CN104245719B - 包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 - Google Patents

包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 Download PDF

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CN104245719B
CN104245719B CN201280069473.6A CN201280069473A CN104245719B CN 104245719 B CN104245719 B CN 104245719B CN 201280069473 A CN201280069473 A CN 201280069473A CN 104245719 B CN104245719 B CN 104245719B
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CN104245719A (zh
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D·B·韦纳
M·P·莫罗
严健
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University of Pennsylvania Penn
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CN201280069473.6A 2011-12-12 2012-12-11 包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 Active CN104245719B (zh)

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US201161569600P 2011-12-12 2011-12-12
US61/569,600 2011-12-12
PCT/US2012/069017 WO2013090296A1 (en) 2011-12-12 2012-12-11 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

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CN104245719A CN104245719A (zh) 2014-12-24
CN104245719B true CN104245719B (zh) 2016-09-14

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US (4) US9272024B2 (https=)
EP (2) EP3336096A1 (https=)
JP (5) JP6333730B2 (https=)
KR (5) KR102277469B1 (https=)
CN (1) CN104245719B (https=)
AU (1) AU2012352457B2 (https=)
BR (1) BR112014014078A2 (https=)
CA (1) CA2858893A1 (https=)
EA (1) EA026926B1 (https=)
MX (2) MX354986B (https=)
WO (1) WO2013090296A1 (https=)
ZA (1) ZA201404199B (https=)

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WO2017209053A1 (ja) 2016-05-30 2017-12-07 アステラス製薬株式会社 新規な遺伝子組換えワクシニアウイルス
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CN106520779A (zh) * 2016-11-09 2017-03-22 华南农业大学 一种通过密码子优化鸡il‑2基因提高鸡的il‑2蛋白表达效率的方法
JP7285220B2 (ja) 2017-05-18 2023-06-01 モデルナティエックス インコーポレイテッド 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
EP3858369A4 (en) 2018-09-26 2022-07-20 Astellas Pharma Inc. Cancer therapy where oncolytic vaccinia virus and immune checkpoint inhibitor are used in combination, and pharmaceutical composition and combination drug used therein
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KR102524247B1 (ko) * 2018-12-21 2023-04-21 가톨릭대학교 산학협력단 p40-EBI3의 복합체 및 이의 용도
KR20220128607A (ko) 2019-09-18 2022-09-21 인터갈락틱 테라퓨틱스, 인크. 합성 dna 벡터 및 사용 방법
US11851466B2 (en) 2019-10-03 2023-12-26 Xencor, Inc. Targeted IL-12 heterodimeric Fc-fusion proteins
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CN119256082A (zh) * 2022-05-27 2025-01-03 北京天一方生物科技发展有限公司 一种恒定地产生IL-12p70的增殖性髓样细胞的制备方法

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