CN104225302A - Composition with pressure-reducing, fat-reducing and sugar-reducing effects, as well as preparation method and application for same - Google Patents
Composition with pressure-reducing, fat-reducing and sugar-reducing effects, as well as preparation method and application for same Download PDFInfo
- Publication number
- CN104225302A CN104225302A CN201410436534.9A CN201410436534A CN104225302A CN 104225302 A CN104225302 A CN 104225302A CN 201410436534 A CN201410436534 A CN 201410436534A CN 104225302 A CN104225302 A CN 104225302A
- Authority
- CN
- China
- Prior art keywords
- parts
- fructus
- compositions
- hypertension
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition with pressure-reducing, fat-reducing and sugar-reducing effects. The composition with pressure-reducing, fat-reducing and sugar-reducing effects is prepared from 50-190 parts of tartary buckwheat, 50-190 parts of lotus leaves, 75-170 parts of cape jasmine, 10-40 parts of bamboo leaves, 10-55 parts of fructus cannabis, 5-38 parts of hawthorns, 5-38 parts of fingered citron, and 10-55 parts of sugar alcohol. The composition provided by the invention is scientific and reasonable in formula, great in pressure-reducing, fat-reducing and sugar-reducing effects, safe and reliable, free from toxic and side effects, instant, convenient to take, and suitable for being taken for a long time. The preparation method provided by the invention is reasonable in process design, fast in effective constituent dissolution speed, complete in dissolution, and high in bioavailability.
Description
Technical field
The present invention relates to a kind of compositions, particularly a kind of composition and method of making the same and application with hypertension and hyperlipemia blood sugar reducing function, belongs to medical art.
Background technology
In recent years, the health of modern in " hypertension, hyperglycemia, hyperlipidemia " three-hypers serious harm.Along with growth in the living standard, " hypertension, hyperlipidemia, hyperglycemia " three-hypers disease is more and more general, and the bad rhythm of life such as to bend over one's desk working for a long time, do not get enough athletic exercise makes obesity, hypertension, hypercholesterolemia annoying crowd.
The number of cardiovascular disease is died from every year up to 1,500 ten thousand people in the whole world, has been human death's cause of disease " number one killer ", serious harm human health." three-hypers " and obesity are the high risk factors causing cardiovascular and cerebrovascular disease, and hyperlipidemia easily causes blood vessel embolism simultaneously; Hypertension may bring out cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.Therefore positive Control Measure should be taked for " three-hypers ".
Existing product substantially all needs long-term taking for the medicine controlling, treat three-hypers disease, though the existing large quantity research of its pharmacology toxic and side effects, cannot get rid of the untoward reaction to human body.Therefore daily life custom and dietetic regulation more highlight its importance.
At present, there is not yet and the medicine and food raw materials materials such as Folium Nelumbinis, Fructus Gardeniae, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis and Radix Et Rhizoma Fagopyri Tatarici are made the compositions with hypertension and hyperlipemia blood sugar reducing function, for prevention, control, treatment hyperlipidemia, hypertension, hyperglycemia.
Summary of the invention
Goal of the invention: the object of the invention is to overcome the deficiencies in the prior art, provides one to have lipid-lowering pressure-reducing hypoglycemic effect, safe without toxic side effect, and be applicable to the compositions of long-term taking, another object of the present invention is to provide the preparation method of said composition.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
Have a compositions for hypertension and hyperlipemia blood sugar reducing function, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 50 ~ 190 parts, 50 ~ 190 parts, Folium Nelumbinis, Fructus Gardeniae 75 ~ 170 parts, 10 ~ 40 parts, Folium Bambusae, Fructus Cannabis 10 ~ 55 parts, Fructus Crataegi 5 ~ 38 parts, Fructus Citri Sarcodactylis 5 ~ 38 parts, sugar alcohol 10 ~ 55 parts.
Preferably, the above-described compositions with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 70 ~ 130 parts, 70 ~ 130 parts, Folium Nelumbinis, Fructus Gardeniae 80 ~ 150 parts, 15 ~ 35 parts, Folium Bambusae, Fructus Cannabis 18 ~ 40 parts, Fructus Crataegi 8 ~ 26 parts, Fructus Citri Sarcodactylis 8 ~ 26 parts, sugar alcohol 15 ~ 45 parts.
As more preferably scheme, the above-described compositions with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 90 parts, 85 parts, Folium Nelumbinis, Fructus Gardeniae 150 parts, 22 parts, Folium Bambusae, Fructus Cannabis 25 parts, Fructus Crataegi 13 parts, Fructus Citri Sarcodactylis 26 parts, sugar alcohol 30 parts.
As another more preferably scheme, the above-described compositions with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 100 parts, 95 parts, Folium Nelumbinis, Fructus Gardeniae 130 parts, 15 parts, Folium Bambusae, Fructus Cannabis 18 parts, Fructus Crataegi 10 parts, Fructus Citri Sarcodactylis 8 parts, sugar alcohol 15 parts.
As another more preferably scheme, the above-described compositions with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 70 parts, 70 parts, Folium Nelumbinis, Fructus Gardeniae 80 parts, 35 parts, Folium Bambusae, Fructus Cannabis 40 parts, Fructus Crataegi 26 parts, Fructus Citri Sarcodactylis 23 parts, sugar alcohol 45 parts.
As another more preferably scheme, the above-described compositions with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 130 parts, 130 parts, Folium Nelumbinis, Fructus Gardeniae 140 parts, 15 parts, Folium Bambusae, Fructus Cannabis 20 parts, Fructus Crataegi 8 parts, Fructus Citri Sarcodactylis 14 parts, sugar alcohol 20 parts.
Preferably, of the present invention have the compositions improved fatty liver, reduce body weight effect, described sugar alcohol is hydroxyl isomaltulose, xylitol, mannitol, erythritol, maltose alcohol, Sorbitol, soybean oligo saccharide, oligomeric xylose, oligomeric isomaltose, oligofructose, oligomeric galactose, Oligomeric manna sugar, or the combination in any of two or more material.Particularly preferably hydroxyl isomaltulose.
The preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function of the present invention, comprises the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with water extraction, extracting liquid filtering, after filtrate is concentrated, dry, pulverize the extract that sieves to obtain;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, sieve;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, dry, to obtain final product.
Preferably, the preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function of the present invention, it comprises the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with 10 ~ 20 times amount water extraction 1 ~ 3 time, each 1 ~ 3 hour, merge extractive liquid, filtered, relative density 1.20 ~ 1.40 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 ~ 90 DEG C, pulverizes and sieves to obtain extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 ~ 200 mesh sieves;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, extruding pelletizing forming, 50 ~ 80 DEG C dry 8 ~ 18 hours, 200 ~ 220 DEG C and cure 2 ~ 5min, natural cooling, packaging and get final product.
As more preferably scheme, the above-described preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with the water extraction 2 times of medical material weight 10 times of volumes, each 1 hour, merge extractive liquid, filter, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, pulverize 100 mesh sieves, obtain extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 mesh sieves;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, extruding pelletizing forming, 60 DEG C dry 12 hours, 200 DEG C and cure 3min, natural cooling, packaging and get final product.
Preferably, the above-described preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function, described sugar alcohol is hydroxyl isomaltulose, xylitol, mannitol, erythritol, maltose alcohol, Sorbitol, soybean oligo saccharide, oligomeric xylose, oligomeric isomaltose, oligofructose, oligomeric galactose, Oligomeric manna sugar, or the combination in any of two or more material.Particularly preferably hydroxyl isomaltulose.
The application of compositions in preparation control hyperlipidemia, hypertension and antihyperglycemic drug or health product with hypertension and hyperlipemia blood sugar reducing function provided by the invention.
Beneficial effect: compared to the prior art the compositions with hypertension and hyperlipemia blood sugar reducing function provided by the invention has the following advantages:
Compositions provided by the invention, best prescription is obtained by great many of experiments screening, said composition proportioning is scientific and reasonable, the present invention adds the Chinese medicine of multiple medicine-food two-purpose on Radix Et Rhizoma Fagopyri Tatarici basis, effect that abundant nuciferine has blood fat reducing, free radical resisting, cholesterol reducing is rich in Folium Nelumbinis in prescription, the Gardenia Yellow that Fructus Gardeniae is rich in and the Radix Et Rhizoma Fagopyri Tatarici flavone that Radix Et Rhizoma Fagopyri Tatarici is rich in have and improve fatty liver, reduce body weight effect, the cool mutual Ji of full side's temperature, reinforcing and reducing concurrently, be intended to eliminating evil and just do not hinder, righting and do not stay heresy.Both blood fat in purged body, blood sugar lowering, blood pressure lowering, strengthen human righteousness again, makes to attack just do not hindering, and mends and do not help heresy.Verify through a large amount of pharmacological testing, compositions provided by the invention has good blood pressure lowering, blood fat reducing, function of reducing blood sugar, and safe and reliable, has no side effect, instant, taking convenience, is applicable to long-term taking.
The preparation method of compositions provided by the invention, technological design is reasonable, workable, after adding sugar alcohol and the compressing chance water of other compositions in the composition, sugar alcohol can be water-soluble fast, makes the compositions of molding form trickle hole, increases the dissolution rate of the effective ingredient such as total flavones, total alkaloid of lotus leaves, Gardenia Yellow in compositions, stripping is more complete, and bioavailability is higher.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.After reading this disclosure, the amendment of those skilled in the art to various unsubstantiality of the present invention all falls within the application's claims limited range.
Embodiment 1
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 90 parts, 85 parts, Folium Nelumbinis, Fructus Gardeniae 150 parts, 22 parts, Folium Bambusae, Fructus Cannabis 25 parts, Fructus Crataegi 13 parts, Fructus Citri Sarcodactylis 26 parts, hydroxyl isomaltulose 30 parts;
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), by above-mentioned Fructus Gardeniae 150 parts, coarse crushing is shelled, mix with 85 parts, Folium Nelumbinis, 22 parts, Folium Bambusae, Fructus Cannabis 25 parts, Fructus Crataegi 13 parts, Fructus Citri Sarcodactylis 26 parts, with the water extraction 2 times of medical material weight 10 times of volumes, each 1 hour, merge extractive liquid, filter, relative density 1.35 when filtrate is concentrated into 60 DEG C, microwave drying at 70 DEG C of temperature, pulverize 100 mesh sieves, obtain extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 90 parts pulverizing, 150 mesh sieves are crossed;
3), hydroxyl isomaltulose 30 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 12 hours for 60 DEG C, 200 DEG C are cured 3min, natural cooling, obtained after packaging.
Embodiment 2
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 100 parts, 95 parts, Folium Nelumbinis, Fructus Gardeniae 130 parts, 15 parts, Folium Bambusae, Fructus Cannabis 18 parts, Fructus Crataegi 10 parts, Fructus Citri Sarcodactylis 8 parts, hydroxyl isomaltulose 15 parts;
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), the 130 parts of coarse crushings of above-mentioned Fructus Gardeniae are shelled, mix with 95 parts, Folium Nelumbinis, 15 parts, Folium Bambusae, Fructus Cannabis 18 parts, Fructus Crataegi 10 parts, Fructus Citri Sarcodactylis 8 parts, with the water extraction 2 times of medical material weight 15 times of volumes, each 1.5 hours, merge extractive liquid, filtered, relative density 1.40 when filtrate is concentrated into 60 DEG C, microwave drying during temperature 80 DEG C, pulverized 100 mesh sieves, obtained extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 100 parts pulverizing, 100 mesh sieves are crossed;
3), hydroxyl isomaltulose 15 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 8 hours for 80 DEG C, 210 DEG C are cured 2min, natural cooling, obtained after packaging.
Embodiment 3
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 70 parts, 70 parts, Folium Nelumbinis, Fructus Gardeniae 80 parts, 35 parts, Folium Bambusae, Fructus Cannabis 40 parts, Fructus Crataegi 26 parts, Fructus Citri Sarcodactylis 23 parts, xylitol 45 parts;
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), the 80 parts of coarse crushings of above-mentioned Fructus Gardeniae are shelled, mix with 70 parts, Folium Nelumbinis, 35 parts, Folium Bambusae, Fructus Cannabis 40 parts, Fructus Crataegi 26 parts, Fructus Citri Sarcodactylis 23 parts, with the water extraction 1 time of medical material weight 20 times of volumes, each 3 hours, merge extractive liquid, filtered, relative density 1.20 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 C, 150 orders that pulverize and sieve obtain extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 70 parts pulverizing, 100 mesh sieves are crossed;
3), xylitol 45 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 8 hours for 70 DEG C, 220 DEG C are cured 2min, natural cooling, the obtained Radix Et Rhizoma Fagopyri Tatarici tea containing Chinese medicine composition after packaging.
Embodiment 4
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 130 parts, 130 parts, Folium Nelumbinis, Fructus Gardeniae 140 parts, 15 parts, Folium Bambusae, Fructus Cannabis 20 parts, Fructus Crataegi 8 parts, Fructus Citri Sarcodactylis 14 parts, oligomeric isomaltose 20 parts;
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), by above-mentioned Fructus Gardeniae 140 parts, coarse crushing is shelled, mix with 130 parts, Folium Nelumbinis, 15 parts, Folium Bambusae, Fructus Cannabis 20 parts, Fructus Crataegi 8 parts, Fructus Citri Sarcodactylis 14 parts, with 15 times amount water extraction 3 times, each 1 hour, merge extractive liquid, filter, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 130 parts pulverizing, sieve 200 orders;
3), oligomeric isomaltose 20 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 18 hours for 50 DEG C, 200 DEG C are cured 5min, natural cooling, obtained after packaging
Embodiment 5
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 190 parts, 50 parts, Folium Nelumbinis, Fructus Gardeniae 170 parts, 40 parts, Folium Bambusae, Fructus Cannabis 10 parts, Fructus Crataegi 5 parts, Fructus Citri Sarcodactylis 38 parts, Sorbitol 55 parts.
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), by above-mentioned Fructus Gardeniae 170 parts, coarse crushing is shelled, mix with 50 parts, Folium Nelumbinis, 40 parts, Folium Bambusae, Fructus Cannabis 10 parts, Fructus Crataegi 5 parts, Fructus Citri Sarcodactylis 38 parts, with 12 times amount water extraction 2 times, each 2 hours, merge extractive liquid, filter, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 190 parts pulverizing, sieve 200 orders;
3), Sorbitol 55 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 18 hours for 50 DEG C, 200 DEG C are cured 5min, natural cooling, obtained after packaging.
Embodiment 6
1, have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 50 parts, 190 parts, Folium Nelumbinis, Fructus Gardeniae 75 parts, 10 parts, Folium Bambusae, Fructus Cannabis 55 parts, Fructus Crataegi 38 parts, Fructus Citri Sarcodactylis 5 parts, maltose alcohol 10 parts.
2, have the preparation method of the compositions of hypertension and hyperlipemia blood sugar reducing function, it comprises the following steps:
1), by above-mentioned Fructus Gardeniae 75 parts, coarse crushing is shelled, mix with 190 parts, Folium Nelumbinis, 10 parts, Folium Bambusae, Fructus Cannabis 55 parts, Fructus Crataegi 38 parts, Fructus Citri Sarcodactylis 5 parts, with 8 times amount water extraction 3 times, each 1 hour, merge extractive liquid, filter, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by above-mentioned Radix Et Rhizoma Fagopyri Tatarici 50 parts pulverizing, sieve 200 orders;
3), maltose alcohol 10 parts is got, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, and dry 18 hours for 50 DEG C, 200 DEG C are cured 5min, natural cooling, obtained after packaging.
Embodiment 7
Compositions in the present invention is observed the regulating action of hyperlipidemia lipid of mice
1. experimental technique:
1. experimental technique: Kunming mouse 36, is divided into 2 groups at random, matched group 12, modeling group 24, modeling group mice gavages high lipoprotein emulsion 0.2ml/10g body weight after 2 weeks every day, record serum TC level comparatively matched group on average add 9.2%.Dividing into groups further according to recording TC level: hyperlipidemia model group and administration group, often organizing 12.Administration group: adopt the compositions that the embodiment of the present invention 3 is made, the solution of 10% is made into 0.5%CMC-Na solution, administration group mice gavages 0.2ml/10g body weight every day, and the 0.5%CMC-Na solution that matched group and hyperlipidemia model group give equivalent gavages, continuous six weeks.At experimental session, weigh Mouse Weight weekly, within every 2 weeks, measure a serum TC and TG level.
2. on the impact of blood fat, shown in table 1 and table 2:
Table 1 administration 2 weeks and 4 weeks time blood lipid level
Compared with hyperlipidemia model group, * P<0.05; * P<0.01
Blood lipid level during table 2 administration 6 weeks
Compared with hyperlipidemia model group, * P<0.05; * P<0.01
To lipid result as shown in Table 1 and Table 2, at whole experimental session, in hyperlipidemia model group Mouse Blood, TC with TG content is compared with Normal group, visible obvious rising (P < 0.05 or P < 0.01), shows hyperlipemia model modeling success.After with present composition process, TC and the TG content in blood is all decreased significantly, in blood HDL-C, ApoAI and ApoB content between each group there are no notable difference.Result shows, Chinese medicine composition provided by the invention has good Adjust-blood lipid effect.
Embodiment 8
Compositions provided by the invention is observed the regulating action of SHR rat blood pressure
Experimental technique: hypertensive SHR rats, male and female half and half, 68,250 ~ 280g, is divided into three administration groups and a model group, often organizes each 17.Administration group: adopt the compositions that the embodiment of the present invention 4 is made, the basic, normal, high dosing solution that mass concentration is 1%, 5% and 10% is made into respectively with 0.5%CMC-Na solution, administration group rat gavages 14ml/kg body weight every day, the 0.5%CMC-Na solution that matched group and model group give equivalent gavages, continuous eight weeks.Measure and contrast each systolic pressure (SBP) of group, the data of diastolic pressure (DBP) before and after administration, specific experiment the results are shown in Table 3.
Table 3 compositions is on the impact of SHR rat blood pressure
Compared with matched group, * P<0.01
Shown by the experimental result of above table 3, mice is to after giving compositions provided by the invention, systolic pressure and diastolic pressure have obvious reduction (P<0.01) compared with before administration, and matched group after-contraction pressure before administration and diastolic pressure are there are no notable difference.Result shows: test composition provided by the invention has adjustment blood pressure effect preferably.
Embodiment 9
Compositions provided by the invention is observed the regulating action of mouse blood sugar
Experimental technique: get healthy adult Kunming mouse, male and female half and half, after adaptability raises 2d, fasting 24h, is divided into matched group and modeling group, and modeling group gives tail vein injection alloxan solution 50mg/kg.After 120h, water 5h is can't help in mice fasting, measures blood glucose from eyeground vein blood sampling, selects blood glucose value 10 ~ 25mmol/L to be hyperglycemia success mice, is divided into three administration groups and a model group, often organizes each 12.Administration group: adopt the made compositions 0.5%CMC-Na solution of the embodiment of the present invention 2 to be made into the basic, normal, high dosing solution that mass concentration is 1%, 5% and 10% respectively, administration group mice gavages 0.2ml/10g body weight every day, the 0.5%CMC-Na solution that matched group and model group give equivalent gavages, continuous eight weeks.Experiment terminates latter stage, and water 5h is can't help in mice fasting, and measure blood glucose from eyeground vein blood sampling, respectively organize fasting blood sugar, specific experiment the results are shown in Table 4.
Table 4 compositions is on the impact of mouse blood sugar
Compare with normal group, * P<0.05; Compared with model group, * * P<0.01
From table 4, mice upon administration fasting blood sugar obviously reduces (P<0.05) compared with before administration, model group before administration after fasting blood sugar there are no notable difference, result shows, test composition provided by the invention has the effect well regulating blood glucose.
Embodiment 10
Compositions of the present invention is to the effect of human body, and by applying three-hypers crowd, the tested crowd's blood fat of result, blood pressure all make moderate progress, and without any untoward reaction.
Observe 69 routine experimenters, wherein male 33 example, women 36 example, 47.3 years old mean age.Take the compositions obtained by the embodiment of the present invention 1, daily twice, each one bag, take three months altogether.
Date processing: the average and the standard deviation that calculate each observation index, and carry out t inspection.Specific experiment result is as shown in table 5:
Table 5 compositions is on the impact of blood sugar for human body, blood fat, blood pressure
Experimental result shows, the indices before taking and after taking has obvious diversity (the equal < 0.01 of P).The indices of tested crowd all has and improves more significantly, also significant discomfort symptom is not had after taking, show that compositions provided by the invention has good blood fat reducing, blood pressure lowering and hypoglycemic effect, and take period there are no untoward reaction, clinical drug safety is good.The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (12)
1. have a compositions for hypertension and hyperlipemia blood sugar reducing function, it is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 50 ~ 190 parts, 50 ~ 190 parts, Folium Nelumbinis, Fructus Gardeniae 75 ~ 170 parts, 10 ~ 40 parts, Folium Bambusae, Fructus Cannabis 10 ~ 55 parts, Fructus Crataegi 5 ~ 38 parts, Fructus Citri Sarcodactylis 5 ~ 38 parts.
2. there is the compositions of hypertension and hyperlipemia blood sugar reducing function according to claim 1, it is characterized in that, comprise sugar alcohol 10-55 part.
3. the compositions with hypertension and hyperlipemia blood sugar reducing function according to claim 1 and 2, is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 70 ~ 130 parts, 70 ~ 130 parts, Folium Nelumbinis, Fructus Gardeniae 80 ~ 150 parts, 15 ~ 35 parts, Folium Bambusae, Fructus Cannabis 18 ~ 40 parts, Fructus Crataegi 8 ~ 26 parts, Fructus Citri Sarcodactylis 8 ~ 26 parts, sugar alcohol 15 ~ 45 parts.
4. the compositions with hypertension and hyperlipemia blood sugar reducing function according to claim 3, is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 90 parts, 85 parts, Folium Nelumbinis, Fructus Gardeniae 150 parts, 22 parts, Folium Bambusae, Fructus Cannabis 25 parts, Fructus Crataegi 13 parts, Fructus Citri Sarcodactylis 26 parts, sugar alcohol 30 parts.
5. the compositions with hypertension and hyperlipemia blood sugar reducing function according to claim 3, is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 100 parts, 95 parts, Folium Nelumbinis, Fructus Gardeniae 130 parts, 15 parts, Folium Bambusae, Fructus Cannabis 18 parts, Fructus Crataegi 10 parts, Fructus Citri Sarcodactylis 8 parts, sugar alcohol 15 parts.
6. the compositions with hypertension and hyperlipemia blood sugar reducing function according to claim 3, is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 70 parts, 70 parts, Folium Nelumbinis, Fructus Gardeniae 80 parts, 35 parts, Folium Bambusae, Fructus Cannabis 40 parts, Fructus Crataegi 26 parts, Fructus Citri Sarcodactylis 23 parts, sugar alcohol 45 parts.
7. the compositions with hypertension and hyperlipemia blood sugar reducing function according to claim 3, is characterized in that, it comprises the raw material of following parts by weight:
Radix Et Rhizoma Fagopyri Tatarici 130 parts, 130 parts, Folium Nelumbinis, Fructus Gardeniae 140 parts, 15 parts, Folium Bambusae, Fructus Cannabis 20 parts, Fructus Crataegi 8 parts, Fructus Citri Sarcodactylis 14 parts, sugar alcohol 20 parts.
8. having according to any one of claim 2 ~ 7 is improved fatty liver, is reduced the compositions of body weight effect, it is characterized in that: described sugar alcohol is selected from hydroxyl isomaltulose, xylitol, mannitol, erythritol, maltose alcohol, Sorbitol, soybean oligo saccharide, oligomeric xylose, oligomeric isomaltose, oligofructose, oligomeric galactose, Oligomeric manna sugar, or the combination in any of two or more material.
9. the preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function described in any one of claim 1 ~ 7, is characterized in that, comprise the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with water extraction, extracting liquid filtering, after filtrate is concentrated, dry, pulverize the extract that sieves to obtain;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, sieve;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, dry, to obtain final product.
10. the preparation method with the compositions of hypertension and hyperlipemia blood sugar reducing function according to claim 9, is characterized in that, comprise the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with the water extraction 1 ~ 3 time of medical material 10 ~ 20 times of volumes, each 1 ~ 3 hour, merge extractive liquid, filtered, relative density 1.20 ~ 1.40 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 ~ 90 DEG C, pulverizes and sieves to obtain extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 ~ 200 mesh sieves;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, extruding pelletizing forming, 50 ~ 80 DEG C dry 8 ~ 18 hours, 200 ~ 220 DEG C and cure 2 ~ 5min, natural cooling, packaging and get final product.
11. preparation methoies with the compositions of hypertension and hyperlipemia blood sugar reducing function according to claim 9, is characterized in that, comprise the following steps:
A, get Fructus Gardeniae by weight, mix with Folium Nelumbinis, Folium Bambusae, Fructus Cannabis, Fructus Crataegi, Fructus Citri Sarcodactylis after coarse crushing, with 10 times amount water extraction 2 times, each 1 hour, merge extractive liquid, filters, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, pulverized 100 mesh sieves, obtained extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 mesh sieves;
C, get sugar alcohol, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A is mixed homogeneously, extruding pelletizing forming, 60 DEG C dry 12 hours, 200 DEG C and cure 3min, natural cooling, packaging and get final product.
The application of the compositions with hypertension and hyperlipemia blood sugar reducing function described in 12. any one of claim 1 ~ 7 in preparation control hyperlipidemia, hypertension, antihyperglycemic drug or health product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410436534.9A CN104225302B (en) | 2014-08-29 | 2014-08-29 | A kind of composition with hypertension and hyperlipemia blood sugar reducing function and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410436534.9A CN104225302B (en) | 2014-08-29 | 2014-08-29 | A kind of composition with hypertension and hyperlipemia blood sugar reducing function and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104225302A true CN104225302A (en) | 2014-12-24 |
| CN104225302B CN104225302B (en) | 2017-06-27 |
Family
ID=52214778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410436534.9A Active CN104225302B (en) | 2014-08-29 | 2014-08-29 | A kind of composition with hypertension and hyperlipemia blood sugar reducing function and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104225302B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072649A (en) * | 2016-06-30 | 2016-11-09 | 成都永安制药有限公司 | A kind of preparation method of blood fat reducing Oligomeric manna sugar oral liquid |
| CN106492011A (en) * | 2016-11-01 | 2017-03-15 | 陈耕 | A kind of with lowering blood pressure and blood fat, the composition of effect of lowering blood sugar and preparation method thereof and drink |
| CN107079989A (en) * | 2017-03-27 | 2017-08-22 | 柳州市雨滴餐饮管理有限公司 | A kind of prebiotics milk tea and preparation method thereof |
| CN107307401A (en) * | 2017-06-27 | 2017-11-03 | 佛山市南海天美事食品有限公司 | A kind of application of composition of integration of drinking and medicinal herbs in lowering blood-fat and reducing weight functional food is prepared |
| CN111000001A (en) * | 2019-12-19 | 2020-04-14 | 广西巴马寿村原生态产品开发有限公司 | Substitutional tea for reducing blood pressure and blood fat and preparation method thereof |
| CN112675156A (en) * | 2021-01-20 | 2021-04-20 | 吉林大学 | Application of erythritol in preparation of medicine for treating non-alcoholic fatty liver disease |
| WO2022021779A1 (en) * | 2020-07-28 | 2022-02-03 | 深圳市老年医学研究所 | Medicated diet and dietary therapy product composition for hyperlipemia and fatty liver and preparation method therefor |
| CN116172065A (en) * | 2021-11-29 | 2023-05-30 | 内蒙古伊利实业集团股份有限公司 | Application of medicinal and edible substances in preparation of viable bacteria-containing fermented milk containing sugar alcohol substances with prolonged shelf life |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664460A (en) * | 2008-09-01 | 2010-03-10 | 陈群 | Chinese herbal medicinal composition for blood fat reducing tea |
| CN103053745A (en) * | 2012-12-28 | 2013-04-24 | 崇左市江州区生产力促进中心 | A fresh bamboo leaf and lotus leaf tea, and a production method thereof |
| CN103156017A (en) * | 2013-03-12 | 2013-06-19 | 胡孔佑 | Brick tea beverage for losing weight and reducing fat and preparation method thereof |
| CN103735897A (en) * | 2013-12-23 | 2014-04-23 | 广西南宁科冠医药科技开发有限公司 | Traditional Chinese medicine oral liquid for lowering blood pressure and regulating blood fat and preparation method thereof |
-
2014
- 2014-08-29 CN CN201410436534.9A patent/CN104225302B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664460A (en) * | 2008-09-01 | 2010-03-10 | 陈群 | Chinese herbal medicinal composition for blood fat reducing tea |
| CN103053745A (en) * | 2012-12-28 | 2013-04-24 | 崇左市江州区生产力促进中心 | A fresh bamboo leaf and lotus leaf tea, and a production method thereof |
| CN103156017A (en) * | 2013-03-12 | 2013-06-19 | 胡孔佑 | Brick tea beverage for losing weight and reducing fat and preparation method thereof |
| CN103735897A (en) * | 2013-12-23 | 2014-04-23 | 广西南宁科冠医药科技开发有限公司 | Traditional Chinese medicine oral liquid for lowering blood pressure and regulating blood fat and preparation method thereof |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072649A (en) * | 2016-06-30 | 2016-11-09 | 成都永安制药有限公司 | A kind of preparation method of blood fat reducing Oligomeric manna sugar oral liquid |
| CN106492011A (en) * | 2016-11-01 | 2017-03-15 | 陈耕 | A kind of with lowering blood pressure and blood fat, the composition of effect of lowering blood sugar and preparation method thereof and drink |
| CN107079989A (en) * | 2017-03-27 | 2017-08-22 | 柳州市雨滴餐饮管理有限公司 | A kind of prebiotics milk tea and preparation method thereof |
| CN107307401A (en) * | 2017-06-27 | 2017-11-03 | 佛山市南海天美事食品有限公司 | A kind of application of composition of integration of drinking and medicinal herbs in lowering blood-fat and reducing weight functional food is prepared |
| CN111000001A (en) * | 2019-12-19 | 2020-04-14 | 广西巴马寿村原生态产品开发有限公司 | Substitutional tea for reducing blood pressure and blood fat and preparation method thereof |
| WO2022021779A1 (en) * | 2020-07-28 | 2022-02-03 | 深圳市老年医学研究所 | Medicated diet and dietary therapy product composition for hyperlipemia and fatty liver and preparation method therefor |
| CN112675156A (en) * | 2021-01-20 | 2021-04-20 | 吉林大学 | Application of erythritol in preparation of medicine for treating non-alcoholic fatty liver disease |
| CN116172065A (en) * | 2021-11-29 | 2023-05-30 | 内蒙古伊利实业集团股份有限公司 | Application of medicinal and edible substances in preparation of viable bacteria-containing fermented milk containing sugar alcohol substances with prolonged shelf life |
| CN116172065B (en) * | 2021-11-29 | 2024-07-16 | 内蒙古伊利实业集团股份有限公司 | Application of medicinal and edible substances in preparation of viable bacteria-containing fermented milk containing sugar alcohol substances with prolonged shelf life |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104225302B (en) | 2017-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104225302A (en) | Composition with pressure-reducing, fat-reducing and sugar-reducing effects, as well as preparation method and application for same | |
| CN104719899B (en) | Ginseng hypoglycemic soft sweets and preparation method | |
| CN101155521B (en) | Novel method for preparing ginseng to obtain increased amount of ginsenoside rg5 | |
| CN102114102B (en) | Traditional Chinese medicine extract mixed preparation and application thereof | |
| CN104208275B (en) | It is a kind of that there is improvement fatty liver, composition of losing weight effect and its preparation method and application | |
| CN102579669B (en) | Chinese medicinal composition for nourishing qi and blood and conditioning menstruation and preparation method thereof | |
| CN102657834A (en) | Traditional Chinese medical composition for treatment of alcoholism and preparation process thereof | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN107115460A (en) | David's-harp compound granules and preparation method thereof | |
| CN102448479B (en) | A novel antidiabetic furostanolic saponin rich (fsr) fraction from fenugreek seeds | |
| CN101843310B (en) | Jiantangcha (blood glucose benefiting tea) capsule for assistantly reducing blood glucose and improving symptoms of diabetes and preparation method thereof | |
| CN105596576A (en) | Tea bag with blood fat reducing action | |
| CN1314345C (en) | Glossy ganoderma tea | |
| CN103223104A (en) | Traditional Chinese medicine composition for treating diabetes and preparation method | |
| CN105030939B (en) | A kind of hypoglycemic granule and capsule | |
| CN103705860B (en) | A kind of Chinese medicine composition for the treatment of infant jaundice and preparation method thereof | |
| CN102579530A (en) | Preparation method of aralia taibaiensis total saponin having diabetes mellitus resisting effect and medicament | |
| CN102266391A (en) | Composition extracted from medicinal and edible plants and able to adjust fasting and postprandial blood glucose simultaneously | |
| CN104232314A (en) | Preparation method and health product of platycodon grandiflorum seed essential oil | |
| CN104258061A (en) | Composition with hypoglycemic effect and preparation method of composition | |
| CN105963549A (en) | Conditioning meal for conditioning stagnant blood constitution and preparation method thereof | |
| CN107233364A (en) | A kind of hypoglycemic method for preparing extractive | |
| CN102389113B (en) | Yinling capsule and preparation method thereof | |
| CN101491645A (en) | Medicine preparation for treating diabetes and complicating disease thereof and preparation method thereof | |
| CN113068832A (en) | A health product with effects of nourishing liver and kidney, fixing hair, and preventing alopecia, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Applicant after: Leiyunshang Pharmaceutical Group Co. Ltd. Address before: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Applicant before: Leiyunshang Pharmaceutical Co., Ltd. |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170515 Address after: 215009, No. 86, Heng Shan Road, Suzhou hi tech Development Zone, Jiangsu, Suzhou Applicant after: Suzhou leiyunshang health Co. Ltd. Address before: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Applicant before: Leiyunshang Pharmaceutical Group Co. Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |