A kind of composition with hypertension and hyperlipemia blood sugar reducing function and its preparation method and application
Technical field
The present invention relates to a kind of composition, more particularly to a kind of composition and its preparation with hypertension and hyperlipemia blood sugar reducing function
Method and application, belong to pharmaceutical technology field.
Background technology
In recent years, the health of modern in " hypertension, hyperglycaemia, high fat of blood " three serious harm high.With living standard
Raising, " hypertension, high fat of blood, hyperglycaemia " three high diseases are more and more universal, the bad life such as bend over one's desk working for a long time, do not get enough athletic exercise
Rhythm makes obesity, hypertension, high cholesterol annoying crowd.
The global annual number for dying from angiocardiopathy is up to 15,000,000 people, has been that human death's cause of disease is " No.1 to kill
Hand ", serious harm human health." three high " and obesity are the high risk factors for causing cardiovascular and cerebrovascular disease, while high fat of blood is easy
Cause blood vessel embolism;Hypertension may induce cerebral hemorrhage and rupture of blood vessel in brain;Hyperglycaemia can cause diabetes.Therefore for " three
It is high " positive Control Measure should be taken.
Existing product is used to control, treat the medicine of three high diseases to be required for long-term taking substantially, though its pharmacology toxic and side effect
Existing numerous studies, but the adverse reaction to human body cannot be excluded.Therefore daily life custom and dietetic regulation more to highlight its important
Property.
At present, there is not yet by the medicine and food raw materials such as lotus leaf, cape jasmine, the leaf of bamboo, fructus cannabis, hawthorn, Buddha's hand material and duck wheat
The composition with hypertension and hyperlipemia blood sugar reducing function is made, for preventing, controlling, treating high fat of blood, hypertension, hyperglycemia.
The content of the invention
Goal of the invention:The invention aims to overcome the deficiencies in the prior art, there is provided a kind of with blood fat-reducing blood pressure-decreasing drop
Sugar effect, safe without toxic side effect is adapted to the composition of long-term taking, and another object of the present invention is to provide the system of said composition
Preparation Method.
Technical scheme:In order to realize the above object the technical scheme that the present invention takes is:
A kind of composition with hypertension and hyperlipemia blood sugar reducing function, its raw material comprising following parts by weight:
50~190 parts of duck wheat, 50~190 parts of lotus leaf, 75~170 parts of cape jasmine, 10~40 parts of the leaf of bamboo, fructus cannabis 10~55
Part, 5~38 parts of hawthorn, 5~38 parts of Buddha's hand, 10~55 parts of sugar alcohol.
Preferably, the above-described composition with hypertension and hyperlipemia blood sugar reducing function, it is by following parts by weight
Raw material be made:
70~130 parts of duck wheat, 70~130 parts of lotus leaf, 80~150 parts of cape jasmine, 15~35 parts of the leaf of bamboo, fructus cannabis 18~40
Part, 8~26 parts of hawthorn, 8~26 parts of Buddha's hand, 15~45 parts of sugar alcohol.
Used as more preferably scheme, the above-described composition with hypertension and hyperlipemia blood sugar reducing function, it is by following weight portion
Several raw materials are made:
90 parts of duck wheat, 85 parts of lotus leaf, 150 parts of cape jasmine, 22 parts of the leaf of bamboo, 25 parts of fructus cannabis, 13 parts of hawthorn, 26 parts of Buddha's hand,
30 parts of sugar alcohol.
Used as another more preferably scheme, the above-described composition with hypertension and hyperlipemia blood sugar reducing function, it is by following heavy
The raw material for measuring number is made:
100 parts of duck wheat, 95 parts of lotus leaf, 130 parts of cape jasmine, 15 parts of the leaf of bamboo, 18 parts of fructus cannabis, 10 parts of hawthorn, 8 parts of Buddha's hand,
15 parts of sugar alcohol.
Used as another more preferably scheme, the above-described composition with hypertension and hyperlipemia blood sugar reducing function, it is by following heavy
The raw material for measuring number is made:
70 parts of duck wheat, 70 parts of lotus leaf, 80 parts of cape jasmine, 35 parts of the leaf of bamboo, 40 parts of fructus cannabis, 26 parts of hawthorn, 23 parts of Buddha's hand, sugar
45 parts of alcohol.
Used as another more preferably scheme, the above-described composition with hypertension and hyperlipemia blood sugar reducing function, it is by following heavy
The raw material for measuring number is made:
130 parts of duck wheat, 130 parts of lotus leaf, 140 parts of cape jasmine, 15 parts of the leaf of bamboo, 20 parts of fructus cannabis, 8 parts of hawthorn, 14 parts of Buddha's hand,
20 parts of sugar alcohol.
Preferably, it is of the present invention with the composition for improving fatty liver, losing weight effect, described sugar
Alcohol is isomalt, xylitol, mannitol, antierythrite, maltitol, D-sorbite, soyabean oligosaccharides, oligomeric wood
Sugar, oligoisomaltose, FOS, galactooligosaccharide, Oligomeric manna sugar, or two or more materials any combination.Especially
It is preferred that isomalt.
The preparation method of the composition with hypertension and hyperlipemia blood sugar reducing function of the present invention, comprises the following steps:
A, cape jasmine is taken by weight, mixed with lotus leaf, the leaf of bamboo, fructus cannabis, hawthorn, Buddha's hand after coarse crushing, extracted with water, carry
Liquid filtering is taken, the extract that sieves to obtain is dry, pulverize after filtrate concentration;
B, take duck wheat crushing, sieving;
C, sugar alcohol is taken, step B gained tartary buckwheat powder extract obtained with step A be well mixed, and drying is obtained final product.
Preferably, the preparation method of the composition with hypertension and hyperlipemia blood sugar reducing function of the present invention, its bag
Include following steps:
A, cape jasmine is taken by weight, mix with lotus leaf, the leaf of bamboo, fructus cannabis, hawthorn, Buddha's hand after coarse crushing, with 10~20 times
Amount water extracts 1~3 time, 1~3 hour every time, merges extract solution, filtration, and relative density 1.20 when filtrate is concentrated into 60 DEG C~
1.40, microwave drying, 50~90 DEG C of temperature pulverizes and sieves to obtain extract;
B, take duck wheat crushing, cross 100~200 mesh sieves;
C, sugar alcohol is taken, step B gained tartary buckwheat powder extract obtained with step A be well mixed, extrudes pelletizing forming, 50
~80 DEG C of drying bakee 2~5min, natural cooling, packagings in 8~18 hours, 200~220 DEG C and obtain final product.
As more preferably scheme, the preparation method of the above-described composition with hypertension and hyperlipemia blood sugar reducing function, its bag
Include following steps:
A, cape jasmine is taken by weight, mixed with lotus leaf, the leaf of bamboo, fructus cannabis, hawthorn, Buddha's hand after coarse crushing, use medicinal material weight
10 times of water of volume are extracted 2 times, 1 hour every time, merge extract solution, are filtered, relative density 1.30 when filtrate is concentrated into 60 DEG C,
Microwave drying, temperature 70 C crushed 100 mesh sieves, obtained extract;
B, take duck wheat crushing, cross 100 mesh sieves;
C, sugar alcohol is taken, step B gained tartary buckwheat powder extract obtained with step A be well mixed, extrudes pelletizing forming, 60
DEG C drying bakees 3min, natural cooling, packagings in 12 hours, 200 DEG C and obtains final product.
Preferably, the preparation method of the above-described composition with hypertension and hyperlipemia blood sugar reducing function, described
Sugar alcohol is isomalt, xylitol, mannitol, antierythrite, maltitol, D-sorbite, soyabean oligosaccharides, oligomeric wood
Sugar, oligoisomaltose, FOS, galactooligosaccharide, Oligomeric manna sugar, or two or more materials any combination.Especially
It is preferred that isomalt.
The composition with hypertension and hyperlipemia blood sugar reducing function that the present invention is provided is preparing preventing and treating high fat of blood, hypertension and blood high
Application in sugared medicine or health products.
Beneficial effect:The present invention provide the composition with hypertension and hyperlipemia blood sugar reducing function compared to the prior art have with
Lower advantage:
The composition that the present invention is provided, is screened by many experiments and obtains optimal prescription, and said composition proportioning is scientific and reasonable,
The present invention adds the Chinese medicine of various medicine-food two-purposes on the basis of duck wheat, has drop rich in abundant Nuciferine in lotus leaf in prescription
Blood fat, Green Tea Extract, effect of norcholesterol, the bitter buckwheat flavone that the Gardenia Yellow and bitter buckwheat that cape jasmine is rich in are rich in has to be improved
Fatty liver, losing weight effect, the cool mutual Ji of full side's temperature, tonification and purgation in combination, it is intended that without wound just, righting is without staying heresy for eliminating evil.Both it is clear
Except internal blood fat, hypoglycemic, step-down strengthen human righteousness again, make to attack and do not hinder just, benefit does not help heresy.Verified through a large amount of pharmacological testings, this
Inventing the composition for providing has good step-down, lipid-loweringing, function of reducing blood sugar, and safe and reliable, has no toxic side effect, instant,
It is convenient to take, it is adapted to long-term taking.
The preparation method of the composition that the present invention is provided, technological design is rationally, workable, and sugar is added in the composition
After alcohol and the compressing chance water of other compositions, sugar alcohol can be quickly dissolved in water, the composition of shaping is formed trickle hole, increase
The dissolution rate of the active ingredient such as general flavone, total alkaloid of lotus leaves, Gardenia Yellow in composition, dissolution is more complete, biological profit
Expenditure is higher.
Specific embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to described reality
Apply among a scope.After reading this disclosure, modification of the those skilled in the art to various unsubstantialities of the invention falls
Within the application appended claims limited range.
Embodiment 1
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
90 parts of duck wheat, 85 parts of lotus leaf, 150 parts of cape jasmine, 22 parts of the leaf of bamboo, 25 parts of fructus cannabis, 13 parts of hawthorn, 26 parts of Buddha's hand,
30 parts of isomalt;
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), by 150 parts of above-mentioned cape jasmine, coarse crushing is shelled, with 85 parts of lotus leaf, 22 parts of the leaf of bamboo, 25 parts of fructus cannabis, 13 parts of hawthorn,
26 parts of mixing of Buddha's hand, are extracted 2 times with the water of 10 times of volumes of medicinal material weight, 1 hour every time, merge extract solution, and filtration, filtrate is dense
100 mesh sieves were crushed in relative density 1.35 when being reduced to 60 DEG C, the microwave drying at a temperature of 70 DEG C, obtained extract;
2), by the 90 parts of crushing of above-mentioned duck wheat, 150 mesh sieves are crossed;
3) 30 parts of isomalt, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Extruding pelletizing forming, 60 DEG C dry 12 hours, and 200 DEG C of baking 3min, natural cooling is obtained after packaging.
Embodiment 2
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
100 parts of duck wheat, 95 parts of lotus leaf, 130 parts of cape jasmine, 15 parts of the leaf of bamboo, 18 parts of fructus cannabis, 10 parts of hawthorn, 8 parts of Buddha's hand,
15 parts of isomalt;
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), the 130 parts of coarse crushings of above-mentioned cape jasmine are shelled, with 95 parts of lotus leaf, 15 parts of the leaf of bamboo, 18 parts of fructus cannabis, 10 parts of hawthorn, Buddhist
8 parts of mixing of hand, are extracted 2 times with the water of 15 times of volumes of medicinal material weight, 1.5 hours every time, merge extract solution, and filtration, filtrate is dense
Microwave drying when relative density 1.40 when being reduced to 60 DEG C, 80 DEG C of temperature, crushed 100 mesh sieves, obtained extract;
2), by the 100 parts of crushing of above-mentioned duck wheat, 100 mesh sieves are crossed;
3) 15 parts of isomalt, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Extruding pelletizing forming, 80 DEG C dry 8 hours, and 210 DEG C of baking 2min, natural cooling is obtained after packaging.
Embodiment 3
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
70 parts of duck wheat, 70 parts of lotus leaf, 80 parts of cape jasmine, 35 parts of the leaf of bamboo, 40 parts of fructus cannabis, 26 parts of hawthorn, 23 parts of Buddha's hand, wood
45 parts of sugar alcohol;
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), the 80 parts of coarse crushings of above-mentioned cape jasmine are shelled, with 70 parts of lotus leaf, 35 parts of the leaf of bamboo, 40 parts of fructus cannabis, 26 parts of hawthorn, Buddhist
23 parts of mixing of hand, are extracted 1 time with the water of 20 times of volumes of medicinal material weight, 3 hours every time, merge extract solution, filtration, filtrate concentration
To relative density 1.20 at 60 DEG C, microwave drying, temperature 50 C, 150 mesh that pulverize and sieve obtain extract;
2), by the 70 parts of crushing of above-mentioned duck wheat, 100 mesh sieves are crossed;
3) 45 parts of xylitol, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, extruding make
Grain shaping, 70 DEG C dry 8 hours, and 220 DEG C of baking 2min, natural cooling is obtained the tartary buckwheat tea containing Chinese medicine composition after packaging.
Embodiment 4
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
130 parts of duck wheat, 130 parts of lotus leaf, 140 parts of cape jasmine, 15 parts of the leaf of bamboo, 20 parts of fructus cannabis, 8 parts of hawthorn, 14 parts of Buddha's hand,
20 parts of oligoisomaltose;
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), by 140 parts of above-mentioned cape jasmine, coarse crushing is shelled, with 130 parts of lotus leaf, 15 parts of the leaf of bamboo, 20 parts of fructus cannabis, 8 parts of hawthorn,
14 parts of mixing of Buddha's hand, are extracted 3 times with 15 times of amount water, 1 hour every time, merge extract solution, are filtered, and filtrate is concentrated into relative at 60 DEG C
Density 1.30, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract;
2), by the 130 parts of crushing of above-mentioned duck wheat, sieve 200 mesh;
3) 20 parts of oligoisomaltose, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Extruding pelletizing forming, 50 DEG C dry 18 hours, and 200 DEG C of baking 5min, natural cooling is obtained after packaging
Embodiment 5
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
190 parts of duck wheat, 50 parts of lotus leaf, 170 parts of cape jasmine, 40 parts of the leaf of bamboo, 10 parts of fructus cannabis, 5 parts of hawthorn, 38 parts of Buddha's hand,
55 parts of D-sorbite.
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), by 170 parts of above-mentioned cape jasmine, coarse crushing is shelled, with 50 parts of lotus leaf, 40 parts of the leaf of bamboo, 10 parts of fructus cannabis, 5 parts of hawthorn, Buddhist
38 parts of mixing of hand, are extracted 2 times with 12 times of amount water, 2 hours every time, merge extract solution, are filtered, and filtrate is concentrated into relatively close at 60 DEG C
Degree 1.30, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract;
2), by the 190 parts of crushing of above-mentioned duck wheat, sieve 200 mesh;
3) 55 parts of D-sorbite, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, extruding
Pelletizing forming, 50 DEG C dry 18 hours, and 200 DEG C of baking 5min, natural cooling is obtained after packaging.
Embodiment 6
1st, a kind of composition with hypertension and hyperlipemia blood sugar reducing function, it is made up of the raw material of following parts by weight:
50 parts of duck wheat, 190 parts of lotus leaf, 75 parts of cape jasmine, 10 parts of the leaf of bamboo, 55 parts of fructus cannabis, 38 parts of hawthorn, 5 parts of Buddha's hand, wheat
10 parts of bud sugar alcohol.
The preparation method of the composition the 2nd, with hypertension and hyperlipemia blood sugar reducing function, it is comprised the following steps:
1), by 75 parts of above-mentioned cape jasmine, coarse crushing is shelled, with 190 parts of lotus leaf, 10 parts of the leaf of bamboo, 55 parts of fructus cannabis, 38 parts of hawthorn,
5 parts of mixing of Buddha's hand, are extracted 3 times with 8 times of amount water, 1 hour every time, merge extract solution, are filtered, and filtrate is concentrated into relatively close at 60 DEG C
Degree 1.30, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract;
2), by the 50 parts of crushing of above-mentioned duck wheat, sieve 200 mesh;
3) 10 parts of maltitol, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, extruding
Pelletizing forming, 50 DEG C dry 18 hours, and 200 DEG C of baking 5min, natural cooling is obtained after packaging.
Embodiment 7
Composition in the present invention is observed the adjustment effect of hyperlipemia lipid of mice
1. experimental technique:
1. experimental technique:Kunming mouse 36, is randomly divided into 2 groups, control group 12, modeling group 24, and modeling group is small
Mouse gavaged lipoprotein emulsion 0.2ml/10g body weight high after 2 weeks daily, measures serum TC level and averagely increased 9.2% compared with control group.Root
Further it is grouped according to TC levels are measured:Hyperlipidemia model group and administration group, every group 12.Administration group:Using the institute of the embodiment of the present invention 3
The composition of system, 10% solution is made into 0.5%CMC-Na solution, and administration group mouse gavages 0.2ml/10g body weight daily, right
The 0.5%CMC-Na solution for giving equivalent according to group and hyperlipidemia model group is gavaged, continuous six weeks.During testing, weigh weekly small
Mouse body weight, determines a serum TC and TG levels in every 2 weeks.
2. the influence of pair blood fat, as shown in Tables 1 and 2:
Blood lipid level when table 1 is administered 2 weeks and 4 weeks
Compared with hyperlipidemia model group, * P<0.05;**P<0.01
Blood lipid level when table 2 is administered 6 weeks
Compared with hyperlipidemia model group, * P<0.05;**P<0.01
To lipid result as shown in Table 1 and Table 2, during whole experiment, TC and TG in hyperlipidemia model group mouse blood
Content is compared with Normal group, it is seen that significantly raised (P < 0.05 or P < 0.01), shows hyperlipemia model modeling success.
After being processed with the present composition, TC the and TG contents in blood are decreased significantly, HDL-C, ApoAI and ApoB content in blood
Notable difference is there are no between each group.Result shows that the Chinese medicine composition that the present invention is provided has good Adjust-blood lipid effect.
Embodiment 8
Adjustment effect observation of the composition that the present invention is provided to SHR rat blood pressures
Experimental technique:Hypertensive SHR rats, male and female half and half, 68,250~280g is divided into three administration groups and a mould
Type group, every group each 17.Administration group:Using the composition that the embodiment of the present invention 4 is made, matched somebody with somebody respectively with 0.5%CMC-Na solution
Into the basic, normal, high dosing solution that mass concentration is 1%, 5% and 10%, administration group rat gavages 14ml/kg body weight daily, right
The 0.5%CMC-Na solution for giving equivalent according to group and model group is gavaged, continuous eight weeks.Determine and contrast the receipts of the front and rear each group of administration
The data of contractive pressure (SBP), diastolic pressure (DBP), specific experiment the results are shown in Table 3.
Influence of the composition of table 3 to SHR rat blood pressures
Compared with control group, * P<0.01
By with upper table 3 test result indicate that, mouse after to the composition for giving present invention offer, systolic pressure and diastole
Pressure has compared with before administration substantially reduces (P<0.01), control group before administration after-contraction pressure and diastolic pressure there are no substantially it is poor
It is different.Result shows:The test composition that the present invention is provided has preferably regulation blood pressure effect.
Embodiment 9
Adjustment effect observation of the composition that the present invention is provided to mouse blood sugar
Experimental technique:Take healthy adult Kunming mouse, male and female half and half, after adaptability raises 2d, fasting 24h, it is right to be divided into
According to group and modeling group, modeling group gives tail vein injection alloxan solution 50mg/kg.Water 5h is can't help in mouse fasting after 120h, from
Eyeground vein blood sampling determine blood sugar, from 10~25mmol/L of blood glucose value be hyperglycaemia success mouse, be divided into three administration groups and
One model group, every group each 12.Administration group:Using the made composition of the embodiment of the present invention 2 0.5%CMC-Na solution point
The basic, normal, high dosing solution that mass concentration is 1%, 5% and 10% is not made into, and administration group mouse gavages 0.2ml/10g bodies daily
The 0.5%CMC-Na solution that weight, control group and model group give equivalent is gavaged, continuous eight weeks.Experiment terminates latter stage, mouse fasting
Can't help water 5h, blood sugar is determined from eyeground vein blood sampling, compare each group fasting blood sugar, specific experiment the results are shown in Table 4.
Influence of the composition of table 4 to mouse blood sugar
Compare with normal group, * P<0.05;Compared with model group, * * P<0.01
From table 4, fasting blood sugar significantly reduces (P to mouse compared with before administration upon administration<0.05), model group
Fasting blood sugar there are no notable difference after before administration, as a result show, the test composition that the present invention is provided has good
Adjust effect of blood sugar.
Embodiment 10
Effect of the composition of the invention to human body, applies, as a result tested crowd's blood fat, blood by three crowds high
Pressure makes moderate progress, and without any adverse reaction.
69 subjects of observation, wherein male 33, women 36, average age 47.3 years old.Take the embodiment of the present invention 1
Obtained composition, is taken twice daily, and one bag every time, takes altogether three months.
Data processing:The average and standard deviation of each observation index are calculated, and carries out t inspections.Specific experiment result such as table 5
It is shown:
The composition of table 5 to blood sugar for human body, blood fat, blood pressure influence
Test result indicate that, there is obvious otherness (the equal < 0.01 of P) with the indices after taking before taking.The experimenter
The indices of group all have more significant improvement, also do not there is significant discomfort symptom after taking, and show the combination of present invention offer
Thing has good reducing blood lipid, hypotensive and hypoglycemic effect, and there are no adverse reaction, clinical application peace during taking
Good perfection.The above is only the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications should also be regarded
It is protection scope of the present invention.