CN104208275B - It is a kind of that there is improvement fatty liver, composition of losing weight effect and its preparation method and application - Google Patents
It is a kind of that there is improvement fatty liver, composition of losing weight effect and its preparation method and application Download PDFInfo
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Abstract
There is improvement fatty liver, composition of losing weight effect and its preparation method and application the invention discloses a kind of, it includes 50 ~ 150 parts of duck wheat, 50 ~ 200 parts of lotus leaf, 50 ~ 250 parts of cape jasmine, 20 ~ 80 parts of Poria cocos, 5 ~ 30 parts of cassia seed, 15 ~ 40 parts of the fruit of Chinese wolfberry, 5 ~ 25 parts of dried orange peel, 15 ~ 45 parts of sugar alcohol.Inventive formulation is scientific and reasonable, selects with common medicine-food two-purpose former material, experiment proves that, the composition that the present invention is provided has to be improved fatty liver, loses weight effect well, and safe and reliable, is had no toxic side effect.Preparation technology scientific and precise of the present invention, active ingredient dissolution rate is fast, and bioavilability is high, and instant is convenient to take, is easy to long-term taking.
Description
Technical field
It is more particularly to a kind of that there is improvement fatty liver, the composition of losing weight effect the present invention relates to a kind of composition
And preparation method and application, belong to pharmaceutical technology field.
Background technology
With the improvement of social overall living condition, obesity is sharply increased, and fatty liver is just seriously threatening the health of compatriots, into
To be only second to the second largest hepatopathy of virus hepatitis, the common cause of disguised hepatic sclerosis has been acknowledged as.
Fatty liver can cause the diseases such as tired sense, poor appetite, lassitude and weak, Nausea and vomiting, hepatic region or upper right abdomen secret anguish
Shape, has a strong impact on live and work.It is long-term not notice that maintenance cause all kinds of serious liver diseases with treatment.
There is not more great technological break-through for the prevention of fatty liver, improvement and treatment method and scheme at present, with length
Based on phase medication and custom of making the life better.
It is used to prevent, improve fatty liver now, product is required for long-term taking substantially, and very big inconvenience is brought to patient, its
Actual effect is simultaneously indefinite, and can not exclude the adverse reaction to human body.Therefore daily life custom and dietetic regulation more highlight it
Importance.
At present, there is not yet by the medicine-food two-purpose such as lotus leaf, cape jasmine, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel raw material and bitter buckwheat
Composition report is made in wheat, the report for preventing, improving fatty liver and losing weight.
The content of the invention
Goal of the invention：The invention aims to overcome the deficiencies in the prior art there is provided one kind have improve fatty liver,
Losing weight is acted on, safe without toxic side effect, is adapted to the composition of long-term taking, and another object of the present invention is to provide the combination
The preparation method of thing.
Technical scheme：In order to realize the above object the technical scheme that the present invention takes is：
A kind of to have improvement fatty liver, the composition of losing weight effect, it includes the raw material of following parts by weight：
50~150 parts of duck wheat, 50~200 parts of lotus leaf, 50~250 parts of cape jasmine, 20~80 parts of Poria cocos, cassia seed 5~30
Part, 15~40 parts of the fruit of Chinese wolfberry, 5~25 parts of dried orange peel.
Preferably, it is above-described that there is improvement fatty liver, the composition of losing weight effect also to include sugar
15~45 parts of alcohol.
Preferably, it is above-described that there is improvement fatty liver, the composition of losing weight effect, each bulk drug
Weight proportion is：
60~100 parts of duck wheat, 80~150 parts of lotus leaf, 90~200 parts of cape jasmine, 30~55 parts of Poria cocos, cassia seed 10~20
Part, 15~30 parts of the fruit of Chinese wolfberry, 9~20 parts of dried orange peel, 25~35 parts of sugar alcohol.
It is above-described that there is improvement fatty liver, the composition of losing weight effect, each raw material as another preferred scheme
The weight proportion of medicine is：
60 parts of duck wheat, 80 parts of lotus leaf, 160 parts of cape jasmine, 45 parts of Poria cocos, 15 parts of cassia seed, 25 parts of the fruit of Chinese wolfberry, dried orange peel 15
Part, 25 parts of sugar alcohol.
It is above-described that there is improvement fatty liver, the composition of losing weight effect, each raw material as another preferred scheme
The weight proportion of medicine is：
100 parts of duck wheat, 120 parts of lotus leaf, 130 parts of cape jasmine, 35 parts of Poria cocos, 18 parts of cassia seed, 22 parts of the fruit of Chinese wolfberry, dried orange peel 20
Part, 33 parts of sugar alcohol.
It is above-described that there is improvement fatty liver, the composition of losing weight effect, each raw material as another preferred scheme
The weight proportion of medicine is：
90 parts of duck wheat, 80 parts of lotus leaf, 90 parts of cape jasmine, 55 parts of Poria cocos, 20 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry, 9 parts of dried orange peel,
25 parts of sugar alcohol.
It is above-described that there is improvement fatty liver, the composition of losing weight effect, each raw material as another preferred scheme
The weight proportion of medicine is：
80 parts of duck wheat, 150 parts of lotus leaf, 200 parts of cape jasmine, 30 parts of Poria cocos, 10 parts of cassia seed, 30 parts of the fruit of Chinese wolfberry, dried orange peel 18
Part, 35 parts of heterosugar alcohol.
Of the present invention to have improvement fatty liver, the composition of losing weight effect, described sugar alcohol is different malt ketone
Sugar alcohol, xylitol, mannitol, antierythrite, maltitol, D-sorbite, soyabean oligosaccharides, xylo-oligosaccharide, oligomeric different malt
Sugar, FOS, galactooligosaccharide, Oligomeric manna sugar, or two or more materials any combination.Particularly preferred isomaltoketose
Alcohol.
It is of the present invention that there is improvement fatty liver, the preparation method of the composition of losing weight effect, including following step
Suddenly：
A, cape jasmine is taken, mix, extracted with water with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel after coarse crushing, extract solution mistake
Filter, the extract that sieves to obtain is dry, pulverize after filtrate concentration；
B, take duck wheat to crush, sieve；
C, sugar alcohol is taken, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, drying is produced.
Preferably, it is of the present invention that there is improvement fatty liver, the preparation side of the composition of losing weight effect
Method, it comprises the following steps：
A, cape jasmine is taken, mixed after coarse crushing with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel, 1 is extracted with 10~20 times of amount water
~3 times, 1~3 hour every time, merge extract solution, filtration, relative density 1.20~1.40 when filtrate is concentrated into 60 DEG C, microwave is done
Dry, temperature 50 C~90 DEG C pulverize and sieve to obtain extract；
B, duck wheat is taken to crush, sieve 100~200 mesh；
C, sugar alcohol is taken, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, extrude pelletizing forming, 50
~80 DEG C of bakings are produced after bakeing 2~5min, natural cooling, packagings within 8~18 hours, 200~220 DEG C.
It is above-described that there is improvement fatty liver, the preparation side of the composition of losing weight effect as more preferably scheme
Method, it comprises the following steps：
A, cape jasmine is taken, is mixed after coarse crushing with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel, extracted 2 times with 10 times of amount water,
1 hour every time, merge extract solution, filtration, relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C is crushed
100 mesh sieves are crossed, extract is obtained；
B, take duck wheat to crush, cross 100 mesh sieves；
C, sugar alcohol is taken, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, extrude pelletizing forming, 60
DEG C dry and to bakee 3min, natural cooling within 12 hours, 200 DEG C, produce after packagings.
It is of the present invention that there is improvement fatty liver, the composition of losing weight effect to prevent and treat fatty liver, obesity in preparation
Or the application in the medicine or health products of radical damage.
Beneficial effect：What the present invention was provided, which has, improves fatty liver, the composition of losing weight effect and prior art phase
Than with advantages below：
The composition containing duck wheat that the present invention is provided, prescription, said composition proportioning section are obtained by many experiments screening
Learn reasonable, the Chinese medicine of a variety of medicine-food two-purposes is added on the basis of duck wheat, the Pharmacological experiment result shows that, the combination that the present invention is provided
Thing has improves fatty liver, reduction blood glucose and the effect lost weight well, and safe without toxic side effect, i.e. punching are used, taken
It is convenient, it is adapted to long-term consumption.
The preparation method for the composition that the present invention is provided, is sieved according to the physicochemical property of each component and its chemical composition contained
Optimal preparation technology is selected, composition is prepared into tartary buckwheat tea, sugar alcohol is added, is dissolved in after water and forms trickle hole, is accelerated bitter
The active ingredient dissolution such as buckwheat general flavone, total alkaloid of lotus leaves, Gardenia Yellow, bioavilability is high.
Embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to described reality
Apply among a scope.After the present invention has been read, modification of the those skilled in the art to the various unsubstantialities of the present invention is equal
Fall within the application appended claims limited range.
Embodiment 1
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
60 parts of duck wheat, 80 parts of lotus leaf, 160 parts of cape jasmine, 45 parts of Poria cocos, 15 parts of cassia seed, 25 parts of the fruit of Chinese wolfberry, dried orange peel 15
Part, 25 parts of isomalt；
2nd, preparation process：
1), by above-mentioned 160 parts of cape jasmine, coarse crushing is shelled, with 80 parts of lotus leaf, 45 parts of Poria cocos, 15 parts of cassia seed, the fruit of Chinese wolfberry 25
Part, 15 parts of mixing of dried orange peel, are extracted 2 times with 10 times of amount water, 1 hour every time, merge extract solution, filter, when filtrate is concentrated into 60 DEG C
Relative density 1.35, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 60 parts of crushing of duck wheat, sieve 150 mesh；
3) 25 parts of isomalt, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Pelletizing forming is extruded, 60 DEG C dry 12 hours, 200 DEG C of baking 3min, natural cooling, the combination containing tartary buckwheat tea is made after packaging
Thing.
Embodiment 2
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
100 parts of duck wheat, 120 parts of lotus leaf, 130 parts of cape jasmine, 35 parts of Poria cocos, 18 parts of cassia seed, 22 parts of the fruit of Chinese wolfberry, dried orange peel 20
Part, 33 parts of isomalt；
2nd, preparation process：
1), above-mentioned 130 parts of coarse crushings of cape jasmine are shelled, with 120 parts of lotus leaf, 35 parts of Poria cocos, 18 parts of cassia seed, the fruit of Chinese wolfberry 22
Part, 20 parts of mixing of dried orange peel, are extracted 2 times with 15 times of amount water, 1.5 hours every time, merge extract solution, filter, filtrate is concentrated into 60 DEG C
When relative density 1.40, microwave drying, 90 DEG C of temperature, 100 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 100 parts of crushing of duck wheat, sieve 100 mesh；
3) 33 parts of isomalt, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Pelletizing forming is extruded, 80 DEG C dry 8 hours, 210 DEG C of baking 2min, natural cooling, the composition containing tartary buckwheat tea is made after packaging.
Embodiment 3
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
90 parts of duck wheat, 80 parts of lotus leaf, 90 parts of cape jasmine, 55 parts of Poria cocos, 20 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry, 9 parts of dried orange peel,
25 parts of xylitol；
2nd, preparation process：
1), above-mentioned 90 parts of coarse crushings of cape jasmine are shelled, with 80 parts of lotus leaf, 55 parts of Poria cocos, 20 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry,
9 parts of mixing of dried orange peel, are extracted 1 time with 20 times of amount water, 3 hours every time, merge extract solution, filter, filtrate is concentrated into relative at 60 DEG C
Density 1.20, microwave drying, temperature 50 C, 150 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 90 parts of crushing of duck wheat, sieve 100 mesh；
3) 25 parts of xylitol, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, extruding make
Grain shaping, 50 DEG C dry 18 hours, 220 DEG C of baking 2min, natural cooling, and the composition containing tartary buckwheat tea is made after packaging.
Embodiment 4
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
80 parts of duck wheat, 150 parts of lotus leaf, 200 parts of cape jasmine, 30 parts of Poria cocos, 10 parts of cassia seed, 30 parts of the fruit of Chinese wolfberry, dried orange peel 18
Part, 35 parts of maltitol；
2nd, preparation process：
1), by above-mentioned 200 parts of cape jasmine, coarse crushing is shelled, with 150 parts of lotus leaf, 30 parts of Poria cocos, 10 parts of cassia seed, the fruit of Chinese wolfberry 30
Part, 18 parts of mixing of dried orange peel, are extracted 3 times with 15 times of amount water, 1 hour every time, merge extract solution, filter, when filtrate is concentrated into 60 DEG C
Relative density 1.30, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 80 parts of crushing of duck wheat, sieve 200 mesh；
3) 35 parts of hydroxyl isomaltulose, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, crowded
Pelletizing forming is pressed, 50 DEG C dry 16 hours, 200 DEG C of baking 5min, natural cooling, the composition containing tartary buckwheat tea is made after packaging.
Embodiment 5
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
150 parts of duck wheat, 50 parts of lotus leaf, 250 parts of cape jasmine, 20 parts of Poria cocos, 30 parts of cassia seed, 40 parts of the fruit of Chinese wolfberry, dried orange peel 5
Part, 45 parts of oligoisomaltose；
2nd, preparation process：
1), by above-mentioned 250 parts of cape jasmine, coarse crushing is shelled, with 50 parts of lotus leaf, 20 parts of Poria cocos, 30 parts of cassia seed, the fruit of Chinese wolfberry 40
Part, 5 parts of mixing of dried orange peel, are extracted 2 times with 12 times of amount water, 1.5 hours every time, merge extract solution, filter, when filtrate is concentrated into 60 DEG C
Relative density 1.20, microwave drying, temperature 70 C, 100 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 150 parts of crushing of duck wheat, sieve 200 mesh；
3) 15 parts of oligoisomaltose, is taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed,
Pelletizing forming is extruded, 70 DEG C dry 12 hours, 200 DEG C of baking 3min, natural cooling, the combination containing tartary buckwheat tea is made after packaging
Thing.
Embodiment 6
1st, with the composition for improving fatty liver, losing weight is acted on, parts by weight of raw materials array turns into：
50 parts of duck wheat, 200 parts of lotus leaf, 50 parts of cape jasmine, 180 parts of Poria cocos, 5 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry, dried orange peel 25
Part, 45 parts of soyabean oligosaccharides；
2nd, preparation process：
1), above-mentioned 50 parts of coarse crushings of cape jasmine are shelled, with 200 parts of lotus leaf, 180 parts of Poria cocos, 5 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry,
25 parts of mixing of dried orange peel, are extracted 1 time with 18 times of amount water, 2 hours every time, merge extract solution, filter, filtrate is concentrated into relative at 60 DEG C
Density 1.20, microwave drying, temperature 60 C, 150 mesh that pulverize and sieve obtain extract；
2), by above-mentioned 50 parts of crushing of duck wheat, sieve 100 mesh；
3) 45 parts of soyabean oligosaccharides, are taken, with step 1) extract obtained, step 2) gained tartary buckwheat powder be well mixed, crowded
Pelletizing forming is pressed, 60 DEG C dry 18 hours, 220 DEG C of baking 2min, natural cooling, the composition containing tartary buckwheat tea is made after packaging.
All compositions containing tartary buckwheat tea that technical solution of the present invention is included, the technology effect of the present invention can be achieved
Really.The composition containing tartary buckwheat tea especially obtained by embodiment 1~6, with more obvious technique effect.
Embodiment 7
The present composition is observed the adjustment effect of hyperlipemia mouse weight and liver fat and liver weight
1. experimental method：Kunming mouse 36, is randomly divided into 2 groups, control group 12, modeling group 24, and modeling group is small
Mouse gavaged high lipoprotein emulsion 0.2ml/10g body weight after 2 weeks daily, measures serum TC level and averagely adds 9.1% compared with control group.Root
Further it is grouped according to TC levels are measured：Hyperlipidemia model group and administration group, every group 12.Administration group：The embodiment of the present invention 3 is made
Composition, be made into 0.5%CMC-Na solution 10% solution, administration group mouse gavages 0.2ml/10g body weight, control group daily
The 0.5%CMC-Na solution for giving equivalent with hyperlipidemia model group is gavaged, continuous six weeks.During testing, Mice Body is weighed weekly
Weight, determines a serum TC and TG levels in every 2 weeks.Liver lipid level and liver weight are surveyed at the 6th week.
2. the influence of pair body weight, is shown in Table 1：
The average weight change (g/ mouse) of mouse weekly during table 1 is tested
Compared * P with hyperlipidemia model group<0.05；
Can be obtained from the experimental result of table 1, administration group upon administration the 3rd, 4, the body weight of 5 and 6 weeks significantly mitigates compared with model group
(P ＜ 0.05), test medicine has certain effect to the tool that loses weight.
3. the influence of pair liver fat and liver weight coefficient
Table 2：Liver lipid level and liver weight coefficient when being administered 6 weeks
Compared with hyperlipidemia model group, * P<0.05；**P<0.01
As a result as shown in table 2, TC and TG contents, liver weight and liver weight index are significantly high in hyperlipidemia model group murine liver tissue
In control group (P ＜ 0.01).Be administered after 6 weeks, TC the and TG contents in administration group liver are remarkably decreased (P ＜ 0.01), liver weight and
Liver weight coefficient also declines (P ＜ 0.01).These results are pointed out, and test medicine plays the role of to reduce liver fat.
Experiment by the composition containing tartary buckwheat tea that provides of the present invention to hyperlipemia mouse shows, what the present invention was provided
Composition can effectively lose weight, while having the effect for significantly reducing TC, TG and liver weight and liver weight coefficient in liver.
Embodiment 8
The present composition improves the clinical observation of fatty liver and body weight
1. case selection, is worked out by the non-fat livers of hepatology branch of Chinese Medical Association in 2010 and AML group
Alcohol fatty liver practice guidelines NASH diagnostic criteria
1) it is less than 140 grams/week without history of drinking history or equivalent amount of alcohol of drinking (women is less than 70 grams/week)；
2) there are obesity, diabetes, hyperlipemia of susceptible factor etc.；
3) in addition to primary disease clinical manifestation, there is the non-specific disease such as weak, indigestion, dull pain in liver, hepatosplenomegaly
Shape and sign；
4) serum transaminase and glutamyl transpeptidase level can be increased by mild to moderate, be raised with ALT
Based on；
5) liver imageology performance meets the imaging diagnosis standard of diffusivity fatty liver；
6) Hepatic biopsy changes the pathological diagnosis standard for meeting fatty liver disease.
All possess any one person in above-mentioned 1st~4 and the 5th or the 6th and can be diagnosed as fatty liver, is used as selected pair
As.
Exclusion standard：1. hepatopath caused by chronic heart, malnutritive and other reasonses；2. with virus hepatitis
Or liver function decompensation person；3. the Chinese and western drugses person of other treatment fatty liver is used；4. there is serious primary disease or have
Alcohol, drug abuser；5. treat the person of mismatching.
2. observation and treatment
This is selected in 51 patients, man 42, female 9,28~61 years old age altogether.
Observation index：Body weight, liver function (ALT, AST), blood fat (TC, TG, HDL-C), B ultrasound, CT values.
Treatment method：The made composition of embodiment 1 is taken, 2 times a day, 1 bag every time, 3 months be a course for the treatment of.During treatment
Keep the identical diet before medication, rule daily life.
Efficacy evaluation：
1) it is effective：Clinical symptom disappearance, body weight has clear improvement, and the index such as ALT, TC, TG recovers normal, B ultrasound or CT
Check that fatty liver feature disappears；
2) effectively：Clinical symptoms take a turn for the better, and body weight makes moderate progress, and the index such as ALT, TC, TG makes moderate progress or close normal, B
Super or CT examination fatty liver feature has mitigated；
3) it is invalid：Clinical symptoms are without change, and body weight is unchanged or increases, and the index such as ALT, TC, TG is without improvement or aggravates, B
Super or CT examination fatty liver feature is unchanged or aggravates.
3. result
Each index change before and after treating of table 3
Compared with before treatment, * P ＜ 0.01
As can be seen that contrast treatment is front and rear from by test result, body weight, ALT, AST, TC, TG and HDL-C level of patient
Have clear improvement (P ＜ 0.01).Through liver imaging diagnosis after treatment, fatty liver feature disappears or with notable mitigation.Treatment is total
Effective percentage is more than 92%.Tested crowd does not have significant discomfort, and show that the present invention has improves fatty liver and losing weight well
Effect.
Only it is the preferred embodiment of the present invention described in upper, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications should also be regarded
For protection scope of the present invention.
Claims (11)
1. it is a kind of have improve fatty liver, losing weight effect composition, it is characterised in that it by lower parts by weight raw material
It is made：
50~150 parts of duck wheat, 50~200 parts of lotus leaf, 50~250 parts of cape jasmine, 20~80 parts of Poria cocos, 5~30 parts of cassia seed, Chinese holly
15~40 parts of matrimony vine, 5~25 parts of dried orange peel, 15~45 parts of sugar alcohol.
2. it is according to claim 1 have improve fatty liver, losing weight effect composition, it is characterised in that it by
The raw material of lower parts by weight is made：
60~100 parts of duck wheat, 80~150 parts of lotus leaf, 90~200 parts of cape jasmine, 30~55 parts of Poria cocos, 10~20 parts of cassia seed,
15~30 parts of the fruit of Chinese wolfberry, 9~20 parts of dried orange peel, 25~35 parts of sugar alcohol.
3. it is according to claim 1 have improve fatty liver, losing weight effect composition, it is characterised in that it by
The raw material of lower parts by weight is made：
60 parts of duck wheat, 80 parts of lotus leaf, 160 parts of cape jasmine, 45 parts of Poria cocos, 15 parts of cassia seed, 25 parts of the fruit of Chinese wolfberry, 15 parts of dried orange peel, sugar
25 parts of alcohol.
4. it is according to claim 1 have improve fatty liver, losing weight effect composition, it is characterised in that it by
The raw material of lower parts by weight is made：
100 parts of duck wheat, 120 parts of lotus leaf, 130 parts of cape jasmine, 35 parts of Poria cocos, 18 parts of cassia seed, 22 parts of the fruit of Chinese wolfberry, 20 parts of dried orange peel,
33 parts of sugar alcohol.
5. it is according to claim 1 have improve fatty liver, losing weight effect composition, it is characterised in that it by
The raw material of lower parts by weight is made：
90 parts of duck wheat, 80 parts of lotus leaf, 90 parts of cape jasmine, 55 parts of Poria cocos, 20 parts of cassia seed, 15 parts of the fruit of Chinese wolfberry, 9 parts of dried orange peel, sugar alcohol
25 parts.
6. it is according to claim 1 have improve fatty liver, losing weight effect composition, it is characterised in that it by
The raw material of lower parts by weight is made：
80 parts of duck wheat, 150 parts of lotus leaf, 200 parts of cape jasmine, 30 parts of Poria cocos, 10 parts of cassia seed, 30 parts of the fruit of Chinese wolfberry, 18 parts of dried orange peel, sugar
35 parts of alcohol.
7. any described the having of claim 1~6 improves fatty liver, the composition of losing weight effect, it is characterised in that：It is former
Sugar alcohol in material can be selected from isomalt, soyabean oligosaccharides, xylo-oligosaccharide, oligoisomaltose, FOS, oligomeric
Galactolipin, Oligomeric manna sugar, xylitol, mannitol, antierythrite, maltitol, D-sorbite, or two or more materials appoint
Meaning combination.
8. having described in any one of claim 1~6 improves fatty liver, the preparation method of the composition of losing weight effect,
It is characterised in that it includes following steps：
A, cape jasmine is taken, mix, extracted with water with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel after coarse crushing, extract solution filtering, filter
The extract that sieves to obtain is dry, pulverize after liquid concentration；
B, take duck wheat to crush, sieve；
C, sugar alcohol is taken, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, drying is produced.
9. according to claim 8 have improvement fatty liver, the preparation method of the composition of losing weight effect, its feature
It is, comprises the following steps：
A, cape jasmine is taken, mixed after coarse crushing with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel, 1~3 is extracted with 10~20 times of amount water
It is secondary, 1~3 hour every time, merge extract solution, filter, relative density 1.20~1.40 when filtrate is concentrated into 60 DEG C, microwave drying,
Temperature 50 C~90 DEG C, pulverize and sieve to obtain extract；
B, duck wheat is taken to crush, sieve 100~200 mesh；
C, sugar alcohol is taken, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, extrude pelletizing forming, 50~80
DEG C drying bakees 2~5min, natural cooling in 8~18 hours, 200~220 DEG C, produced after packagings.
10. according to claim 9 have improvement fatty liver, the preparation method of the composition of losing weight effect, it is special
Levy and be, comprise the following steps：
A, cape jasmine is taken, mixed after coarse crushing with lotus leaf, Poria cocos, cassia seed, the fruit of Chinese wolfberry, dried orange peel, 2 times are extracted with 10 times of amount water, every time 1
Hour, merge extract solution, filter, relative density 1.30, microwave drying, temperature 70 C, crushed 100 when filtrate is concentrated into 60 DEG C
Mesh sieve, obtains extract；
B, take duck wheat to crush, cross 100 mesh sieves；
C, take sugar alcohol, tartary buckwheat powder obtained by, step B extract obtained with step A be well mixed, extruding pelletizing forming, 60 DEG C dry
Produced after dry 12 hours, 200 DEG C of baking 3min, natural cooling, packagings.
11. having described in any one of claim 1~6 improves fatty liver, the composition of losing weight effect is preparing preventing and treating
Application in fatty liver, obesity, the medicine of hyperglycaemia or radical damage.
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|---|---|---|---|---|
| CN105999209A (en) * | 2016-08-18 | 2016-10-12 | 张志航 | Traditional Chinese medicine for treating fatty liver and preparing method of traditional Chinese medicine |
| CN108651788A (en) * | 2017-03-29 | 2018-10-16 | 康师傅饮品控股有限公司 | Ragopyrum tataricum beverage and preparation method thereof |
| CN108743727A (en) * | 2018-07-06 | 2018-11-06 | 天津科技大学 | A kind of compound flavones and its preparation method and application with antioxidant activity |
| CN112353850A (en) * | 2020-07-28 | 2021-02-12 | 深圳市老年医学研究所 | Medicated diet food product composition for hyperlipidemia and fatty liver and preparation method thereof |
| CN113349376A (en) * | 2021-05-28 | 2021-09-07 | 华东理工大学 | Oligosaccharide-based lipid-lowering liver-protecting special medical application formula food and preparation method thereof |
| CN113476561A (en) * | 2021-07-09 | 2021-10-08 | 赖秀珍 | Traditional Chinese medicine formula for treating diabetes |
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| CN1143516A (en) * | 1996-04-05 | 1997-02-26 | 何志信 | Balanced nutritious food-kangfusu and preparing process thereof |
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