CN102293866A - Camellia chrysantha capsule assisting hypoglycemic effect and preparation method thereof - Google Patents
Camellia chrysantha capsule assisting hypoglycemic effect and preparation method thereof Download PDFInfo
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- CN102293866A CN102293866A CN2011101410156A CN201110141015A CN102293866A CN 102293866 A CN102293866 A CN 102293866A CN 2011101410156 A CN2011101410156 A CN 2011101410156A CN 201110141015 A CN201110141015 A CN 201110141015A CN 102293866 A CN102293866 A CN 102293866A
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Abstract
The invention relates to a camellia chrysantha activity of assisting hypoglycemic effect, and a camellia chrysantha capsule assisting hypoglycemic effect and a preparation method thereof. A prescription of the camellia chrysantha capsule assisting hypoglycemic effect is as below: 33-66% of camellia chrysantha extractive and 67-34% of pharmaceutic adjuvant. The preparation method comprises steps of: weighing the camellia chrysantha extractive and the pharmaceutic adjuvant according to the prescription, and preparing into hard capsules. The camellia chrysantha extractive is obtained by immersing, extracting and concentrating the camellia chrysantha with a proper solvent; the pharmaceutic adjuvant is medicinal starch or dextrin, or a mixture of the two; and the solvent is water or ethanol, or a mixture of the two. The camellia chrysantha capsule has substantial hypoglycemic effect on high blood sugar mice caused by alloxan. The camellia chrysantha capsule of the invention and the assistant hypoglycemic effect thereof have not been reported and are discovered by the inventor through experiments; therefore, the invention is applied to be protected by patent right.
Description
Technical field
The present invention relates to a kind of leaf of Camellia nitidissima Chi capsule, be specifically related to a kind of active leaf of Camellia nitidissima Chi extract capsule of auxiliary hyperglycemic agent preparation method that has.
Background technology
Diabetes are one of principal diseases that threaten human health, and along with the prolongation of socioeconomic fast development, growth in the living standard and the average life span, population obese degree and aging degree increase, and the prevalence of diabetes rises year by year.By the end of 2003, there were nearly 200,000,000 diabeticss in the whole world, expects the year two thousand thirty, and global diabetics number will increase to 3.6 hundred million.One piece of recent posts that New England Journal of Medicine (New England journal of medicine) was delivered in 2010 points out that the ratio of China's diabetics in the adult is 9.7%, and the prediabetes patient is 15.5%; Crowd's sickness rate is up to 20.4% more than 60 years old, and being equivalent to just has a patient among per 5 old men.The diabetics of China has reached 9,200 ten thousand, and prediabetes patient number more reaches 1.48 hundred million, and China has surpassed India, becomes the maximum country of global diabetes patient.Diabetes have become a serious day by day public health problem, take practicable means prevention and treatment diabetes extremely urgent.
The prevention of diabetes is based on life intervention means at present, interference method and effect are all indeterminate, and the medicine of treatment diabetes is a lot, but because diabetics need be taken medicine mostly throughout one's life, the medical expense costliness, and adverse effect is more, and the appearance of drug resistance and insulin resistant has simultaneously seriously reduced the curative effect of medicine.Therefore, solve China's diabetes problem and also need to seek more cheap, more effective medicine.In recent years, natural product and plant extract have been subjected to extensive approval to the intervention functions of diabetes, from natural plants, seek low toxicity, effectively preventing diabetes means more and more come into one's own, especially some teas plants such as Folium camelliae assamicae, Ampelopsis grossedentata, Folium hydrangeae strigosae, being proved to be the function of blood sugar regulation or auxiliary adjustment blood glucose, is that food and the health product that key component is developed have obtained market approval widely with them.
Camellia nitidissima Chi [Camellia chrysantha (Hu) Tuyama] is a Flos Camelliae Japonicae section Camellia plant, and nineteen sixty finds in Guangxi that first the wild Camellia nitidissima Chi in the whole world 95% all is distributed in the area, Guangxi so far, is the peculiar resource in the Guangxi of preciousness.Camellia nitidissima Chi is rich in various active compositions such as natural trace element and aminoacid, tea Saponin, flavonoid, is one of Zhuang folk tradition medical herbs, has effects such as heat-clearing and toxic substances removing, diuresis dampness removing, is usually used in treatment of diseases such as pharyngolaryngitis, dysentery, edema, hypertension.Modern study finds that Camellia nitidissima Chi has multiple pharmacologically active, comprises effects such as suppressing tumor, antibacterial, antioxidation, enhancing human body immunity, blood fat reducing.What is more important, Zhuang nationality in Guangxi diabetics among the people is often drunk Camellia nitidissima Chi in order to health care, our animal preliminary experiment in early stage is also found first, in the hyperglycemia mouse model that alloxan causes, the leaf of Camellia nitidissima Chi water extract can suppress the rising of diabetic mice fasting glucose, and (model is lived blood glucose value: 35.14 ± 10.34mmol/L, Camellia nitidissima Chi group blood glucose value 26.28 ± 10.83mmol/L), and the use of leaf of Camellia nitidissima Chi water extract can keep the stable of diabetic mice body weight, shows that it does not have tangible toxic reaction in the control animal blood glucose.Do not see the research of its hypoglycemic activity at present in the active report of the leaf of Camellia nitidissima Chi of announcing.For making this hypoglycemic activity of leaf of Camellia nitidissima Chi serve vast diabetics, consider leaf of Camellia nitidissima Chi is made the capsule of auxiliary hyperglycemic.
Summary of the invention
The purpose of this invention is to provide a kind of employing modern pharmaceutical technology, unique production process protects the kind leaf of Camellia nitidissima Chi to make to meet national health food standard and determined curative effect, steady quality, capsule safe in utilization, easy to carry with Guangxi.
Technical solution of the present invention is: leaf of Camellia nitidissima Chi capsule of a kind of auxiliary hyperglycemic and preparation method thereof is characterized in that being prepared from by following compositions in weight percentage: leaf of Camellia nitidissima Chi extract 33%～66%, pharmaceutic adjuvant 67%～34%.
The leaf of Camellia nitidissima Chi extract has the function of auxiliary hyperglycemic in the side.Not seeing before this has report, and this is that the inventor herein finds by zoopery, therefore, and the special requisition patent protection.
Its preparation method is: takes by weighing leaf of Camellia nitidissima Chi extract, pharmaceutic adjuvant by the prescription percentage by weight, makes soft material, and the system wet granular, drying, granulate is sub-packed in the hard capsule case.Wherein, the leaf of Camellia nitidissima Chi extract means uses suitable solvent, to leaf of Camellia nitidissima Chi soak → heat carries → floods → heat carries → concentrate the extract that supervisor processing obtains; Pharmaceutic adjuvant means medical starch or dextrin or both mixture; Solvent means water or ethanol or both mixture.
The specific embodiment
Embodiment one
The leaf of Camellia nitidissima Chi extract causes the hypoglycemic activity of hyperglycemia mice to alloxan
1.1 reagent: alloxan (U.S. Sigma company product); Metformin (Zhonghui Pharmaceutical Co.,Ltd., Beijing's product); Blood sugar test test kit (glucose oxidase method, Sichuan Maker Biological Science and Technology Co., Ltd.'s product).
1.2 laboratory animal: the Kunming kind is a white mice, body weight 20 ± 2g, male and female half and half.Provide by Colleges Of Traditional Chinese Medicine Of Guangxi's Experimental Animal Center.
1.3 modeling, grouping and administration: getting normal Kunming kind is mice, after water 12h is can't help in fasting, every mice is pressed the alloxan normal saline solution of the new preparation of dosage intravenous injection of 65mg/kg body weight, after 72h is finished in injection, water 12h is can't help in fasting, detect fasting blood sugar, the mice of fasting blood sugar in 10.0～25.0mmol/L scope is the hyperglycemia mice of modeling success.Get the mice random packet of modeling success, every group 15, establish dosage group, leaf of Camellia nitidissima Chi extract low dose group in blank group (irritating the stomach normal saline), model group (irritating the stomach normal saline), positive control (metformin 600mg/kg) group, leaf of Camellia nitidissima Chi extract high dose group, the leaf of Camellia nitidissima Chi extract.Each treated animal is all to gastric infusion, and 1 time/day, continuous 28 days.After the administration respectively at the fasting blood sugar that detected after water 12h is can't help in fasting in the 7th, 14,21 and 28 day.
1.4 statistical analysis: experimental result is all represented with mean+SD.Adopt each group difference of t check analysis.
1.5 experimental result: the leaf of Camellia nitidissima Chi extract sees Table one to the blood sugar influence that alloxan causes the hyperglycemia mice.Continuous 4 weeks are irritated the stomach treatment to the hyperglycemia mice with the leaf of Camellia nitidissima Chi extract, compare with model group, remarkable blood sugar reducing function (P＜0.05) was promptly arranged after dosage group and the high dose group medication in the leaf of Camellia nitidissima Chi extract in the 3rd week, continue medication to the 4th week, in the blood sugar reducing function still extremely significantly (P＜0.05) of dosage, high dose group still has blood sugar lowering trend after around the medication, but with model group difference not significantly (P＞0.05).
Table one leaf of Camellia nitidissima Chi extract is to the influence of alloxan hyperglycemia mouse blood sugar
Annotate:
*P＜0.05,
*P＜0.01,
* *P＜0.001 with blank group of time relatively:
#P＜0.05,
##P＜0.01,
###P＜0.001, and relatively with the time model group.
1.6 conclusion: the leaf of Camellia nitidissima Chi extract of doses has significant hypoglycemic activity, and leaf of Camellia nitidissima Chi can be used as the primary raw material of auxiliary hyperglycemic food, health food.
Embodiment two
Depletion scented tea leaf is an amount of, through immersions → heat carry → flood → heat carries → concentrates supervisor, obtains the leaf of Camellia nitidissima Chi extract, by 50% adding starch of total amount, makes soft material, makes wet granular, drying, granulate is sub-packed in the hard capsule case.
Embodiment three
Depletion scented tea leaf is an amount of, through immersions → heat carry → flood → heat carries → concentrates supervisor, obtains the leaf of Camellia nitidissima Chi extract, by 35% adding dextrin of total amount, makes soft material, makes wet granular, drying, granulate is sub-packed in the hard capsule case.
Embodiment four
Depletion scented tea leaf is an amount of, through immersions → heat carry → flood → heat carries → concentrates supervisor, obtains the leaf of Camellia nitidissima Chi extract, by 40% adding starch, the dextrin mixture of total amount, makes soft material, makes wet granular, drying, granulate is sub-packed in the hard capsule case.
Claims (7)
1. the preparation method of the capsule of the activity of a leaf of Camellia nitidissima Chi extract auxiliary hyperglycemic and leaf of Camellia nitidissima Chi extract auxiliary hyperglycemic.
2. as right 1 described leaf of Camellia nitidissima Chi extract, mean and use suitable solvent, to leaf of Camellia nitidissima Chi soak → heat carries → floods → heat carries → concentrate the extract that supervisor processing obtains.
3. as the activity of right 1 described leaf of Camellia nitidissima Chi extract auxiliary hyperglycemic, mean that described extract comprises the auxiliary hyperglycemic activity of leaf of Camellia nitidissima Chi, with described extract is the auxiliary hyperglycemic activity of the food of main component preparation, is the auxiliary hyperglycemic activity of the health food of main component preparation with described extract.
4. as the activity of right 1 described leaf of Camellia nitidissima Chi extract auxiliary hyperglycemic, it is characterized in that the inhibition of the hyperglycemia index of correlation that described extract is generally acknowledged fasting blood sugar and modern medicine.
5. as the capsule of right 2 described leaf of Camellia nitidissima Chi extracts, it is characterized in that being prepared from: leaf of Camellia nitidissima Chi extract 33%～66%, pharmaceutic adjuvant 67%～34% by following compositions in weight percentage.
6. the preparation method as right 2 described leaf of Camellia nitidissima Chi blood sugar lowering capsules is: take by weighing leaf of Camellia nitidissima Chi extract, pharmaceutic adjuvant by above-mentioned percentage by weight, make soft material, and the system wet granular, drying, granulate is sub-packed in the hard capsule case.As described solvent in the right 2, mean water or ethanol or both mixture.
7. as right 3 described pharmaceutic adjuvants, mean medical starch or dextrin or both mixture.
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| CN2011101410156A CN102293866A (en) | 2011-05-30 | 2011-05-30 | Camellia chrysantha capsule assisting hypoglycemic effect and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549087A (en) * | 2013-11-11 | 2014-02-05 | 红河五里冲生态茶业有限公司 | Golden camellia paste and preparation method |
| CN104027478A (en) * | 2013-03-06 | 2014-09-10 | 广西医科大学 | Camellia nitidissima tea active site, preparation method and application thereof |
| CN104274611A (en) * | 2014-10-31 | 2015-01-14 | 防城港市万景林业有限公司 | Golden camellia leaf extract and application thereof |
| CN105250497A (en) * | 2015-10-20 | 2016-01-20 | 广西中医药大学 | Preparation process of camellia nitidissima capsules for assisting in reduction of blood glucose |
| CN105455120A (en) * | 2015-10-20 | 2016-04-06 | 广西中医药大学 | Golden camellia tea assisted blood sugar lowering capsule |
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| CN1460438A (en) * | 2003-06-18 | 2003-12-10 | 广西富新科技股份有限公司 | Lonicera tea uncentrate liguor |
| CN1476767A (en) * | 2003-06-05 | 2004-02-25 | 广西富新科技股份有限公司 | Extract liquor of camellia chrysantha |
| CN1669453A (en) * | 2005-04-22 | 2005-09-21 | 黄扶民 | Health product containing camellia chrysantha |
| CN101156686A (en) * | 2007-11-15 | 2008-04-09 | 黄曦 | A nutritional agent containing superoxide dismutase |
| CN101558875A (en) * | 2009-05-08 | 2009-10-21 | 广西桂人堂金花茶产业集团股份有限公司 | Granule prepared by camellia chrysantha tea and preparation method thereof |
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2011
- 2011-05-30 CN CN2011101410156A patent/CN102293866A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1476767A (en) * | 2003-06-05 | 2004-02-25 | 广西富新科技股份有限公司 | Extract liquor of camellia chrysantha |
| CN1460438A (en) * | 2003-06-18 | 2003-12-10 | 广西富新科技股份有限公司 | Lonicera tea uncentrate liguor |
| CN1669453A (en) * | 2005-04-22 | 2005-09-21 | 黄扶民 | Health product containing camellia chrysantha |
| CN101156686A (en) * | 2007-11-15 | 2008-04-09 | 黄曦 | A nutritional agent containing superoxide dismutase |
| CN101558875A (en) * | 2009-05-08 | 2009-10-21 | 广西桂人堂金花茶产业集团股份有限公司 | Granule prepared by camellia chrysantha tea and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027478A (en) * | 2013-03-06 | 2014-09-10 | 广西医科大学 | Camellia nitidissima tea active site, preparation method and application thereof |
| CN103549087A (en) * | 2013-11-11 | 2014-02-05 | 红河五里冲生态茶业有限公司 | Golden camellia paste and preparation method |
| CN104274611A (en) * | 2014-10-31 | 2015-01-14 | 防城港市万景林业有限公司 | Golden camellia leaf extract and application thereof |
| CN105250497A (en) * | 2015-10-20 | 2016-01-20 | 广西中医药大学 | Preparation process of camellia nitidissima capsules for assisting in reduction of blood glucose |
| CN105455120A (en) * | 2015-10-20 | 2016-04-06 | 广西中医药大学 | Golden camellia tea assisted blood sugar lowering capsule |
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Application publication date: 20111228 |