CN101843310A - Jiantangcha (blood glucose benefiting tea) capsule for adjunctively reducing blood glucose and improving symptoms of diabetes and preparation method thereof - Google Patents
Jiantangcha (blood glucose benefiting tea) capsule for adjunctively reducing blood glucose and improving symptoms of diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health-care food, in particular to a Jiantangcha (blood glucose benefiting tea) capsule which is used for preventing, delaying or relieving the occurrence and the development of hyperglycemia of diabetes high-risk people and has the functions of adjunctively reducing blood glucose and improving symptoms of diabetes and a preparation method thereof. The Jiantangcha capsule comprises crude aged tea extracts, mulberry leaf extracts, starch and auxiliary materials and is prepared by sufficiently mixing the crude aged tea extracts, the mulberry leaf extracts and the starch uniformly, adding an appropriate amount of edible alcohol for granulation, sieving through 15 to 30 meshes, drying at 50 DEG C to 60 DEG C and encapsulating with capsules. Crude polysaccharide is acquired by scientific technology including low-temperature extraction, purification, refinement, and the like. The crude polysaccharide and polysaccharide from mulberry leaves are used as main raw mateirals and prepared into the Jiantangcha capsule by a scientific prescription, and the Jiantangcha capsule has no toxic or side effect. The product has the advantages of safety, no toxicity, obvious effect on adjunctively reducing the blood glucose and clear action mechanism.
Description
Technical field
The present invention relates to a kind of health food, especially for prevention, delay or generation, the development of diabetes-alleviating people at highest risk hyperglycemia, play auxiliary hyperglycemic and improve strong sugared tea capsule of diabetic symptom effect and preparation method thereof.
Background technology
Diabetes are the serious threat mankind's physical and mental health, and the incidence of disease reaches the elderly more than 3.0%, 40 years old more up to 5.3%, and, also have the incidence of disease to raise year by year in recent years and the trend of the rejuvenation of falling ill, enjoy the concern of countries in the world.China is one of maximum country of the diabetic of the world today, the diabetic is up to 4000～4,500 ten thousand, and speed increment with annual 80～1,000,000, in addition, it is sugar tolerance rising person that more than 7,000 ten thousand people are still arranged, and its huge medical expense that causes brings heavy financial burden for country, society and individual.Therefore, diabetes take place and development in order to prevent, to control, and it is extremely important that developmental research has the natural health care of preventing and treating the diabetes effect, will produce obvious social and economic benefit.
From natural plants, seek pure natural, the health food of preventing and treating diabetes, auxiliary hyperglycemic safe, nontoxic, that have no side effect is an economically viable effective way.China be tealeaves the native place, be to produce tea big country, tea resources is very abundant, coarse tea is the Lao Ye of old tea tree, go out of use because of taste is not good enough for a long time is not utilized effectively always, causes the wasting of resources.Control the tradition of diabetes according to putting down in writing China and Japan all useful coarse tea among the people, Recent study shows that its main functional component is a tea polysaccharide.Tea polysaccharide mainly in the Lao Ye of old tea tree content abundant, and the age of tree is high more, the thick more old content of tealeaves is high more.Both at home and abroad about effect of lowering blood sugar composition in the tealeaves extracts, the hypoglycemic activity bibliographical information is more, but, exist the extraction yield to hang down and difficult problems such as purity is low, and lack the research of hypoglycemic activity mechanism and the industrialization development research of its system, restricted the development that industrialization is produced, do not seen that also relevant coarse tea assistant hypoglycemia healthcare food comes out.
China also is the native place of mulberry leaf, and the mulberry leaf resource is very abundant.Put down in writing according to Compendium of Materia Medica
[1]: " mulberry leaf are the medicine of brothers Yang Ming, and juice is fried in shallow oil Dai Ming, can only quench one's thirst the item long hair." all useful mulberry leaf of China's successive dynasties control the record of diabetes.Recent study shows, mulberry leaf are rich in polysaccharide, flavones, alkaloid, protein, amino acid, vitamin, micro-isoreactivity composition, have hypoglycemic, reducing blood lipid, anti-stress, effect such as anti-ageing, anticoagulation, and mulberry leaf polysaccharide is the main functional component of its hypoglycemic activity.But still there is not this type of launch in the market.
Summary of the invention
The purpose of this invention is to provide a kind of prescription complete, have no side effect, the auxiliary hyperglycemic effect is obvious, and the mechanism of action is clear and definite, extraction yield height, the purity height, safety, nontoxic can prevention, delay or generation, the development of diabetes-alleviating people at highest risk hyperglycemia, play auxiliary hyperglycemic and improve health food---strong sugared tea capsule and preparation method thereof of diabetic symptom effect.
The present invention is made up of coarse tea extract, mulberry-leaf extract, starch and auxiliary material, with coarse tea extract, mulberry-leaf extract, the abundant mixing of starch, adds proper amount of edible alcohol and granulates, crosses 15～30 orders, 50～60 ℃ of oven dry, encapsulates and win.Adopting low temperature extraction, purifying, scientific technology such as refining to obtain thick polysaccharide, is primary raw material with thick polysaccharide and mulberry leaf polysaccharide, by scientific formula, be prepared into hypoglycemic capsule, has no side effect.This product safety, nontoxic, the auxiliary hyperglycemic effect is obvious, and the mechanism of action is clear and definite.
Auxiliary hyperglycemic and the prescription that improves the strong sugared tea capsule of diabetic symptom are made up of coarse tea extract (thick polysaccharide 〉=5%) 100～900 grams, mulberry-leaf extract (thick polysaccharide 〉=12%) 100～900 grams, starch 200～350 grams and right amount of auxiliary materials.
The preparation method of the strong sugared tea capsule of the present invention, adopt low temperature extraction, purifying, refining scientific technology to obtain thick polysaccharide, with thick polysaccharide and mulberry leaf polysaccharide is primary raw material, coarse tea extract, mulberry-leaf extract, starch are filled a prescription by weight ratio, fully mixing, add proper amount of edible alcohol and granulate, cross 15～30 orders, 50～60 ℃ of oven dry, make capsule promptly.
Auxiliary hyperglycemic is as follows with the concrete preparation process of strong sugared tea capsule of improving diabetic symptom:
1, draw materials coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch;
2, be equipped with proper amount of edible alcohol and make auxiliary material (meeting the related standards regulation is checked and accepted);
3, select coarse tea to be up to the standards, weighing adds 5 times of amount 95% alcohol, mixes thoroughly;
4,30 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filter residue while hot, and alcohol reclaims;
5, add 10 times of water gagings;
6,50 ℃ of water-baths reflux, lixiviate 1 hour, and suction filtration is got filtrate while hot;
7, get filter residue repetition water and carry 2 times, get filtrate, merge 3 times filtrate;
8,50 ℃ of water-baths reflux, and are evaporated to thick shape, add 95% alcohol and make and contain the alcohol amount and reach 80%;
9, mixing leaves standstill, spends the night, and precipitation is removed supernatant, gets precipitation, and alcohol reclaims;
10, (add alcohol and mixed thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant, alcohol reclaims with 95% alcohol washing 3 times; Taking precipitate repeats 3 times)
11, freeze drying is pulverized, and gets finished product, is up to the standards, and is stand-by.
12, with coarse tea extract 100～900 gram, mulberry-leaf extract 100～900 grams, cornstarch 200～350 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing promptly.
Product safety of the present invention, nontoxic, the auxiliary hyperglycemic effect is obvious, and the mechanism of action is clear and definite.
(1). show that through toxicologic study auxiliary hyperglycemic belongs to non-toxic type with the strong sugared tea capsule that improves diabetic symptom, concrete result of the test is as follows:
1. large and small mouse acute oral toxicity test: all establish 20.0g/kg body weight dosage group by the mtd test method, female, male each 10.Take by weighing sample 100 grams, be mixed with the 200ml suspension as solvent with 1% carboxymethyl cellulose.Large and small mouse stopped eating 16 hours before irritating stomach, pressed the 20ml/kg body weight and irritated gastric capacity secondary filling stomach, 6 hours at interval.Experimental session, each is organized large and small mouse and there is no manifest symptom and sign, does not also have dead.Strong sugared tea capsule all greater than the 20.0g/kg body weight, belongs to non-toxic type to the large and small mouse per os of male and female median lethal dose.
2. mouse marrow cell micro nuclear test result: female, male each dosage group (strong sugared tea capsule 2.5,5.0,10.0g/kg body weight) mouse and negative control group comparison, micronucleus permillage there are no significant difference, the positive controls micronuclear rates then is significantly higher than negative control group, and its difference has highly significant meaning (P＜0.01).Show that being good for sugared tea capsule does not see obvious influence to the PCEMNR micronuclear rates, testing result is negative.
3. mouse sperm deformity result of the test: each dosage group (strong sugared tea capsule 2.5,5.0,10.0g/kg body weight) mouse and negative control group comparison, mouse sperm deformity incidence there are no significant difference, positive controls is then apparently higher than negative control group, its difference has highly significant meaning (P＜0.01), show that being good for sugared tea capsule does not see obvious influence to the mouse sperm deformity incidence, testing result is negative.
4.Ames result of the test: the strong sugared tea capsule of variable concentrations is adding and is not adding S
9Under the condition return to become clump count close with negative control group, and positive control returns change bacterium colony number average and is higher than negative control and returns the change clump count more than 2 times.Strong sugared tea capsules A mes test testing result is negative.
5. 30 days feeding trial results of rat: 30 days feeding trials of strong sugared tea capsule rat establish 1.25,2.50, three dosage groups of 5.00g/kg body weight, are equivalent to 25,50,100 times of human body recommended amounts.Experimental result does not see that poisoning symptom appears in animal, and gross anatomy and histological observation be the no abnormality seen pathological change also, and routine blood test and biochemical indicator are not seen the influence of infringement property yet.It is the 5.0g/kg body weight that the strong sugared tea capsule of this experiment is not observed illeffects dosage.
Conclusion: strong sugared tea capsule belongs to nontoxic level; Do not see potential mutagenesis; To 30 days feeding trials of rat, do not see the overt toxicity reaction.Under this experiment condition, drawing strong sugared tea capsule is the 5.00g/kg body weight to the illeffects maximum dose of not observing of rat.
(2), auxiliary hyperglycemic test and Study on mechanism thereof show that strong sugared tea capsule auxiliary hyperglycemic effect is obvious, and the mechanism of action is clear and definite, concrete result of the test is as follows:
1. auxiliary hyperglycemic and the strong sugared tea capsule that improves diabetic symptom the results are shown in Table 1 to the influence of blood glucose in diabetic mice value, show that strong sugared tea capsule has obvious control diabetic mice fasting blood sugar and raises, reduces the effect of its blood glucose value, and have certain dose-response relationship.
The strong sugared tea capsule of table 1 to the influence of blood glucose in diabetic mice value (mmol/l,
)
Annotate: a and model control group compare, p＜0.01.
2. strong sugared tea capsule the results are shown in Table 2 to the influence of diabetic mice sugar tolerance experiment.Three dosage group mouse blood sugar TG-AUCs all are lower than model control group, and middle and high dosage group and model control group comparison, and its difference all has highly significant meaning (P＜0.01).Show that strong sugared tea capsule has the effect of obvious reduction blood glucose in diabetic mice TG-AUC.
The influence that the strong sugared tea capsule of table 2 is tested the diabetic mice sugar tolerance (mmol/l,
)
A/a and model control group compare, p＜0.05/p＜0.01.
3. strong sugared tea capsule to the diabetic mice body weight influence model control group and three dosage group mouse body weight all obviously alleviate after modeling, with before the modeling relatively, highly significant meaning (P＜0.01) is all arranged.At experimental session, each organizes the mouse body weight all certain rise, but model control group mouse body weight is starkly lower than the preceding level of modeling always.In three dosage groups, along with the increase of dosage, body weight gain is obvious, high dose group 2W after administration rises, in, low dose group 3W after administration plays all level (P＜0.01) before the modeling; And the most obvious with the high dose group body weight gain, 2W rises all apparently higher than model control group after administration, and its difference all has conspicuousness meaning (P＜0.05 or P＜0.01).Show that strong sugared tea capsule has the effect that promotes the diabetic mice weight recovery, and have certain dose-response relationship.
4. strong sugared tea capsule the results are shown in Table 3 to the influence of diabetic mice saccharification haemocyanin, shows that diabetic mice saccharification serum albumin content obviously increases; Strong sugared tea capsule has the effect that reduces diabetic mice saccharification serum albumin content.
The strong sugared tea capsule of table 3. to the influence of diabetic mice saccharification haemocyanin (mmol/L,
)
Annotate: a, compare p＜0.01 with model control group.
5. glycometabolic influence the results are shown in Table 4 to strong sugared tea capsule to diabetic mice, shows that the secretion of alloxan diabetes mice serum insulin, liver hexokinase and the synthetic of liver glycogen obviously reduce; Strong sugared tea capsule has the effect such as synthetic of the secretion that promotes its serum insulin, liver hexokinase and liver glycogen.
The strong sugared tea capsule of table 4. is to the glycometabolic influence of diabetic mice
Annotate: A/a, compare p＜0.05/p＜0.01 with model control group.
6. strong sugared tea capsule the results are shown in Table 5 to the influence of diabetic mice antioxidation, shows that alloxan diabetes Mouse Liver SOD vigor obviously reduces, liver MDA content obviously increases; Strong sugared tea capsule has its liver SOD vigor of obvious raising, reduces the effect of liver MDA content, and not obvious to liver GSH-Px effect of vigor.
The strong sugared tea capsule of table 5. is to the influence of diabetic mice antioxidation
Annotate: A/a and model control group compare, p＜0.05/p＜0.01.
7. strong sugared tea capsule the results are shown in Table 6 to the influence of the heavy and dirty body ratio of diabetic mice internal organs, show that diabetic mice liver body ratio, kidney weigh and the kidney body increases than all, and strong sugared tea capsule has the effect that makes its reduction.
The strong sugared tea capsule of table 6 is to the influence of diabetic mice internal organs weight and dirty body ratio
Annotate: A/a and model control group compare, p＜0.05/p＜0.01.
8. strong sugared tea capsule the results are shown in Figure 1 to the influence of diabetic mice Histopathology, and Fig. 2 shows the obvious swelling of alloxan diabetes mouse liver cell, sex change, and pancreas islet quantity obviously reduces, volume-diminished, and islet cells reduces; Internal organs such as kidney, spleen show no obvious abnormalities change.Along with increasing of strong sugared tea capsule dosage, the mouse liver cell denaturation degrees alleviates to some extent, and middle and high dosage group murine liver tissue pathological change PTS all is starkly lower than model control group, and its difference all has utmost point conspicuousness meaning (P＜0.01); Pancreas islet quantity is obviously recovered, volume increases, islet cells reparation, regeneration, and three dosage group mouse islets quantity are apparently higher than model control group, and its difference all has conspicuousness meaning (P＜0.05 or P＜0.01).
Conclusion: this experimental result shows that strong sugared tea capsule can obviously promote the alleviation of alloxan diabetes mouse symptom, reduces area under its fasting blood-glucose and the blood glucose curve, promotes the effect of its weight recovery.By improving the alloxan diabetes anti-oxidative ability of mice, promote the effect that beta Cell of islet reparation, regeneration, function are improved and recovered; Promote the reparation of mouse liver cell and the improvement of liver function; Pancreas islet reparation and regeneration, insulin secretion are increased, improve comprehensive functions such as liver hexokinase, liver pyruvate kinase vigor simultaneously, impel blood sugar to enter liver cell, make the synthetic increase of liver glycogen, glucose oxidase decomposes to be accelerated, thereby reach the adjusting glycometabolism, reduce blood sugar, improve the effect of diabetic symptom.
(3), the protective effect to the beta Cell of islet damage studies show that strong sugared tea capsule is to H
2O
2The beta Cell of islet damage of inducing has the certain protection effect.Concrete outcome is as follows:
1. to the influence of Beta-TC-6 cell motility rate: the results are shown in Table 1.Strong sugared tea capsule 100 μ g/mL are to Beta-TC-6 cell motility rate do not make significant difference (P＞0.05).
The strong sugared tea capsule of table .1. influences Beta-TC-6 cell motility rate.
2. strong sugared tea capsule is to H
2O
2The protective effect of the Beta-TC-6 cellular damage of inducing: the results are shown in Table 2.3 μ mol/L H
2O
2Can induce the Beta-TC-6 cellular damage, cell motility rate significantly descend (P＜0.001); Strong sugared tea capsule 100 μ g/mL are to H
2O
2The Beta-TC-6 cellular damage of inducing has certain protection effect (P＜0.05).
The strong sugared tea capsule of table .2. is to H
2O
2The protective effect of the Beta-TC-6 cellular damage of inducing
Annotate: compare with control group
###Compare with model group P＜0.001
*P＜0.05.
Conclusion: strong sugared tea capsule is to H
2O
2The Beta-TC-6 cellular damage of inducing has certain protective role.
The present invention is that the Zhejiang Academy of Medical Sciences is through years of researches, Lao Ye with the old tea tree of the age of tree more than 50 years is a raw material, adopt low temperature extraction, purifying, scientific technology such as refining to obtain thick polysaccharide, with thick polysaccharide and mulberry leaf polysaccharide is primary raw material, by scientific formula, be prepared into strong sugared tea capsule, its auxiliary hyperglycemic effect is obvious, and the mechanism of action clear and definite, have no side effect.
Description of drawings
Fig. 1 is the influence of strong sugared tea capsule to hepatic tissue, wherein 1) be model control group * 400,2) be 0.25g/kg body weight group * 400,3) be 0.50g/kg body weight group * 400,4) be 1.00g/kg body weight group * 200.
Fig. 2 is the influence of strong sugared tea capsule to islet tissue, 1) be model control group * 4002) be 0.25g/kg body weight group * 400,3) 0.50g/kg body weight group * 400,4) 1.00g/kg body weight group * 400.
The specific embodiment
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
With coarse tea extract 334 gram, mulberry-leaf extract 333 grams, cornstarch 333 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing is promptly.
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
With coarse tea extract 100 gram, mulberry-leaf extract 100 grams, cornstarch 200 grams, mix, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing is promptly.
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 500 gram, mulberry-leaf extract 250 grams, cornstarch 250 grams are mixed, add 95% alcohol, 50～100ml and granulate, 50～55 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing promptly.
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 250g, mulberry-leaf extract 500g, cornstarch 250g are mixed, add 95% alcohol, 50～100ml and granulate, 5～560 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing promptly.
Embodiment 5
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 400g, mulberry-leaf extract 400g, cornstarch 200g are mixed, add 95% alcohol, 50～100ml and granulate, 50～55 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing promptly.
Embodiment 6
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 350g, mulberry-leaf extract 350g, cornstarch 300g are mixed, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing promptly.
Embodiment 7
Must meet the related standards regulation to various supplementary materials such as coarse tea, coarse tea extract, mulberry-leaf extract, cornstarch in the prescription is is just checked and accepted.With coarse tea through water carry, technologies such as alcohol is analysed, purifying, refining, drying, pulverizing obtain the coarse tea extract.
Select tealeaves to be up to the standards, weighing adds 5 times of amount 95% alcohol and mixes thoroughly, 30 ℃ of water-baths, and backflow lixiviate 1 hour, suction filtration is got filter residue while hot, and alcohol reclaims.Add 10 times of water gagings, 50 ℃ of water-bath backflow lixiviates 1 hour, suction filtration is while hot got filter residue and is repeated water and carry 2 times, gets filtrate, merge 3 times filtrate, 50 ℃ of water-baths are evaporated to thick shape, add 95% alcohol and make and contain alcohol amount and reach 80%, mixing, leave standstill, spend the night, precipitation is removed supernatant, gets precipitation, alcohol reclaims, and (adds alcohol and mixes thoroughly 15-30 minute, precipitate 2-3 hour, remove supernatant for 3 times with the washing of 95% alcohol again, alcohol reclaims, and taking precipitate repeats 3 times), freeze drying, pulverize, get finished product, check, stand-by.
Coarse tea extract 900 gram, mulberry-leaf extract 900 grams, cornstarch 350 grams are mixed, add 95% alcohol, 50～100ml and granulate, 55～60 ℃ of temperature are cured drying, are crossed 15～30 orders, whole grain, fill, and packing obtains.
Claims (2)
1. an auxiliary hyperglycemic and improve the strong sugared tea capsule of health food of diabetic symptom is characterized in that it is made up of coarse tea extract, mulberry-leaf extract, starch and auxiliary material; Weight proportion is that coarse tea extract 100～900 grams, mulberry-leaf extract 100～900 grams, starch 200～350 grams and auxiliary material make.
2. auxiliary hyperglycemic according to claim 1 and the preparation method who improves the strong sugared tea capsule of diabetic symptom, it is characterized in that adopting low temperature extraction, purifying, refining scientific technology to obtain thick polysaccharide, with thick polysaccharide and mulberry leaf polysaccharide is primary raw material, coarse tea extract, mulberry-leaf extract, starch are filled a prescription by weight ratio, fully mixing, add proper amount of edible alcohol and granulate, cross 15～30 orders, 50～60 ℃ of oven dry, make capsule promptly.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316152A (en) * | 2012-03-20 | 2013-09-25 | 黑龙江福和华星制药集团股份有限公司 | Adjuvant hypoglycemic composition and methods for preparing and detecting the same |
| CN103652089A (en) * | 2013-12-10 | 2014-03-26 | 华中农业大学 | Tea polysaccharide lozenge and preparation method thereof |
| CN104738776A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation method thereof |
| CN104738775A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation technology thereof |
| CN104738773A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation technology thereof |
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| CN1219446C (en) * | 2003-08-15 | 2005-09-21 | 黄秀兰 | Technique for processing health-care tea made of small pieces of folium mori |
| CN101519458A (en) * | 2009-03-26 | 2009-09-02 | 天津大学 | Method for extracting tea polysaccharides and tea polyphenol from coarse old green tea |
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|---|---|---|---|---|
| CN1219446C (en) * | 2003-08-15 | 2005-09-21 | 黄秀兰 | Technique for processing health-care tea made of small pieces of folium mori |
| CN101519458A (en) * | 2009-03-26 | 2009-09-02 | 天津大学 | Method for extracting tea polysaccharides and tea polyphenol from coarse old green tea |
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| 《中国实验方剂学杂志》 20081231 陈敏 等 桑叶、茶叶及枸杞粗多糖样品的含量分析 6-7 1-2 , * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316152A (en) * | 2012-03-20 | 2013-09-25 | 黑龙江福和华星制药集团股份有限公司 | Adjuvant hypoglycemic composition and methods for preparing and detecting the same |
| CN103652089A (en) * | 2013-12-10 | 2014-03-26 | 华中农业大学 | Tea polysaccharide lozenge and preparation method thereof |
| CN103652089B (en) * | 2013-12-10 | 2015-06-03 | 华中农业大学 | Tea polysaccharide lozenge and preparation method thereof |
| CN104738776A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation method thereof |
| CN104738775A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation technology thereof |
| CN104738773A (en) * | 2013-12-26 | 2015-07-01 | 天津中新药业研究中心 | Plant beverage and preparation technology thereof |
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| CN101843310B (en) | 2013-03-13 |
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