CN105455120A - Golden camellia tea assisted blood sugar lowering capsule - Google Patents
Golden camellia tea assisted blood sugar lowering capsule Download PDFInfo
- Publication number
- CN105455120A CN105455120A CN201510682772.2A CN201510682772A CN105455120A CN 105455120 A CN105455120 A CN 105455120A CN 201510682772 A CN201510682772 A CN 201510682772A CN 105455120 A CN105455120 A CN 105455120A
- Authority
- CN
- China
- Prior art keywords
- capsule
- golden camellia
- camellia tea
- blood sugar
- sugar lowering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002775 capsule Substances 0.000 title claims abstract description 40
- 240000001548 Camellia japonica Species 0.000 title claims description 26
- 239000008280 blood Substances 0.000 title abstract description 13
- 210000004369 blood Anatomy 0.000 title abstract description 13
- 235000000346 sugar Nutrition 0.000 title abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 229920001353 Dextrin Polymers 0.000 claims abstract description 6
- 239000004375 Dextrin Substances 0.000 claims abstract description 6
- 235000019425 dextrin Nutrition 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000007908 dry granulation Methods 0.000 claims abstract description 4
- 238000005550 wet granulation Methods 0.000 claims abstract description 3
- 230000003345 hyperglycaemic effect Effects 0.000 claims description 15
- 241001328788 Camellia nitidissima Species 0.000 claims description 8
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 5
- 235000013824 polyphenols Nutrition 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 11
- 239000003814 drug Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 241000209507 Camellia Species 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000011049 filling Methods 0.000 abstract 1
- 235000013402 health food Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000002218 hypoglycaemic effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- 235000013616 tea Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229960004329 metformin hydrochloride Drugs 0.000 description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 2
- 235000019224 Camellia sinensis var Qingmao Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012490 blank solution Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000020339 pu-erh tea Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a golden camellia tea assisted blood sugar lowering capsule, and belongs to the technical field of health drugs. The golden camellia tea assisted blood sugar lowering capsule is prepared through the following steps: decocting golden camellia tea dry leaves, concentrating the obtained decoction, and drying the obtained concentrate to prepare drug powder; and mixing the drug powder with soluble starch or dextrin according to a weight ratio of 2:1, stirring above materials until uniformity, carrying out 30-75% ethanol wet granulation or dry granulation, drying obtained granules, and filling capsules with the granules. The golden camellia tea assisted blood sugar lowering capsule has the efficacy of blood sugar lowering, blood fat lowering, heat clearing and detoxifying, has a good effect on initial stage diabetes patients, can prevent diabetes, and can be taken as a health food for a long term; and the capsule has the advantages of low preparation cost, safety and no side effects.
Description
Technical field
The present invention relates to health medicine technical field, specifically a kind of golden camellia tea auxiliary hyperglycemic capsule.
Background technology
Diabetes are one of principal diseases threatening human health, and along with socioeconomic fast development, growth in the living standard and the prolongation of the average life span, population obese degree and aging degree increase, and the illness rate of diabetes rises year by year.Therefore, solve China's diabetes problem also to need to find more cheap, more effective medicine.In recent years, natural products and plant extracts have been subjected to extensive accreditation to the intervention functions of diabetes, from natural plants, find low toxicity, effectively preventing diabetes means more and more come into one's own, especially some teas plants such as Pu'er tea, vine tea, sweet tea, be proved to be the function regulating blood sugar or auxiliary adjustment blood sugar, the food being key component exploitation with them and health products obtain market accreditation widely.
Camellia nitidissima is camellia section Camellia Plants.Camellia nitidissima is rich in the various active composition such as natural trace element and amino acid, TS, flavonoids, is one of Zhuang folk tradition herbal medicine, has the effects such as clearing heat and detoxicating, diuresis dampness removing, is usually used in the treatment of the diseases such as sphagitis, dysentery, oedema, hypertension.Modern study finds, Camellia nitidissima has multiple pharmacologically active, comprise Tumor suppression, antibacterial, anti-oxidant, strengthen immunity of organism, reduce the effect such as blood fat.Zhuang nationality in Guangxi diabetic among the people often drinks Camellia nitidissima in order to health care, golden camellia tea is made capsule, facilitates extensive patients to take.
Summary of the invention
The technical problem to be solved in the present invention be to provide a kind of auxiliary drug effect significantly, the golden camellia tea auxiliary hyperglycemic capsule of the health-care efficacy such as hypoglycemic that has no side effect, has.
The present invention takes following technical scheme:
The hypoglycemic capsule of a kind of golden camellia tea, adopts golden camellia tea, soluble starch or dextrin obtained.
Further, the hypoglycemic capsule of described golden camellia tea adopts Camellia nitidissima cured leaf, by decoction, concentrated, dry obtained medicinal powder; Described medicinal powder, soluble starch, with weight ratio 2:1 mixing and stirring, with 30%-75% ethanol for wetting agent wet granulation or dry granulation, dry granular incapsulates.
Further, described capsule is No. 1 capsule, and entering dose is every 0.3g.
Further, described capsule 's content is pale yellow powder or particle, and every capsules polyphenol content is 19.4mg ~ 23.7mg.
Golden camellia tea auxiliary hyperglycemic capsule content of the present invention measures:
Prepared by reference substance solution: take the gallic acid standard items being dried to constant weight and be about 10mg, accurately weighed, is placed in 100mL volumetric flask, is dissolved in water to scale, shakes up, obtain reference substance solution, stand-by.
Prepared by need testing solution: get the hypoglycemic capsule 's content of 0.3g golden camellia tea, accurately weighed, put with 10mL centrifuge tube, add 70% methanol solution 5mL preheated in 100 DEG C, stir with glass bar moistening, move in 70 DEG C of water-baths immediately, after lixiviate 20min (stirring once every 5min) lixiviate, be cooled to room temperature, proceed to centrifuge under 3500r/min rotating speed centrifugal 10 minutes, supernatant is transferred to 10mL volumetric flask.Residue extracts once with 70% methanol solution of 5mL again, repeats above operation.Merge extract and be settled to 10mL, shake up, precision measures the above-mentioned solution of 1mL, is placed in 10mL volumetric flask, is diluted with water to scale, shake up, and filters stand-by.
Assay method: pipette reference substance solution, each 1.0mL of need testing solution in scale in vitro, each in vitro add 5.0mL respectively newly join 10% forint phenol reagent, shake up.Reaction 3-8min, add 4.0mL7.5% sodium carbonate liquor, add water and be settled to scale, shake up, ambient temperatare puts 1h.And do blank with distilled water.Blank solution, reference substance solution, need testing solution are done UV scanning under 754nm, measures, to obtain final product.
Repeat 5 above-mentioned tests, obtain polyphenol content in every capsules and be respectively: 22.5mg, 21.8mg, 21.5mg, 19.4mg, 23.0mg, mean value is 21.6mg.
This capsule is used for the clinical testing of institute of traditional Chinese medicine of tourist resources, 60 routine diabetics are chosen from diabetic, be divided into golden camellia tea hypoglycemic capsule for treating group (giving Primary Care, metformin hydrochloride tablet, the hypoglycemic capsule for treating of golden camellia tea) and control group (giving Primary Care, metformin hydrochloride tablet treatment) each 30 examples at random, treatment group man 11 example, female 19 example; 30 ~ 70 years old age, average 56.5 ± 73.1 years old; The course of disease is the shortest 2 years, the longest 25 years, average 10.25 ± 7.68 years.Every 0.3g, 1 time 3, every day 3 times, oral, within one month, be 1 course for the treatment of; Control group man 12 example, female 18 example; 31 ~ 69 years old age, average 55.8 ± 7.1 years old; The course of disease is the shortest 1 year, the longest 24 years, average 10.15 ± 7.14 years.Within one month, be 1 course for the treatment of, all treat 3 courses for the treatment of for two groups, terminate rear observation two groups of curative effects, blood glucose target situation of change whole course for the treatment of, and carry out safety evaluatio.Result: effective 5 examples for the treatment of group, effective 23 examples, invalid 2 examples, total effective rate 93.33%; Effective 2 examples of control group, effective 17 examples, invalid 11 examples, total effective rate 63.33%; Two groups of differences have statistical significance (P < 0.05).Treatment group FBG (fasting blood-glucose), F2BG (after the meal 2 hours blood glucoses) index compares with control group and declines obviously, and difference all has statistical significance (P < 0.05).Show that golden camellia tea auxiliary hyperglycemic capsule has good auxiliary hyperglycemic effect, and security is high.
The invention has the beneficial effects as follows:
A kind of golden camellia tea auxiliary hyperglycemic capsule of the present invention, has reducing blood sugar and blood fat, the curative effect such as clearing heat and detoxicating, and for diabetes mellitus patient, and prevention diabetes all have good effect, can be used as health products long-term taking; And this product preparation cost is low, safety has no side effect.
Detailed description of the invention
Embodiment one
A kind of golden camellia tea auxiliary hyperglycemic capsule, adopts golden camellia tea, soluble starch to obtain.Adopt Camellia nitidissima cured leaf to be crushed to 30 orders, by decocting, concentrated, filter, dry obtained medicinal powder; Again described medicinal powder, soluble starch are granulated for wetting agent with weight ratio 2:1 mixing and stirring, 75% appropriate amount of ethanol; The powder that will wet is dry at 60 DEG C, crosses 16 mesh sieves, be filled into No. 1 capsule for medicine by 0.3g/ grain specification after dry.Obtained golden camellia tea auxiliary hyperglycemic capsule 's content is pale yellow powder or particle, and every capsules polyphenol content is 19.4mg ~ 23.7mg.
Embodiment two
A kind of golden camellia tea auxiliary hyperglycemic capsule, adopts golden camellia tea, dextrin to obtain.Adopt Camellia nitidissima cured leaf to be crushed to 30 orders, by decocting, concentrated, filter, dry obtained medicinal powder; Again by described medicinal powder, dextrin with weight ratio 2:1 mixing and stirring, adopt dry granulation; And obtained powder is crossed 16 mesh sieves, be filled into No. 1 capsule for medicine by 0.3g/ grain specification.Obtained golden camellia tea auxiliary hyperglycemic capsule 's content is pale yellow powder or particle, and every capsules polyphenol content is 19.4mg ~ 23.7mg.
Claims (4)
1. a golden camellia tea auxiliary hyperglycemic capsule, is characterized in that, adopts golden camellia tea, soluble starch or dextrin obtained.
2. a kind of golden camellia tea auxiliary hyperglycemic capsule as claimed in claim 1, is characterized in that, adopts Camellia nitidissima cured leaf, by decoction, concentrated, dry obtained medicinal powder; Described medicinal powder, soluble starch or dextrin, with weight ratio 2:1 mixing and stirring, with 30%-75% ethanol for wetting agent wet granulation or dry granulation, dry granular incapsulates.
3. a kind of golden camellia tea auxiliary hyperglycemic capsule as claimed in claim 1 or 2, it is characterized in that, described capsule is No. 1 capsule, and entering dose is every 0.3g.
4. a kind of golden camellia tea auxiliary hyperglycemic capsule as claimed in claim 1 or 2, it is characterized in that, described capsule 's content is pale yellow powder or particle, and every capsules polyphenol content is 19.4mg ~ 23.7mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510682772.2A CN105455120A (en) | 2015-10-20 | 2015-10-20 | Golden camellia tea assisted blood sugar lowering capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510682772.2A CN105455120A (en) | 2015-10-20 | 2015-10-20 | Golden camellia tea assisted blood sugar lowering capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105455120A true CN105455120A (en) | 2016-04-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510682772.2A Pending CN105455120A (en) | 2015-10-20 | 2015-10-20 | Golden camellia tea assisted blood sugar lowering capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105455120A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106035877A (en) * | 2016-07-08 | 2016-10-26 | 广西桂人堂金花茶产业集团股份有限公司 | Preparation process of golden camellia instant granules for regulating intestinal factors |
| CN107737193A (en) * | 2017-11-24 | 2018-02-27 | 广西中港高科国宝金花茶产业有限公司 | A kind of application of golden flower tea extractions in hyperlipidemia is treated |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101558875A (en) * | 2009-05-08 | 2009-10-21 | 广西桂人堂金花茶产业集团股份有限公司 | Granule prepared by camellia chrysantha tea and preparation method thereof |
| CN102293866A (en) * | 2011-05-30 | 2011-12-28 | 防城港市万景林业有限公司 | Camellia chrysantha capsule assisting hypoglycemic effect and preparation method thereof |
| CN104027478A (en) * | 2013-03-06 | 2014-09-10 | 广西医科大学 | Camellia nitidissima tea active site, preparation method and application thereof |
| CN104274611A (en) * | 2014-10-31 | 2015-01-14 | 防城港市万景林业有限公司 | Golden camellia leaf extract and application thereof |
| CN104383123A (en) * | 2014-11-14 | 2015-03-04 | 程金生 | Method for preparing golden camellia lipid-lowering blood sugar-reducing preparation |
-
2015
- 2015-10-20 CN CN201510682772.2A patent/CN105455120A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101558875A (en) * | 2009-05-08 | 2009-10-21 | 广西桂人堂金花茶产业集团股份有限公司 | Granule prepared by camellia chrysantha tea and preparation method thereof |
| CN102293866A (en) * | 2011-05-30 | 2011-12-28 | 防城港市万景林业有限公司 | Camellia chrysantha capsule assisting hypoglycemic effect and preparation method thereof |
| CN104027478A (en) * | 2013-03-06 | 2014-09-10 | 广西医科大学 | Camellia nitidissima tea active site, preparation method and application thereof |
| CN104274611A (en) * | 2014-10-31 | 2015-01-14 | 防城港市万景林业有限公司 | Golden camellia leaf extract and application thereof |
| CN104383123A (en) * | 2014-11-14 | 2015-03-04 | 程金生 | Method for preparing golden camellia lipid-lowering blood sugar-reducing preparation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106035877A (en) * | 2016-07-08 | 2016-10-26 | 广西桂人堂金花茶产业集团股份有限公司 | Preparation process of golden camellia instant granules for regulating intestinal factors |
| CN107737193A (en) * | 2017-11-24 | 2018-02-27 | 广西中港高科国宝金花茶产业有限公司 | A kind of application of golden flower tea extractions in hyperlipidemia is treated |
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Application publication date: 20160406 |