CN101843310B - Jiantangcha (blood glucose benefiting tea) capsule for assistantly reducing blood glucose and improving symptoms of diabetes and preparation method thereof - Google Patents
Jiantangcha (blood glucose benefiting tea) capsule for assistantly reducing blood glucose and improving symptoms of diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health-care food, in particular to a Jiantangcha (blood glucose benefiting tea) capsule which is used for preventing, delaying or relieving the occurrence and the development of hyperglycemia of diabetes high-risk people and has the functions of adjunctively reducing blood glucose and improving symptoms of diabetes and a preparation method thereof. The Jiantangcha capsule comprises crude aged tea extracts, mulberry leaf extracts, starch and auxiliary materials and is prepared by sufficiently mixing the crude aged tea extracts, the mulberry leaf extracts and the starch uniformly, adding an appropriate amount of edible alcohol for granulation, sieving through 15 to 30 meshes, drying at 50 DEG C to 60 DEG C and encapsulating with capsules. Crude polysaccharide is acquired by scientific technology including low-temperature extraction, purification, refinement, and the like. The crude polysaccharide and polysaccharide from mulberry leaves are used as main raw mateirals and prepared into the Jiantangcha capsule by a scientific prescription, and the Jiantangcha capsule has no toxic or side effect. The product has the advantages of safety, no toxicity, obvious effect on adjunctively reducing the blood glucose and clear action mechanism.
Description
Technical field
The present invention relates to a kind of health food, especially for prevention, delay or generation, the development of diabetes-alleviating people at highest risk hyperglycemia, play auxiliary hyperglycemic and improve strong sugared tea capsule of diabetic symptom effect and preparation method thereof.
Background technology
Diabetes are the serious threat mankind's physical and mental health, and the incidence of disease reaches the elderly more than 3.0%, 40 years old more up to 5.3%, and, also have in recent years the incidence of disease to raise year by year and the trend of the rejuvenation of falling ill, enjoy the concern of countries in the world.China is one of maximum country of the diabetic of the world today, the diabetic is up to 4000～4,500 ten thousand, and the speed increment with annual 80～1,000,000, in addition, it is sugar tolerance rising person that more than 7,000 ten thousand people are still arranged, and its huge medical expense that causes brings heavy financial burden for country, society and individual.Therefore, diabetes occur and development in order to prevent, to control, and it is extremely important that developmental research has the natural health care of preventing and treating the diabetes effect, will produce obvious Social benefit and economic benefit.
From natural plants, seek pure natural, the health food of preventing and treating diabetes, auxiliary hyperglycemic safe, nontoxic, that have no side effect is an economically viable effective way.China be tealeaves the native place, be to produce tea big country, tea resources is very abundant, coarse tea is the Lao Ye of old tea tree, go out of use because taste is not good enough for a long time is not utilized effectively always, causes the wasting of resources.Control the tradition of diabetes according to record China with Japan all useful coarse teas among the people, Recent study shows that its main composition is tea polysaccharide.Tea polysaccharide is rich content in the Lao Ye of old tea tree mainly, and the age of tree is higher, the thicker old content of tealeaves is higher.Both at home and abroad about effect of lowering blood sugar composition in the tealeaves extracts, the hypoglycemic activity bibliographical information is more, but, exist the extraction yield to hang down and the difficult problems such as purity is low, and lack the research of hypoglycemic activity mechanism and the industrialization development research of its system, restricted the development that industrialization is produced, also had no relevant coarse tea assistant hypoglycemia healthcare food and come out.
China also is the native place of mulberry leaf, and the mulberry leaf resource is very abundant.Put down in writing according to Compendium of Materia Medica
[1]: " mulberry leaf are the medicine of brothers Yang Ming, and juice is fried in shallow oil Dai Ming, can only quench one's thirst the item long hair." China's successive dynasties all useful mulberry leaf control the record of diabetes.Recent study shows, mulberry leaf are rich in polysaccharide, flavones, alkaloid, protein, amino acid, vitamin, micro-isoreactivity composition, have hypoglycemic, reducing blood lipid, anti-stress, the effect such as anti-ageing, anticoagulation, and mulberry leaf polysaccharide is the main composition of its hypoglycemic activity.But there is no in the market this type of launch.
Summary of the invention
The purpose of this invention is to provide a kind of prescription complete, have no side effect, the auxiliary hyperglycemic successful, and the mechanism of action is clear and definite, the extraction yield is high, purity is high, safety, nontoxic can prevention, delay or generation, the development of diabetes-alleviating people at highest risk hyperglycemia, play auxiliary hyperglycemic and improve health food---strong sugared tea capsule and preparation method thereof of diabetic symptom effect.
The present invention is comprised of coarse tea extract, mulberry-leaf extract, starch and auxiliary material, with coarse tea extract, mulberry-leaf extract, the abundant mixing of starch, adds proper amount of edible alcohol and granulates, crosses 15～30 orders, 50～60 ℃ of oven dry, Rubber Capsules acquisition.Adopting low temperature extraction, purifying, the scientific technology such as refining to obtain thick polysaccharide, is primary raw material with thick polysaccharide and mulberry leaf polysaccharide, by scientific formula, be prepared into hypoglycemic capsule, has no side effect.This product safety, nontoxic, the auxiliary hyperglycemic successful, and the mechanism of action is clear and definite.
Auxiliary hyperglycemic and the prescription that improves the strong sugared tea capsule of diabetic symptom are comprised of coarse tea extract (thick polysaccharide 〉=5%) 100～900 grams, mulberry-leaf extract (thick polysaccharide 〉=12%) 100～900 grams, starch 200～350 grams and right amount of auxiliary materials.
The preparation method of the strong sugared tea capsule of the present invention, adopt low temperature extraction, purifying, refining scientific technology to obtain thick polysaccharide, be primary raw material with thick polysaccharide and mulberry leaf polysaccharide, coarse tea extract, mulberry-leaf extract, starch are filled a prescription by weight ratio, fully mixing, add proper amount of edible alcohol and granulate, cross 15～30 orders, 50～60 ℃ of oven dry, make capsule and get final product.
Auxiliary hyperglycemic is as follows with the concrete preparation process of strong sugared tea capsule of improving diabetic symptom:
1, draw materials coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch;
2, standby proper amount of edible alcohol is made auxiliary material (meeting the related standards regulation is checked and accepted);
3, select coarse tea to be up to the standards, weighing adds 5 times of amount 95% alcohol, mixes thoroughly;
4,30 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filter residue while hot, and alcohol reclaims;
5, add 10 times of water gagings;
6,50 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filtrate while hot;
7, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate;
8,50 ℃ of water-baths reflux, and are evaporated to thick shape, add 95% alcohol and make and contain the alcohol amount and reach 80%;
9, mixing leaves standstill, spends the night, and precipitation is removed supernatant, gets precipitation, and alcohol reclaims;
10, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant, alcohol reclaims with 95% alcohol washing 3 times; Taking precipitate repeats 3 times)
11, freeze drying is pulverized, and gets finished product, is up to the standards, and is stand-by.
12, with coarse tea extract 100～900 gram, mulberry-leaf extract 100～900 grams, cornstarch 200～350 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Product safety of the present invention, nontoxic, auxiliary hyperglycemic successful, and the mechanism of action is clear and definite.
(1). show that through toxicologic study auxiliary hyperglycemic belongs to non-toxic type with the strong sugared tea capsule that improves diabetic symptom, concrete result of the test is as follows:
1. large and small mouse acute oral toxicity test: all establish 20.0g/kg body weight dosage group by the mtd test method, female, male each 10.Take by weighing sample 100 grams, be mixed with the 200ml suspension with 1% carboxymethyl cellulose as solvent.Stopped eating 16 hours before the large and small mouse gavage, press 20ml/kg body weight gavage capacity secondary gavage, interval 6 hours.Experimental session, each is organized large and small mouse and is showed no manifest symptom and sign, also without dead.Strong sugared tea capsule all greater than the 20.0g/kg body weight, belongs to non-toxic type to the large and small mouse per os of male and female median lethal dose.
2. mouse marrow cell micro nuclear test result: female, male each dosage group (strong sugared tea capsule 2.5,5.0,10.0g/kg body weight) mouse and negative control group comparison, micronucleus permillage there are no significant difference, the positive controls micronuclear rates then is significantly higher than negative control group, and its difference is very significant (P＜0.01).Show that strong sugared tea capsule has no obvious impact to the PCEMNR micronuclear rates, testing result is negative.
3. mouse sperm deformity result of the test: each dosage group (strong sugared tea capsule 2.5,5.0,10.0g/kg body weight) mouse and negative control group comparison, Sperm Abnormalities of Mice there are no significant difference, positive controls is then apparently higher than negative control group, its difference is very significant (P＜0.01), show that strong sugared tea capsule has no obvious impact to Sperm Abnormalities of Mice, testing result is negative.
4.Ames result of the test: the strong sugared tea capsule of variable concentrations is adding and is not adding S
9Under the condition return to become clump count close with negative control group, and positive control returns change bacterium colony number average and is higher than negative control and returns the change clump count more than 2 times.Strong sugared tea capsules A mes test testing result is negative.
5. 30 days feeding trial results of rat: 30 days feeding trials of strong sugared tea Capsules on Rats establish 1.25,2.50, three dosage groups of 5.00g/kg body weight, are equivalent to 25,50,100 times of human body recommended amounts.Experimental result has no animal and poisoning symptom occurs, and gross anatomy and histological observation be the no abnormality seen pathological change also, and routine blood test and biochemical indicator also have no the damaging impact.It is the 5.0g/kg body weight that the strong sugared tea capsule of this experiment is not observed illeffects dosage.
Conclusion: strong sugared tea capsule belongs to nontoxic level; Have no potential mutagenesis; To 30 days feeding trials of rat, have no the overt toxicity reaction.Under this experiment condition, the illeffects maximum dose of not observing that draws strong sugared tea Capsule in Rats is the 5.00g/kg body weight.
(2), auxiliary hyperglycemic test and Study on mechanism thereof show that be good for sugared tea capsule auxiliary hyperglycemic successful, and the mechanism of action is clear and definite, concrete result of the test is as follows:
1. auxiliary hyperglycemic and the strong sugared tea capsule that improves diabetic symptom the results are shown in Table 1 to the impact of blood glucose in diabetic mice value, show that strong sugared tea capsule has obvious control diabetic mice fasting blood sugar and raises, reduces the effect of its blood glucose value, and have certain dose-response relationship.
The strong sugared tea capsule of table 1 on the impact of blood glucose in diabetic mice value (mmol/l,
)
Annotate: a and model control group compare, p＜0.01.
2. strong sugared tea capsule the results are shown in Table 2 to the impact of diabetic mice sugar tolerance experiment.Three dosage group mouse blood sugar TG-AUCs all are lower than model control group, and middle and high dosage group and model control group comparison, and its difference is very significant (P＜0.01).Show that strong sugared tea capsule has the effect of obvious reduction blood glucose in diabetic mice TG-AUC.
The impact that the strong sugared tea capsule of table 2 is tested the diabetic mice sugar tolerance (mmol/l,
)
A/a and model control group compare, p＜0.05/p＜0.01.
Strong sugared tea capsule on the diabetic mice body weight affect model control group and three dosage group Mouse Weights all obviously alleviate after modeling, with before the modeling relatively, be very significant (P＜0.01).At experimental session, each organizes the Mice Body weight average certain rise, but the model control group Mouse Weight is starkly lower than the front level of modeling always.In three dosage groups, along with the increase of dosage, body weight gain is obvious, high dose group 2W after administration rises, in, low dose group 3W after administration plays all level (P＜0.01) before the modeling; And the most obvious with the high dose group body weight gain, 2W rises all apparently higher than model control group after administration, and its difference all has significant (P＜0.05 or P＜0.01).Show that strong sugared tea capsule has the effect that promotes the diabetic mice weight recovery, and have certain dose-response relationship.
4. strong sugared tea capsule the results are shown in Table 3 to the impact of diabetic mice glycated serum protein, shows that diabetic mice glycated serum protein content obviously increases; Strong sugared tea capsule has the effect that reduces diabetic mice glycated serum protein content.
The strong sugared tea capsule of table 3. on the impact of diabetic mice glycated serum protein (mmol/L,
)
Annotate: a, compare p＜0.01 with model control group.
5. glycometabolic impact the results are shown in Table 4 to strong sugared tea capsule on diabetic mice, shows that the secretion of alloxan diabetes mice serum insulin, liver hexokinase and the synthetic of liver glycogen obviously reduce; Strong sugared tea capsule has the effect such as synthetic of the secretion that promotes its serum insulin, liver hexokinase and liver glycogen.
The strong sugared tea capsule of table 4. is on the glycometabolic impact of diabetic mice
Annotate: A/a, compare p＜0.05/p＜0.01 with model control group.
6. strong sugared tea capsule the results are shown in Table 5 to the impact of diabetic mice antioxidation, shows that alloxan diabetes Mouse Liver SOD vigor obviously reduces, liver MDA content obviously increases; Strong sugared tea capsule has its liver SOD vigor of obvious raising, reduces the effect of liver MDA content, and not obvious to liver GSH-Px effect of vigor.
The strong sugared tea capsule of table 5. is on the impact of diabetic mice antioxidation
Annotate: A/a and model control group compare, p＜0.05/p＜0.01.
7. strong sugared tea capsule the results are shown in Table 6 to the impact of the heavy and dirty body ratio of diabetic mice internal organs, show that diabetic mice liver body ratio, kidney weigh and the kidney body increases than all, and strong sugared tea capsule has the effect that makes its reduction.
The strong sugared tea capsule of table 6 is on the impact of diabetic mice internal organs weight and dirty body ratio
Annotate: A/a and model control group compare, p＜0.05/p＜0.01.
8. strong sugared tea capsule the results are shown in Figure 1, Fig. 2 to the impact of diabetic mice Histopathology, shows alloxan diabetes mouse liver cell obvious tumefaction, sex change, and pancreas islet quantity obviously reduces, volume-diminished, and islet cells reduces; The internal organs such as kidney, spleen are showed no obvious abnormalities change.Along with increasing of strong sugared tea capsule dosage, the mouse liver cell denaturation degrees alleviates to some extent, and middle and high dosage group murine liver tissue pathological change PTS all is starkly lower than model control group, and its difference all has utmost point significant (P＜0.01); Pancreas islet quantity is obviously recovered, volume increases, islet cells reparation, regeneration, and three dosage group mouse islets quantity are apparently higher than model control group, and its difference all has significant (P＜0.05 or P＜0.01).
Conclusion: this experimental result shows that strong sugared tea capsule can obviously promote the alleviation of alloxan diabetes mouse symptom, reduces its fasting blood-glucose and Area under the curve of blood glucose, promotes the effect of its weight recovery.By improving the alloxan diabetes anti-oxidative ability of mice, promote the effect that beta Cell of islet reparation, regeneration, function are improved and recovered; Promote the reparation of mouse liver cell and the improvement of liver function; Pancreas islet reparation and regeneration, insulin secretion are increased, improve simultaneously the comprehensive functions such as liver hexokinase, liver pyruvate kinase vigor, impel blood sugar to enter liver cell, make the synthetic increase of liver glycogen, glucose oxidase decomposes to be accelerated, thereby reach the adjusting glycometabolism, reduce blood sugar, improve the effect of diabetic symptom.
(3), the protective effect of beta Cell of islet damage be studies show that strong sugared tea capsule is to H
2O
2The beta Cell of islet damage of inducing has certain protective effect.Concrete outcome is as follows:
1. on the impact of Beta-TC-6 Cell viability: the results are shown in Table 1.Strong sugared tea capsule 100 μ g/mL are to Beta-TC-6 Cell viability do not make significant difference (P＞0.05).
The strong sugared tea capsule of table .1. affects the Beta-TC-6 Cell viability.
2. strong sugared tea capsule is to H
2O
2The protective effect of the Beta-TC-6 cellular damage of inducing: the results are shown in Table 2.3 μ mol/L H
2O
2Can induce the Beta-TC-6 cellular damage, Cell viability significantly descend (P＜0.001); Strong sugared tea capsule 100 μ g/mL are to H
2O
2The Beta-TC-6 cellular damage of inducing has certain protective effect (P＜0.05).
The strong sugared tea capsule of table .2. is to H
2O
2The protective effect of the Beta-TC-6 cellular damage of inducing
Annotate: compare with control group
###Compare with model group P＜0.001
*P＜0.05.
Conclusion: strong sugared tea capsule is to H
2O
2The Beta-TC-6 cellular damage of inducing has certain protective role.
The present invention is that the Zhejiang Academy of Medical Sciences is through years of researches, take the Lao Ye of the old tea tree of the age of tree more than 50 years as raw material, adopt low temperature extraction, purifying, the scientific technology such as refining to obtain thick polysaccharide, be primary raw material with thick polysaccharide and mulberry leaf polysaccharide, by scientific formula, be prepared into strong sugared tea capsule, its auxiliary hyperglycemic successful, and the mechanism of action clear and definite, have no side effect.
Description of drawings
Fig. 1 is the impact of strong sugared tea capsule on hepatic tissue, wherein 1) be model control group * 400,2) be 0.25g/kg body weight group * 400,3) be 0.50g/kg body weight group * 400,4) be 1.00g/kg body weight group * 200.
Fig. 2 is the impact of strong sugared tea capsule on islet tissue, 1) be model control group * 4002) be 0.25g/kg body weight group * 400,3) 0.50g/kg body weight group * 400,4) 1.00g/kg body weight group * 400.
The specific embodiment
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
With coarse tea extract 334 gram, mulberry-leaf extract 333 grams, cornstarch 333 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
With coarse tea extract 100 gram, mulberry-leaf extract 100 grams, cornstarch 200 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 500 gram, mulberry-leaf extract 250 grams, cornstarch 250 grams are mixed, add 95% alcohol, 50～100ml and granulate, 50～55 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 250g, mulberry-leaf extract 500g, cornstarch 250g are mixed, add 95% alcohol, 50～100ml and granulate, 5～560 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Embodiment 5
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 400g, mulberry-leaf extract 400g, cornstarch 200g are mixed, add 95% alcohol, 50～100ml and granulate, 50～55 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Embodiment 6
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 350g, mulberry-leaf extract 350g, cornstarch 300g are mixed, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Embodiment 7
Must meet the related standards regulation to the various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water extraction, alcohol analyse, the techniques such as purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, while hot suction filtration, get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing leaves standstill, spends the night, precipitation, remove supernatant, get precipitation, alcohol reclaims, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 900 gram, mulberry-leaf extract 900 grams, cornstarch 350 grams are mixed, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing obtains.
Claims (1)
1. an auxiliary hyperglycemic is good for sugared tea capsule with the health food that improves diabetic symptom, it is characterized in that it is comprised of coarse tea extract, mulberry-leaf extract, starch and auxiliary material; Weight proportion is coarse tea extract 100～900 grams, mulberry-leaf extract 100～900 grams, starch 200～350 gram and auxiliary materials; Preparation method: adopt low temperature extraction, purifying, refining scientific technology to obtain the coarse tea extract, coarse tea extract, mulberry-leaf extract, starch are filled a prescription by weight ratio, fully mixing, granulate, dry, whole grain, fill with edible alcohol, packing and get final product;
Concrete preparation process is as follows:
1) select coarse tea to be up to the standards, weighing adds 5 times of amount 95% alcohol, mixes thoroughly;
2) 30 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filter residue while hot, and alcohol reclaims;
3) add 10 times of water gagings;
4) 50 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filtrate while hot;
5) get filter residue and repeat water extraction 2 times, get filtrate, merge 3 times filtrate;
6) 50 ℃ of water-baths reflux, and are evaporated to thick shape, add 95% alcohol and make and contain the alcohol amount and reach 80%;
7) mixing leaves standstill, spends the night, and precipitation is removed supernatant, gets precipitation, and alcohol reclaims;
8) with 95% alcohol washing 3 times, add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant, alcohol reclaims; Taking precipitate repeats 3 times;
9) freeze drying is pulverized, and gets finished product, is up to the standards, and is stand-by;
10) with coarse tea extract 100～900 gram, mulberry-leaf extract 100～900 grams, cornstarch 200～350 grams, mix, add 95% alcohol and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, packing and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101622653A CN101843310B (en) | 2010-04-30 | 2010-04-30 | Jiantangcha (blood glucose benefiting tea) capsule for assistantly reducing blood glucose and improving symptoms of diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101622653A CN101843310B (en) | 2010-04-30 | 2010-04-30 | Jiantangcha (blood glucose benefiting tea) capsule for assistantly reducing blood glucose and improving symptoms of diabetes and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101843310A CN101843310A (en) | 2010-09-29 |
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| CN103652089B (en) * | 2013-12-10 | 2015-06-03 | 华中农业大学 | Tea polysaccharide lozenge and preparation method thereof |
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| CN1219446C (en) * | 2003-08-15 | 2005-09-21 | 黄秀兰 | Technique for processing health-care tea made of small pieces of folium mori |
| CN101519458A (en) * | 2009-03-26 | 2009-09-02 | 天津大学 | Method for extracting tea polysaccharides and tea polyphenol from coarse old green tea |
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| CN1219446C (en) * | 2003-08-15 | 2005-09-21 | 黄秀兰 | Technique for processing health-care tea made of small pieces of folium mori |
| CN101519458A (en) * | 2009-03-26 | 2009-09-02 | 天津大学 | Method for extracting tea polysaccharides and tea polyphenol from coarse old green tea |
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| 陈敏 等.桑叶、茶叶及枸杞粗多糖样品的含量分析.《中国实验方剂学杂志》.2008,6-7. * |
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