeling of stuffiness in chest coerces swollen, dyspepsia, and gas is vomitted inverse, after diarrhea Weight, prolapse of the anus, the prolapse of uterus.It is because that its nature and flavor is salty from the shell of seaear, puts down, enter liver and kidney channel, there is calming the liver, heat extraction, improving eyesight Function, controls wind-yang and up-boring, and dizziness of having a headache is frightened to jerk, hectic fever due to yin labor heat, optic atrophy.It is because that its nature and flavor is sweet from caulis bambusae in taenian, it is cool, enter Stomach, gallbladder channel, there is heat-clearing, and cool blood, resolving sputum, the function of antiemetic controls dysphoria with smothery sensation vomiting, hiccup, and the hot cough and asthma of phlegm is spitted blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, Vomiting during early pregnancy, movement of the foetus ， Jing Epilepsy.It is because that its nature and flavor is bitter from rough gentian, trembles with fear, enter liver, gallbladder channel has purging the liver of pathogenic fire excess fire, except the work(of damp-heat in lower-JIAO Can, control Liver Channel heat manic, encephalitis B of containing ， Jing Epilepsy, headache, hot eyes, pharyngalgia, jaundice, hot dysentery, carbuncle swells sore, scrotum swells and ache, cloudy Portion is wet to itch.It is because that its nature and flavor is bitter from cape jasmine, trembles with fear, enter the heart, liver, lung, stomach has heat-clearing, and purging intense heat, the function of cool blood controls heat Sick restlessness of asrhenia type and insomnia, jaundice, gonorrhoea is quenched one's thirst, hot eyes, pharyngalgia, is spitted blood, and bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer is sprained and swollen and ache.Choosing It is because that its nature and flavor is salty with mother-of-pearl, cool, enter the heart, the Jing of liver two have flat liver, and checking exuberance of yang, arresting convulsion, the function of hemostasis controls dizzy a, ear Ring, palpitaition, insomnia, demented ， Jing Epilepsy is spitted blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia.It is because that its nature and flavor is sweet, salty from Lapis Micae Aureus, puts down, returns Lung, the heart, Liver Channel, there is gas under pendant phlegm, checking hyperfunction of the liver and relieving convulsion function, and it is cementing to control stupid phlegm, cough it is inverse breathe heavily urgency, epilepsy is gone mad, fidgety uncomfortable in chest, is shied Wind knots.It is because that its nature and flavor is worked hard from grass-leaved sweetflag, tepor, enter the heart, liver, the spleen channel have and have one's ideas straightened out, slit phlegm, qi-regulating, promoting blood circulation dissipates Wind, the function of drying, Zhi Dian Epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, wind-cold-dampness arthralgia, Swollen ulcer drug, traumatic injury.Its nature and flavor toil is because from polygala root, temperature, enter the heart, kidney channel have tranquilize the mind and promote the intelligence, eliminating the phlegm, Xie Yu Function, control palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, ulcer sore swells.It is because that its nature and flavor is sweet from Tabasheer, the thoughts of returning home, Liver Channel, there is heat phlegm, and the function of cool heart arresting convulsion controls pyreticosis coma, and middle wind phlegm fan, the hot frightened epilepsy of children's phlegm is twitched, the morbid night crying of babies.Choosing Its nature and flavor toil is because with rhizoma arisaematis, temperature is poisonous, enters lung, liver, the spleen channel, there is eliminating dampness and eliminating phlegm, dispelling wind and relieving convulsion, dispersing swelling and dissipating binds Function, controls middle wind phlegm scrofula, and deviation of the eye and mouth, hemiplegia, insane Epilepsy, infantile convulsion, lockjaw, anemophlegmatic vertigo, larynx numbness, scrofula, carbuncle swells are fallen Flutter damage, snake bite and insect sting.Its nature and flavor bitter sweet is because from peach kernel, is put down, enter the heart, liver, large intestine channel have the blood-breaking row stasis of blood, moisturize cunning The function of Jing, controlling through closing ， Disorder lumps in the abdomen, pyreticosis stores blood, blood-arthralgia, malaria, traumatic injury, blood stasis and swelling pain, the dry constipation of blood.It is from safflower Because its nature and flavor is pungent, temperature, enter the heart, Liver Channel have invigorate blood circulation, and the function of stasis eliminatings pain relieving, controlling through closing ， Disorder lumps in the abdomen, difficult labour, stillborn foetus is produced Lochia afterwards, hemostasis is had a pain, carbuncle swells, injury from falling down.It is because that its nature and flavor is pungent from perilla seed, temperature enters lung, large intestine channel, has Lower gas, dissolving phlegm, moistening lung, the function of wide intestines is controlled and coughs inverse, asthma due to excessive phlegm, the stagnation of the circulation of vital energy, constipation.It is because that its nature and flavor is sweet from the root bark of white mulberry, trembles with fear, Enter lung, the spleen channel, there is removing heat from lung and relieving asthma, the function of line water detumescence controls dyspnea and cough due to lung-heat, spit blood, oedema, tinea pedis, difficult urination.From white Chinese herbaceous peony is because its nature and flavor picric acid, and cool, enter liver, the spleen channel have nourishing blood and liver, pain relieving in delaying, and holds back the cloudy function of receiving sweat, controls chest and abdomen side of body rib Pain, diarrhea dysentery abdominal pain, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band.It is because that its nature and flavor is worked hard from root tuber of aromatic turmeric, Cool, enter the heart, lung, Liver Channel have promoting the circulation of qi solution with the function of cool blood broken stasis of blood controls all pains of chest and abdomen side of body rib, and the mistake heart is demented, and pyreticosis coma is told Blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, jaundice.It is because that its nature and flavor is pungent from Moschus, temperature, enter the heart, spleen, Liver Channel have out Key, wards off dirty, dredging collateral, dissipates the function of the stasis of blood, controls apoplexy, coma due to blocking of the respiratory system ， Jing Epilepsy, middle evil unhappiness, the trusted subordinate sudden and violent pain ， Disorder lump in the abdomen hypochondriac lumps, traumatic injury, Swollen ulcer drug.Its nature and flavor bitter sweet is because from cow-bezoar, cool, enter the heart, Liver Channel have and clear away heart-fire, and resolving sputum, cholagogic, relieving convulsion function is controlled Pyreticosis coma, delirious speech ， Dian Epilepsy are gone mad, and child convulsion is taken out and fallen, noma, and larynx swells, aphthae, ulcer, serious case of furuncle.From cinnabar be because It is sweet cool for its nature and flavor, it is poisonous, the heart channel of Hang-Shaoyin is included into, have and calm the nerves, to calm the frightened, improving eyesight, the function of removing toxic substances controls demented, palpitates with fear, vexed, insomnia, Dizziness, blurred vision.It is because that its nature and flavor is sweet from amber, puts down, enter the heart, liver, small intestinl channel have tranquillizing the mind by relieving convulsion, dissipate stasis of blood hemostasis, Li Shui leads to The function of pouring, controls infantile convulsion Dian Epilepsy, and insomnia of palpitating with fear, blood strangury blood urine, urinary obstruction, women's amenorrhoea, postpartum stops stasis of blood stomachache, ulcer sore Poison, traumatic injuries.

Specific embodiment

The drug dose of instant component is also that inventor summarizes what is drawn through groping in a large number, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：

7-11 gram of radix bupleuri, 10-20 gram of the root of large-flowered skullcap, 10-14 gram of the tuber of pinellia, 7-11 gram of rascal, 7-11 gram of Fructus Aurantii, 15-25 gram of the shell of seaear, bamboo Eat 7-11 gram, 7-11 gram of rough gentian, 7-11 gram of cape jasmine, 20-30 gram of mother-of-pearl, 20-30 gram of Lapis Micae Aureus, 7-11 gram of grass-leaved sweetflag, polygala root 4-8 gram, 7-11 gram of Tabasheer, 4-8 gram of rhizoma arisaematis, 10-20 gram of peach kernel, 10-20 gram of safflower, 15-25 gram of perilla seed, the root bark of white mulberry 10-20 gram, 10-25 gram of the root of herbaceous peony, 5-15 gram of root tuber of aromatic turmeric, 0.4-0.6 gram of Moschus, 0.4-0.6 gram of cow-bezoar, 2-3 gram of cinnabar, amber 2-3 Gram.

Preferably：

9 grams of radix bupleuri, 15 grams of the root of large-flowered skullcap, 12 grams of the tuber of pinellia, 9 grams of rascal, 9 grams of Fructus Aurantii, 20 grams of the shell of seaear, 9 grams of caulis bambusae in taenian, 9 grams of rough gentian, cape jasmine 9 grams, 25 grams of mother-of-pearl, 25 grams of Lapis Micae Aureus, 9 grams of grass-leaved sweetflag, 6 grams of polygala root, 9 grams of Tabasheer, 6 grams of rhizoma arisaematis, 15 grams of peach kernel, safflower 15 grams, 20 grams of perilla seed, 15 grams of the root bark of white mulberry, 15 grams of the root of herbaceous peony, 10 grams of root tuber of aromatic turmeric, 0.5 gram of Moschus, 0.5 gram of cow-bezoar, 2 grams of cinnabar, amber 3 grams.

The preparation method of medicine of the present invention is as follows

First, get the raw materials ready

1st, radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, is pulled out, section in time, dries immediately after running through；

2nd, the root of large-flowered skullcap：Impurity is picked, residual stem is removed, is infiltrated or is put slightly to soak in boiling water with cold water and pull out, cut into slices, dried；

3rd, the tuber of pinellia：Impurity is picked, grey bits are weeded out；

4th, rascal：Net impurity is picked, is soaked in water, pulled out, run through, cut into slices, dried；

5th, Fructus Aurantii：Flesh, core are removed, edulcoration slightly soaks, pulls out, softens, pinching doubling with hand, section is dried；

6th, the shell of seaear：Clean and dry, knock fragment；

7th, caulis bambusae in taenian：Hard bamboo let, impurity are removed, grey bits are shaked off, little group or segment is kneaded into；

8th, rough gentian：Impurity is picked, residual stem is removed, is cleaned, run through rear segment, dried；

9th, cape jasmine：Grey bits are weeded out, impurity is picked, two ends are cut off；

10th, mother-of-pearl：Impurity is picked, knock fragment weeds out grey bits；

11st, Lapis Micae Aureus：Impurity is removed, fragment is broken into；

12nd, grass-leaved sweetflag：Impurity is picked, is cleaned, soaked slightly, run through, cut into slices, dried；

13rd, polygala root：Impurity is picked, segment weeds out grey bits；

14th, Tabasheer：Crude drug is taken, impurity, ash bits are removed；

15th, rhizoma arisaematis：Impurity is picked, ash bits are cleaned, is dried；

16th, peach kernel：Duricrust impurity is removed, is put in boiling water pot and is boiled to crust microcreping, pulled out, in immersion cold water, kind of a skin is removed in stranding, is shone It is dry, winnow with a dustpan net；

17th, safflower：Net impurity is picked, cauline leaf, base of a fruit head is removed, is dried；

18th, perilla seed：Dedusting of winnowing with a dustpan is considered to be worth doing, is cleaned, and is dried；

19th, the root bark of white mulberry：Grey bits are brushed away, is cleaned, run through rear chopping, dried；

20th, the root of herbaceous peony：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pulled out, solarization is dried in the air, moisten uniform to inside and outside humidity, Section, is dried；

21st, root tuber of aromatic turmeric：It is soaked in water, cleans, pull solarization out and dry in the air, run through, cut into slices, dries；

22nd, Moschus：Sachet is infiltrated with warm water, fur inner membrance impurity is removed after cutting open, the used time takes Moschus benevolence and pulverizes；

23rd, cow-bezoar：Pulverize；

24th, cinnabar：With magnet exhaustion iron filings, pulverize；

25th, amber：Net impurity is picked, the used time smashs to pieces.

2nd, prepare

1st, the Moschus of the weight, cow-bezoar, cinnabar, amber are put into container, mixing is ground into powder；

2nd, by the radix bupleuri of the weight, the root of large-flowered skullcap, the tuber of pinellia, rascal, Fructus Aurantii, the shell of seaear, caulis bambusae in taenian, rough gentian, cape jasmine, mother-of-pearl, gold Meng Stone, grass-leaved sweetflag, polygala root, Tabasheer, rhizoma arisaematis, peach kernel, safflower, perilla seed, the root bark of white mulberry, the root of herbaceous peony, root tuber of aromatic turmeric add water to cook twice, the Once add water 8 times and measure, decoct 1.5 hours, add water for the second time 6 times and measure, decoct 1 hour, merge decoction liquor twice, be condensed into proportion For 1.35 medicinal extract, by medicinal extract plus the ethanol of 90%-95%, stirring, precipitation are reclaimed ethanol and are concentrated, be dried at 45-50 DEG C, system Obtain dry extract；

3rd, dry extract is broken into powder, adds Moschus, cow-bezoar, cinnabar, amber powder, be well mixed, then be ground into fine powder, plus Enter ethanol and make binder, add starch to make filler, be pressed into granule.

Grass-leaved sweetflag has and has one's ideas straightened out in prescription, slit phlegm, qi-regulating, promoting blood circulation, dissipates wind, and the function of drying is monarch drug in a prescription；Polygala root has benefit of calming the nerves Intelligence, eliminating the phlegm, the function of Xie Yu；Tabasheer has a heat phlegm, the function of cool heart arresting convulsion, and the two is ministerial drug, and three taste medicines are played jointly Have one's ideas straightened out slit phlegm, vital energy regualting and blood circulation-promoting, tranquilize the mind and promote the intelligence, the effect of cool heart arresting convulsion, treatment schizophrenia effect comprehensively, and with qi-regulating work Blood, tranquilize the mind and promote the intelligence can effect a permanent cure based on the arresting convulsion of the cool heart, and rhizoma arisaematis has eliminating dampness and eliminating phlegm, dispelling wind and relieving convulsion, and the function of dispersing swelling and dissipating binds is assistant Medicine, root tuber of aromatic turmeric has promoting the circulation of qi solution with to make medicine, all medicines are to take stopgap measures to the function of cool blood broken stasis of blood with being left.

Medicine of the present invention has has one's ideas straightened out slit phlegm, vital energy regualting and blood circulation-promoting, tranquilize the mind and promote the intelligence, cool heart arresting convulsion, promoting the circulation of qi solution with function, be used for Treatment schizophrenia, short treating period, instant effect, non-relapse after healing.

The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples are including this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.

The animal toxicity test report of [test example 1] medicine of the present invention：

Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and 15 per group, one of which is overdose test Group, another group is normal amount test group.Super quantity group is 0.2 gram/kg, and normal amount is 0.1 gram/kg, and administering mode is administration by gavage Administration, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is invariably Good toxic and side effect.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1st, physical data

Accept schizophrenia out-patient totally 28 for medical treatment.

2nd, diagnostic criteria

Classical symptom is thinking, emotion and behavior disorder.It is odd that the disturbance of thought shows as incoherence of speech, content, it is difficult to for people's reason Solution；The disturbance of emotion shows as that anxious state of mind is big, happiness is happy variable, when and wail, when and laugh, become rude passion again in a twinkle, make us difficult To fathom；Behavior disorder shows as action naivety, foolishness, makes faces, laughs foolishly, and makes one to receive.

3rd, treatment method

Taken after mixing it with water to patient from the granule of above-mentioned compacting, each take 4 grams, early daily, evening respectively takes 1 time, is a treatment within 15 days Journey, continuously takes 3 courses for the treatment of.

4th, efficacy assessment standard

It is effective：The symptoms of schizophrenia disappears, and mental restoration is normal, recovery from illness；

Take a turn for the better：The symptoms of schizophrenia is clearly better, and emotion thinking mistake area progressively takes a turn for the better, and phrenoblabia is progressively recovered；

It is invalid：Improvement standard person is not reached.

5th, treatment results（See the table below）

In above-mentioned treatment, with drug therapy schizophreniac of the present invention 28, as a result effective 23, obvious effective rate is 82.1%, take a turn for the better 3, improvement rate is 10.7%, and invalid 2, total effective rate is 92.8%.

Claims

1. one kind treats schizoid medicine, it is characterised in that：It is made up of the bulk drug in following weight range：

2. medicine according to claim 1, wherein the consumption of each bulk drug is：

3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：

（One）Get the raw materials ready

（1）Radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, is pulled out, section in time, dries immediately after running through；

（2）The root of large-flowered skullcap：Impurity is picked, residual stem is removed, is infiltrated or is put slightly to soak in boiling water with cold water and pull out, cut into slices, dried；

（3）The tuber of pinellia：Impurity is picked, grey bits are weeded out；

（4）Rascal：Net impurity is picked, is soaked in water, pulled out, run through, cut into slices, dried；

（5）Fructus Aurantii：Flesh, core are removed, edulcoration slightly soaks, pulls out, softens, pinching doubling with hand, section is dried；

（6）The shell of seaear：Clean and dry, knock fragment；

（7）Caulis bambusae in taenian：Hard bamboo let, impurity are removed, grey bits are shaked off, little group or segment is kneaded into；

（8）Rough gentian：Impurity is picked, residual stem is removed, is cleaned, run through rear segment, dried；

（9）Cape jasmine：Grey bits are weeded out, impurity is picked, two ends are cut off；

（10）Mother-of-pearl：Impurity is picked, knock fragment weeds out grey bits；

（11）Lapis Micae Aureus：Impurity is removed, fragment is broken into；

（12）Grass-leaved sweetflag：Impurity is picked, is cleaned, soaked slightly, run through, cut into slices, dried；

（13）Polygala root：Impurity is picked, segment weeds out grey bits；

（14）Tabasheer：Crude drug is taken, impurity, ash bits are removed；

（15）Rhizoma arisaematis：Impurity is picked, ash bits are cleaned, is dried；

（16）Peach kernel：Duricrust impurity is removed, is put in boiling water pot and is boiled to crust microcreping, pulled out, in immersion cold water, kind of a skin is removed in stranding, is shone It is dry, winnow with a dustpan net；

（17）Safflower：Net impurity is picked, cauline leaf, base of a fruit head is removed, is dried；

（18）Perilla seed：Dedusting of winnowing with a dustpan is considered to be worth doing, is cleaned, and is dried；

（19）The root bark of white mulberry：Grey bits are brushed away, is cleaned, run through rear chopping, dried；

（20）The root of herbaceous peony：Impurity is picked, separates size, be soaked in water to eighty per cant thoroughly, pulled out, solarization is dried in the air, moisten uniform to inside and outside humidity, Section, is dried；

（21）Root tuber of aromatic turmeric：It is soaked in water, cleans, pull solarization out and dry in the air, run through, cut into slices, dries；

（22）Moschus：Sachet is infiltrated with warm water, fur inner membrance impurity is removed after cutting open, the used time takes Moschus benevolence and pulverizes；

（23）Cow-bezoar：Pulverize；

（24）Cinnabar：With magnet exhaustion iron filings, pulverize；

（25）Amber：Net impurity is picked, the used time smashs to pieces；

（Two）Prepare

（1）The Moschus of the weight, cow-bezoar, cinnabar, amber are put into container, mixing is ground into powder；

（2）By the radix bupleuri of the weight, the root of large-flowered skullcap, the tuber of pinellia, rascal, Fructus Aurantii, the shell of seaear, caulis bambusae in taenian, rough gentian, cape jasmine, mother-of-pearl, gold Meng Stone, grass-leaved sweetflag, polygala root, Tabasheer, rhizoma arisaematis, peach kernel, safflower, perilla seed, the root bark of white mulberry, the root of herbaceous peony, root tuber of aromatic turmeric add water to cook twice, the Once add water 8 times and measure, decoct 1.5 hours, add water for the second time 6 times and measure, decoct 1 hour, merge decoction liquor twice, be condensed into proportion For 1.35 medicinal extract, by medicinal extract plus the ethanol of 90%-95%, stirring, precipitation are reclaimed ethanol and are concentrated, be dried at 45-50 DEG C, system Obtain dry extract；

（3）Dry extract is broken into powder, Moschus, cow-bezoar, cinnabar, amber powder is added, is well mixed, then be ground into fine powder, Add ethanol to make binder, add starch to make filler, be pressed into granule.