CN104248638A - 用于调节干细胞生长的含前列腺素的组合物 - Google Patents
用于调节干细胞生长的含前列腺素的组合物 Download PDFInfo
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- CN104248638A CN104248638A CN201410464976.4A CN201410464976A CN104248638A CN 104248638 A CN104248638 A CN 104248638A CN 201410464976 A CN201410464976 A CN 201410464976A CN 104248638 A CN104248638 A CN 104248638A
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
- C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| CN200980114702XA Pending CN102014921A (zh) | 2008-02-19 | 2009-02-19 | 用于调节干细胞生长的含前列腺素的组合物 |
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| EP (2) | EP2303278A1 (https=) |
| JP (1) | JP2011512323A (https=) |
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| CN (2) | CN104248638A (https=) |
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| AU (1) | AU2009216067B2 (https=) |
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| WO2010108028A2 (en) * | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same |
| US8569279B2 (en) | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
| EP2435049A1 (en) * | 2009-05-27 | 2012-04-04 | Sucampo AG | Pharmaceutical composition comprising prostaglandin derivatives for use in modulating claudin mediated functions and in the treatment of dermatological disorders |
| KR101171912B1 (ko) | 2010-11-29 | 2012-08-07 | 기아자동차주식회사 | 밸브브릿지 일체형 가변 밸브 액츄에이터 |
| EP2785350B1 (en) | 2011-12-02 | 2018-05-02 | Fate Therapeutics, Inc. | Improved methods of treating ischemia |
| JP6220791B2 (ja) | 2011-12-02 | 2017-10-25 | フェイト セラピューティクス，インコーポレイテッド | 増強された幹細胞組成物 |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US20140371304A1 (en) * | 2013-06-13 | 2014-12-18 | Sucampo Ag | Method for suppressing tumorigenicity of stem cells |
| US9918994B2 (en) | 2016-03-04 | 2018-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for muscle regeneration using prostaglandin E2 |
| JP2019513010A (ja) * | 2016-03-04 | 2019-05-23 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | プロスタグランジンｅ２を用いる、筋再生のための組成物および方法 |
| WO2018227138A1 (en) | 2017-06-09 | 2018-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for preventing or treating muscle conditions |
| RU2686718C1 (ru) * | 2018-03-12 | 2019-04-30 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Средство, стимулирующее функции мезенхимальных клеток-предшественников in vitro |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0503887A2 (en) * | 1991-03-14 | 1992-09-16 | R-Tech Ueno Ltd. | Promotion of wound-healing with 15-keto-prostaglandin compounds |
| WO2006080549A2 (en) * | 2005-01-27 | 2006-08-03 | Sucampo Ag | Method and composition for treating central nervous system disorders |
| WO2006093348A2 (en) * | 2005-03-04 | 2006-09-08 | Sucampo Ag | Method and composition for treating peripheral vascular diseases |
| WO2007112084A2 (en) * | 2006-03-24 | 2007-10-04 | Children's Medical Center Corporation | Method to modulate hematopoietic stem cell growth |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1322749C (en) * | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5221763A (en) * | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| TW224942B (https=) * | 1990-04-04 | 1994-06-11 | Adka Ueno Kk | |
| CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| US5703108A (en) * | 1996-02-28 | 1997-12-30 | Pfizer Inc. | Bone deposition by certain prostaglandin agonists |
| JP3187438B2 (ja) * | 1996-06-10 | 2001-07-11 | 株式会社アールテック・ウエノ | エンドセリン拮抗剤 |
| EP1267882B1 (en) | 2000-03-24 | 2009-04-15 | Sucampo AG | Prostaglandins for the treatment of eye disease caused by light irradiation like photoretinitis |
| JP4557288B2 (ja) * | 2005-01-28 | 2010-10-06 | アイシン・エィ・ダブリュ株式会社 | 画像認識装置及び画像認識方法、並びにそれを用いた位置特定装置、車両制御装置及びナビゲーション装置 |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| AU2006326853B2 (en) | 2005-12-22 | 2012-02-16 | Es Cell International Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| EP2094839B1 (en) | 2006-12-08 | 2020-02-05 | University of Rochester | Expansion of hematopoietic stem cells |
| EP2114411A2 (en) * | 2007-02-27 | 2009-11-11 | Sucampo AG | Composition and method for protecting mitochondria |
| FI20075417A0 (fi) * | 2007-06-05 | 2007-06-05 | Marjo-Riitta Suuronen | Koostumuksia ja menetelmiä alkion kantasolujen kasvatukseen |
-
2009
- 2009-02-18 US US12/388,048 patent/US8871752B2/en not_active Expired - Fee Related
- 2009-02-19 EP EP09712320A patent/EP2303278A1/en not_active Withdrawn
- 2009-02-19 JP JP2010533155A patent/JP2011512323A/ja not_active Ceased
- 2009-02-19 WO PCT/JP2009/053474 patent/WO2009104807A1/en not_active Ceased
- 2009-02-19 MX MX2010009131A patent/MX2010009131A/es not_active Application Discontinuation
- 2009-02-19 CA CA2715486A patent/CA2715486A1/en not_active Abandoned
- 2009-02-19 AU AU2009216067A patent/AU2009216067B2/en not_active Ceased
- 2009-02-19 BR BRPI0907831A patent/BRPI0907831A2/pt not_active IP Right Cessation
- 2009-02-19 CN CN201410464976.4A patent/CN104248638A/zh active Pending
- 2009-02-19 AR ARP090100582A patent/AR073158A1/es unknown
- 2009-02-19 KR KR1020107021031A patent/KR20100119803A/ko not_active Ceased
- 2009-02-19 EP EP13178225.2A patent/EP2656845A1/en not_active Withdrawn
- 2009-02-19 NZ NZ587348A patent/NZ587348A/en not_active IP Right Cessation
- 2009-02-19 CN CN200980114702XA patent/CN102014921A/zh active Pending
- 2009-02-19 RU RU2010138603/15A patent/RU2010138603A/ru not_active Application Discontinuation
- 2009-02-19 TW TW098105222A patent/TW200942614A/zh unknown
-
2010
- 2010-08-17 IL IL207652A patent/IL207652A0/en unknown
- 2010-08-27 ZA ZA2010/06125A patent/ZA201006125B/en unknown
-
2014
- 2014-09-16 US US14/487,153 patent/US20150005381A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0503887A2 (en) * | 1991-03-14 | 1992-09-16 | R-Tech Ueno Ltd. | Promotion of wound-healing with 15-keto-prostaglandin compounds |
| WO2006080549A2 (en) * | 2005-01-27 | 2006-08-03 | Sucampo Ag | Method and composition for treating central nervous system disorders |
| WO2006093348A2 (en) * | 2005-03-04 | 2006-09-08 | Sucampo Ag | Method and composition for treating peripheral vascular diseases |
| WO2007112084A2 (en) * | 2006-03-24 | 2007-10-04 | Children's Medical Center Corporation | Method to modulate hematopoietic stem cell growth |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090209643A1 (en) | 2009-08-20 |
| CN102014921A (zh) | 2011-04-13 |
| AR073158A1 (es) | 2010-10-20 |
| AU2009216067B2 (en) | 2014-02-13 |
| TW200942614A (en) | 2009-10-16 |
| WO2009104807A1 (en) | 2009-08-27 |
| NZ587348A (en) | 2012-04-27 |
| ZA201006125B (en) | 2011-05-25 |
| CA2715486A1 (en) | 2009-08-27 |
| IL207652A0 (en) | 2010-12-30 |
| BRPI0907831A2 (pt) | 2017-04-11 |
| US8871752B2 (en) | 2014-10-28 |
| EP2303278A1 (en) | 2011-04-06 |
| RU2010138603A (ru) | 2012-03-27 |
| US20150005381A1 (en) | 2015-01-01 |
| KR20100119803A (ko) | 2010-11-10 |
| JP2011512323A (ja) | 2011-04-21 |
| AU2009216067A1 (en) | 2009-08-27 |
| MX2010009131A (es) | 2010-12-06 |
| EP2656845A1 (en) | 2013-10-30 |
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